ライフサイエンスコーパス: guanine nucleotide exchange

1 ociation, thereby preventing agonist-induced guanine nucleotide exchange.

2 ing heterotrimeric G protein Galphai subunit guanine nucleotide exchange.

3 diazaspiro[4,4]nonane nucleus to target the guanine nucleotide exchange activity of DOCK5, which is

4 reen utilizing two complementary fluorescent guanine nucleotide exchange assays to identify small mol

5 Surprisingly, unlike in eEF1A and EF-Tu, the guanine nucleotide exchange does not cause a major confo

6 how considerably lower intrinsic activity in guanine nucleotide exchange experiments at D2R and conse

7 ways mediated by the ADP ribosylation factor guanine nucleotide exchange factor (ARF-GEF) GNOM.

8 recruiting GBF1, an ADP ribosylation factor-guanine nucleotide exchange factor (ARF-GEF), to the Gol

9 ta1, Ggamma2, and/or Ggamma5, PAK-associated guanine nucleotide exchange factor (betaPIX, ARHGEF7), a

10 The cAMP-dependent guanine nucleotide exchange factor (EPAC) exchange-prote

11 -1/CXCL12, effects mediated by P-Rex1, a Rac-guanine nucleotide exchange factor (GEF) aberrantly expr

12 Cytosolic Ric-8A has guanine nucleotide exchange factor (GEF) activity and is

13 GIV (a.k.a. Girdin) is the first for which a guanine nucleotide exchange factor (GEF) activity has be

14 ng and activating (GBA) motif, which confers guanine nucleotide exchange factor (GEF) activity in vit

15 activation domain, known to be required for guanine nucleotide exchange factor (GEF) activity of VAV

16 A missense mutation that disrupts DOCK8 guanine nucleotide exchange factor (GEF) activity while

17 or embryonic development that acts as both a guanine nucleotide exchange factor (GEF) and a chaperone

18 protein alpha-subunits (Galpha), acting as a guanine nucleotide exchange factor (GEF) and a chaperone

19 monitor GTPase cycling in the presence of a guanine nucleotide exchange factor (GEF) and a GTPase ac

20 n, we evaluated the structure and stability, guanine nucleotide exchange factor (GEF) and GTPase-acti

21 Moreover, in vitro guanine nucleotide exchange factor (GEF) assays revealed

22 risingly, this occurred independently of the guanine nucleotide exchange factor (GEF) catalytic activ

23 Here, we identify a cryptic guanine nucleotide exchange factor (GEF) domain in the O

24 TRIO9 contains two guanine nucleotide exchange factor (GEF) domains with di

25 ino-terminal portion of the delta subunit of guanine nucleotide exchange factor (GEF) eIF2B.

26 The guanine nucleotide exchange factor (GEF) epithelial cell

27 in normal.SIGNIFICANCE STATEMENT Ric-8b is a guanine nucleotide exchange factor (GEF) expressed in th

28 sed in epithelial cells, cytohesin-2/ARNO, a guanine nucleotide exchange factor (GEF) for ARF small G

29 Thus, SBDS acts as a guanine nucleotide exchange factor (GEF) for EFL1 promot

30 y by regulating the localization of Daple, a guanine nucleotide exchange factor (GEF) for Galphai.

31 eIF2B acts as a guanine nucleotide exchange factor (GEF) for its GTP-bin

32 Here, we have identified DOCK6, a guanine nucleotide exchange factor (GEF) for Rac1 and CD

33 zed that the ability of PLC to function as a guanine nucleotide exchange factor (GEF) for Rap1 suppor

34 ropose that TRAPPII is likely to behave as a guanine nucleotide exchange factor (GEF) for the RAB-A2a

35 PIP3)-dependent Rac exchanger 2 (PREX2) is a guanine nucleotide exchange factor (GEF) for the Ras-rel

36 rimeric G protein Galphai by the nonreceptor guanine nucleotide exchange factor (GEF) GIV (also known

37 The C-terminal guanine nucleotide exchange factor (GEF) module of Trio

38 1, a PI3K- and G protein betagamma-regulated guanine nucleotide exchange factor (GEF) of the Rac smal

39 We find that the guanine nucleotide exchange factor (GEF) of Ypt7 (the Mo

40 3-dependent Rac exchanger 1 (PREX1) is a Rac-guanine nucleotide exchange factor (GEF) overexpressed i

41 Ras activation required the Ras/Rap guanine nucleotide exchange factor (GEF) PDZ-GEF1.

42 Rab11 traffics the guanine nucleotide exchange factor (GEF) Rabin8 to the c

43 eukaryotic Ras-related nuclear protein (Ran) guanine nucleotide exchange factor (GEF) RCC1.

44 ECT-2, the guanine nucleotide exchange factor (GEF) required for Rh

45 The guanine nucleotide exchange factor (GEF) Son of Sevenles

46 The guanine nucleotide exchange factor (GEF) Son of Sevenles

47 ry and endocytic recycling pathways, yet the guanine nucleotide exchange factor (GEF) that activates

48 Ric-8A is a cytosolic Guanine Nucleotide exchange Factor (GEF) that activates

49 Lys168, which was then detected by RalGDS, a guanine nucleotide exchange factor (GEF) that precipitat

50 ion and metastasis 1 (Tiam1) is a Dbl-family guanine nucleotide exchange factor (GEF) that specifical

51 We identified the dual Rac1/RhoA Rho guanine nucleotide exchange factor (GEF) Trio as a criti

52 The Rac1 guanine nucleotide exchange factor (GEF) Trio is essenti

53 NC-73, the C. elegans ortholog of Trio, as a guanine nucleotide exchange factor (GEF) upstream of bot

54 However, the guanine nucleotide exchange factor (GEF) which activates

55 LARG (leukemia-associated Rho guanine nucleotide exchange factor (GEF)), PDZ-RhoGEF, a

56 acking GEF-H1 (GEF-H1(-/-)), a RhoA-specific guanine nucleotide exchange factor (GEF), displayed limi

57 ysis, eIF2-GDP is recycled back to TC by its guanine nucleotide exchange factor (GEF), eIF2B.

58 Multiplexing revealed guanine nucleotide exchange factor (GEF), GTPase-activat

59 ntly impairs Rab8A activation by its cognate guanine nucleotide exchange factor (GEF), Rabin8 (by usi

60 Muk1, a Rab5-specific guanine nucleotide exchange factor (GEF), was identified

61 Rab activation requires a guanine nucleotide exchange factor (GEF), which is Mon1-

62 Here we show that the microtubule-associated guanine nucleotide exchange factor (GEF)-H1, is required

63 ll differentiation and function and requires guanine nucleotide exchange factor (GEF)-mediated activa

64 oma invasion and metastasis 1 (TIAM1), a Rac guanine nucleotide exchange factor (GEF).

65 we show that son of sevenless 1 (SOS1), rho guanine nucleotide exchange factor (GEF)1 (ARHGEF1), and

66 r soluble factors: a soluble SNARE (Vam7), a guanine nucleotide exchange factor (GEF, Mon1-Ccz1), a R

67 o and stimulates the catalytic activity of a guanine nucleotide exchange factor (P-REX1) that itself

68 Pix is a conserved Rho-type guanine nucleotide exchange factor (Rho-GEF) homologous

69 The Rho-guanine nucleotide exchange factor (RhoGEF) TRIO acts as

70 The Rho guanine nucleotide exchange factor (RhoGEF) Trio promote

71 (Rap-1), an effect that depended on CalDAG- guanine nucleotide exchange factor 1 (GEF1) and cell div

72 e-specific deletion of the gene encoding RAB guanine nucleotide exchange factor 1 (RABGEF1, also know

73 ariants in GBF1 (Golgi brefeldin A-resistant guanine nucleotide exchange factor 1) in four unrelated

74 nt and actomyosin contraction, including Rho guanine nucleotide exchange factor 2 (GEF-H1, ARHGEF2) a

75 Remarkably, expression of a single gene, Rap guanine nucleotide exchange factor 3 (Rapgef3), was stro

76 Here, an MS-based analysis revealed the Vav guanine nucleotide exchange factor 3 (VAV3), an activato

77 trate 1 by transcriptionally controlling Rap guanine nucleotide exchange factor 3/exchange factor dir

78 GDP-dissociation inhibitor 2 [ARHGDIB], Rho guanine nucleotide exchange factor 6, angiotensin-II typ

79 ab35 (a small monomeric GTPase) and DennD1C (guanine nucleotide exchange factor [GEF]) to the IL-17R/

80 tivating protein-stimulated GTPase, and ARL3 guanine nucleotide exchange factor activities.

81 plexes and one of the essential subunits for guanine nucleotide exchange factor activity for Rab1 GTP

82 25n, 25u, 25e, and 25f, which promote EPAC1 guanine nucleotide exchange factor activity in vitro.

83 We determined that the guanine nucleotide exchange factor activity of DOCK8 is

84 tide exchange factor Sos1, eliciting its Rac-guanine nucleotide exchange factor activity, and Rac reg

85 oma homology domain of Cb, which carries the guanine nucleotide exchange factor activity, leads to ep

86 EF appears to function independently of Rac1 guanine nucleotide exchange factor activity.

87 protein alpha-subunits (Galpha), acting as a guanine nucleotide exchange factor and a chaperone.

88 RASGRP1 is an important guanine nucleotide exchange factor and activator of the

89 s feedback activation of FAK depends on both guanine nucleotide exchange factor and Tyr(P) GIV signal

90 t enhanced the protein expression of the Rho guanine nucleotide exchange factor ARHGEF1, MLC20 , MYPT

91 scle-specific loss of G(12)/G(13) or the Rho guanine nucleotide exchange factor ARHGEF12 have lost my

92 c GTPase-activating protein ARHGAP17 and the guanine nucleotide exchange factor ARHGEF6 as new PKA an

93 ly, beta-arrestin2 can interact with the ARF guanine nucleotide exchange factor ARNO, although the C-

94 interaction with the b isoform of Rac/Cdc42 guanine nucleotide exchange factor beta-PIX, regulates t

95 ed that CRK proteins coordinate with the RAP guanine nucleotide exchange factor C3G and the adhesion

96 analyzed together, increased intrinsic RhoA guanine nucleotide exchange factor catalytic activity co

97 quires the scaffold protein gephyrin and the guanine nucleotide exchange factor collybistin (Cb).

98 critically dependent upon the brain-specific guanine nucleotide exchange factor Collybistin (Cb).

99 we show that microexon switching in the Arf6 guanine nucleotide exchange factor cytohesin-1 controls

100 mic domain of the receptor that recruits the guanine nucleotide exchange factor dedicator of cytokine

101 e small GTPase RAB11 as an interactor of the guanine nucleotide exchange factor DEF6, and find disrup

102 that DCs from Nlrp10 knockout mice lack the guanine nucleotide exchange factor DOCK8 (dedicator of c

103 Mice lacking the guanine nucleotide exchange factor DOCK8 or CD19 lost IL

104 Her work has shown that the guanine nucleotide exchange factor Dock8 plays a role in

105 GTP-binding Rho family protein Cdc42 by the guanine nucleotide exchange factor DOCK8.

106 e central spindle that concentrates the RhoA guanine nucleotide exchange factor ECT2.

107 tein levels of an Ras1 GTPase activator, the guanine nucleotide exchange factor Efc25, by phosphoryla

108 ARHGEF1 is a RhoA-specific guanine nucleotide exchange factor expressed in hematopo

109 he long isoform of intersectin-1 (ITSN-1), a guanine nucleotide exchange factor for Cdc42, as a novel

110 tinct sites in their common target, eIF2B, a guanine nucleotide exchange factor for eIF2.

111 use embryos depends on beta-Pix (Arhgef7), a guanine nucleotide exchange factor for Rac1 and Cdc42.

112 Ran with GTP, which is mediated by RCC1, the guanine nucleotide exchange factor for Ran, is critical

113 mponent of the ERK/MAPK pathway, and VAV1, a guanine nucleotide exchange factor for Rho family GTPase

114 vated G(s) can also directly interact with a guanine nucleotide exchange factor for Rho family small

115 ial cell-transforming sequence 2 (ECT2) is a guanine nucleotide exchange factor for Rho GTPases that

116 SmgGDS is a guanine nucleotide exchange factor for RhoA, but we repo

117 cation requires the cellular protein GBF1, a guanine nucleotide exchange factor for small Arf GTPases

118 tokinesis 180 (Elmo1/Dock180) is a bipartite guanine nucleotide exchange factor for the monomeric GTP

119 ulated the fMAPK pathway through Cdc24p, the guanine nucleotide exchange factor for the polarity esta

120 ound an interaction between TKS5 and FGD1, a guanine nucleotide exchange factor for the Rho-GTPase CD

121 an inhibitor of the cellular protein GBF1, a guanine nucleotide exchange factor for the small cellula

122 More specifically, alphaPIX, a known guanine nucleotide exchange factor for the small GTPases

123 In this work, we show that the guanine nucleotide exchange factor GBF1, relevant for CO

124 We report that the guanine nucleotide exchange factor GBF1, which activates

125 filin/PP2A-mediated dephosphorylation of the guanine nucleotide exchange factor GEF-H1, thereby stimu

126 ts activity by recruiting its activator, the guanine nucleotide exchange factor GEF-H1.

127 ls induced activation and phosphorylation of guanine nucleotide exchange factor H1 (GEF-H1), leading

128 ndent actin polymerization is activated by a guanine nucleotide exchange factor known as Dedicator of

129 ow that this common pathway involves Trio, a guanine nucleotide exchange factor known to promote cyto

130 subsequently link cargo proteins such as the guanine nucleotide exchange factor Lfc or the small GTPa

131 pathway initiated through the cAMP-activated guanine nucleotide exchange factor NCS-Rapgef2 in mice.

132 omain-containing protein that functions as a guanine nucleotide exchange factor of ADP-ribosylation f

133 iting proteins that can interact with C3G, a guanine nucleotide exchange factor of the small GTPase R

134 We further identify the guanine nucleotide exchange factor P-Rex1 as the primary

135 we discovered a function for a RhoA-specific guanine nucleotide exchange factor PDZ-RhoGEF (Arhgef11)

136 appears to be the first evidence that a Rho-guanine nucleotide exchange factor plays a critical role

137 Here, we show that an Arabidopsis guanine nucleotide exchange factor protein RopGEF1 is ra

138 logical, and lentiviral techniques, that the guanine nucleotide exchange factor RasGRF2 mediates coca

139 Mice deficient in guanine nucleotide exchange factor RasGRP1 exhibit dysre

140 facilitates the nuclear transport of the Ran guanine nucleotide exchange factor RCC1.

141 INTERPRETATION: AKAP13 is a Rho guanine nucleotide exchange factor regulating activation

142 ctions as a Galpha-stimulated, Rap1-specific guanine nucleotide exchange factor required to balance R

143 The guanine nucleotide exchange factor Rgnef (also known as

144 synthesis, is controlled by signaling of the guanine nucleotide exchange factor Rom2, initiating at t

145 Collybistin (CB) is a guanine nucleotide exchange factor selectively localized

146 The chaperone protein and guanine nucleotide exchange factor SmgGDS (RAP1GDS1) is

147 forms partly regulated by the binding of the guanine nucleotide exchange factor Son of Sevenless (Sos

148 t Abl has been reported to phosphorylate the guanine nucleotide exchange factor Sos1, eliciting its R

149 GRB2 to interfere with its association with guanine nucleotide exchange factor SOS1.

150 GIV (aka Girdin) is a guanine nucleotide exchange factor that activates hetero

151 ARHGEF18 encodes ARHGEF18, a guanine nucleotide exchange factor that activates RHOA,

152 Sec2p is a guanine nucleotide exchange factor that activates Sec4p,

153 nge protein, activated by cAMP 1 (EPAC-1), a guanine nucleotide exchange factor that activates the sm

154 lyubiquitylated, and destabilized RAPGEF2, a guanine nucleotide exchange factor that activates the sm

155 fically, we found that GIV is a non-receptor guanine nucleotide exchange factor that activates trimer

156 C3G (RapGEF1) is a ubiquitously expressed guanine nucleotide exchange factor that functions in sig

157 We identified beta-PIX as a predominant guanine nucleotide exchange factor that interacts with C

158 Rgnef (ARHGEF28/p190RhoGEF) is a guanine nucleotide exchange factor that is activated dow

159 Epac is a cAMP-activated guanine nucleotide exchange factor that mediates cAMP si

160 P-eIF2alpha inhibits eIF2B, the guanine nucleotide exchange factor that recycles inactiv

161 nteracts through a PDZ ligand motif with the guanine nucleotide exchange factor TIAM-1/GEF in a compl

162 The Rac1 guanine nucleotide exchange factor Tiam1 mediates an OGD

163 hatidylinositol 3-kinase (PI3K) and the Rac1 guanine nucleotide exchange factor Tiam1.

164 ified the Rac subfamily and the Rac-specific guanine nucleotide exchange factor Tiam2 as key componen

165 lusters in cooperation with the Rac-specific guanine nucleotide exchange factor Tiam2.

166 by the repulsive receptors, mutations in the guanine nucleotide exchange factor Trio strongly enhance

167 We identify the Rho-family guanine nucleotide exchange factor Vav2 in a comprehensi

168 the multistep process by which the Ras GEF (guanine nucleotide exchange factor) activity of SOS is a

169 ssion, such as the RAB13 GTPase and the NET1 guanine nucleotide exchange factor, and are regulated by

170 ex involving many proteins including Vav1, a guanine nucleotide exchange factor, and the activation o

171 , beta and gamma) and P-Rex1, a Rac-specific guanine nucleotide exchange factor, are fundamental Gbet

172 regulation of the G-protein ARF1 or the ARF1 guanine nucleotide exchange factor, ARNO, by small, inte

173 of SOS1/EPS8/ABI1 complex as a Rac1-specific guanine nucleotide exchange factor, depleting Rac1 resul

174 The messenger RNA (mRNA) encoding the guanine nucleotide exchange factor, DOCK4, mutations of

175 1 activation via expression of the bacterial guanine nucleotide exchange factor, EspT.

176 sis revealed that microtubule-associated Rho guanine nucleotide exchange factor, GEF-H1, participates

177 otein (also known as Tuba), a Cdc42-specific guanine nucleotide exchange factor, in ciliogenesis and

178 Ric-8b, a guanine nucleotide exchange factor, interacts with Galph

179 to interact with the ADP-ribosylation-factor guanine nucleotide exchange factor, MIN7/BEN1 (HOPM INTE

180 ent membrane recruitment of p115-RHOGEF (RHO guanine nucleotide exchange factor, molecular weight 115

181 ght patterning, we previously identified the guanine nucleotide exchange factor, RAPGEF5.

182 of the drug ISRIB, an activator of the eIF2 guanine nucleotide exchange factor, rescues the cell gro

183 n adaptor protein that recruits Ras-specific guanine nucleotide exchange factor, Son of Sevenless 1 (

184 Here, we show the guanine nucleotide exchange factor, Tiam1, and its cogna

185 d Ras homologue gene family, member A (RhoA) guanine nucleotide exchange factor, upregulated in human

186 As N-Ras is activated by Sos, a guanine nucleotide exchange factor, we modeled the N-Ras

187 how no evidence that the DH domain acts as a guanine nucleotide exchange factor, whereas the PH domai

188 on impairs Rho protein binding and increases guanine nucleotide exchange factor-catalyzed nucleotide

189 vity via activation of MT-bound Rho-specific guanine nucleotide exchange factor-H1 (GEF-H1) and was a

190 ic QTR-FRET technique enables the linking of guanine nucleotide exchange factor-induced Eu(3+)-GTP as

191 terized Scribble binding partner beta-PIX, a guanine nucleotide exchange factor.

192 ng proteins, such as RIN3, a RAB5-activating guanine nucleotide exchange factor.

193 Son of Sevenless (SOS) is a Ras guanine nucleotide exchange factor.

194 initiation factor 2B (eIF2B), a multisubunit guanine nucleotide exchange factor.

195 n with the SERGEF gene (secretion-regulating guanine nucleotide exchange factor; beta=0.0137; P=2.98x

196 In yeast, Arf guanine nucleotide-exchange factor (GEF) Syt1p activates

197 ational change contributed to a high rate of guanine nucleotide-exchange factor (GEF)-dependent and -

198 ion of BIG1 and/or BIG2 or overexpression of guanine nucleotide-exchange factor inactive mutant, but

199 omotes PAK1 binding to beta-PAK1-interacting guanine-nucleotide exchange factor (betaPIX) and G prote

200 hil recruitment during inflammation, but its guanine-nucleotide exchange factor (GEF) activators seem

201 eric G proteins are usually activated by the guanine-nucleotide exchange factor (GEF) activity of GPC

202 ane trafficking, and their activation by the guanine-nucleotide exchange factor (GEF) Brag2, which co

203 P-Rex1 is a guanine-nucleotide exchange factor (GEF) that activates

204 dent vesicular trafficking of Rabin8, a Rab8 guanine-nucleotide exchange factor (GEF), to the mother

205 eracting vesicle-associated protein (GIV), a guanine-nucleotide exchange factor (GEF), transactivates

206 Rho guanine-nucleotide exchange factor (RhoGEF) proteins as

207 hat endosome-associated VPS9a, the conserved guanine-nucleotide exchange factor activating Rab5 GTPas

208 utophagy (autophagy) and is activated by the guanine-nucleotide exchange factor DENND3.

209 We identify the guanine-nucleotide exchange factor dPix as an effector o

210 Rho, activated by the guanine-nucleotide exchange factor ECT-2, is upstream of

211 bed an early decrease of Kalirin-7 (Kal7), a guanine-nucleotide exchange factor for Rho-like small GT

212 GBF1 encodes a guanine-nucleotide exchange factor that facilitates the

213 -dependent Rac exchanger 1 (P-Rex1) is a Rho guanine-nucleotide exchange factor that was originally d

214 Here we investigate whether the RhoGEF (Rho guanine-nucleotide exchange factor) protein Tiam1 plays

215 Kalirin-7 is a multifunctional guanine-nucleotide-exchange factor (GEF) for Rho GTPases

216 umferential single septin filaments, the Rho guanine-nucleotide-exchange factor (RhoGEF) Bud3, and th

217 three protein families: the ARF GTPases, the guanine nucleotide exchange factors (ARF GEFs) that acti

218 Arf guanine nucleotide exchange factors (Arf-GEFs) regulate

219 ll GTPases can generate patterns by coupling guanine nucleotide exchange factors (GEF) to effectors,

220 TR-associated ligand), PDZ domain-containing guanine nucleotide exchange factors (GEFs) 1 and 2, regu

221 Guanine nucleotide exchange factors (GEFs) activate and

222 Guanine nucleotide exchange factors (GEFs) activate and

223 pendent Rac exchange factor (PREX) family of guanine nucleotide exchange factors (GEFs) activates Rho

224 ich are regulated by the opposing actions of guanine nucleotide exchange factors (GEFs) and GTPase-ac

225 s are established by their specific, cognate guanine nucleotide exchange factors (GEFs) and GTPase-ac

226 Guanine nucleotide exchange factors (GEFs) are the initi

227 he localization of Tiam1 and Trio, which are guanine nucleotide exchange factors (GEFs) for Rac, ther

228 tor of cytokinesis) proteins are multidomain guanine nucleotide exchange factors (GEFs) for RHO GTPas

229 By comprehensive screening of guanine nucleotide exchange factors (GEFs) in human bron

230 Vps9 and Muk1 are guanine nucleotide exchange factors (GEFs) in Saccharomy

231 Ric-8 proteins also act as Galpha-subunit guanine nucleotide exchange factors (GEFs) in vitro.

232 The synaptic Ras homologous (Rho) guanine nucleotide exchange factors (GEFs) Kalirin and T

233 haromyces cerevisiae VPS9-domain Rab5-family guanine nucleotide exchange factors (GEFs) Muk1 and Vps9

234 The action of guanine nucleotide exchange factors (GEFs) on the ADP-ri

235 t either the RAS interaction with activating guanine nucleotide exchange factors (GEFs) or receptor t

236 PIX proteins are guanine nucleotide exchange factors (GEFs) that activate

237 in Caenorhabditis elegans, we show that the guanine nucleotide exchange factors (GEFs) UNC-73/Trio a

238 Rho GTPases, activated by Rho guanine nucleotide exchange factors (GEFs), are conserve

239 Rho GTPases, activated by guanine nucleotide exchange factors (GEFs), are essentia

240 of a newly identified family of non-receptor guanine nucleotide exchange factors (GEFs), GIV/Girdin,

241 proteins is controlled by their regulators; guanine nucleotide exchange factors (GEFs), GTPase activ

242 The activity of KRAS is regulated by guanine nucleotide exchange factors (GEFs), GTPase-activ

243 Two related guanine nucleotide exchange factors (GEFs), PDZ-RhoGEF a

244 Upon activation by guanine nucleotide exchange factors (GEFs), Rac1 associa

245 es of binary interactors, both effectors and guanine nucleotide exchange factors (GEFs), showed induc

246 ess is known, however, about the function of guanine nucleotide exchange factors (GEFs), which activa

247 vated with precise spatiotemporal control by guanine nucleotide exchange factors (GEFs).

248 ila orthologue of the SH3BP5 family of Rab11 guanine nucleotide exchange factors (GEFs).

249 rged as the largest family of Rab-activating guanine nucleotide exchange factors (GEFs).

250 Cdc42 is activated by guanine nucleotide exchange factors (GEFs).

251 activation of Rho GTPases is governed by Rho guanine nucleotide exchange factors (GEFs).

252 s of Ras GTPases are triggered by Ras GTPase guanine nucleotide exchange factors (RasGEFs) in general

253 anger) family (P-Rex1 and P-Rex2) of the Rho guanine nucleotide exchange factors (Rho GEFs) activate

254 in humans, are controlled by 145 multidomain guanine nucleotide exchange factors (RhoGEFs) and GTPase

255 phospholipase C (PLC)-beta isozymes and Rho guanine nucleotide exchange factors (RhoGEFs) related to

256 ays form in response to prepatterning by Rho guanine nucleotide exchange factors (RhoGEFs), a family

257 e role of their upstream regulators, the Rho guanine nucleotide exchange factors (RhoGEFs).

258 in cytoskeleton dynamics, including numerous guanine nucleotide exchange factors and GTPase-activatin

259 RAPPs) are multi-protein complexes acting as guanine nucleotide exchange factors and possibly as teth

260 ctions between endogenous GPR124 and the Rho guanine nucleotide exchange factors Elmo/Dock and inters

261 DOCK proteins are guanine nucleotide exchange factors for Rac and Cdc42 GT

262 plex formed of atypical and conventional Rho guanine nucleotide exchange factors for Rac and Cdc42 th

263 IQSEC1-3 encode guanine nucleotide exchange factors for the small GTPase

264 1 and Rac2 activation was independent of Rac guanine nucleotide exchange factors known to regulate T

265 roteins directly activated by cAMP (EPAC) as guanine nucleotide exchange factors mediate the effects

266 Morpholinos targeting two other guanine nucleotide exchange factors not known to be in t

267 These guanine nucleotide exchange factors regulate the spatiot

268 educed after T cell-specific deletion of the guanine nucleotide exchange factors Sos1 and Sos2, which

269 ity-based ligation assay, BioID, to identify guanine nucleotide exchange factors that activate Cdc42

270 RasGRPs are guanine nucleotide exchange factors that are specific fo

271 G protein-coupled receptors stimulate Rho guanine nucleotide exchange factors that promote mammali

272 DOCK3 is a member of the DOCK family of guanine nucleotide exchange factors that regulate cell m

273 main-bearing proteins that function as GEFs (guanine nucleotide exchange factors) for the small GTPas

274 are known to be Rab effectors and Rab GEFs (Guanine nucleotide Exchange Factors) that regulate vesic

275 via Rho-family small GTPases, their upstream guanine nucleotide exchange factors, and GTPase-activati

276 uiting two related brefeldin A-resistant Arf guanine nucleotide exchange factors, BRAG1 and BRAG2, in

277 Arf1 is activated by guanine nucleotide exchange factors, but essential roles

278 nitially, SmgGDS proteins were classified as guanine nucleotide exchange factors, but recent findings

279 nvolve gain-of-function mutations in Rac and guanine nucleotide exchange factors, defects in Rac1 deg

280 transcriptional upregulation of Rac-specific guanine nucleotide exchange factors, Rac activation, and

281 Thus, Rho guanine nucleotide exchange factors, the activators of t

282 reduce the levels of active RAS is to target guanine nucleotide exchange factors, which allow RAS to

283 g via direct interactions with RhoA-specific guanine nucleotide exchange factors.

284 focal adhesion-associated proteins, and Rho guanine nucleotide exchange factors.

285 G proteins, most prominently, G12/13, to Rho guanine nucleotide exchange factors.

286 screens targeting Rho-GTPases effectors and guanine nucleotide exchange factors.

287 tive factor (GBF1) and brefeldin A-inhibited guanine nucleotide-exchange factors (BIG1 and BIG2).

288 by antibodies against brefeldin A-inhibited guanine nucleotide-exchange factors 1 and 2 (BIG1 or BIG

289 mulatory effects of heterologously expressed guanine nucleotide-exchange factors or of constitutively

290 factor ARF GTPase by the SEC7 domain of ARF guanine-nucleotide exchange factors (ARF-GEFs), resultin

291 tein-coupled receptors (GPCRs), non-receptor guanine-nucleotide exchange factors (GEFs) have emerged

292 The 2 EPAC isoforms, EPAC1 and EPAC2, are guanine-nucleotide exchange factors for the Ras-like GTP

293 Several Rac guanine nucleotide exchange-factors (Rac-GEFs) were also

294 kDa cytosolic protein that has chaperone and guanine nucleotide exchange (GEF) activity toward hetero

295 cess and modulate G proteins via a cytosolic guanine-nucleotide exchange modulator (GEM), GIV/girdin;

296 Upon growth factor stimulation, the guanine-nucleotide exchange modulator dissociates Galpha

297 nt G protein activation by a novel family of guanine-nucleotide exchange modulators (GEMs) remains un

298 but rather, through direct activation of the guanine nucleotide exchange protein Epac by cAMP.

299 Guanine nucleotide exchange proteins directly activated

300 -G279S(7.44) was more effective in promoting guanine nucleotide exchange than wild-type A(1)R.