ライフサイエンスコーパス: guanidine

1 ation of an N-guanidyl pyrrole by a sulfonyl guanidine.

2 es a thiourea, which can be converted into a guanidine.

3 ept-5-enals catalyzed by the Misaki-Sugimura guanidine.

4 nal antibody by increasing concentrations of guanidine.

5 unit and the signature carbamoylated cyclic guanidine.

6 solvent and replacement of the peptide with guanidine.

7 ot observed with VWF predenatured with 1.5 M guanidine.

8 hereas IgG2-B was enriched in the absence of guanidine.

9 ch candidate, naturally sense and respond to guanidine.

10 cteria are capable of endogenously producing guanidine.

11 derives from the class of compounds known as guanidines.

12 anidine to deliver N(3)-protected cyclic ene-guanidines.

13 system for the amination of arylhalides with guanidines.

14 ive investigations of the analogous bicyclic guanidine 1,4,6-triazabicyclo[3.3.0]oct-4-ene (TBO) reve

15 The bicyclic guanidine 1,5,7- triazabicyclo[4.4.0]dec-5-ene (TBD) is

16 18)F-N-[3-bromo-4-(3-fluoro-propoxy)-benzyl]-guanidine ((18)F-LMI1195) is a new PET tracer designed f

17 -tetrahydro-[1,3,5]triazin-2-ylamino]-ethyl}-guanidine ((18)F-PC-10).

18 lopentyl]methyl}-3-[2-(pheny lsulfanyl)ethyl]guanidine ((1S,3S)-UR-RG98, 39a) was the most potent H4R

19 rs were 2-(7-methoxy-4-methylquinazolin-2-yl)guanidine (28) and (R)-2-(1-((2,3-dihydro-1H-imidazol-2-

20 of the muraymycins is the 6-membered cyclic guanidine, (2S,3S)-muraymycidine (or epi-capreomycidine)

21 ylalanine esters of [3-(hydroxymethyl)phenyl]guanidine (3-HPG) were synthesized and evaluated for tra

22 The small molecule 2-guanidine-4-methylquinazoline (GMQ) was recently shown t

23 h protons and the non-proton ASIC3 agonist 2-guanidine-4-methylquinazoline.

24 Here we demonstrate that chemically defined guanidine 5'-diphosphate-beta-l-fucose (GDP-fucose), the

25 l-piperidin-4-yl)-3-trifluoromethyl-benzoyl]-guanidine (60).

26 Amidine 6 and guanidine 7 were comparably effective against a panel of

27 N-(4-Aminobutyl)-N'-(2-methoxyethyl)guanidine (8a) is a potent inhibitor targeting the hDDAH

28 (1-(3-bromo-4-(3-(18)F-fluoro-propoxy)benzyl)guanidine), a metaiodobenzylguanidine (MIBG) analog, for

29 detected several metabolites (e.g., betaine, guanidine acetic acid, and 2-aminoheptanoic acid) that d

30 e this undesirable property, two of the acyl guanidines achieved free brain concentrations (Cfree,bra

31 gth (Asn/Asp much worse than Asn/Glu), while guanidine/acid pairs are largely insensitive.

32 n the same molecular framework, of a neutral guanidine acting as a general base and a protonated guan

33 ne acting as a general base and a protonated guanidine acting as an electrophilic activator.

34 earrangements and the free and mono-glycated guanidine also formed imidazolinone derivatives and thei

35 etimines has been achieved by using a chiral guanidine-amide organocatalyst.

36 ing moieties were examined: spirocyclic acyl guanidines, aminooxazolines, and aminothiazolines in ord

37 nism provides a foundation for the design of guanidine analogs for the therapeutic intervention of ne

38 Therefore, the design of guanidine analogs with improved therapeutic indices is d

39 rfactants when tested alone, combinations of guanidine and acetonitrile improve performance of all su

40 he most active organo-catalyst compared with guanidine and amidine bases.

41 the rates and mechanisms of decomposition of guanidine and amidine derivatives in aqueous solution an

42 dicted side chain but by a 1,3-disubstituted guanidine and are shown to be interesting A3AR antagonis

43 The analysis of the data indicated that guanidine and arginine formed both covalent and non-cova

44 To investigate the reactivity of free guanidine and arginine in the formation of imidazolinone

45 Inhibition of NOS2 and COX2 using amino-guanidine and aspirin/indomethacin yielded an additive r

46 ntal cycle of Bacillus subtilis , to develop guanidine and biguanide compounds with up to 20-fold inc

47 ng a DNA amplicon that had a high content of guanidine and cytidine.

48 inhibitors used in silica-based extractions (guanidine and isopropanol).

49 Guanidine and its alkyl analogs stimulate the neuromuscu

50 The identification of guanidine and related compounds in French lilac plant (G

51 However, retention of the guanidine and replacement of the dimethylallyl group by

52 d is that the capture matrix eliminates both guanidine and the 2-propanol wash that can inhibit downs

53 is largely organized by the type of amidine/guanidine and transition metal used and covers literatur

54 of temperature T; the denaturant m values in guanidine and urea; the pH-temperature-salt phase diagra

55 We recently reported a series of (bis)guanidines and (bis)biguanides that are potent inhibitor

56 phate, sodium alginate and poly(methylene-co-guanidine) and attached to the surface of miniaturised o

57 aracter (both choice of cation (amine versus guanidine) and relative proportion present).

58 zed oligocholate foldamers bound Zn(OAc)(2), guanidine, and even amine compounds with surprisingly hi

59 guanylurea degraded effectively to ammonia, guanidine, and presumably CO(2).

60 torial review highlights the use of amidine, guanidine, and related isothiourea catalysts in organic

61 th other N-centered nucleophiles (hydrazine, guanidine, and urea), the formation of 2-R-anthra[2,1-b]

62 functional groups, notably ureas, thioureas, guanidines, and cyanoguanidines, owing in part to their

63 (K(i) = 18 muM) and derived from a series of guanidine- and amidine-based inhibitors.

64 iew covering the N-arylation of amidines and guanidines appeared.

65 Herein, we report that a novel guanidine-appended SI derivative AAD-66 resulted in more

66 fundamental entities in medicinal chemistry, guanidines are amongst the most interesting, attractive,

67 Amidines and guanidines are considered as fundamental entities in med

68 Amidines and guanidines are often only thought of as strong organic b

69 (Phe, Trp, Tyr, and His)/amide (Asn and Gln)/Guanidine (Arg)) side-chains and charged hydrophilic (su

70 Ullmann reaction using p-methoxybenzyl (PMB) guanidine as guanidinylation agent yielded various aryl

71 -soluble resorcinarene cavitand bearing four guanidines at the feet were investigated in water and do

72 bonds formation of 2-bromo-2-alkenones with guanidine avoiding its NH-protection/derivatization prer

73 A weak Bronsted acid-catalyzed asymmetric guanidine aza-conjugate addition reaction has been devel

74 Herein we report the invention of a new guanidine-based chlorinating reagent, CBMG or "Palau'chl

75 general method for preparing optically pure guanidine-based gamma-peptide nucleic acid (gammaGPNA) m

76 s the use of direct cell lysis with a phenol guanidine-based reagent or an animal origin-free proteas

77 d structure-activity relationship studies of guanidine-based SphK inhibitors bearing an oxadiazole ri

78 ss-coupling reaction was expanded to include guanidine-based systems, offering a versatile preparatio

79 located one nanometre from either amine- or guanidine-bearing subunits.

80 Our results demonstrate that guanidines bind within the intracellular pore of the cha

81 We reported that (bis)guanidines, (bis)biguanides, and their urea- and thioure

82 halins incorporating a diversely substituted guanidine bridge have been prepared to assess the potent

83 Compounds 7a (thiourea bridge) and 10a (N-Me-guanidine bridge) showed nanomolar affinity toward mu re

84 lar uptake, polymer amines were converted to guanidines by reaction with O-methylisourea.

85 hesized in one step using formic acid, urea, guanidine carbonate, and phenylisocyanate, respectively,

86 ain amide of flap residue Gln73 and the acyl guanidine carbonyl group, and a cation-pi interaction be

87 eveal that these proteins likely function as guanidine carboxylases and guanidine transporters, respe

88 ied five plausible binding modes between the guanidine catalyst and substrates for this reaction.

89 ent reaction of ketones, arylacetylenes, and guanidine catalyzed by the KOBu(t)/DMSO system leads to

90 computational analysis of the [5,5] bicyclic guanidine-catalyzed asymmetric cycloaddition reaction of

91 ions was revealed in a DFT study of bicyclic guanidine-catalyzed thio-Michael reaction.

92 bilization of this transition state by 1.0 M guanidine cation (Gua(+)).

93 unique hydration properties of the arginine guanidine cation facilitates charge transfer during volt

94 inhibitor series containing an unusual acyl guanidine chemotype that was originally synthesized as p

95 orded the amine, which was elaborated to the guanidine, completing short and efficient syntheses of t

96 UV254 exposure of chlorinated imidazole and guanidine compounds, which suggested that these groups c

97 coincident in time following the removal of guanidine, consistent with PV RNA functioning simultaneo

98 diamines and isocyanides furnishing valuable guanidine-containing heterocycles.

99 alytic shellfish poisons are a collection of guanidine-containing natural products that are biosynthe

100 We report the development of a new class of guanidine-containing peptides as multifunctional ligands

101 cancer cells more than their analogues with guanidine-containing side chains.

102 lent substrate scope, is amenable to diverse guanidine-containing substrates, and introduces distinct

103 and systems has revealed the importance of a guanidine core and the discovery of 1,1-dimethylguanidin

104 iverse compounds based on cyclic amidine and guanidine cores were synthesized with the goal of findin

105 xis with immunomodulatory cytosine-phosphate-guanidine (CpG) oligodeoxynucleotide (ODN), a toll-like

106 ses to challenge doses of cytidine-phosphate-guanidine (CpG)-containing DNA, which stimulates TLR9.

107 nd then used electrochemistry to monitor its guanidine denaturation and determine its folding free en

108 even though these epitopes are revealed with guanidine denaturation.

109 ted the identification of a series of linear guanidine derivatives and their antibacterial properties

110 In this respect, amidine and guanidine derived catalysts have been shown to be effect

111 that members of its regulon are involved in guanidine detoxification and export.

112 A new method for synthesizing deoxynucleic guanidine (DNG) oligonucleotides that uses iodine as a m

113 as a core subunit of the mammalian Mon1-Ccz1 guanidine exchange factor (GEF) for Rab7, required for c

114 ge that paradigm and show that GIV/Girdin, a guanidine exchange factor (GEF) for the trimeric G prote

115 As a guanidine exchange factor (GEF), GIV modulates signals i

116 m1 (T lymphoma invasion and metastasis 1), a guanidine exchange factor for Rac.

117 Comprised of the unique modular makeup of guanidine exchange factor Galpha-interacting vesicle-ass

118 We present compelling evidence that TIAM1, a guanidine exchange factor of the Rac GTPase, is a direct

119 g vesicle-associated protein (GIV)/girdin, a guanidine exchange factor that links G proteins to a var

120 in epithelial cells by interacting with RhoA guanidine exchange factors.

121 otein tyrosine phosphatase LAR, and the RAC1 guanidine-exchange factor TRIO.

122 Analyses of the insoluble residues from guanidine extraction revealed that a fraction of several

123 alau'chlor (2-chloro-1,3-bis(methoxycarbonyl)guanidine) followed by hydrolysis of the hydrazone moiet

124 lts verify and rationalize the importance of guanidines for enhanced antibacterial activity of oligoT

125 he reactions of silver nitrate with K-FOX or guanidine-FOX in water, aqueous ammonia, and amines, res

126 roup, was labeled with (18)F by reacting the guanidine function with N-succinimidyl-4-(18)F-fluoroben

127 containing amidine, and to a lesser extent, guanidine functional groups.

128 rature on the N-arylation of the amidine and guanidine functionalities.

129 ent with solid-state proton transfer between guanidine functionalities.

130 hetic approach for building novel small peri-guanidine-fused naphthalene monoimide and perylene monoi

131 nonclassical bioisosteric replacement of the guanidine group in arginine by a functionalized carbamoy

132 catalyses an oxidative rearrangement of the guanidine group of N(omega)-methyl-L-arginine to generat

133 due D112 and residues S181 and R211, and the guanidine group positioned in the proximity of R211.

134 Substitution of the guanidine group with an N-cyano group and replacement of

135 BIBP3226, bearing carbamoyl moieties at the guanidine group, revealed subnanomolar Ki values and cau

136 ino]-ethyl}-guanidine, which contains a free guanidine group, was labeled with (18)F by reacting the

137 (GFX) solubility-enhancing property of a six-guanidine group-containing dendrimer (g6 DPT) was invest

138 ine, all being iminic compounds containing a guanidine group.

139 ructural considerations, it appears that the guanidine(+) group of the M8 arginine replaces Na(+) at

140 The additional guanidinium (guanidine) group in the diprotonated (monoprotonated) tr

141 Relative to amines, guanidine groups demonstrated improved antibacterial act

142 ridine substituted with one and two bicyclic guanidine groups has been studied as a potential source

143 for antibacterial activity and suggests that guanidine groups improve antibacterial activity by incre

144 n strengths on co-immobilization of amine or guanidine groups.

145 ed at the hydroxymethyl uracil and tricyclic guanidine groups; uracil moiety cleavage/fragmentation a

146 The [(o-chlorobenzylidene)amino]guanidines (Guanabenz and Sephin1) have been proposed to

147 al kinetic data highlight the operation of a guanidine-guanidinium catalytic dyad that can act both i

148 te is conceivably promoted by the "built-in" guanidine/guanidinium catalytic dyad.

149 s between the two groups, indicating a mixed guanidine/guanidinium.

150 uchwald-Hartwig protocol leading to bicyclic guanidines has been elaborated.

151 Guanidine HCl (2 mM), a reversible inhibitor of PV 2C(AT

152 ified from Extract PBS by two rounds of CsCl/guanidine HCl ultracentrifugation as well as in vitro re

153 anic solvent, and chaotropic reagents (urea, guanidine HCl) by monitoring the yield of released desul

154 lities, which were measured independently by guanidine HCl-induced unfolding titrations using purifie

155 ilized against chemical denaturants urea and guanidine HCl.

156 nce as a function of pH and concentration of guanidine HCl.

157 rop in secondary structure between 0 and 1 M guanidine-HCl and a slower decrease above 1 M guanidine-

158 ormation in the denatured state at 3 and 6 M guanidine-HCl concentration.

159 proteolytic activity toward VWF73 peptides, guanidine-HCl denatured VWF, and native VWF under fluid

160 fied LPS was only slightly more resistant to guanidine-HCl induced denaturation compared to unbound p

161 2.26 +/- 0.13 and 1.97 +/- 0.04 in 3 and 6 M guanidine-HCl, respectively.

162 uanidine-HCl and a slower decrease above 1 M guanidine-HCl.

163 ine affords arginine analogues with modified guanidine head groups.

164 ed, across all models, was 1-(4-chlorobenzyl)guanidine hemisulfate, which gave an average daily weigh

165 ntrations were tested in the presence of 1 M guanidine hydrochloride (Gdn), at pH values ranging from

166 To fill this gap, we studied the effects of guanidine hydrochloride (GdnHCl) and heating on PrP(Sc)

167 loop formation are measured as a function of guanidine hydrochloride (GdnHCl) concentration for loop

168 s provide further insight into the effect of guanidine hydrochloride (GdnHCl) on Sup35 aggregates.

169 places chaotropic reagents, such as urea and guanidine hydrochloride (GdnHCl) with an acid labile sur

170 n buffers with specific amounts of glycerol, guanidine hydrochloride (GdnHCl), and sodium chloride (N

171 ity of PrP(Sc) as determined by unfolding in guanidine hydrochloride (GdnHCl), which is tightly and p

172 ranging from 22 to 46 in 1.5, 3.0, and 6.0 M guanidine hydrochloride (GdnHCl).

173 ter solutions, with chemical denaturation by guanidine hydrochloride (GdnHCl).

174 ity of these viral products to inhibition by guanidine hydrochloride (GuHCl) (which targets minus-str

175 asuring their structural stabilities through guanidine hydrochloride (GuHCl) denaturation.

176 unfolding of bovine serum albumin (BSA) with guanidine hydrochloride (GuHCl) has been investigated us

177 acy of three sample preparation methods [6 M guanidine hydrochloride (GuHCl) protein extraction + in-

178 In increasing levels of guanidine hydrochloride (GuHCl), a sharp red shift in fl

179 ed unfolded-state dimensions from 1.4 to 5 M guanidine hydrochloride (GuHCl), and by smFRET (at 25 de

180 aturants sodium dodecyl sulfate (SDS), urea, guanidine hydrochloride (GuHCl), and trifluoroacetic aci

181 case of two different denaturants, urea and guanidine hydrochloride (GuHCl).

182 CaCl(2) +92.2, MgCl(2) +54.0, butanol +37.4, guanidine hydrochloride +31.9, urea +16.6, glycerol [> 6

183 nds in the presence of increasing amounts of guanidine hydrochloride and alkylation with [(12)C]iodoa

184 Plasma was extracted in the presence of guanidine hydrochloride and analysed by LC-MS/MS.

185 16 heterodimer designs, denaturation in 5 M guanidine hydrochloride and reannealing-almost all of th

186 on and withstands even high concentration of guanidine hydrochloride and reducing agents.

187 e also resistant to chemical denaturation by guanidine hydrochloride and retain their secondary struc

188 the spectrum of human prion strains to both guanidine hydrochloride and thermal unfolding.

189 Treatment of Mia40 with guanidine hydrochloride and triscarboxyethylphosphine hy

190 We have demonstrated that an approach using guanidine hydrochloride at low concentrations to progres

191 Furthermore, the addition of guanidine hydrochloride decreased, whereas the addition

192 on the folding stability of AR by FoldX and guanidine hydrochloride denaturation experiment, and fou

193 comparable responses of both prion types to guanidine hydrochloride denaturation indicated this occu

194 ation profile of the protein, treatment with guanidine hydrochloride did not.

195 pparent pK(a) for His 26-heme binding in 3 M guanidine hydrochloride indicates that the P25A mutation

196 a function of the chemical denaturant (e.g., guanidine hydrochloride or urea) concentration.

197 nificantly altered by the presence of either guanidine hydrochloride or urea.

198 We serendipitously discovered that guanidine hydrochloride rescues septin function in cdc10

199 he unfolding of lysozyme with either urea or guanidine hydrochloride results in different phasor traj

200 ic studies on His-heme loop formation in 3 M guanidine hydrochloride reveal significant stabilization

201 he protease site with trypsin, denaturing in guanidine hydrochloride to disrupt the complex, separati

202 insensitivity of the intrinsic viscosity to guanidine hydrochloride treatment all suggest that LigBC

203 of cholesteryl ester transfer protein or by guanidine hydrochloride treatment, a fraction of apoA-I,

204 [SW+] can be eliminated by guanidine hydrochloride treatment, HSP104 deletion or lo

205 bovine cytochrome c is induced to unfold by guanidine hydrochloride via a stepwise mechanism, but it

206 A solution containing 6M guanidine hydrochloride, 0.2% nondenaturing detergent, a

207 ( T(m) ~ 75 degrees C) or denatured by 1.5 M guanidine hydrochloride, the Ico8 cages remained folded

208 ns-to-heme distances resembling those in the guanidine hydrochloride-denatured state.

209 Guanidine hydrochloride-induced extension of the substra

210 its retention was not diminished by urea and guanidine hydrochloride.

211 ained folded even at 120 degrees C or in 8 M guanidine hydrochloride.

212 age of all membrane proteins, in contrast to guanidine hydrochloride.

213 ltimers were solubilized into monomers using guanidine hydrochloride.

214 for the displacement of apo A-I from HDL by guanidine hydrochloride.

215 ive boiling in sodium dodecyl sulfate or 5 M guanidine hydrochloride.

216 in numbers while growing in the presence of guanidine hydrochloride.

217 pared to the complete unfolding caused by 6M guanidine hydrochloride.

218 roism and visible absorbance measurements of guanidine-hydrochloride-induced disassembly of methemogl

219 H and AMSH-LP are nearly identical; however, guanidine-hydrochloride-induced unfolding studies show t

220 udoknot formation by the aptamer domain of a guanidine III riboswitch from Legionella pneumophila has

221 ly, reports regarding the importance of free guanidine in biology are sparse, and no biological recep

222 on agent yielded various aryl and heteroaryl guanidines in good yields.

223 protein was substantially more resistant to guanidine-induced denaturation compared to unbound prote

224 Here, we show that guanidine-induced pseudoknot formation by the aptamer do

225 ded HP35-(CN)(2) are compared to that of the guanidine-induced unfolded peptide, as well as the nitri

226 esses IPAG [1-(4-iodophenyl)-3-(2-adamantyl) guanidine] induced UPR marker and autophagosome levels,

227 subcutaneous administration in rats, an acyl guanidine inhibitor with single-digit nanomolar activity

228 biological evaluation of aminothiazole-based guanidine inhibitors of SphK.

229 y steps involve the use of a new reagent for guanidine installation, a remarkably selective C-H funct

230 ion provide indication that the deprotonated guanidine involved in such a catalysis acts as a general

231 e and related findings demonstrate that free guanidine is a biologically relevant compound, and sever

232 nyl compounds catalyzed by an axially chiral guanidine is investigated by density functional theory m

233 The therapeutic use of guanidine is limited, however, because of side effects t

234 ot method for the synthesis of monoprotected guanidines is presented.

235 -[3-bromo-4-(3-(18)F-fluoro-propoxy)-benzyl]-guanidine), is being developed for sympathetic nerve ima

236 ion of its canonical CpG (cytidine-phosphate-guanidine) island (CGI) promoter in gastric cancer (GC).

237 From this, we identified a bis-cyclic guanidine library that displayed strong antibacterial ac

238 -[3-bromo-4-(3-(18)F-fluoro-propoxy)-benzyl]-guanidine [LMI1195]) is in clinical development for mapp

239 dure for the synthesis of acyclic and cyclic guanidines mediated by the Ph3P/I2 system is described.

240 pH but also by additives including arginine, guanidine, methionine, and thiocyanate.

241 hich the 2-aminoimidazole moiety serves as a guanidine mimetic.

242 ification of the N-Methyl-N'-nitro-N-nitroso-guanidine (MNNG) HOS transforming gene (MET) oncogene as

243 fide units in the HPAE backbone (HPAESS) and guanidine moieties (HPAESG) at the extremities.

244 tify plausible replacements for highly basic guanidine moiety contained in potent MC4R agonists, as e

245 in site of PTM by glyoxal was the side chain guanidine moiety of the arginine residue.

246 An acyl guanidine moiety provided the most potent analogues.

247 ces a strong decrease in the basicity of the guanidine moiety.

248 Using N-methyl-N-nitro-N-nitroso-guanidine mutagenesis and selection, a mutant strain Apm

249 , indicating that the OH-bearing, protonated guanidine N(omega) nitrogen of l-NHA has substantial sp(

250 cyandiamide, ascorbic acid, sodium benzoate, guanidine nitrate, and potassium perchlorate) were detec

251 BCR recruited a guanidine nucleotide exchange factor (GEF) domain to the

252 ivate RhoA-ROCK1/PKN2 signaling via the RhoA guanidine nucleotide exchange factor (GEF) Ect2 to contr

253 rate-limiting enzyme in de novo synthesis of guanidine nucleotides.

254 Cyclic guanidines of various sizes can be obtained with general

255 oxybenzyl)-N'[4-(4-fluorophenyl)thiazol-2-yl]guanidine), on the intrinsic membrane properties and syn

256 replacing the amino group with a more basic guanidine one while maintaining a proper distance betwee

257 For cyclic amidines/guanidines only systems which possess an exocyclic nitro

258 s self-interaction and interaction with free guanidine or arginine and glucose, were also observed.

259 imidazolinone derivatives, model systems of guanidine or arginine/glucose or (13)[C-6]-glucose were

260 catalysts composed of a Lewis base (amidine, guanidine, or quaternary onium salts) and a Lewis acid (

261 n of phenyl or butyl hydrophobic groups into guanidine-oxanorbornene polymers increased the amount of

262 hat pyrrolidine bis-piperazines and bicyclic guanidines represent promising initial leads for the opt

263 ord highly substituted ureas, thioureas, and guanidines, respectively.

264 ge the view that [(o-chlorobenzylidene)amino]guanidines restore proteostasis by interfering with eIF2

265 none formation with 3-deoxy-glucosone at the guanidine side-chain.

266 nitroanilines, chlorophenols, triclosan, and guanidines significantly increased in both farmworker an

267 Significantly higher levels of guanidine-soluble Abeta and plaque loads were observed i

268 s at 80-120 degrees C, which regenerates the guanidine sorbent quantitatively.

269 Herein we report a simple aqueous guanidine sorbent that captures CO2 from ambient air and

270 logues identified contain relatively small N-guanidine substituents (N-methyl and N-hydroxyl) and dis

271 Higher-order cyclopropenimine and guanidine superbase stability to hydrolysis was found to

272 phosphoric acid (CPA) and (b) CPA and chiral guanidine (TBO).

273 (4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)methyl)guanidine} that targets the bacterial cell division prot

274 Nelson and colleagues (2017) determined that guanidine, the prevalent protein denaturant, is the long

275 immobilized on the "charged" (as a result of guanidine thiocyanate treatment) gold surface at pH 5.0.

276 ed for potential RNA contaminants, including guanidine thiocyanate, ethanol, formamide, ethylenediami

277 The synthesis of halogenated cyclic guanidines through iodine(III)-mediated umpolung of hali

278 Addition of guanidine to a 6-methylhexahydroindenone in MeOH at 85 d

279 Reaction of the cyclic guanidine TolN horizontal lineSIMe with the aluminum(I)

280 and several gene families that can alleviate guanidine toxicity exist.

281 ikely function as guanidine carboxylases and guanidine transporters, respectively.

282 tion in lungs of N-methyl-N'-nitro-N-nitroso-guanidine-treated mice or H(2)O(2)-treated cells.

283 erbase N,N',N"-tris[(3-dimethylamino)propyl]-guanidine (tris-DMPG), whereas estimated pK(a) values in

284 The parent scaffold exhibits two guanidine-type portions, both likely candidates for prot

285 This stimulatory effect of guanidine underlies its use in the therapy for the neuro

286 Guanidine underwent three sequential Amadori rearrangeme

287 eltamivir analogues bearing an N-substituted guanidine unit were prepared and evaluated as inhibitors

288 lmethane derivatives 1-3, decorated with two guanidine units, are effective catalysts of HPNP transes

289 dazol-4-yl)butyl]-3-[2-(phenylsulfanyl)ethyl]guanidine (UR-PI376, 1) is a potent and selective agonis

290 ationic nature, specifically the presence of guanidine versus amine functional groups using sequence-

291 n bases: nitriles, azoles, azines, amidines, guanidines, vinamidines, biguanides, and phosphazenes.

292 ulfide isoforms converted to IgG2-A when 1 m guanidine was used, whereas IgG2-B was enriched in the a

293 tetrahydro-[1,3, 5]triazin-2-ylamino]-ethyl}-guanidine, which contains a free guanidine group, was la

294 library features functional moieties such as guanidine, which interacts strongly with aspartate of th

295 ity was optimized by the complete removal of guanidine, which is a known trypsin inhibitor, from the

296 tly employed to yield N(3)-Cbz-protected ene-guanidines, which found utility in the synthesis of naam

297 oup with an N-cyano group and replacement of guanidine with amidine, pyrimidine, pyridine, or the imi

298 Thus, bioisosteric replacement of the 5-guanidine with an acetamidine-in the form of its N-hydro

299 It is shown that N,N',N"-substitution of guanidine with appropriate substituents results in new o

300 of new aminoalkyl derivatives of diaromatic guanidines with potential as DNA minor groove binders an