ライフサイエンスコーパス: guanosine

1 dducts with the C8 position of adenosine and guanosine.

2 hydrogen bonding and cation-coordination of guanosines.

3 mic acid (3) forms hydrogels when mixed with guanosine (1) and KCl.

4 R downstream signaling molecule cGMP (cyclic guanosine 3',5' monophosphate) from 0.91+/-0.3 to 3.1+/-

5 l class of peptidic hormones that signal via guanosine 3',5'-cyclic monophosphate (cGMP) and systemic

6 /PEL-negative individuals exhibited a normal guanosine 3',5'-cyclic monophosphate level, suggesting a

7 ty, leading to elevated intracellular cyclic guanosine 3',5'-monophosphate (cGMP) and subsequent vasc

8 We identified 1189 5'-cytosine-phosphate-guanosine-3' (CpG) sites that were differentially methyl

9 The cyclic guanosine-3',5'-monophosphate (cGMP)-dependent protein k

10 ersion of guanosine triphosphate into cyclic guanosine-3',5'-monophosphate, a key second messenger in

11 Pharmacological studies using radiolabeled guanosine 5'-3-O-([(35)S]thio)triphosphate and [(3)H]ket

12 ed agonist Emax) in signaling events such as guanosine 5'-3-O-(thio)triphosphate binding and beta-arr

13 In guanosine 5'-3-O-(thio)triphosphate binding and INS1 832

14 mined by opioid receptor binding and [(35)S] guanosine 5'-3-O-(thio)triphosphate binding.

15 hydrolyzes GTP and readily binds its analog guanosine 5'-3-O-(thio)triphosphate.

16 ular docking resulted into identification of guanosine 5'-diphosphate (GDP) as a promising hepcidin-b

17 plexes between K-Ras or the G12X mutants and guanosine 5'-diphosphate (GDP) or GDPnP (a stable GTP an

18 , we observed that in solution, farnesylated guanosine 5'-diphosphate (GDP)-bound K-Ras4B is predomin

19 review, we discuss newly elucidated roles of guanosine 5'-diphosphate 3'-diphosphate (ppGpp) in trans

20 This could be prevented by guanosine 5'-diphosphate inhibition of UCP1.

21 onsequently, drugs targeting the inactive or guanosine 5'-diphosphate-bound conformation are not expe

22 ility of G-quartet stacks formed by disodium guanosine 5'-monophosphate (Na25'-GMP).

23 of the enzymes involved in ppGpp, pppGpp and guanosine 5'-monophosphate 3'-diphosphate (pGpp) (collec

24 The Leishmania guanosine 5'-monophosphate reductase (GMPR) and inosine

25 Guanosine 5'-monophosphate reductase (GMPR) is involved

26 Indeed, guanosine 5'-O-(thiotriphosphate) and GPCR agonists only

27 h end-binding protein 1 (EB1) for binding to guanosine 5'-O-[gamma-thio]triphosphate (GTPgammaS)-stab

28 initial hit, 36 showed improved potency in a guanosine 5'-O-[gamma-thio]triphosphate assay, exhibited

29 generating conditions in up to 95% yield and guanosine 5'-oligophosphates in up to 35% yield.

30 y redistribution and pinpoint why the TS for guanosine 5'-triphosphate (GTP) hydrolysis is higher in

31 s), proteins that catalyze the hydrolysis of guanosine 5'-triphosphate (GTP) to promote conformationa

32 ), Sec23-Sec24, and blocked upon addition of guanosine-5'-[(beta,gamma)-imido]triphosphate, a poorly

33 Guanosine-5'-hydroxamic acid (3) forms hydrogels when mi

34 inone (H2Q), N-acetyl-tyrosine (N-Ac-Tyr) or guanosine-5'-monophosphate (GMP) was investigated at var

35 Guanosine-5'-monophosphate reductase (GMPR) catalyzes th

36 for potential existence of a third alarmone, guanosine-5'-monophosphate-3'-diphosphate (pGpp), with l

37 of the two enzymes, tyrosine hydroxylase and guanosine-5'-tri-phosphate-cyclohydrolase-1, bilaterally

38 Septins (SEPTs) are filamentous guanosine-5'-triphosphate (GTP)-binding proteins, which

39 8-Oxo-7,8-dihydro-2'-guanosine (8-oxo-G) is a common oxidized nucleobase whos

40 r containing a template 8-oxo-7,8-dihydro-2'-guanosine (8OG) by Family X Polymerase mu (Pol mu) in st

41 nome encapsidation, indicating that unpaired guanosines act synergistically to promote packaging.

42 e using FSCV, which can be used to study the guanosine-adenosine interaction and better understand th

43 A guanosine-adenosine interaction has been proposed in whi

44 While all tested guanosine analogs stimulate the splitting activity of Hf

45 ions at their 5' end: an inverted methylated guanosine and a unique 2'O-methylation on the ribose of

46 Both exogenously applied guanosine and adenosine and endogenous transient release

47 Guanosine and adenosine are important neuromodulators in

48 c voltammetry (FSCV) has been used to detect guanosine and adenosine independently, but codetection h

49 Protected guanosine and adenosine ribonucleosides and guanine nucl

50 We show the first method for codetecting guanosine and adenosine using FSCV, which can be used to

51 loped a novel "scalene waveform" to codetect guanosine and adenosine with nanomolar limits of detecti

52 se the separation of the oxidative peaks for guanosine and adenosine.

53 ition unmodified 5'-(R)- and 5'-(S)-C-methyl guanosine and evaluation of these nucleotides in the con

54 molecular chaperone for gelation of water by guanosine and lithium borate.

55 8-Hydroxy-deoxy guanosine and malondialdehyde levels as markers of oxida

56 involving either inosine and hypoxanthine or guanosine and xanthosine as intermediates.

57 phate, inosine monophosphate, adenosine, and guanosine) and kokumi (gamma-l-glutamyl-l-valine) taste-

58 lipid, and protein metabolisms, glutathione, guanosine, and L-glutamic acid, which are implicated in

59 identify METTL1-dependent N7-methylation of guanosine as a new RNA modification pathway that regulat

60 periments demonstrated strong preference for guanosine at nt 22 of miR-122.

61 xamined the roles of single-stranded exposed guanosines at NC binding sites in RNA genome packaging u

62 The addition of three guanosines at the 5' end of the substrate significantly

63 lobacter-infecting phages, which replace all guanosine bases in the genome in a genus-specific manner

64 within a cellular setting, whereby cytosine-guanosine binding appeared to disrupt this cell-surface

65 ndicate that the PRNTase domain has a unique guanosine-binding mode different from that of eukaryotic

66 hat ThT increases the stiffness of the Li(+) guanosine-borate (GB) hydrogel.

67 ulating levels of bis-(3',5')-cyclic-dimeric-guanosine (c-di-GMP), a second messenger that stimulates

68 ) catalyses the formation of a N7-methylated guanosine cap structure on the 5' end of nascent RNA pol

69 hat viral RNAs containing a single 5' capped guanosine ((Cap)1G) are specifically selected for packag

70 ed RNAs beginning with one, two, or three 5'-guanosines ((Cap)1G, (Cap)2G, or (Cap)3G, respectively)

71 n interchangeable and hierarchical nature of guanosine-containing sites, which was not previously est

72 tide combination of a cytosine followed by a guanosine (CpG), indicating that they are detrimental to

73 nthine dehydrogenase, nucleoside hydrolases, guanosine deaminase, and hypoxanthine guanine phosphorib

74 anthine, and that xanthosine is derived from guanosine deamination and a second source, likely xantho

75 Taken together, the results suggest that a guanosine-dependent metabolic switch determines the mode

76 (S-IIP) that is present only in the inactive guanosine diphosphate (GDP)-bound form of KRAS(G12C), sp

77 T2/6/7 has a modest preference for GTP- over guanosine diphosphate (GDP)-bound MT lattice and compete

78 BACKGROUND & AIMS: De novo synthesis of guanosine diphosphate (GDP)-fucose, a substrate for fuco

79 De novo synthesis of guanosine diphosphate (GDP)-fucose, a substrate for fuco

80 ab1b that is commonly dictated by binding to guanosine diphosphate or guanosine triphosphate.

81 Guanosine triphosphate (GTP) turnover, guanosine diphosphate release, GTP binding, and G protei

82 dimeric conformations upon binding to GTP or guanosine diphosphate, and that the Parkinson's disease

83 activating Ras into inactive Ras is bound to guanosine diphosphate, inactivating Ras.

84 However, not all guanosines examined have the same effect; instead, a hie

85 These guanosines frequently divide poly(A) tails into interspe

86 of alternating non-templated uridine (U) and guanosine (G) ribonucleotides to the 3' termini of these

87 Thienoguanosine ((th)G) is an isomorphic guanosine (G) surrogate that almost perfectly mimics G i

88 an 10% of poly(A) tails contain at least one guanosine (G); among them, the G-content varies from 0.8

89 e of a pre-catalytic state of this RNA shows guanosine G40 and adenosine A32 close to the G53-U54 cle

90 nucleobases adenine, thymine, cytosine, and guanosine has been performed.

91 We also demonstrated that a guanosine homopolymer of various lengths located between

92 Inosine (IC50 = 3.7 microM) and guanosine (IC50 = 21.3 microM) had the highest affinitie

93 by the nucleobases of conserved uridine and guanosine in helix P4 of the RNA subunit (P RNA).

94 udies demonstrate the importance of specific guanosines in HIV-2 5'UTR in mediating genome packaging.

95 at reveal that METTL1 N7-methylates internal guanosines in mRNAs and miRNAs to increase translation e

96 rus and HIV-1, we hypothesized that unpaired guanosines in the 5' untranslated region (UTR) play an i

97 Structural properties of 5'-(R)-C-methyl guanosine incorporated into an RNA octamer were analysed

98 s structure-for example, by incorporation of guanosine into poly(A)-inhibits deadenylation by both Pa

99 ch antiparallel strand assembly in which syn-guanosine is adjacent to the complex at the 5' end of th

100 Protected guanosine is trifluoromethylated at the C8 position unde

101 ing of the second messenger ppGpp to inosine-guanosine kinase (Gsk) in E. coli modulates the levels o

102 inhibition for one target, Gsk, the inosine-guanosine kinase.

103 improved malondialdehyde and 8-hydroxy-deoxy guanosine levels, and also deteriorated renal function.

104 To test our hypothesis, we targeted 18 guanosines located in 9 sites within the HIV-2 5' UTR an

105 Methyl-7-guanosine (m(7)G) "capping" of coding and some noncoding

106 g facilitating the discovery of the methyl-7-guanosine (m(7)G) cap on the 5' end of RNAs.

107 c mRNAs generally possess a 5' end N7 methyl guanosine (m(7)G) cap that promotes their translation an

108 mRNAs) normally possess a 5' end N(7)-methyl guanosine (m(7)G) cap, a non-canonical 5' nicotinamide a

109 'ppp is capped by the addition of a 7-methyl guanosine (m7G) (Cap-0) and a 2'-O-methyl (2'-OMe) group

110 To date, two genomic guanosine modifications have been observed in phage geno

111 ported as analytical techniques improve, but guanosine modifications have been underreported.

112 of a G-C base pair, explains how a single 5'-guanosine modifies the function of a ~9-kilobase HIV-1 t

113 osine interaction has been proposed in which guanosine modulates adenosine levels, and the two work t

114 second messenger bis-(3'-5')-cyclic-dimeric-guanosine monophosphate (c-di-GMP) acts as an innate imm

115 he bacterial second messenger cyclic dimeric guanosine monophosphate (c-di-GMP) by posttranscriptiona

116 The second messenger bis-3,5-cyclic di-guanosine monophosphate (c-di-GMP) determines when Strep

117 Bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP) is a dynamic intracel

118 e bacterial second messenger cyclic di-3',5'-guanosine monophosphate (c-di-GMP) is a key regulator of

119 second messenger bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP).

120 3B (PDE3B), and a membrane-permeable cyclic guanosine monophosphate (cGMP) analog on KATP channel ac

121 G protein-coupled receptors and cyclic guanosine monophosphate (cGMP) are implicated in the res

122 ic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) are now recognized as imp

123 m in dogs that results in lower basal cyclic guanosine monophosphate (cGMP) concentrations than in wi

124 duction of the second messenger 3',5'-cyclic guanosine monophosphate (cGMP) have been shown to protec

125 trength and fluorescence response for cyclic guanosine monophosphate (cGMP) in an aqueous solution.

126 9-I dose-dependently increased plasma cyclic guanosine monophosphate (cGMP) in normal sheep (p < 0.05

127 Phosphodiesterase 5 (PDE5) hydrolyzes cyclic guanosine monophosphate (cGMP) leading to increased leve

128 tive (soluble) guanylyl cyclase (sGC)-cyclic guanosine monophosphate (cGMP) pathway regulates diverse

129 The cyclic guanosine monophosphate (cGMP) specific phosphodiesteras

130 itric oxide pathway effector molecule cyclic guanosine monophosphate (cGMP), has been implicated in t

131 ic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), is preferentially expres

132 ownstream target of sildenafil in the cyclic guanosine monophosphate (cGMP)-activated protein kinase

133 el from Caenorhabditis elegans in the cyclic guanosine monophosphate (cGMP)-bound open state.

134 reas the response to ascr#3 relies on cyclic guanosine monophosphate (cGMP)-gated channels and activi

135 lyl-cyclase, GCY-8, which synthesizes cyclic guanosine monophosphate (cGMP).

136 The elevated cyclic guanosine monophosphate (cGMP)/cGMP-dependent protein ki

137 We show that the coassembly of guanosine monophosphate (GMP) with an azobenzene-contain

138 Cyclic guanosine monophosphate (GMP)-adenosine monophosphate (A

139 riggers the innate immune response is cyclic guanosine monophosphate (GMP)-adenosine monophosphate (A

140 the recognition of cytosolic mtDNA by cyclic guanosine monophosphate (GMP)-AMP synthase (cGAS).

141 97%, -0.61%; P = 0.04) and attenuated cyclic guanosine monophosphate concentrations.

142 Other strategies to increase tissue cyclic guanosine monophosphate have been attempted, such as PDE

143 Cyclic guanosine monophosphate is mainly hydrolyzed by PDE (pho

144 Reduced cyclic guanosine monophosphate levels contribute to HF progress

145 which they detect through a rhodopsin-cyclic guanosine monophosphate pathway.

146 and influencing the adenosine monophosphate/guanosine monophosphate ratio.

147 We further demonstrate that the gene for guanosine monophosphate reductase (GMPR) is a direct MIT

148 sphodiesterase-5 inhibitors and other cyclic guanosine monophosphate signaling activators worked syne

149 d treatment with N-acetylcysteine and cyclic guanosine monophosphate signaling enhancers warrants fur

150 Abnormal cyclic guanosine monophosphate signaling may contribute to phys

151 guanosine triphosphate to cGMP (cyclic 3',5'-guanosine monophosphate) on binding of ANP, BNP (atrial

152 ssenger c-di-GMP (Bis-(3'-5')-cyclic dimeric guanosine monophosphate), to make a vital choice: whethe

153 , Na2 [(HGMP)2 Mo5 O15 ]7 H2 O (1; where GMP=guanosine monophosphate), which spontaneously assembles

154 Guanosine monophosphate, among the nucleotides, has the

155 phodiesterases (PDEs), which degrade cGMP to guanosine monophosphate, play key role in controlling th

156 -treated kidneys had higher levels of cyclic guanosine monophosphate, potentially explaining the perf

157 the synthesis of a second messenger, cyclic guanosine monophosphate-adenosine monophosphate (2'3'-cG

158 2'3'-cyclic guanosine monophosphate-adenosine monophosphate (2'3'-cG

159 Here we show that cytoplasmic sensor cyclic guanosine monophosphate-adenosine monophosphate (AMP) sy

160 tin without linker histone stimulates cyclic guanosine monophosphate-adenosine monophosphate (cGAMP)

161 The DNA sensor cyclic guanosine monophosphate-adenosine monophosphate (cGAMP)

162 led that SR-717 functions as a direct cyclic guanosine monophosphate-adenosine monophosphate (cGAMP)

163 mimetic liposomes encapsulating 2',3'-cyclic guanosine monophosphate-adenosine monophosphate (cGAMP),

164 endogenous CDN ligand for STING, 2'3' cyclic guanosine monophosphate-adenosine monophosphate (cGAMP).

165 ed liposome loaded with STING agonist cyclic guanosine monophosphate-adenosine monophosphate (NP-cGAM

166 a pathway dependent on the DNA sensor cyclic guanosine monophosphate-adenosine monophosphate synthase

167 ed an altered distribution of nuclear cyclic guanosine monophosphate-adenosine monophosphate synthase

168 The cyclic guanosine monophosphate-adenosine monophosphate synthase

169 riggered activation of the DNA sensor cyclic guanosine monophosphate-adenosine monophosphate synthase

170 Low myocardial cGMP-PKG (cyclic guanosine monophosphate-protein kinase G) activity has b

171 ieties implicate modification on an internal guanosine N-2, rather than a ribose hydroxyl.

172 the same for both nucleotides, suggesting a guanosine nucleoside or ribose-first mechanism for nucle

173 nvolving formation of the C4' radical of the guanosine nucleoside that is subsequently excised.

174 ults in excision of most atoms of a specific guanosine nucleoside.

175 expectedly contains a zinc ion complex and a guanosine nucleotide binding site.

176 RL13b) is a small GTPase that functions as a guanosine nucleotide exchange factor (GEF) for ARL3-GDP.

177 In this issue, Fine et al. identify the guanosine nucleotide exchange factor GEF-H1 as critical

178 nt paradigm holds that the inhibition of Rho guanosine nucleotide exchange factors (GEFs), the enzyme

179 nd then recapping it with an affinity-tagged guanosine nucleotide.

180 Despite supplementation, depletion of guanosine nucleotides (p < 0.001 at 24 and 72 h; 5, 100,

181 reviously reported IMPDH complexes harboring guanosine nucleotides at the second canonical site, TbIM

182 ans MUT-2, that adds alternating uridine and guanosine nucleotides to form poly(UG) tails.

183 Rel proteins synthesize hyperphosphorylated guanosine nucleotides, denoted as (p)ppGpp, which by inh

184 To understand how 5'-guanosine number influences fate, we probed the structur

185 receptor 9 (TLR9) agonist cytidine-phosphate-guanosine oligodeoxynucleotide (CpG) to determine effect

186 ), the Toll-like-receptor-9 agonist cytosine-guanosine oligodeoxynucleotide and one or multiple leuka

187 e ligands include phosphorothioated cytosine-guanosine oligonucleotides, a motif often seen in bacter

188 Urinary oxidized guanine/guanosine (OxGua) concentrations, including 8-hydroxy-2'

189 hat is mediated by the signaling nucleotides guanosine penta- and tetraphosphate (ppGpp).

190 titoxin modules, adenosine triphosphate, and guanosine (penta) tetraphosphate, respectively.

191 at is dependent on the UvrD helicase and the guanosine pentaphosphate (ppGpp) alarmone/stringent resp

192 The alarmone nucleotides guanosine pentaphosphate (pppGpp) and tetraphosphate (pp

193 armones guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) in response to nutrien

194 s tested in this report, substituting 3 to 4 guanosines resulted in <2-fold defects in packaging.

195 Telomere DNA is guanosine rich and, as such, can form highly stable seco

196 We found that mutating as few as three guanosines significantly reduce RNA packaging efficiency

197 and discover unexpectedly that PGL-1 DD is a guanosine-specific, single-stranded endonuclease.

198 ely spaced runs of three or more consecutive guanosines strongly tend to fold into stable G-quadruple

199 Effects of MPA exposure and guanosine supplementation on nucleotide concentrations i

200 ine monophasphate dehydrogenase dedicated to guanosine synthesis, GuaB2, displayed the opposite expre

201 signalling system mediated by the alarmones guanosine tetraphosphate (ppGpp) and guanosine pentaphos

202 t has been linked to this persister state is guanosine tetraphosphate (ppGpp), the alarmone that was

203 The alarmone nucleotides guanosine tetraphosphate and pentaphosphate, commonly re

204 r normal growth conditions is implemented by guanosine tetraphosphate.

205 Intriguingly, the second messenger, guanosine-tetraphosphate (ppGpp), which is produced duri

206 repair, at the mRNA level, a disease-causing guanosine to adenosine (G > A) mutation in the mouse MeC

207 ters containing a family of paralogs of tRNA guanosine transglycosylase genes, called tgtA5, alongsid

208 nthesizing enzymes, tyrosine hydroxylase and guanosine-tri-phosphate-cyclohydrolase-1, offers a new a

209 in complex 1 (mTORC1) protein kinase via its guanosine triphosphatase (GTPase) activating protein (GA

210 eins are constitutively active because their guanosine triphosphatase (GTPase) activity is disabled.

211 LRRK2 has guanosine triphosphatase (GTPase) and kinase activities,

212 erestingly, ciliary trafficking of the small guanosine triphosphatase (GTPase) Arl13b, loss of which

213 SKIP binds to the small guanosine triphosphatase (GTPase) ARL8 on the lysosomal

214 During mitochondrial division, the mechano-guanosine triphosphatase (GTPase) dynamin-related protei

215 s targeting KRAS(G12C), a mutant form of the guanosine triphosphatase (GTPase) KRAS, are a promising

216 ornavirus infection was a large set encoding guanosine triphosphatase (GTPase) of immunity-associated

217 The Cdc42 guanosine triphosphatase (GTPase) plays a central role i

218 The guanosine triphosphatase (GTPase) Rab32 coordinates a ce

219 ration and cell migration, whereas the small guanosine triphosphatase (GTPase) Rac1 mediates cell mig

220 ly of heterotrimeric G proteins to the small guanosine triphosphatase (GTPase) RhoA, enabling Galpha(

221 ein synthesis, elongation factor G (EF-G), a guanosine triphosphatase (GTPase), binds to the ribosoma

222 re its Raptor subunit interacts with the Rag guanosine triphosphatase (GTPase)-Ragulator complex.

223 is a disease-associated RAS subfamily small guanosine triphosphatase (GTPase).

224 , and CTNNB1 (encoding beta-catenin) and RHO guanosine triphosphatase [RHO GTPase, RHO], two signalin

225 treadmilling predominantly determined by its guanosine triphosphatase activity.

226 The loss of the small guanosine triphosphatase ADP-ribosylation factor 1 (Arf1

227 We identified Arf6 guanosine triphosphatase and its activators, cytohesins,

228 is issue, Rafiq et al. reveal that the small guanosine triphosphatase ARF1, a well-known orchestrator

229 Here, we examine the function of Rho guanosine triphosphatase CDC-42 in AJ formation and regu

230 e cortical PAR proteins (including the small guanosine triphosphatase CDC-42) have an active role in

231 on is a multistep process facilitated by the guanosine triphosphatase elongation factor (EF)-Tu.

232 es bound to tRNAs, nascent polypeptides, the guanosine triphosphatase elongation factors mtEF-Tu and

233 idermal growth factor receptor (EGFR) or the guanosine triphosphatase KRAS.

234 Proteolytic cleavage of the dynamin-like guanosine triphosphatase OPA1 in mitochondria is emergin

235 PIX and decreasing the activity of the small guanosine triphosphatase Rac1 and Cdc42.

236 l adhesion reduction by activating the small guanosine triphosphatase Ras homolog family member J by

237 f early growth response 3 (EGR3) and the Rho guanosine triphosphatase RhoA.

238 show that mouse embryos that lack the small guanosine triphosphatase RSG1 die at embryonic day 12.5,

239 eIF2 is a guanosine triphosphatase that becomes activated by eIF2B

240 -membrane receptor for DRP1, the cytoplasmic guanosine triphosphatase that catalyzes mitochondrial fi

241 echanistically distinct enzymes (a kinase, a guanosine triphosphatase, and a ubiquitin protein hydrol

242 pecifically binds to the IQ motif-containing guanosine triphosphatase-activating protein 1 (IQGAP1) s

243 ng the genes small ARF GAP1 (SMAP1), an ARF6 guanosine triphosphatase-activating protein that functio

244 C1 is activated on lysosomes by Rag and Rheb guanosine triphosphatases (GTPases) and drives biosynthe

245 (mTORC1) is recruited to the lysosome by Rag guanosine triphosphatases (GTPases) and regulates anabol

246 Rho guanosine triphosphatases (GTPases) are master regulator

247 yclical activation and inactivation of small guanosine triphosphatases (GTPases) by their specific gu

248 Rab guanosine triphosphatases (GTPases) control cellular tra

249 creasing the activity of the recycling small guanosine triphosphatases (GTPases) Rab4 or Rab11 was su

250 The Rag guanosine triphosphatases (GTPases) recruit the master k

251 al cells, signaling pathways involving small guanosine triphosphatases (GTPases) regulate cell polari

252 Ras guanosine triphosphatases (GTPases) regulate signaling p

253 Nutrients signal via the Rag guanosine triphosphatases (GTPases) to promote the local

254 involving the Ragulator complex and the Rag guanosine triphosphatases (GTPases), causing release of

255 e group of proteins, the Rho family of small guanosine triphosphatases (GTPases), is critical for thi

256 ce of RIT1 to other members of the Ras small guanosine triphosphatases (GTPases), mutations affecting

257 Many of those factors are guanosine triphosphatases (GTPases), proteins that catal

258 These processes all involve Rho family small guanosine triphosphatases (GTPases), which are regulated

259 tment to the surface of lysosomes by the Rag guanosine triphosphatases (GTPases).

260 nse proteins, including interferon-inducible guanosine triphosphatases and the antimicrobial cathelic

261 importance and activates mTORC1 via the Rag guanosine triphosphatases and their regulators GATOR1 an

262 d into motility signaling proteins (kinases, guanosine triphosphatases, and guanine exchange factors)

263 pparatus and physically interacts with small guanosine triphosphatases.

264 Guanosine triphosphate (GTP) cyclohydrolase I (GCH1) cat

265 tyrosine kinase (RTK) ligands increase RhoA-guanosine triphosphate (GTP) in untransformed and transf

266 rtical motor complexes that depends on a Ran-guanosine triphosphate (GTP) signal [12], which is suffi

267 Here, we find that the binding of guanosine triphosphate (GTP) to one subunit inhibits the

268 Guanosine triphosphate (GTP) turnover, guanosine diphosp

269 d the availability of ATP, which regenerates guanosine triphosphate (GTP), powers ribosomes, and prom

270 heir reduced intrinsic rate of hydrolysis of guanosine triphosphate (GTP), which results in their acc

271 he authors demonstrate that TBSV co-opts the guanosine triphosphate (GTP)-bound active form of the en

272 ng podosome formation increased the level of guanosine triphosphate (GTP)-bound ARF1.

273 C2[E62K] displayed characteristics of active guanosine triphosphate (GTP)-bound RAC2 including enhanc

274 rnesyl-dependent, but neither palmitoyl- nor guanosine triphosphate (GTP)-dependent, fashion.

275 activated and deactivated for assembly by a guanosine triphosphate (GTP)-driven reaction cycle, and

276 s sustained by karyopherins (Kaps) and a Ran guanosine triphosphate (RanGTP) gradient that imports nu

277 d, and escort NLS-NCs through NPCs while Ran guanosine triphosphate (RanGTP) promotes their release f

278 ll polarity in the context of elevated Cdc42-guanosine triphosphate activity, similar to nonmalignant

279 App, and an associated depletion of cellular guanosine triphosphate and adenosine triphosphate pools,

280 otein synthesis via assembly of the 7-methyl-guanosine triphosphate cap-dependent translation complex

281 properties, including the requirement for a guanosine triphosphate cofactor and the generation of lo

282 Additionally, we infer that the bound guanosine triphosphate cofactor interacts with the termi

283 egulates actin (dis-)assembly, and catalytic guanosine triphosphate hydrolysis is found in tubulin (d

284 te cyclase (sGC) catalyzes the conversion of guanosine triphosphate into cyclic guanosine-3',5'-monop

285 echanism of action may be related to altered guanosine triphosphate loading.

286 BB, which are associated with CDC42, a small guanosine triphosphate protein linked to T-cell activati

287 Resting and activated sGC enzyme converts guanosine triphosphate to an important second messenger

288 -A catalyzes the intracellular conversion of guanosine triphosphate to cGMP (cyclic 3',5'-guanosine m

289 the conformational change of EF-Tu from the guanosine triphosphate to guanine diphosphate conformati

290 at microtubules elongate by addition of bent guanosine triphosphate tubulin to the tips of curving pr

291 gnaling by converting active Ras is bound to guanosine triphosphate, activating Ras into inactive Ras

292 t retain the intrinsic capacity to hydrolyze guanosine triphosphate, suggesting that the mechanism of

293 NRAS is a guanosine triphosphate-binding protein whose most well-c

294 l-length Trio, led to increased abundance of guanosine triphosphate-bound RhoA (RhoA.GTP) in human ce

295 tated by binding to guanosine diphosphate or guanosine triphosphate.

296 uses the widely available starting material guanosine via a short sequence ending in a Mukaiyama hyd

297 es, namely cytidine, uridine, adenosine, and guanosine, were identified.

298 rmation of ANKRD9/IMPDH2 rods is reversed by guanosine, which restores ANKRD9 associations with the v

299 sis of a photocaged nucleotide that releases guanosine within microseconds upon photosolvolysis with

300 spectrometry methods, we map m7G to a single guanosine within the let-7e-5p miRNA.