ライフサイエンスコーパス: haematopoietic stem cell

1 nvironments necessary for the maintenance of haematopoietic stem cells.

2 the action of a small number of multipotent haematopoietic stem cells.

3 r of stem cell maintenance in germ cells and haematopoietic stem cells.

4 on, proliferation and eventual exhaustion of haematopoietic stem cells.

5 ilar to that of normal and myeloid leukaemia haematopoietic stem cells.

6 CML or AML progenitor cells and from normal haematopoietic stem cells.

7 key regulators of lineage fate decisions in haematopoietic stem cells.

8 ncer, resulting in increased self-renewal of haematopoietic stem cells.

9 hro-myeloid progenitors (EMPs) distinct from haematopoietic stem cells.

10 eneration potential similar to healthy young haematopoietic stem cells.

11 to preserve the regenerative capacity of old haematopoietic stem cells.

12 homologous recombination at the HBB gene in haematopoietic stem cells.

13 tic stem cells and their downregulation upon haematopoietic stem cell activation and proliferation.

14 re by sequentially mobilizing and harvesting haematopoietic stem cells, administering an immunosuppre

15 tor 5 in haematopoietic stem cells increases haematopoietic stem cell and progenitor adhesion.

16 This haematopoietic stem cell and progenitor defect is associ

17 4(Y288C) strain causes a progressive loss of haematopoietic stem cells and bone marrow cellularity du

18 n that central nervous system stem cells and haematopoietic stem cells and early progenitors contain

19 ic stem-cell self-renewal, expanding splenic haematopoietic stem cells and erythropoiesis during preg

20 ic development, and find that the numbers of haematopoietic stem cells and multilineage-differentiate

21 supports self-renewal and differentiation of haematopoietic stem cells and multipotent progenitors (H

22 T-cell differentiation, are most related to haematopoietic stem cells and myeloid progenitors.

23 c stem cell microenvironment, revealing that haematopoietic stem cells and neurons are regulated by s

24 f vascular origin have increased circulating haematopoietic stem cells and progenitors (HSC/P).

25 we show that Kruppel-like factor 5-deficient haematopoietic stem cells and progenitors fail to engraf

26 r adhesion, homing, lodging and retention of haematopoietic stem cells and progenitors in the bone ma

27 endosome, is decreased in Klf5(Delta/Delta) haematopoietic stem cells and progenitors.

28 and bone marrow homing of Klf5(Delta/Delta) haematopoietic stem cells and progenitors.

29 toxicity to normal CXCR4(+) tissues, sparing haematopoietic stem cells and progenitors.

30 ity and competitive repopulation assay, that haematopoietic stem cells and short-term progenitors are

31 ication of Usp16 reduces the self-renewal of haematopoietic stem cells and the expansion of mammary e

32 ncluding in the H19-Igf2 locus, in long-term haematopoietic stem cells and their downregulation upon

33 fic alterations of the niches, which support haematopoietic stem cells and their progeny, can act as

34 f-renewal capacity similar to those of adult haematopoietic stem cells, and can be used for clonal en

35 state required for long-term maintenance of haematopoietic stem cells, and compromises haematopoieti

36 ation of cyan-fluorescent-protein-expressing haematopoietic stem cells, and parabiosis between geneti

37 Haematopoietic stem cells are an excellent model for the

38 Haematopoietic stem cells are generated from the haemoge

39 progenitors, rather than classically defined haematopoietic stem cells, are the main drivers of stead

40 miR-22 in self-renewal and transformation of haematopoietic stem cells, as well as their ability to i

41 ine a CRISPR-based methodology for targeting haematopoietic stem cells by homologous recombination at

42 This process relies on quiescent haematopoietic stem cells capable of differentiating, se

43 Here we show that loss of autophagy in haematopoietic stem cells causes accumulation of mitocho

44 ne transfer in osteoclasts in the absence of haematopoietic-stem-cell chimerism, and can rescue an ad

45 In the mammalian haematopoietic system, haematopoietic stem cells contain low levels of ROS.

46 cells into autologous authentic engraftable haematopoietic stem cells could aid treatment of haemato

47 aemia with arrested erythropoiesis, a marked haematopoietic stem cell defect, and rapid lethality.

48 Yet, timely transfusion of haematopoietic-stem-cell-derived monocytic cells in newb

49 ipotent stem cell technologies for modelling haematopoietic stem cell development and blood therapies

50 antifibrotic agent and negative regulator of haematopoietic stem cell differentiation which is proces

51 Chronic myeloid leukaemia is a paradigmatic haematopoietic stem cell disease in which the leukaemia-

52 alpha from haematopoietic stem cells reduced haematopoietic stem-cell division in female, but not mal

53 ne produced mainly in the ovaries, increased haematopoietic stem-cell division in males and females.

54 evels increased during pregnancy, increasing haematopoietic stem-cell division, haematopoietic stem-c

55 t male, mice and attenuated the increases in haematopoietic stem-cell division, haematopoietic stem-c

56 ts that the first lineage commitment step of haematopoietic stem cells does not result in strict sepa

57 of the fusion tyrosine kinase BCR-ABL1 in a haematopoietic stem cell drives its transformation to be

58 deregulate normal haematopoiesis by causing haematopoietic stem cell dysfunction.

59 Here, using human haematopoietic stem cell-engrafted NSG-HLA-DQ8 transgeni

60 otrophic factor partners are produced in the haematopoietic stem cell environment.

61 However, approximately one-third of aged haematopoietic stem cells exhibit high autophagy levels

62 Here we show that mouse haematopoietic stem cells exhibit sex differences in cel

63 We find that haematopoietic stem cells express RET and that its neuro

64 Haematopoietic stem cells expressed high levels of oestr

65 Ex vivo gene correction in patient-derived haematopoietic stem cells followed by autologous transpl

66 reases in haematopoietic stem-cell division, haematopoietic stem-cell frequency, and erythropoiesis d

67 ncreasing haematopoietic stem-cell division, haematopoietic stem-cell frequency, cellularity, and ery

68 d 588-A successfully isolates ALDH(hi) human haematopoietic stem cells from heterogeneous cord blood

69 nd longevity, and is critical for protecting haematopoietic stem cells from metabolic stress.

70 serve that germline genetic variation shapes haematopoietic stem cell function, leading to CHIP throu

71 a composition associated with less efficient haematopoietic stem cell function.

72 f haematopoietic stem cells, and compromises haematopoietic stem cell function.

73 tic cells are regulated by sex hormones, but haematopoietic stem-cell function is thought to be simil

74 T) with pegylated bovine ADA, and autologous haematopoietic stem cell gene therapy (GT).

75 Here we show that haematopoietic stem cell gene therapy can prevent the oc

76 ing and the number of long-term repopulating haematopoietic stem cells, haematopoietic stem cell mobi

77 s to identify common mechanisms operative in haematopoietic stem cells, heart and liver.

78 However, the mechanisms that regulate haematopoietic stem cell homeostasis and function remain

79 in is a potent oncogene playing key roles in haematopoietic stem cell homeostasis and malignant haema

80 With ageing, intrinsic haematopoietic stem cell (HSC) activity decreases, resul

81 in complex that protects telomeres, improves haematopoietic stem cell (HSC) activity during aging.

82 In the blood, haematopoietic stem cell (HSC) ageing is linked to sever

83 called Stk11) gene in mice caused increased haematopoietic stem cell (HSC) division, rapid HSC deple

84 ssociation with numerous processes including haematopoietic stem cell (HSC) fate, inflammation and tu

85 Haematopoietic stem cell (HSC) gene therapy has demonstr

86 orta-gonad-mesonephros (AGM) region prior to haematopoietic stem cell (HSC) generation.

87 chanism of how it activates transcription of haematopoietic stem cell (HSC) genes is still elusive.

88 Haematopoietic stem cell (HSC) homeostasis is tightly co

89 e we show that Lkb1 has an essential role in haematopoietic stem cell (HSC) homeostasis.

90 oclast precursors arose independently of the haematopoietic stem cell (HSC) lineage and the data from

91 Integrins play an important role in haematopoietic stem cell (HSC) maintenance in the bone m

92 scence is a critical feature contributing to haematopoietic stem cell (HSC) maintenance.

93 The cellular constituents forming the haematopoietic stem cell (HSC) niche in the bone marrow

94 mmalian stem cells and their niches, but the haematopoietic stem cell (HSC) niche remains incompletel

95 Haematopoietic stem cell (HSC) niches provide an environ

96 Haematopoietic stem cell (HSC) niches, although proposed

97 Pten deletion also promoted haematopoietic stem cell (HSC) proliferation.

98 le, only p18 and p27 can negatively regulate haematopoietic stem cell (HSC) self-renewal.

99 lt haematopoiesis is the outcome of distinct haematopoietic stem cell (HSC) subtypes with self-renewa

100 e, but whether they affect haematopoiesis or haematopoietic stem cell (HSC)-mediated reconstitution a

101 protein quality checkpoint that controls the haematopoietic stem cell (HSC)-niche interaction and det

102 omes that were more similar to those of both haematopoietic stem cells (HSC) and megakaryocyte-erythr

103 Repeated cell divisions induce DNA damage in haematopoietic stem cells (HSC) and telomeres are sensit

104 Over their lifetime, long-term haematopoietic stem cells (HSC) are exposed to a variety

105 Microenvironment cues received by haematopoietic stem cells (HSC) are important in regulat

106 Herein, we advance the notion that haematopoietic stem cells (HSC), which sustain haematopo

107 Here we develop an in vivo assay for adult haematopoietic stem-cell (HSC) niche formation.

108 metabolic differences between murine normal haematopoietic stem cells (HSCs) and CML stem cells usin

109 have an increased bone marrow (BM) long-term haematopoietic stem cells (HSCs) and granulocyte-macroph

110 aemia (AML) to demonstrate that transforming haematopoietic stem cells (HSCs) and multipotent progeni

111 e we set out to compare protein synthesis in haematopoietic stem cells (HSCs) and restricted haematop

112 Haematopoietic stem cells (HSCs) are a self-renewing pop

113 Haematopoietic stem cells (HSCs) are arguably the most e

114 Although haematopoietic stem cells (HSCs) are commonly assumed to

115 Murine haematopoietic stem cells (HSCs) are contained in the Ki

116 Umbilical cord blood-derived haematopoietic stem cells (HSCs) are essential for many

117 Haematopoietic stem cells (HSCs) are maintained by bone

118 Haematopoietic stem cells (HSCs) are produced during emb

119 Haematopoietic stem cells (HSCs) are responsible for the

120 Haematopoietic stem cells (HSCs) are the founder cells o

121 Haematopoietic stem cells (HSCs) are the founding cells

122 Genetic defects that accumulate in haematopoietic stem cells (HSCs) are thought to be respo

123 maintain lifelong production of blood cells, haematopoietic stem cells (HSCs) are tightly regulated b

124 oiesis, including regulating self-renewal of haematopoietic stem cells (HSCs) as well as myeloid and

125 How transplanted haematopoietic stem cells (HSCs) behave soon after they

126 s are thought to promote clonal expansion of haematopoietic stem cells (HSCs) by increasing self-rene

127 Haematopoietic stem cells (HSCs) can convert between gro

128 In mice, deletion of PTEN in haematopoietic stem cells (HSCs) causes perturbed haemat

129 Haematopoietic stem cells (HSCs) circulate in the bloods

130 ls in 5q-MDS patients, it is unclear whether haematopoietic stem cells (HSCs) could also be the initi

131 Haematopoietic stem cells (HSCs) derive from haemogenic

132 alling plays a key role in the generation of haematopoietic stem cells (HSCs) during vertebrate devel

133 Haematopoietic stem cells (HSCs) emerge during embryogen

134 During embryonic development, adult haematopoietic stem cells (HSCs) emerge preferentially i

135 Haematopoietic stem cells (HSCs) first arise during deve

136 hat generates the first adult populations of haematopoietic stem cells (HSCs) from hemogenic endothel

137 Generation of haematopoietic stem cells (HSCs) from iPSCs or embryonic

138 Haematopoietic stresses mobilize haematopoietic stem cells (HSCs) from the bone marrow to

139 Aged haematopoietic stem cells (HSCs) generate more myeloid c

140 is maintained by a hierarchical system where haematopoietic stem cells (HSCs) give rise to multipoten

141 The biology of haematopoietic stem cells (HSCs) has predominantly been

142 r, its application to long-term repopulating haematopoietic stem cells (HSCs) has remained elusive.

143 n haematopoiesis, where the consequences for haematopoietic stem cells (HSCs) have only recently star

144 thway yielded high levels of gene editing in haematopoietic stem cells (HSCs) in a mouse model of hum

145 One day prior to mass emergence of haematopoietic stem cells (HSCs) in the foetal liver at

146 oteins, are known to support the activity of haematopoietic stem cells (HSCs) in vitro and in vivo.

147 Adult haematopoietic stem cells (HSCs) mainly reside in the bo

148 Haematopoietic stem cells (HSCs) maintain balanced self-

149 Haematopoietic stem cells (HSCs) must achieve a balance

150 Haematopoietic stem cells (HSCs) primarily reside in the

151 Haematopoietic stem cells (HSCs) regenerate blood cells

152 Multipotent self-renewing haematopoietic stem cells (HSCs) regenerate the adult bl

153 Haematopoietic stem cells (HSCs) require the right compo

154 Haematopoietic stem cells (HSCs) reside in a perivascula

155 Haematopoietic stem cells (HSCs) reside in distinct nich

156 Haematopoietic stem cells (HSCs) reside in specialized m

157 Inactivation of Bcor in haematopoietic stem cells (HSCs) results in expansion of

158 Haematopoietic stem cells (HSCs) self-renew for life, th

159 The self-renewal capacity of multipotent haematopoietic stem cells (HSCs) supports blood system h

160 The blood system is sustained by a pool of haematopoietic stem cells (HSCs) that are long-lived due

161 Haematopoiesis is governed by haematopoietic stem cells (HSCs) that produce all lineag

162 sleep deprivation reduces the ability of its haematopoietic stem cells (HSCs) to engraft and reconsti

163 tly from tissues and use it to compare mouse haematopoietic stem cells (HSCs) to restricted haematopo

164 g chronic infection, but the contribution of haematopoietic stem cells (HSCs) to this process is larg

165 es on the life-long regenerative capacity of haematopoietic stem cells (HSCs)(1,2).

166 ulations in zebrafish embryos, including the haematopoietic stem cells (HSCs), and found that it take

167 anisms that govern the self-renewal of human haematopoietic stem cells (HSCs), and why this fails in

168 Most haematopoietic cells renew from adult haematopoietic stem cells (HSCs), however, macrophages i

169 lood system is maintained by a small pool of haematopoietic stem cells (HSCs), which are required and

170 Here we tested these hypotheses in haematopoietic stem cells (HSCs), which can be highly pu

171 atopoiesis in adult animals is maintained by haematopoietic stem cells (HSCs), which self-renew and c

172 Haematopoietic stem cells (HSCs), which sustain producti

173 MPN through profound detrimental effects on haematopoietic stem cells (HSCs).

174 e acquisition of somatic driver mutations in haematopoietic stem cells (HSCs).

175 myelopoiesis, despite normal development of haematopoietic stem cells (HSCs).

176 production is ensured by rare, self-renewing haematopoietic stem cells (HSCs).

177 ypes have been proposed to create niches for haematopoietic stem cells (HSCs).

178 ss permeable arterial blood vessels maintain haematopoietic stem cells in a low reactive oxygen speci

179 Strikingly, most haematopoietic stem cells in aged mice share these alter

180 ve selection of certain somatic mutations in haematopoietic stem cells in ageing humans.

181 Haematopoietic stem cells in female mice divide signific

182 e been generated from adult peripheral blood haematopoietic stem cells in laboratory culture without

183 um constitute functional niches that support haematopoietic stem cells in mammalian bone marrow.

184 e candidate cells that constitute niches for haematopoietic stem cells in the marrow, including osteo

185 fusion of monocytic precursors derived from haematopoietic stem cells in the presence of CSF1 and RA

186 vailability of cultured human red cells from haematopoietic stem cells in the quantities required for

187 gain-of-function of Kruppel-like factor 5 in haematopoietic stem cells increases haematopoietic stem

188 meric mice were generated by injecting human haematopoietic stem cells into irradiated NOD-scid-IL2Rg

189 Gene therapy using autologous gene-corrected haematopoietic stem cells is an alternative for patients

190 Since the regenerative capacity of normal haematopoietic stem cells is limited by the accumulation

191 Here we show that Pten deletion in mouse haematopoietic stem cells leads to a myeloproliferative

192 while tracking its development (pre-leukemic haematopoietic stem cells, leukemic stem cells [LSCs], a

193 Yet the expression of BRAF(V600E) in the haematopoietic stem cell lineage causes leukaemic and tu

194 idence for alternative cellular pathways for haematopoietic stem cell lineage commitment.

195 With age, haematopoietic stem cells lose their ability to regenera

196 leukaemia protein (PML) tumour suppressor in haematopoietic stem cell maintenance, and present a new

197 esumed cell of origin for GIST-as well as in haematopoietic stem cells, melanocytes, mast cells and g

198 ature granulocytes and stem cells, including haematopoietic stem cells, mesenchymal stem cells and fi

199 monstrate that autophagy actively suppresses haematopoietic stem-cell metabolism by clearing active,

200 otrophic factors are novel components of the haematopoietic stem cell microenvironment, revealing tha

201 g for heterogeneity in dose distribution and haematopoietic stem cell migration results in lower risk

202 term repopulating haematopoietic stem cells, haematopoietic stem cell mobilization and lineage determ

203 Bone-marrow endothelial cells in the haematopoietic stem-cell niche form a network of blood v

204 7/G-CSF axis, and rhythmic modulation of the haematopoietic stem-cell niche.

205 lethal while conditional inactivation in the haematopoietic stem cell pool confers profound aplastic

206 ing-related genes in a highly purified mouse haematopoietic stem cell population.

207 hat lead to clonal expansion in regenerating haematopoietic stem cell populations has recently been a

208 production of haemogenic endothelial cells, haematopoietic stem cell precursors and increased colony

209 In the absence of vascular Dll4, haematopoietic stem cells prematurely induced a myeloid

210 tes that manifested concurrent expression of haematopoietic stem cell/progenitor and myeloid progenit

211 astable intermediates that had collapsed the haematopoietic stem cell/progenitor gene expression prog

212 Subsequent activation of Notch signalling in haematopoietic stem cell progenitors induces the maligna

213 ) cells, CD8(+) T cell memory precursors and haematopoietic stem cell progenitors, but that was disti

214 l but not the paternal H19-DMR reduces adult haematopoietic stem cell quiescence, a state required fo

215 termination cytokines that normally restore haematopoietic stem-cell quiescence.

216 programming adult mouse endothelial cells to haematopoietic stem cells (rEC-HSCs) through transient e

217 Conditional deletion of ERalpha from haematopoietic stem cells reduced haematopoietic stem-ce

218 leeting transition of endothelial cells into haematopoietic stem cells remain undefined.

219 sential component of the Hh pathway, impairs haematopoietic stem cell renewal and decreases induction

220 We have tested these hypotheses by examining haematopoietic stem cell reserves and function with age

221 niche and function coordinately to regulate haematopoietic stem cell self-renewal and mobilization.

222 While Asxl2 was required for normal haematopoietic stem cell self-renewal, Asxl2 loss promot

223 hrough epigenetic deregulations, and impairs haematopoietic stem-cell self-renewal activity and regen

224 Oestrogen/ERalpha signalling promotes haematopoietic stem-cell self-renewal, expanding splenic

225 t cells of the haematopoietic system (namely haematopoietic stem cells, semi-committed progenitors or

226 The first haematopoietic stem cells share a common origin with the

227 helium followed by screening of 26 candidate haematopoietic stem-cell-specifying transcription factor

228 RET (rearranged during transfection) drives haematopoietic stem cell survival, expansion and functio

229 Activation of RET results in improved haematopoietic stem cell survival, expansion and in vivo

230 Compared with haematopoietic stem cells, these multipotent progenitor

231 Together with previous work on haematopoietic stem cells, this study suggests that the

232 We analyse individual haematopoietic stem cells throughout differentiation int

233 es not have a mandatory role in multi-potent haematopoietic stem cells to cause cancer and indicates

234 The sensitivity of haematopoietic stem cells to non-homologous end-joining

235 D-H) to create matched siblings suitable for haematopoietic stem cell transplant (HSCT) are discussed

236 Case reports suggest potential benefit after haematopoietic stem cell transplant (HSCT) for patients

237 eraction between age at cancer diagnosis and haematopoietic stem-cell transplant.

238 Autologous haematopoietic stem cell transplantation (AHSCT) has bee

239 Allogeneic haematopoietic stem cell transplantation (allo-HSCT) was

240 za vaccination (IIV) schedules in autologous haematopoietic stem cell transplantation (autoHCT) patie

241 yelodysplastic syndromes (MDS) is allogeneic haematopoietic stem cell transplantation (HCT).

242 drenoleukodystrophy (X-ALD) before and after haematopoietic stem cell transplantation (HSCT) and to e

243 omising source of stem cells to use in early haematopoietic stem cell transplantation (HSCT) approach

244 dence and severity of lung dysfunction after haematopoietic stem cell transplantation (HSCT) for prev

245 5, and CDKN2A/B deletion status, and whether haematopoietic stem cell transplantation (HSCT) had been

246 ne editing strategies, matched sibling donor haematopoietic stem cell transplantation (HSCT) in child

247 Survival outcomes from haematopoietic stem cell transplantation (HSCT) in sever

248 al and imaging outcomes following allogeneic haematopoietic stem cell transplantation (HSCT) in two p

249 Haematopoietic stem cell transplantation (HSCT) is the m

250 portant infections to occur after allogeneic haematopoietic stem cell transplantation (HSCT), and an

251 lastic syndrome received upfront therapy (14 haematopoietic stem cell transplantation and 4 chemother

252 Haematopoietic stem cell transplantation and imatinib lo

253 ese findings may have relevance for clinical haematopoietic stem cell transplantation and mobilizatio

254 l encephalomyopathy who underwent allogeneic haematopoietic stem cell transplantation between 2005 an

255 Allogeneic haematopoietic stem cell transplantation can restore thy

256 nitoring for non-diagnostic purposes such as haematopoietic stem cell transplantation donor screening

257 Haematopoietic stem cell transplantation following immun

258 g, early progression halted after allogeneic haematopoietic stem cell transplantation from a related

259 ge 25 years (range 10-41 years) treated with haematopoietic stem cell transplantation from related (n

260 noglobulin, anti TNF agents, thalidomide and haematopoietic stem cell transplantation has also led to

261 Allogeneic haematopoietic stem cell transplantation has been demons

262 Haematopoietic stem cell transplantation has been propos

263 Autologous haematopoietic stem cell transplantation has been tried

264 long-term neurological benefit of allogeneic haematopoietic stem cell transplantation in adult cerebr

265 of a disorder may be possible, for example, haematopoietic stem cell transplantation in FA and NBS,

266 Allogeneic haematopoietic stem cell transplantation is curative in

267 Haematopoietic stem cell transplantation is the major tr

268 pathy with axonal spheroids and suggest that haematopoietic stem cell transplantation might have a th

269 adrenoleukodystrophy treated with allogeneic haematopoietic stem cell transplantation on a compassion

270 Allogeneic haematopoietic stem cell transplantation remains the onl

271 One trial with non-myeloablative autologous haematopoietic stem cell transplantation reported clinic

272 Allogeneic haematopoietic stem cell transplantation should be consi

273 beta; and was more depleted after autologous haematopoietic stem cell transplantation than in patient

274 rosis following non-myeloablative autologous haematopoietic stem cell transplantation with a conditio

275 usly been observed only following allogeneic haematopoietic stem cell transplantation(2,3), may be fe

276 igh-dose chemotherapy followed by autologous haematopoietic stem cell transplantation, and prospectiv

277 luding immunoablation followed by autologous haematopoietic stem cell transplantation, mesenchymal an

278 blished as causing limbic encephalitis after haematopoietic stem cell transplantation, particularly a

279 Haematopoietic stem cell transplantation, the oral formu

280 displayed chimerism in CSF1R acquired after haematopoietic stem cell transplantation.

281 way for exploration of RET agonists in human haematopoietic stem cell transplantation.

282 atological malignancies, marrow failure, and haematopoietic stem cell transplantation.

283 nditioning regimens are increasingly used in haematopoietic stem cell transplantation.

284 r eliminating latently infected cells before haematopoietic stem cell transplantation.

285 normalize within 1 year after treatment with haematopoietic stem cell transplantation.

286 ed no benefit of mobilisation and autologous haematopoietic stem-cell transplantation (HSCT) compared

287 he 'Berlin patient'-underwent two allogeneic haematopoietic stem-cell transplantation (HSCT) procedur

288 study, treatment before and after autologous haematopoietic stem-cell transplantation (HSCT) with dar

289 o received a myeloablative 10/10 HLA-matched haematopoietic stem-cell transplantation (HSCT).

290 three additional courses of chemotherapy or haematopoietic stem-cell transplantation (HSCT).

291 ated acute myeloid leukaemia (two [3%]), and haematopoietic stem-cell transplantation complications (

292 gents, proteasome inhibitors, and autologous haematopoietic stem-cell transplantation has improved ou

293 ight who had previously undergone allogeneic haematopoietic stem-cell transplantation) were enrolled

294 on predictors in both models were history of haematopoietic stem-cell transplantation, cumulative alk

295 C-mediated tolerance to both solid organ and haematopoietic stem cell transplants.

296 rning the generation of red blood cells from haematopoietic stem cells using laboratory culture and d

297 Here, to yield functional human haematopoietic stem cells, we perform morphogen-directed

298 tablishing the principles of self-renewal in haematopoietic stem cells will lead to insights into the

299 Strikingly, RET signals provide haematopoietic stem cells with critical Bcl2 and Bcl2l1

300 to impaired survival and reduced numbers of haematopoietic stem cells with normal differentiation po