ライフサイエンスコーパス: grossly normal

1 including disorders where the brain appears grossly normal.

2 gene expression profile of RGC precursors is grossly normal.

3 Mice deficient for Ptp4a3 were grossly normal.

4 Lim2-null lenses were grossly normal.

5 which we found to be unexpectedly viable and grossly normal.

6 including looping and chamber formation are grossly normal.

7 ce, but the myelin that was present appeared grossly normal.

8 e generated in expected numbers and appeared grossly normal.

9 re born at expected frequencies and appeared grossly normal.

10 eart chambers (left ventricle and atria) are grossly normal.

11 fically in the retina, survived and appeared grossly normal.

12 periostin-deficient (peri(lacZ)) embryos are grossly normal.

13 he morphology of the olfactory epithelium is grossly normal.

14 ough cell division and the cell cycle appear grossly normal.

15 n non-neuronal tissues are viable and appear grossly normal.

16 However, SA/SA mice were viable and grossly normal.

17 The transgenic mice were grossly normal.

18 Auditory tissues were grossly normal (26/26) but had microscopic haemorrhages

19 ugh the early steps of ovary development are grossly normal, a defect becomes apparent in meiosis II

20 nches of the developing limb nerves appeared grossly normal, a dorsal nerve identified as the anterio

21 inoma (HNSCC) malignant lesions, but also in grossly normal adjacent buccal mucosa.

22 t embryonic day 9-10, half survive to become grossly normal adult mice with no bleeding diathesis.

23 d veterinary pathologic approaches comparing grossly normal and abnormal animals collected from 23 si

24 Adult knockout mice (beta2-AR -/-) appear grossly normal and are fertile.

25 Mmp1a-deficient mice are grossly normal and born in Mendelian ratios; however, de

26 Homozygous R1441C KI mice appear grossly normal and exhibit no dopaminergic (DA) neurodeg

27 ygous mutant mice on C57BL/6 background were grossly normal and showed normal growth when fed a low-f

28 ygenase in platelets and epidermis, appeared grossly normal, and exhibited an increase in basal trans

29 The results of blood work-up were grossly normal, and the results of an extensive toxicolo

30 olesteryl ester was significantly greater in grossly normal aortic areas of D-HL swine compared with

31 The knockout mice had grossly normal appearance, but grew approximately 20% sl

32 Dense inflammatory cell infiltrates underlay grossly normal appearing, non-polypoid colonic and gastr

33 are present in areas of MS brains that were grossly normal appearing.

34 Mfap5(-/-) mice appear grossly normal, are fertile, and have no reduction in li

35 Sox1; however, expression of these genes is grossly normal, as is expression of Eya1, Eya2, Pax6, an

36 These mice appeared grossly normal at 2 weeks of age but exhibited growth re

37 re born at the expected Mendelian ratio, are grossly normal at birth but have shorter lifespans than

38 The Lkb1-deficient pancreas, although grossly normal at birth, demonstrates a defective acinar

39 deficient (Tle1(Delta/Delta)) mice, although grossly normal at birth, exhibit skin defects, lung hypo

40 While grossly normal at birth, we observed an unexpected pheno

41 -knockout EKLF(-/-) or KLF2(-/-) embryos are grossly normal at E10.5 and die later than EKLF(-/-)KLF2

42 tion of wild-type and mutant PPT enzymes was grossly normal at the level of the phosphotransferase re

43 Although displaying a grossly normal behavior, Df(h15q13)/+ mice are more aggr

44 Parkin-/- mice are viable and exhibit grossly normal brain morphology.

45 termined phenotypes of cultured neurons from grossly normal brains, suggesting that subtle in vivo at

46 x2 promoter, we generated mice that appeared grossly normal but had undetectable levels of Casr mRNA

47 Brain morphology is grossly normal, but a number of behaviors are abnormal,

48 These mice appeared grossly normal, but careful examination revealed a thinn

49 Newborn mutant livers appeared grossly normal, but displayed a dark-red color that was

50 We found that mutants lacking pgrn-1 appear grossly normal, but exhibit fewer apoptotic cell corpses

51 development in LIM kinase 1 knockout mice is grossly normal, but the animals have deficits in spatial

52 ctivity rhythms in mPER3-deficient mice were grossly normal, but the circadian cycle length was signi

53 rozygous Ripk1(D325A/+) mice were viable and grossly normal, but were hyper-responsive to inflammator

54 Thirty patients, 14 with grossly normal cardiac anatomy and 16 with major congeni

55 icates that although initial NP formation is grossly normal, cells in the Fgf8-expressing domain unde

56 ozygous mice are viable and fertile and have grossly normal cerebellar cytoarchitecture.

57 crocephaly (MCPH) show a small but otherwise grossly normal cerebral cortex associated with mild to m

58 n FAP patients in comparison to the adjacent grossly normal colonic mucosa.

59 es that are identifiedmicroscopically in the grossly normal colonic mucosas of rodents treated with c

60 copy of the gene (Cbr1 +/-) were healthy and grossly normal despite having decreased levels of Cbr1 t

61 Nonetheless, retinal histology was grossly normal, despite widespread persistent Math5 expr

62 and endophilin 3 (Sh3gl3) triple-KO mice had grossly normal embryonic development, these mutants fail

63 ian frequency, developed normally, possessed grossly normal epidermis and hair, and were healthy and

64 Field cancerization refers to areas of grossly normal epithelium that exhibit increased risk fo

65 KSR-deficient mice were grossly normal even though ERK kinase activation was att

66 rtile, with impaired MSCI despite displaying grossly normal events of early prophase I, including syn

67 growth and phenotype of AQP3 null mice were grossly normal except for polyuria.

68 en approximately 40 and 200 repeats, express grossly normal FMRP levels and such carriers are widely

69 tants kit(j1e99) and skiv2l2(j24e1) that are grossly normal for the overall ontogenetic pattern also

70 Although these mice are grossly normal for up to 18 months, the ectopic expressi

71 d proteinuria is present at birth, despite a grossly normal glomerular basement membrane.

72 yonic day (E) 10.5, both mutant embryos were grossly normal, had initiated primitive hematopoiesis, a

73 zebrafish generated by genome editing showed grossly normal heart development and adult cardiac anato

74 L-NCoRDeltaID mice appear grossly normal, however, when made hypothyroid the repre

75 uman PanINs by analysing 46 large samples of grossly normal human pancreas with a machine-learning pi

76 d globally that are commonly associated with grossly normal (i.e., healthy or asymptomatic) animals.

77 re of the articular joint cartilage appeared grossly normal in 1-mo-old miR-140(-/-) mice.

78 Neural development is grossly normal in heterozygotes and neural tube defects

79 east 15 lymph nodes, preferably with 5 cm of grossly normal in situ proximal esophagus for those with

80 Although the knockout mice were grossly normal in terms of survival, physical appearance

81 velopment and plasticity of the mouse V1b is grossly normal in the absence of C1q.SIGNIFICANCE STATEM

82 f the trigeminal and dorsal root ganglia was grossly normal in the absence of Islet1.

83 However, stereocilia patterning was grossly normal in the cochlea, indicating planar cell po

84 affected and olfactory marker expression was grossly normal in these animals.

85 that recruitment of primary visual cortex is grossly normal in Williams syndrome, consistent with the

86 verall number and spacing of neuroblasts was grossly normal, indicating that DE-cadherin-mediated adh

87 Unperturbed Tfeb (DeltaIEC) mice exhibited grossly normal intestinal epithelia, except for a defect

88 tant mice were viable, fertile, and appeared grossly normal into adulthood.

89 Hoxb3os -null mice were viable and had grossly normal kidney morphology but displayed activatio

90 ors were found to be CXCR2 positive, whereas grossly normal kidney tissues from tumor patients or ren

91 allele of Fgfr2 or Fgfr3 was sufficient for grossly normal lens development, while mice possessing o

92 s of 10 donors (age range, 58-93 years) with grossly normal maculas that were preserved in 4% parafor

93 Human eyes with grossly normal maculas were preserved <4 hours after don

94 Conditional Hus1 knockout females retained grossly normal mammary gland morphology, suggesting comp

95 bnormally placed pyramidal neurons exhibited grossly normal morphology and polarity.

96 Munc18-1(-/-) mouse mutants documented their grossly normal nervous system, but its molecular differe

97 Although Snx27(+/-) mice have grossly normal neuroanatomy, we found defects in synapti

98 E47 knockout mice have grossly normal numbers of self-renewing hematopoietic st

99 The grossly normal phenotype in human subjects deficient in

100 A grossly normal phenotype of alpha1-deficient mice sugges

101 variant (Copb2R254C/R254C) appear to have a grossly normal phenotype, likely due to differences in c

102 mutant Col14a1 genotypes were viable with a grossly normal phenotype; however, mature skin exhibited

103 Mutant photoreceptor axons formed grossly normal projections and synaptic terminals in the

104 We examined grossly normal rectal mucosa in patients with adenomas a

105 +/+)- and NF90(-/-)-RAG chimeric mice showed grossly normal repopulation of the thymus and spleen, bu

106 velopment, and adults in the laboratory have grossly normal skeletal muscle and life span.

107 Runx2(neo7/neo7) mice have grossly normal skeletons with no abnormalities observed

108 Heterozygous Runx2-II-deficient mice had grossly normal skeletons, but were osteopenic.

109 lassified as either Type I, characterized by grossly normal somite formation but having neural tube,

110 gnosis (4 [10%]) compared with patients with grossly normal specimens (4 of 49 [8%]; P < .001).

111 functional and metabolic abnormalities, but grossly normal structure, in the hippocampal formation (

112 midal neurons and initial axon outgrowth are grossly normal, suggesting that these processes are unde

113 Although unc-73 RhoGEF-2 mutants have grossly normal synaptic morphology and weak resistance t

114 pha-/- mice are markedly lymphopenic despite grossly normal T and B lymphocyte development.

115 Although grossly normal, these mice have a subtly altered prolife

116 Although Sdc1-/- mice are grossly normal, they are systemically smaller, suggestin

117 ga) and Jbeta1(DJbeta/DJbeta) mice exhibited grossly normal thymocyte development and TCRbeta allelic

118 c, and bcl-xl was significantly increased in grossly normal transgenic mammary glands starting the fi

119 OGR1 knockout mice (ogr1(-/-)) are grossly normal under physiological conditions, however,

120 Although swimming in water appeared grossly normal, use of automated methods for tracking th

121 though the overall cerebellar morphology was grossly normal, we observed that the entry into mitosis

122 sFRP-1 gene deletion mice were grossly normal with no difference in mortality but devel

123 Knock-out lenses appeared grossly normal with the exception of caspase-3(-/-) lens

124 Confocal microscopy was grossly normal, with evidence of early redistribution of

125 ed a high degree of engraftment and appeared grossly normal, with no evidence for spontaneous hemorrh

126 Brain development is otherwise grossly normal without signs of striatal interneuron los

127 gh Zar1-null (Zar1(-/-)) mice are viable and grossly normal, Zar1(-/-) females are infertile.