ライフサイエンスコーパス: haemoglobin

1 tissue fluorophores (flavins) and absorbers (haemoglobin).

2 P = 0.03] without significant differences in haemoglobin.

3 with a small but significant improvement in haemoglobin.

4 les, is common in biological systems such as haemoglobin.

5 ne, and reduced levels of random glucose and haemoglobin.

6 concentrations, and deferrals because of low haemoglobin.

7 f the T. congolense receptor in complex with haemoglobin.

8 sickle-cell disease that are based on fetal haemoglobin.

9 cription of HpuA's role in direct binding of haemoglobin.

10 de chains for packing against the surface of haemoglobin.

11 ly adapted to hypoxia and have high affinity haemoglobin.

12 12 years, no signs of critical illness, and haemoglobin 100 g/L or lower (if aged 3 months or younge

13 ent adverse events were anaemia or decreased haemoglobin (45 [22%] patients), and elevations in alani

14 edema (9 [23%] of 40 patients) and decreased haemoglobin (6 [15%]).

15 f grade 3 or higher was anaemia or decreased haemoglobin (80 [22%] patients in the rucaparib group vs

16 orrectly spliced beta-globin mRNA and led to haemoglobin A synthesis, and consequently improved thala

17 high cardiovascular risk with high glycated haemoglobin A(1c) (HbA(1c)) concentrations.

18 ssays to elucidate the origins of vertebrate haemoglobin, a heterotetramer of paralogous alpha- and b

19 enrolment, and centrally confirmed glycated haemoglobin A1c (HbA(1c)) of 48-58 mmol/mol (6.5-7.5%) a

20 Haemoglobin A1c (HbA1c) is a significant glycaemic marke

21 abetic patients, including disease duration, haemoglobin A1c (HbA1c) levels and urine albumin creatin

22 trol-specified as a decrease in glycosylated haemoglobin A1C (HbA1c) of >/=2% points over 3 months.

23 luding alcohol misuse, well-being, change in haemoglobin A1c (HbA1c), and smoking cessation.

24 ng: achievement of all recommended levels of haemoglobin A1c (HbA1c), BP, and cholesterol; risky pres

25 ve at correcting hyperglycaemia and lowering haemoglobin A1c levels than Exendin-4, suggesting that G

26 ratory data including serum fasting glucose, haemoglobin A1c levels, creatinine levels, and the urina

27 t, fasting glucose, 2-h glucose and insulin, haemoglobin A1c, high-density lipoprotein or blood press

28 , lipid profile, glucose tolerance, glycated haemoglobin A1c, salivary cortisol, sitting height, and

29 S children than in HbAA children with normal haemoglobin (adjusted incidence rate ratio [aIRR] 0.66 [

30 sing the Fick equation, we model how altered haemoglobin affinity and the associated haemoglobin conc

31 cations, with regard to exercise, of altered haemoglobin affinity for oxygen are not fully understood

32 How chronic alterations in haemoglobin affinity impact physiology is unknown.

33 a and hypoxia to determine how their altered haemoglobin affinity impacts hypoxic exercise tolerance.

34 Haemoglobin affinity is an integral concept in exercise

35 in BMC Gastroenterology evaluated the faecal haemoglobin, age and sex test (FAST) score in the assess

36 sensitivity cardiac troponin T (cTnT-hs) and haemoglobin, age, and previous bleeding.

37 y, the presence of the NO scavenging protein haemoglobin alpha (Hbalpha) within nanometer proximity t

38 V4(EC) channels with eNOS and the absence of haemoglobin alpha favour TRPV4(EC) -eNOS signalling in p

39 ence of the nitric oxide-scavenging protein, haemoglobin alpha, limits TRPV4(EC) -eNOS signalling in

40 lobin were recorded in any individual in the haemoglobin analysis (n=70) during follow-up.

41 High affinity haemoglobin and compensatory polycythaemia mitigated the

42 We studied humans with high affinity haemoglobin and compensatory polycythaemia.

43 atment groups for the stratification factors haemoglobin and corrected serum calcium.

44 ed symptoms potentially related to donation, haemoglobin and ferritin concentrations, and deferrals b

45 tion, physical activity, cognitive function, haemoglobin and ferritin concentrations, and deferrals b

46 g men [for all listed symptoms]), lower mean haemoglobin and ferritin concentrations, and more deferr

47 Haemoglobin and haem fractionation assays suggest a mode

48 xidative stress, agents that counteract free haemoglobin and haem, anti-inflammatory agents, anti-thr

49 Treatment also increased haemoglobin and haematocrit, and decreased red blood cel

50 567, combined P = 5.5 x 10 - 8 adjusted for haemoglobin and hydroxyurea) and validated it in indepen

51 ositive correlation between mean corpuscular haemoglobin and in vitro growth of BCG in whole blood fr

52 sis indicated a negative correlation between haemoglobin and mean MCAv (r = -0.589, regression coeffi

53 ging protein that binds and neutralises free haemoglobin and modulates inflammation and endothelial p

54 concentrations, and deferrals because of low haemoglobin and other factors.

55 Within FEAST participants, we also compared haemoglobin and plasma biochemistry between bolus and no

56 al (ie, maternal and child anthropometry and haemoglobin and preterm birth) and socioenvironmental de

57 The combination of low oxygen affinity haemoglobin and reduced haemoglobin concentration seen i

58 Secondary outcomes included helminths, haemoglobin, and hepatosplenomegaly.

59 rate (ESR), C-reactive protein (CRP) values, haemoglobin, and leukocyte values.

60 re admission, poor nutritional status, lower haemoglobin, and positive urine tests (TB-LAM and/or Xpe

61 Cholesterols, fasting glucose, glycosylated haemoglobin, and proinflammatory markers in the blood as

62 ow baseline clinical severity, high baseline haemoglobin, and week 4 clinical remission were associat

63 score (age, biomarkers [GDF-15, cTnT-hs, and haemoglobin], and clinical history [previous bleeding])

64 sses, including agents that reactivate fetal haemoglobin, anti-sickling agents, anti-adhesion agents,

65 However, ticks require dietary haemoglobin as an exogenous source of haem since, feedin

66 oea and endocarditis, and extracts haem from haemoglobin as an important iron source within the iron-

67 The changes in glycated haemoglobin, as the primary outcome, in the probiotics+B

68 The primary outcome was the amount of haemoglobin at day 84 and was measured as the difference

69 ded regimen, the difference in the amount of haemoglobin at day 84 was -2.2 g/L (95% CI -4.6 to 0.1)

70 used a block design stratified by amount of haemoglobin at enrolment (above and below the median amo

71 t calcium activity in the presence of strong haemoglobin background absorption.

72 lpha-thalassaemia, haemoglobin H disease and haemoglobin Bart's hydrops fetalis, are an important pub

73 racorporeal pulsatile-perfusion system and a haemoglobin-based, acellular, non-coagulative, echogenic

74 sify functional sequences and yet retain the haemoglobin binding function.

75 ein we report crystal structures of apo- and haemoglobin-bound HpuA, an essential component of this h

76 lood cell variants were haemoglobin S (HbS), haemoglobin C (HbC), alpha thalassaemia, ABO blood group

77 The WHO Haemoglobin Colour Scale (HCS) is a simple, cheap quanti

78 and regional databases up to Nov 14, 2014, "haemoglobin colour scale" in alternative spellings publi

79 quire haem through the uptake of haptoglobin-haemoglobin complexes.

80 nan assay, body-mass index <18.5 kg/m(2), or haemoglobin concentration <100 g/L) were recommended to

81 st common of which were anaemia or decreased haemoglobin concentration (70 [19%] vs one [1%]) and inc

82 metadata-only and combined models predicted haemoglobin concentration (in g dl(-1)) with mean absolu

83 fter CaO2 was reduced by 10% by lowering the haemoglobin concentration (isovolaemic haemodilution; Lo

84 placed with 5% human serum albumin to reduce haemoglobin concentration (n = 8).

85 aemocrit and higher total bilirubin and free haemoglobin concentration (P < 0.05 for all).

86 logy Group (ECOG) performance status of 0-3, haemoglobin concentration 9 g/dL or higher, absolute neu

87 an 0.33 g/dL (95% CI 0.20-0.46) reduction in haemoglobin concentration after 8 h (p<0.0001), and at 2

88 This increase may be caused by the reduced haemoglobin concentration after long-duration spacefligh

89 nverse correlation (r = -0.82) between blood haemoglobin concentration and P(50) , an index of oxygen

90 The mean haemoglobin concentration at the end of the transmission

91 ntrations (lower bound of the 95% CI for the haemoglobin concentration at which the OR of death equal

92 core by 0.26 (95% CI 0.09-0.43; p=0.003) and haemoglobin concentration by 2.9 g/L (95% CI 0.90-4.90;

93 ndpoint was the mean within-person change in haemoglobin concentration during 28 days of study follow

94 l below 80 g/L) or liberal (transfusion when haemoglobin concentration fell below 100 g/L) RBC transf

95 g) to either a restrictive (transfusion when haemoglobin concentration fell below 80 g/L) or liberal

96 ally appropriate and relatively safe minimum haemoglobin concentration for proceeding to surgery coul

97 l improvement-erythroid (HI-E), defined as a haemoglobin concentration increase of 1.5 g/dL or higher

98 ered haemoglobin affinity and the associated haemoglobin concentration influences oxygen consumption

99 The primary outcome was mean change in haemoglobin concentration measured during the third trim

100 simple, cheap quantitative method to assess haemoglobin concentration outside of the laboratory.

101 characteristics and the interference of high haemoglobin concentration released by erythrocyte lysis

102 low oxygen affinity haemoglobin and reduced haemoglobin concentration seen in vivo may be unable to

103 gs, heart rate, systolic blood pressure, and haemoglobin concentration strongly discriminated safe di

104 Mean last recorded haemoglobin concentration was 116 (SD 24) g/L for patien

105 0.16 (95% CI 0.08-0.23) higher and the mean haemoglobin concentration was 2.03 g/L (1.28-2.79) highe

106 Haemoglobin concentration was measured using the portabl

107 ed with improved survival when the admission haemoglobin concentration was up to 77 g/L (95% CI 65-11

108 orted diabetes, the combined model predicted haemoglobin concentration with a mean absolute error of

109 's r 0.918-0.957) and was less influenced by haemoglobin concentration, number of RBCs and number of

110 low-affinity haemoglobin, which predicts low haemoglobin concentration, oxygen consumption at rest ca

111 s were recruitment rate, protocol adherence, haemoglobin concentration, RBC exposure, selection bias,

112 ot significantly associated with harm at any haemoglobin concentration-ie, the OR of death comparing

113 , hyperchloraemic acidosis, and reduction in haemoglobin concentration.

114 oglobin for oxygen is highly correlated with haemoglobin concentration.

115 cerebral blood flow, possibly due to reduced haemoglobin concentration.

116 WASH intervention had no effect on length or haemoglobin concentration.

117 iants (13, 26 and 39 mmHg) and corresponding haemoglobin concentrations (19.5, 15.5 and 11.4 g dL(-1)

118 for haemoglobin (FIT), which examine faecal haemoglobin concentrations (f-Hb), assist in deciding wh

119 LSPAC), we examined associations of maternal haemoglobin concentrations (g/dL) in pregnancy with hayf

120 versus not transfused was less than 1 at all haemoglobin concentrations (lower bound of the 95% CI fo

121 Secondary outcomes were the changes in haemoglobin concentrations 24 h and 28 days after transf

122 ion was associated with improved survival at haemoglobin concentrations above the currently recommend

123 shortages, for donors who maintain adequate haemoglobin concentrations and iron stores.

124 However, donors had decreased haemoglobin concentrations and more self-reported sympto

125 comes were infant length-for-age Z score and haemoglobin concentrations at 18 months of age among chi

126 ant factor to consider preoperatively as low haemoglobin concentrations can have a negative effect on

127 To investigate the relation between maternal haemoglobin concentrations in pregnancy and childhood re

128 esting of anaemia, and methods of optimising haemoglobin concentrations in the context of paediatric

129 rdiovascular disease, and with postoperative haemoglobin concentrations lower than 100 g/L within 3 d

130 ion was associated with improved survival at haemoglobin concentrations up to 105 g/L (95% CI 71-115)

131 The mean change in haemoglobin concentrations was 3.5 g/L (SD 16.1) in the

132 lly significant dose-dependent reductions in haemoglobin concentrations were the most common laborato

133 had recorded pre-delivery and post-delivery haemoglobin concentrations, and overall 1412 women deliv

134 sis symptoms, body-mass index, point-of-care haemoglobin concentrations, and urine lipoarabinomannan

135 In terms of effects on haemoglobin concentrations, neither oxytocin nor misopro

136 nd hygiene (WASH) on child linear growth and haemoglobin concentrations.

137 prepared by the spontaneous self-assembly of haemoglobin-containing erythrocyte membrane fragments on

138 iogenesis, showed a significant reduction of haemoglobin content (54.2%) in sponges implanted into Sl

139 videnced by increased numbers of vessels and haemoglobin content in these implants.

140 Surprisingly, haemoglobin could be completely substituted by serum pro

141 sociations were observed with lung function, haemoglobin, creatinine, glucose levels or resting blood

142 , history of bleeding, and three biomarkers (haemoglobin, cTn-hs, and GDF-15 or cystatin C/CKD-EPI) w

143 n volumes remained stable for 12 months (ie, haemoglobin decrease not more than 15 g/L, platelet coun

144 Haemoglobin decreased significantly after spaceflight (1

145 d for cluster design, the mean difference in haemoglobin decreases between groups was not significant

146 th host haem, a product of parasite-mediated haemoglobin degradation.

147 In response to haemoglobin deoxygenation, red blood cells (RBCs) releas

148 exogenous source of haem since, feeding with haemoglobin-depleted serum led to aborted embryogenesis.

149 s female siblings fed either bovine blood or haemoglobin-depleted serum.

150 Haemoglobin-derived compounds, eumelanic pigments and pr

151 ticks do not acquire bioavailable iron from haemoglobin-derived haem.

152 d 1.10 [1.06-1.14] in women), and lower mean haemoglobin (difference per week shorter inter-donation

153 th amplification of plasmepsin 2-3, encoding haemoglobin-digesting proteases, regardless of the locat

154 th amplification of plasmepsin 2-3, encoding haemoglobin-digesting proteases, regardless of the locat

155 , blood meal concentration, novel methods of haemoglobin digestion, haem detoxification, vitellogenes

156 Inherited haemoglobin disorders, including thalassaemia and sickle

157 Most notably, changes in cortical oxy-haemoglobin during a Japanese phonetic fluency task can

158 the co-inheritance of beta-thalassaemia with haemoglobin E resulting in haemoglobin E/beta-thalassaem

159 thalassaemia with haemoglobin E resulting in haemoglobin E/beta-thalassaemia, have been described.

160 Haemoglobin electrophoresis by isoelectric focusing was

161 We show that modern haemoglobin evolved from an ancient monomer and characte

162 ctors that regulate the binding of oxygen to haemoglobin, explored the determinants of a human's accl

163 rly for reagents designed to increase foetal haemoglobin expression as we have additionally demonstra

164 .11-0.62) and in those with higher levels of haemoglobin F (HbF; adjusted IRR 0.40, 0.17-0.94).

165 d copy number and known genetic modifiers of haemoglobin F production.

166 Quantitative faecal immunochemical tests for haemoglobin (FIT), which examine faecal haemoglobin conc

167 ariants, we demonstrate that the affinity of haemoglobin for oxygen is highly correlated with haemogl

168 Supplementation of serum with haemoglobin fully restored egg fertility.

169 re the only vertebrates that lack functional haemoglobin genes and red blood cells.

170 Severe forms of alpha-thalassaemia, haemoglobin H disease and haemoglobin Bart's hydrops fet

171 Those with high affinity haemoglobin had no worsening of pulmonary gas exchange d

172 study was to determine whether high affinity haemoglobin (HAH) affects maximal and submaximal exercis

173 The HP2 allele associated with lower CSF haemoglobin-haptoglobin complex levels.

174 Haemoglobin-haptoglobin complexes were measured in cereb

175 macrophages, where it acts as a receptor for haemoglobin:haptoglobin complexes.

176 Lower haemoglobin (Hb) and high WBC counts were also significa

177 is that humans exhibit an acute reduction in haemoglobin (Hb) binding affinity for oxygen that facili

178 oietic response, resulting in near sea-level haemoglobin (Hb) concentration.

179 barachnoid haemorrhage (aSAH), extracellular haemoglobin (Hb) in the subarachnoid space is bound by h

180 Furthermore, leakage of haemoglobin (Hb) inside the RBCs at high melittin concen

181 gating vascular function in humans ABSTRACT: Haemoglobin (Hb) may impact the transduction of endothel

182 eased following the experimental addition of haemoglobin (Hb) or ferric iron, and reduced following a

183 e sphingonisne kinase 1 (Sphk1) activity and haemoglobin (Hb) oxygen (O2) release capacity.

184 sult, spectrophotometry result in U/gHb, and haemoglobin (Hb) reading.

185 arm: a negative intervention effect on mean haemoglobin (Hb) status (-2.6 g/l; 95% CI -4.5, -0.8; p

186 -upper arm circumference [MUAC], oedema) and haemoglobin (Hb) were measured in children aged 6-59 mon

187 ments for type 2 diabetes, lowering glycated haemoglobin (HbA(1c)) and weight, but are currently only

188 agnosed with type 2 diabetes with a glycated haemoglobin (HbA(1c)) concentration of 7.5% or higher (>

189 Glycated haemoglobin (HbA(1c)) is considered the gold standard fo

190 mmol/L, triglycerides <=1.7 mmol/L, glycated haemoglobin (HbA1c) <=53 mmol/mol (<=7.0%), systolic blo

191 d remission of diabetes, defined as glycated haemoglobin (HbA1c) of less than 6.5% (<48 mmol/mol) aft

192 BS), random blood glucose (RBS), or glycated haemoglobin (HbA1c) were reported.

193 Mean changes in glycated haemoglobin (HbA1c), and mean changes in fasting blood s

194 ssociations between multimorbidity, glycated haemoglobin (HbA1c), and mortality in people with T2D ha

195 se and insulin measures, as well as glycated haemoglobin (HbA1c), are used to diagnose and monitor di

196 nsification: age, sex, deprivation, glycated haemoglobin (HbA1c), body mass index (BMI), smoking stat

197 age, waist-to-hip ratio (WHR), glycosylated haemoglobin (HbA1c), diabetes duration, retinopathy, nep

198 iated with improvements in glucose, glycated haemoglobin (HbA1c), weight, waist circumference, anxiet

199 surement of serum uric acid and glycosylated haemoglobin (HbA1C).

200 y (pump or injections) and baseline glycated haemoglobin (HbA1c).

201 ipoprotein cholesterol (HDL-C), and glycated haemoglobin (HbA1c).

202 and HDL], triglycerides [TGs], and glycated haemoglobin [HbA1c]).

203 A and HbC (HbAC), and 2774 (77%) with normal haemoglobin (HbAA).

204 racellular vesicles (STBEVs) and free foetal haemoglobin (HbF) into the maternal circulation.

205 ly occurring Hereditary Persistance of Fetal Haemoglobin (HPFH) -175T>C point mutation associated wit

206 day 84 and was measured as the difference in haemoglobin in each screen-and-treat group compared with

207 ary outcomes were length for age Z score and haemoglobin in infants at 18 months of age.

208 Lower maternal haemoglobin in pregnancy may be a risk factor for allerg

209 Patients with MDD had smaller changes in oxy-haemoglobin in the frontal and temporal cortices than HC

210 sing a 52-channel system, and changes in oxy-haemoglobin in the frontal and temporal regions were qua

211 th symptomatic recurrence after AL, the mean haemoglobin increased 0.13 g/dL (95% CI 0.01-0.26) for e

212 Haemoglobin increased by a median of 26 g/L (IQR 21-31)

213 rterial hypotension, tachycardia, decreasing haemoglobin, increasing acute phase reactants tests, and

214 lassemia represents a heterogeneous group of haemoglobin inherited disorders, among the most common g

215 ing ribavirin required dose modification for haemoglobin less than 100 g/L or anaemia.

216 Anaemia was defined as haemoglobin less than 130 g/L for men and 120 g/L for wo

217 microscopy, anaemia (study defined values or haemoglobin less than age-adjusted and sex-adjusted valu

218 on during deep breathing was associated with haemoglobin level (regression coefficient = 0.022; p < 0

219 they received blood transfusion to maintain haemoglobin level at 100 g/L or higher, or restrictive t

220 itial blood testing was unremarkable, with a haemoglobin level of 9.4 g/dl.

221 n which they received blood transfusion when haemoglobin level was lower than 80 g/L or if they had s

222 e-induced AI in mice (indicated by increased haemoglobin level, serum iron, FPN expression and decrea

223 genetic variation associated with the fetal haemoglobin level, the mouse orthologue of which is nece

224 an 12 months, 11-15); patients with baseline haemoglobin levels 10 g/dL or greater (median 17 months,

225 d heterozygous animals IUGT normalised blood haemoglobin levels and spleen weight.

226 phenotype, with sustained elevation of blood haemoglobin levels into the normal range, reduced reticu

227 ian 17 months, 14-NA) than for patients with haemoglobin levels less than 10 g/dL (median 10 months,

228 Despite unchanged phosphate and haemoglobin levels, FC reduced ESA dose, RDW, and C-term

229 y-mass index, total cholesterol and glycated-haemoglobin levels.

230 ble haematoma; 11 patients had also anaemia (haemoglobin < 7 g/dl).

231 eing ART experienced, having severe anaemia (haemoglobin < 80 g/l), being unable to walk unaided, and

232 n the 8 weeks before treatment (and baseline haemoglobin <10 g/dL), or high transfusion burden, defin

233 Anaemia (haemoglobin <11 g/dL) in late pregnancy was negatively a

234 e undernutrition or moderate/severe anaemia (haemoglobin <11 g/dL)).

235 actate dehydrogenase >upper limit of normal, haemoglobin <110 g/L for women or <120 g/L for men, and

236 .60-0.86; p=0.04) in anaemic pregnant women (haemoglobin <110g/L) as compared with non-anaemic pregna

237 per L; for patients with polycythaemia vera, haemoglobin <15.0 g/L without phlebotomy) with complete

238 V(O2peak), peak cardiac output (Q(peak)), haemoglobin mass (Hb(mass)) and blood volumes were asses

239 He had a normal haemoglobin, mean cell volume, platelet and clotting fun

240 termination of the trial and the omission of haemoglobin measurement after day 42, resulting in an in

241 However, the first haemoglobin measurement in pregnancy (<18 weeks' gestati

242 The last haemoglobin measurement was also negatively associated w

243 onsequently from pathophysiologic process of haemoglobin metabolism and its products, causing chronic

244 ger duration of diabetes and higher glycated haemoglobin, non-HDL cholesterol, and waist-to-height ra

245 reduced O(2crit)), associated with increased haemoglobin-O(2) affinity (~32% fall in P(50)) of red bl

246 also assessed blood acid-base chemistry and haemoglobin-O(2) binding affinity of sea bass in hypoxic

247 donation resulted in more deferrals for low haemoglobin (odds ratio per week shorter inter-donation

248 Baseline median haemoglobin of 10.3 g/dL (IQR 9.3-11.7) increased to 11.

249 6 x 10(9) per L or higher (1.88, 1.27-2.79), haemoglobin of 11 g/dL or lower (1.71, 1.13-2.57), a pla

250 nd in those with anaemia, as any increase in haemoglobin of 20 g/L or higher observed in at least two

251 to 12 years with severe anaemia, defined as haemoglobin of less than 6 g/dL, at admission to hospita

252 tional cardiovascular risk factors, glycated haemoglobin of up to 9.5% (80 mmol/mol) on a maximum of

253 olment (above and below the median amount of haemoglobin on every enrolment day) and stage of gestati

254 monthly transfusions to maintain 30% sickle haemoglobin or lower, while those assigned to the altern

255 o creatinine, thyrotropin, calcium, glycated haemoglobin, or lithium measurements between Oct 1, 1982

256 r coupled to a reaction whereby nonsymbiotic haemoglobin oxidizes NO to nitrate.

257 y using photoacoustic imaging to measure the haemoglobin oxygen change (that is, the oxygen consumpti

258 , including capillarization and acid-induced haemoglobin oxygen unloading.

259 n concentrations, and more deferrals for low haemoglobin (p<0.0001 for each) than those observed in t

260 The high affinity haemoglobin participants demonstrated an attenuated decl

261 ine plasma powder; seven peptides for bovine haemoglobin powder, including six peptides for bovine bl

262 mproved knowledge of the regulation of fetal haemoglobin production in human beings and the developme

263 Induction of fetal haemoglobin production is a promising strategy for the t

264 tantly, unlike iPSCs, the line maintains the haemoglobin profile of the patient's red blood cells.

265 program a spatially coupled glucose oxidase/haemoglobin reaction cascade, which in the presence of g

266 The haptoglobin-haemoglobin receptor of the African trypanosome species,

267 occurs in the tsetse fly, where it acts as a haemoglobin receptor.

268 11A erythroid enhancer as a target for fetal haemoglobin reinduction.

269 sified using frontal and temporal region oxy-haemoglobin, respectively.

270 (RBCs), the parasite replicates and consumes haemoglobin resulting in the release of free heme which

271 To address specific adaptations to the haemoglobin-rich diet, we compared the midgut transcript

272 Red blood cell variants were haemoglobin S (HbS), haemoglobin C (HbC), alpha thalassa

273 e growing understanding of the mechanisms of haemoglobin S polymerization and its effects on red bloo

274 tution in the beta-globin gene that produces haemoglobin S, which leads to the systemic manifestation

275 e blood Collectively, our data point towards haemoglobin scavenging of nitric oxide as a key regulato

276 ough alterations in shear stress stimuli and haemoglobin scavenging of nitric oxide; these two regula

277 Collectively, these findings indicate that haemoglobin scavenging of NO appears to be an important

278 Haptoglobin is a haemoglobin-scavenging protein that binds and neutralise

279 tified age, smoking status, body mass index, haemoglobin, serum uric acid, serum albumin, albuminuria

280 In haemoglobin the change from the low-spin (LS) hexacoordi

281 With high-affinity haemoglobin, the model shows that normal levels of oxyge

282 ival, haematological improvement measured by haemoglobin, time to next treatment, and patient-reporte

283 int mutation in the beta-globin chain causes haemoglobin to polymerise within erythrocytes during deo

284 suggest there is no benefit of high affinity haemoglobin to preserve maximal oxygen uptake in acute h

285 logy that have brought reactivation of fetal haemoglobin to the forefront of sickle-cell disease rese

286 e plasmepsins are involved in the parasite's haemoglobin-to-haemozoin conversion pathway, targeted by

287 xploratory objective was to estimate optimal haemoglobin transfusion thresholds using generalised add

288 levels and might involve inhibition of host haemoglobin uptake into intra-erythrocytic parasites.

289 ues for high, normal and low oxygen-affinity haemoglobin variants (13, 26 and 39 mmHg) and correspond

290 o Clinic Laboratories database of rare human haemoglobin variants reveal a strong inverse correlation

291 Using human haemoglobin variants, we demonstrate that the affinity o

292 In both regions of interest, oxy-haemoglobin was not associated with any of the clinical

293 Maternal haemoglobin was not associated with offspring hayfever,

294 However, maternal haemoglobin was not associated with risk of childhood as

295 phic candidate genes, however only one, beta haemoglobin, was differentially expressed in both the fo

296 ntage of the intrinsic optical properties of haemoglobin, we show that raster-scanning optoacoustic m

297 Changes in fasting glucose and glycated haemoglobin were not different between groups at 12 mont

298 ingful or statistically significant drops in haemoglobin were recorded in any individual in the haemo

299 haemolysis and anaemia by increasing foetal haemoglobin, which leads to lower hypoxic transcriptiona

300 With low-affinity haemoglobin, which predicts low haemoglobin concentratio

301 ECISE-DAPT score (age, creatinine clearance, haemoglobin, white-blood-cell count, and previous sponta