ライフサイエンスコーパス: gustatory

1 lted in significant reorganization of mature gustatory afferent terminal fields in the nucleus of the

2 We investigated whether gustatory afferents express functional 5-HT3 receptors a

3 ying interactions, via transmitters, between gustatory and chemosensory afferents inside taste buds w

4 ters mainly project on a prominent secondary gustatory and general visceral nucleus (SGN/V) located i

5 Insect gustatory and odorant receptors (GRs and ORs) form a sup

6 hould be considered during the evaluation of gustatory and olfactory epileptic seizures.

7 The integration of gustatory and olfactory information is essential to the

8 role of insular cortex in the processing of gustatory and olfactory inputs, the exact location of ol

9 vivo functional imaging techniques to trace gustatory and olfactory pheromone circuits to their poin

10 construction of a "flavor" percept when both gustatory and olfactory stimuli are present.

11 (odor-only), or bimodal, responding to both gustatory and olfactory stimuli.

12 erts its potent reinforcing effects via both gustatory and post-ingestive pathways.

13 ucleus of the solitary tract (NST) processes gustatory and related somatosensory information rostrall

14 ctopic taste buds form independently of both gustatory and somatosensory innervation.

15 nalyses to reveal major distinctions between gustatory and somatosensory neurons and subclusters of g

16 hich, by anterograde labeling, correspond to gustatory and somatosensory neurons.

17 r integration centers for olfactory, visual, gustatory and tactile information.

18 yramine receptors are involved in modulating gustatory and tactile perception.

19 GNIFICANCE STATEMENT Prior data suggest that gustatory and trigeminal neural pathways intersect and o

20 Ex4-induced hypophagia, as the PBN receives gustatory and visceral afferent relays and descending in

21 tional and affective states, but not primary gustatory and viscerosensory information, has direct acc

22 Three sensory systems, the olfactory, gustatory, and solitary chemosensory cell (SCC) systems

23 The smallest subcluster expresses both gustatory- and mechanosensory-related genes, suggesting

24 anterior insula that may include the primary gustatory area (area G) and other cortical taste-process

25 rall liking scores for visual, olfactory and gustatory aspects.

26 sociation of taste sensor outputs with human gustatory assessment, salt content, and bioactivity.

27 mice, tongue innervation was disrupted, and gustatory axons failed to reach their targets.

28 Gustatory axons from internal and external taste sensill

29 novel hosts, mediated by plasticity in their gustatory capabilities along with an increased ability t

30 Our results reveal a novel role for PbN gustatory cells in cross-system signaling related to pro

31 ctivation to aversive nociceptive stimuli in gustatory cells was associated with responding to behavi

32 Main primary gustatory centers (facial and vagal lobes) received sens

33 The connectivity between diencephalic gustatory centers and the telencephalon was also investi

34 and specific diversification of orosensory, gustatory centers in the hindbrain.

35 n the basis of food-predicting cues, whereas gustatory circuits are believed to be involved in the ev

36 essary for the normal maintenance of central gustatory circuits at adulthood and highlights a level o

37 little is known, however, about higher-order gustatory circuits in the highly tractable model for neu

38 the functional and structural development of gustatory circuits.

39 eural activity has a role in shaping central gustatory circuits.

40 g a taste association paradigm revealed that gustatory conditioning also requires the mushroom bodies

41 The present results showed that the gustatory connections of the adult zebrafish are rather

42 neuroimaging experiments have pointed to the gustatory cortex (GC) as one of the areas involved in me

43 signal revealed that neurons in the primary gustatory cortex (GC) can respond to anticipatory cues.

44 Primary gustatory cortex (GC) is connected (both mono- and polys

45 The gustatory cortex (GC) is widely regarded for its integra

46 Our prior studies showed bilateral gustatory cortex (GC) lesions significantly impair taste

47 es of indirect evidence suggest that primary gustatory cortex (GC) may be a part of a distributed for

48 Here, we provide evidence that gustatory cortex (GC) may be part of the forebrain circu

49 ties, whether and how response properties of gustatory cortex (GC) neurons change as a function of th

50 somatosensory, and olfactory stimuli in the gustatory cortex (GC) of alert rats before and after ass

51 g of taste has focused on either the primary gustatory cortex (GC) or the orbitofrontal cortex (OFC).

52 The primary gustatory cortex (GC) receives projections from the baso

53 ell type-specific distinctions generalize to gustatory cortex (GC) remains unknown.

54 Taste responses in the rodent gustatory cortex (GC) span this sensorimotor divide, pro

55 Gustatory cortex (GC), an assemblage of taste-responsive

56 out the organization of taste information in gustatory cortex (GC).

57 n the brainstem and sends projections to the gustatory cortex (GC).

58 irst, we demonstrate that ZIP infusions into gustatory cortex begin interfering with CTA memory 43-45

59 et and bitter are represented in the primary gustatory cortex by neurons organized in a spatial map,

60 Here we found that neurons in gustatory cortex can respond either exclusively to tasta

61 The primary gustatory cortex has been proposed to integrate chemosen

62 tudies investigating taste coding within the gustatory cortex have reported highly segregated, taste-

63 (N=8), targeting the conventionally defined gustatory cortex in each hemisphere, and were implanted

64 taste types is a defining feature of primary gustatory cortex in other animals, their identification

65 findings do not rule out involvement of the gustatory cortex in palatability processing, they make e

66 study has revealed an important role for the gustatory cortex in such odor processing.

67 ough multiple neural stations to the primary gustatory cortex in the brain.

68 Our results provide evidence of the human gustatory cortex in the insula.

69 alysis of multielectrode recordings from the gustatory cortex of alert rats revealed ongoing sequence

70 ndent acceleration of coding observed in the gustatory cortex of alert rats.

71 ulus information in LFPs and spikes from the gustatory cortex of awake rats subjected to tastants and

72 Altogether, our results show that the gustatory cortex represents cross-modal stimuli accordin

73 demonstrate that inactivation of the insular gustatory cortex selectively impairs expression of retro

74 ste responses, and illustrate the ability of gustatory cortex to recapitulate complex behaviours in t

75 in humans, leaving the demarcation of human gustatory cortex unclear.

76 d that, on average, approximately 94% of the gustatory cortex was destroyed.

77 cally coupling microelectrode array to rat's gustatory cortex with brain-machine interface (BMI) tech

78 al taste reactivity behavior, lesions of the gustatory cortex, a region that has been suggested to be

79 stimulated neurons were found throughout the gustatory cortex, but a "hot spot" was observed in its a

80 human insular cortex, which contains primary gustatory cortex.

81 synaptic properties of the BLA input to the gustatory cortex.

82 the subregion approximating the dysgranular gustatory cortex.

83 merous studies in monkeys have reported that gustatory cortical neurons are broadly-tuned to multiple

84 tern, recording the activity of ensembles of gustatory cortical single neurons as rats that normally

85 Together our data suggest that different gustatory cues can modulate the activities of distinct s

86 Experimental gustatory curves have been fitted for four sugars (sucro

87 We conclude that gustatory detection of Ca(2+) represents an additional s

88 MAPK pathways, in particular, ERK1/2, in the gustatory detection of fatty acids.

89 egarding clinical characteristics, olfactory-gustatory disorders were more frequent in COVID-GBS than

90 th confirmed COVID-19 reported olfactory and gustatory dysfunction, indicating the significance of th

91 s of taste 2 receptor genes expressed in the gustatory end organs enable bony vertebrates (Euteleosto

92 d neurotrophic factor (BDNF) is expressed in gustatory epithelia and is required for gustatory neuron

93 ted that DEGs between gustatory (GE) and non-gustatory epithelium (NGE), and between GE and the under

94 led cucumbers giving different olfactory and gustatory evaluations.

95 e the likely area of insular cortex given to gustatory function and to characterize taste responses w

96 ilaments of threadfins have both tactile and gustatory functions.

97 local taste receptor gene expression in the gustatory ganglia and the brain.

98 estored until after reinnervation by distant gustatory ganglion neurons.

99 f oral cavity demonstrated that DEGs between gustatory (GE) and non-gustatory epithelium (NGE), and b

100 The central connections of the gustatory/general visceral system of the adult zebrafish

101 Olfactory and gustatory genes are reduced across the genus relative to

102 ed different gene expression profiles in the gustatory (geniculate) ganglion.

103 ity, associated derealisation, olfactory and gustatory hallucinations, physical symptoms such as head

104 c) of rats may mediate opioid enhancement of gustatory hedonic impact or "liking".

105 We also note that the gustatory influence on lifespan does not necessarily dep

106 Gustatory information can also reach another frontal reg

107 rvae employ a surprisingly different mode of gustatory information coding.

108 how the gustatory thalamus (VPMpc) processes gustatory information in behaving rats.

109 via serotonergic signaling during processing gustatory information in taste buds.

110 ) is the part of the thalamus that processes gustatory information.

111 ch less is known on how VPMpc neurons encode gustatory information.

112 for the dependence of taste cell renewal on gustatory innervation, neurotrophic support of taste bud

113 te buds is intimately dependent on an intact gustatory innervation, yet the molecular nature of this

114 to identify a neural circuit that integrates gustatory input and hunger state to modulate food ingest

115 amic causal modeling supports unidirectional gustatory input from basolateral amygdala (BLA) to hypot

116 In contrast, during hunger, gustatory inputs enter the hypothalamus and drive bidire

117 ence shows that the VPMpc receives ascending gustatory inputs from the parabrachial nucleus (PbN) in

118 ty is necessary for the normal maturation of gustatory inputs into the brain.

119 room bodies, revealing the essential role of gustatory inputs not only as rewards and punishments but

120 rch over the past decade has established the gustatory insular cortex (GC) as a model for studying ho

121 atial organization of taste responses in the gustatory insular cortex (GC) is currently debated, with

122 otentially reinforcing, inputs from putative gustatory interneurons or lateral horn neurons, which ca

123 Numerous sensory structures (e.g., auditory, gustatory, lateral line, olfactory, and visual nuclei) a

124 Our results demonstrate a gustatory mechanism that mediates the detection and bloc

125 generalized damage to biological systems, no gustatory mechanism to prevent ingestion of such materia

126 s) perceive chemical stimuli of one specific gustatory modality associated with a stereotyped behavio

127 ent responses in a subset of sweet-sensitive gustatory nerve fibers but did not affect other types of

128 5-HT released from type III cells activates gustatory nerve fibers via 5-HT3 receptors, accounting f

129 ells (TCs) that relay quality information to gustatory nerve fibers.

130 Moreover, gustatory nerve responses in Otop1-KO mice were severely

131 the contribution of Otop1 to taste cell and gustatory nerve responses to acids in mice in which Otop

132 These surprising results suggest that gustatory nerve terminal fields remain plastic well into

133 tor site which fires a minimal response at a gustatory nerve.

134 gehog (Hh) pathway inhibitor (HPI), and that gustatory nerves are a source of sonic hedgehog (Shh) fo

135 Remarkably, when lingual gustatory nerves are surgically rerouted to inappropriat

136 ed epithelial cells, which are innervated by gustatory nerves that transmit taste information to the

137 leased 5-HT activates 5-HT3 receptors on the gustatory nerves.

138 actions and taste coding.Characterization of gustatory neural pathways has suffered due to a lack of

139 This study used sweet tastes to interrogate gustatory neurocircuitry involving the anterior insula a

140 drogen peroxide and oxygen, functions in the gustatory neuron ASER to mediate C. elegans pathogen avo

141 in a directionally asymmetric manner in the gustatory neuron pair ASE left (ASEL) and ASE right (ASE

142 h two other CNG subunits, TAX-2 and TAX-4, a gustatory neuron-specific heteromeric CNG channel comple

143 lp dissect the functional distinctions among gustatory neurons and address questions regarding target

144 Here we found that parabrachial gustatory neurons can receive afferent projections from

145 ay strong aversive responses to LPS and that gustatory neurons expressing Gr66a bitter receptors medi

146 ults demonstrated that individual peripheral-gustatory neurons generate a unique and reliable firing

147 fects on feeding by activating or inhibiting gustatory neurons in closed-loop - effectively creating

148 receives input from the vagal-responsive and gustatory neurons in the basal part of the ventral media

149 chorda tympani nerve activity and activated gustatory neurons in the rostral nucleus tractus solitar

150 no was coexpressed with Gr66a in a subset of gustatory neurons in the terminal organ of third-instar

151 The disruption of sano gene expression in gustatory neurons led to the specific loss of high-salt

152 tens lifespan, whereas a different subset of gustatory neurons lengthens it.

153 Many basic characteristics of gustatory neurons remain unknown, partly due to the abse

154 anterior tongue had the strongest effect on gustatory neurons that responded best to NaCl stimulatio

155 d in gustatory epithelia and is required for gustatory neurons to locate and innervate their correct

156 Gustatory neurons were also tested to follow electrical

157 and somatosensory neurons and subclusters of gustatory neurons with unique molecular and functional p

158 g the AWC olfactory neurons, the ASJ and ASK gustatory neurons, and the ASH and ADL nociceptors, resp

159 In Caenorhabditis elegans, a subset of gustatory neurons, as well as olfactory neurons, shorten

160 Among the gustatory neurons, three subclusters are present, each w

161 ed GLP-1 and its receptors were expressed in gustatory neurons.

162 of different combinations of bitter-sensing gustatory neurons.

163 te these effects, we silenced bitter-sensing gustatory neurons.

164 plying that trigeminal projections reach PbN gustatory neurons.

165 immunoreactivity) in subregions of hindbrain gustatory nuclei were restored if the posterior tongue,

166 The posterior thalamic nucleus, tertiary gustatory nucleus proper, and nucleus of the lateral rec

167 d fiber-rich region termed here the tertiary gustatory nucleus proper, but not to a nucleus formerly

168 d in other cyprinids, excepting the tertiary gustatory nucleus.

169 of taste quality information in the primary gustatory nucleus.

170 ormerly considered as the zebrafish tertiary gustatory nucleus.

171 Our data also show a spatial overlap between gustatory, olfactory, and oral somatosensory representat

172 tive states, and processing information from gustatory, olfactory, auditory, somatosensory, and nocic

173 ion and function that link and interact with gustatory, olfactory, homeostatic, visceral, and cogniti

174 a variety of sensory information, including gustatory, olfactory, somatosensory, visual, and auditor

175 is critical to early nutrition but is also a gustatory-olfactory aspect of early infant social behavi

176 no are required in the neurons of the larval gustatory organs for the detection of high-salt concentr

177 that flies detect bacterial endotoxins via a gustatory pathway through TRPA1 activation as conserved

178 (NTS; the first neural relay in the central gustatory pathway) in awake, freely licking rats.

179 neurotransmitter to activate afferent neural gustatory pathways.

180 TAS2Rs such as TAS2R16 help define gustatory perception and dietary preferences that ultima

181 Finally, we show that gustatory perception is required for survival, specifica

182 bud cells regulates fatty acid signaling and gustatory perception of fat in mice and humans.

183 We determined that gustatory perception of sweetness is both necessary and

184 se results demonstrate an important role for gustatory perception when environmental food availabilit

185 Gustatory pheromones are thought to activate P1 neurons

186 t it influences a learning behavior known as gustatory plasticity, in which it is functionally couple

187 CTA depends on the gustatory portion of the insular cortex (GC) and the bas

188 rk has shown that most cells in the rostral, gustatory portion of the nucleus tractus solitarius (rNT

189 The gustatory, primary auditory, primary visual, rostrolater

190 Olfactory and gustatory processes especially need to be adaptive and r

191 ur results provide a foundation for studying gustatory processing and its modulation by the internal

192 physicochemical parameters, colour, olfacto-gustatory profile, and volatile compounds were tested.

193 Here we report second-order sweet gustatory projection neurons (sGPNs) in the Drosophila b

194 re coexpressed with bitter- or sugar-sensing Gustatory receptor (Gr) genes.

195 LITE-1, a seven-transmembrane gustatory receptor (GR) homolog, mediates UV-light-induc

196 e gene GR66, which encodes a putative bitter gustatory receptor (GR) that is responsible for the mulb

197 cluding receptors of the odor receptor (Or), gustatory receptor (Gr), ionotropic receptor (IR), Pickp

198 havior as well as many novel loci, including gustatory receptor 63a (Gr63a), which encodes a subunit

199 ygous mutant silkworm strains with truncated gustatory receptor 66 (GR66) proteins were established.

200 female sexual pheromones through a specific gustatory receptor expressed in a subset of foreleg neur

201 The gustatory receptor family members LITE-1 and GUR-3 are r

202 gical recordings, we demonstrate that bitter gustatory receptor neurons (GRNs) and mechanosensory neu

203 nd Gr98b in Gr66a-expressing, bitter-sensing gustatory receptor neurons (GRNs) confers responsiveness

204 Here we identify sour gustatory receptor neurons (GRNs) in tarsal taste sensil

205 In adult Drosophila, gustatory receptor neurons (GRNs) perceive chemical stim

206 mechanisms-activation of a specific class of gustatory receptor neurons (GRNs), which suppresses feed

207 ds fatty acids are mediated by sweet sensing Gustatory Receptor Neurons (GRNs).

208 TPNs receive input from gustatory receptor neurons and respond selectively to sw

209 ques to deliver taste stimuli and to examine gustatory receptor neurons and their immediate followers

210 : (1) initially encoded in the population of gustatory receptor neurons as broadly distributed spatio

211 ila opsins, Rh1, Rh4, and Rh7, are needed in gustatory receptor neurons to sense a plant-derived bitt

212 investigate the function of pharyngeal sweet gustatory receptor neurons, demonstrating that they expr

213 s the directionally asymmetric expression of gustatory receptor proteins in the ASE neurons and the a

214 hese neurons express many drivers of the Gr (Gustatory receptor) family.

215 Here we identify homologues of GRs (Gustatory receptor-like (Grl) genes) in genomes across P

216 revious analyses have identified homologous 'Gustatory Receptor-Like' (GRL) proteins across Animalia,

217 proteins, including odorant receptors (ORs), gustatory receptors (GRs) and ionotropic receptors (IRs)

218 Drosophila sweet neurons express eight gustatory receptors (Grs) belonging to a highly conserve

219 eleted each of six commonly expressed bitter gustatory receptors (Grs) from Drosophila melanogaster.

220 y repertoires of Odorant Receptors (ORs) and Gustatory Receptors (GRs) together represent one of the

221 ionotropic receptors (IR) and in some cases gustatory receptors (GRs).

222 Gustatory receptors and peripheral taste cells have been

223 associated with carbohydrate metabolism and gustatory receptors are substantially expanded in the we

224 We discuss the identification of odorant and gustatory receptors in Glossina morsitans morsitans and

225 However, the minimal subunit composition of gustatory receptors required for sensing aversive chemic

226 The mammalian tongue contains gustatory receptors tuned to basic taste types, providin

227 quences representing putative ionotropic and gustatory receptors were also identified.

228 Here we report that three gustatory receptors, GR8a, GR66a and GR98b function toge

229 scular junction and reliable activation of a gustatory reflex pathway.

230 Gustatory reflexes modulate the amount and composition o

231 hough the basolateral amygdala (BLA) and the gustatory region of insular cortex (IC) have been implic

232 and weaker connectivity with homeostasis and gustatory-related brain regions than lean women.

233 : Our study provides a functional mapping of gustatory representation in the insular posterior short

234 ar region that partially overlapped with the gustatory representation.

235 Our work provides insight into gustatory representations in the mushroom bodies, reveal

236 The gustatory requirements for these opsins are light-indepe

237 in host vitellogenin, insulin signaling, and gustatory response.

238 we provide a functional mapping of olfactory-gustatory responses to stimulation of the human insular

239 rh2 was restricted to the putative secondary gustatory/secondary visceral nucleus, which also express

240 the thalamus, the thalamic relay nucleus for gustatory sensation, receives primary input from the par

241 Gustatory sensations were evoked in 15 (2.7%) of the 550

242 thousands of mechanosensory, olfactory, and gustatory sensilla.

243 While gustatory sensing of the five primary flavors (sweet, sa

244 lation of appetitive and aversive peripheral gustatory sensitivity permits flexible, adaptive feeding

245 owever, ultimately constrained by pollinator gustatory sensitivity.

246 ior nucleus of the torus semicircularis, the gustatory sensory and motor nuclei, and in the hypothala

247 rosophila brain processes mechanosensory and gustatory sensory input from sensilla located on the hea

248 ensory receptors regulate Galpha pathways in gustatory sensory neurons that extend cilia through the

249 elease channels, and have important roles in gustatory signalling and neuronal toxicity(1-3).

250 n the concurrent processing of olfactory and gustatory signals from the mouth.

251 EZ), suggesting integration of olfactory and gustatory signals occurs in this brain region.

252 his work provides an example of how discrete gustatory signals recruit nutrient-dependent endocrine s

253 Finally, we calculated when the gustatory stimulation phase is short or absent.

254 cumulative intake that universally describes gustatory stimulation, satiation, and maximal food intak

255 l for cumulative intake curves that captures gustatory stimulation, satiation, and maximal food intak

256 atic functions have not simultaneously taken gustatory stimulation, satiation, and maximal food intak

257 aminergic neurons phenocopies the absence of gustatory stimulation, suggesting a specific role for th

258 h ArchT) to demonstrate that, indeed, during gustatory stimulation, taste-selective information is tr

259 olfactory processing even in the absence of gustatory stimulation: GCx alters PC responses to olfact

260 Gustatory stimuli are detected by taste buds and transmi

261 In natural conditions, gustatory stimuli are typically expected.

262 while umami sensor responses were related to gustatory sweetness, bitterness and umami, as well as an

263 Here we show that the Drosophila gustatory system also affects lifespan in a bidirectiona

264 underscore the remarkable plasticity of the gustatory system and also help clarify the functional an

265 eurotrophins exert their unique roles on the gustatory system by regulating different sets of downstr

266 Animals' gustatory system has been widely acknowledged as one of

267 Detection of NaCl by the gustatory system is fundamental for salt intake and tiss

268 The gustatory system is ideal for examining this issue becau

269 s inedibility, the potential to use rodent's gustatory system is investigated to detect bitter compou

270 anssynaptic tracer barley lectin (BL) in the gustatory system of mice.

271 ophysiological recordings from the tractable gustatory system of the moth Manduca sexta, we found che

272 of research has focused on the olfactory and gustatory system over the years, it is only recently tha

273 The gustatory system provides vital sensory information to d

274 However, the mechanism through which the gustatory system senses thermal input and integrates tem

275 Recent work in the mouse gustatory system showed that selectively deleting the pr

276 Here, we used the Drosophila melanogaster gustatory system to dissect one component of sensory reg

277 ein-coupled receptors first described in the gustatory system, but have also been shown to have extra

278 critical role in acid detection in the mouse gustatory system, evidence that it is a bona fide sour t

279 In the gustatory system, experimental manipulations now exist,

280 vel method for calcium imaging in the larval gustatory system, we identify a multimodal GRN that resp

281 actory system and then implemented it in the gustatory system, where projections beyond the first-ord

282 f neurons in the first neural station of the gustatory system.

283 uality representations and perception in the gustatory system.

284 nd functional organization of the peripheral gustatory system.

285 ining structural integrity of the peripheral gustatory system.

286 s modulate the functioning of the peripheral gustatory system.

287 are consistent with an emerging view of the gustatory system: rather than constructing basic taste c

288 tle is known about how acids are detected by gustatory systems and whether they have a potential role

289 Sensory impairments of the olfactory and gustatory systems have also been reported in a large pro

290 reasing neural activity in the olfactory and gustatory systems in animals across phyla.

291 ransduction and coding of information by the gustatory systems of vertebrates and invertebrates.

292 Similarities between the gustatory systems of zebrafish and other fishes are also

293 Alas, virtually nothing is known on how the gustatory thalamus (VPMpc) processes gustatory informati

294 To reveal the unique properties of the gustatory thalamus in comparison with archetypical senso

295 g unique anatomical properties of the rodent gustatory thalamus.

296 urnover cycle, our data suggest that chicken gustatory tissue provides an ideal system for multidisci

297 d the transcriptomic architecture of chicken gustatory tissues.

298 ed new light on the role of GAD65(+) TBCs in gustatory transduction and taste-mediated behavior.

299 n 1) second-order sensory neurons processing gustatory, vestibulo-ocular, and visceral sensation; 2)

300 eful for characterizing a putative secondary gustatory/visceral nucleus in the isthmus, and for disti