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1 around the conserved GPGRA apex of the beta-hairpin loop.
2 l regulatory sequence (TRS) is folded into a hairpin loop.
3 lease active site in the absence of the beta hairpin loop.
4 acts occur in the signaling domains near the hairpin loop.
5 ons from a flexible stretch of residues to a hairpin loop.
6 number of interactions, such as a stable DNA hairpin loop.
7 long C-terminal extension and an N-terminal hairpin loop.
8 ibosomal protein contains a conserved UUAAGU hairpin loop.
9 easing the stacking among nucleotides in the hairpin loop.
10 tive (zinc-binding) site, including the beta-hairpin loop.
11 ing 5-iodoUMP positioned specifically in the hairpin loop.
12 the penultimate base pair than is the 5 base hairpin loop.
13 start site is at the start of this conserved hairpin loop.
14 G5 H2-A1O N7 and A10 NH6-G5 O2') closes the hairpin loop.
15 HBsAg peptide epitope revealed a stabilized hairpin loop.
16 ng from 5'-incision of an abasic site in the hairpin loop.
17 atory effect on DNA ligation during BER in a hairpin loop.
18 introducing a single-strand breakage in the hairpin loop.
19 gle-stranded regions of a bulged helix and a hairpin loop.
20 ome extent with the hinge region near the P3 hairpin loop.
21 elices connected by an intervening 8-residue hairpin loop.
22 g-Phe-Phe pharmacophores are on exposed beta-hairpin loops.
23 port even for base pairs, double helices, or hairpin loops.
24 ll experimentally determined four-nucleotide hairpin loops.
25 zing the structure and thermodynamics of RNA hairpin loops.
26 with this affinity to regular A-form RNA or hairpin loops.
27 epeats and covalently closed single-stranded hairpin loops.
28 y, as shown by the asymmetric opening of DNA hairpin loops.
29 a2 helix and the betaC-betaD and betaE-betaF hairpin loops.
30 s a common closing mismatch in ribosomal RNA hairpin loops.
31 therefore be common structural units of RNA hairpin loops.
32 three sequences joining the duplexes and two hairpin loops.
33 substrate-binding site-associated re-entrant hairpin loops.
34 tory miRNA binding and siRNA binding to mRNA hairpin loops.
35 tructural motifs such as internal, bulge and hairpin loops.
36 and template during replication and in short hairpin loops.
37 ner that depends crucially on the myotrophin hairpin loops.
38 ntial base pairing between the two predicted hairpin-loops.
39 organization, follow the order: cruciform<or=hairpin<.
40 x alpha1, or either Lys-37 or Arg-33 in beta-hairpin loop-1, impairs binding of yeast eIF1 to 40 S.eI
41 ts are a purine located at the center of the hairpin loop (-11G) and a base at the hairpin stem (-8G)
42 ts specifically with the central base of the hairpin loop (-11G) and a base at the stem (-8G) and tha
43 orters, Thr-352 and Met-362 of the reentrant hairpin loop 2 are replaced by the smaller Ala and Thr,
44 ing and transport of glutamate suggests that hairpin loop 2 not only plays a role in the selection of
46 0.9 min(-1) at pH 7.8) and substrates with a hairpin-loop 3' to the cleavage site (approximately 40 m
51 domain helices demonstrate that the N-domain hairpin loop acts as a structural mediator of the allost
52 il dimerization of two symmetry-related stem-hairpin loops, adjacent strands which are antiparallel t
53 imensional combinatorial screening approach, hairpin loops (among a variety of RNA motifs) were the p
54 hairpin complex formed between the HIV-2 TAR hairpin loop and a hairpin with a complementary loop seq
56 rent, including increased ordering of a beta-hairpin loop and a shift of the SxN active site motif su
57 ructures involving the recognition of an RNA hairpin loop and an RNA tertiary structure, reveals the
60 e structure, the relative stabilities of the hairpin loop and core quadruplex, and the ability to for
61 oop flanked on one side by a 2-bp stem and a hairpin loop and on the other side by a longer stem whos
67 This region bears the same sequences in the hairpin loops and four-arm junction as the short palindr
68 cers to investigate the expandability of DNA hairpin loops and the coupling between the loop and clos
69 orating modular 4-way junction (4WJ) motifs, hairpin loops and their cognate loop-receptors to create
70 o their propensity for forming complementary hairpin loops and their elevated mutation rates, tandem
72 DC3 are composed of residues in the opposing hairpin loops and unwound portions of adjacent helices.
73 "thumb loop," which binds right into the RNA hairpin loop, and a 10 degree hinge movement of the C-te
74 s of different lengths, sequence identity of hairpin loop, and hairpin loop biotinylation at differen
75 tein are braced by the N-terminus and a beta-hairpin loop, and interconnected along the tail by the s
77 g induces a conformational change around the hairpin loop, and the most specific compound recognizes
78 files were searched for internal, bulge and hairpin loops, and each loop's structural information, i
79 tructure motifs, including base-pair stacks, hairpin loops, and internal loops, using their statistic
80 es that are common to other RNA internal and hairpin loops, and molecular recognition principles comm
81 presented to mini-vRNAP in the context of a hairpin loop, appears to interact with mini-vRNAP Trp-12
82 s, selected basic amino acid residues in the hairpin loop are not critical for heparin binding, altho
84 additional evidence that small, fast folding hairpin loops are characterized by a rugged energy lands
87 es composing the predicted III-A and SUR-III hairpin-loops are crucial for optimal RNA accumulation a
88 C(4) oligonucleotide, mimicking the unfolded hairpin loop, are consistent with a right-handed A-form-
89 uclei has been proposed to possess a unique "hairpin-loop" arrangement, which is hypothesized to aid
90 e predominant and alternate conformations of hairpin loops, as shown in the most well represented tet
91 iation point mapped to a sequence within the hairpin loop at one end of the VACV genome and to the sa
92 tains a helix around the cleavage site and a hairpin loop at the corresponding position of the T stem
94 ree single-stranded regions, consisting of a hairpin loop at the end of P3 and two sequences joining
95 ts own, the extended NTD protein has no beta-hairpin loop at the N terminus of CA and that the molecu
96 haeroides groESL1 operon contains a putative hairpin loop at the start of the transcript that is pres
100 ical strategy to encourage formation of beta-hairpin loops because natural sequences are often unstru
101 lete bevacizumab binding site, including the hairpin loop (beta5-turn-beta6) and the structure-suppor
102 Furthermore, PgaB310-672 contains a beta-hairpin loop (betaHL) important for binding PNAG that wa
103 are the first to examine small molecule-RNA hairpin loop binding in detail and are a necessary step
104 into the minor groove of a helix, and a GAAA hairpin loop binds to a conserved 11-nucleotide internal
105 gths, sequence identity of hairpin loop, and hairpin loop biotinylation at different loop residues on
106 three nucleotides on the 3' side of the RNA hairpin loop by (ethylene glycol)6-18 spacers does not s
107 s in the structure are constrained to form a hairpin loop by the single disulfide bond in amylin.
108 s self-complementary sequence able to form a hairpin loop, by replacing dC with N:4-ethyldeoxycytidin
109 ssential platform upon which a stable d(GNA) hairpin loop can fold and that this loop can undergo 3'-
110 We have previously shown that BER in a TNR hairpin loop can lead to removal of the hairpin, attenua
111 ing of tryptophan 49, at the tip of the beta-hairpin loop, changes from a low value characteristic of
112 UG have approximately the same stability as hairpin loops closed by AU/UA base pairs, while the loop
117 ously developed to predict the stability for hairpin loops closed by Watson-Crick base pairs, allow f
119 f the N terminus and adjoining transmembrane hairpin loop compared with PheP in a PE-containing strai
120 4R inverse agonist, contains an exposed beta-hairpin loop composed of six residues (Arg-Phe-Phe-Asn-A
121 wo closely related structures and the unique hairpin loop conformation are specific to the P1G4 seque
122 ther, the domino effect and the altered beta-hairpin loop conformation explain how IMP-6 can evolve t
123 ns reveal that Met(73)influences beta3-beta4 hairpin loop conformation, whereas its substitution affe
134 following model to predict the stability of hairpin loops: delta G degree 37L(n) = delta G degree 37
135 ly developed to predict the stability of RNA hairpin loops: DeltaG degrees (37L(n) = DeltaG degrees (
136 in the model to predict the stability of RNA hairpin loops: DeltaG degrees (37L(n) = DeltaG degrees (
137 eine-knot motifs in both subunits create two hairpin loops, designated L1 and L3, on one side of the
138 m8 mapped to a missense mutation in the RHD3 hairpin loop domain, causing accumulation of the mutant
141 diate and specifically by the closure of the hairpin loop driven by formation of two native backbone
146 ces (e.g. (CAG)(16)(CTG)(4)), we resolve all hairpin loops formed and measure their slippage and expa
147 asmic domain and a construct containing the "hairpin loop," formed by the second and third membrane-s
151 , including an amino-terminal segment with a hairpin loop, four kringle domains, and a serine proteas
152 to plasminogen, including an amino-terminal hairpin loop, four kringle domains, and a serine proteas
153 a-Phe-DPro], comprised the hexa-peptide beta-hairpin loop from AGRP cyclized through a DPro-Pro motif
159 arious kringle domains or the amino-terminal hairpin loop had various effects in the multiple assays.
163 d secondary structure of SP genomic RNA: (i) hairpin loops; (ii) hairpin stems; and (iii) the 5' regi
165 s from a previous X-ray structure to model a hairpin loop in TAR, the best-fit RDC assignment solutio
168 The results suggest that an extended beta-hairpin loop in the endonuclease domain that contains re
170 with the nucleotides encoding the 11-aa beta-hairpin loop in the mouse Slc4a1 gene replaced with sequ
171 isms involve formation of a quasipalindromic hairpin loop in the template and dissociation of DNA pol
177 and kink-turn internal loops or T- and GNRA hairpin loops) in any PDB file or across a whole set of
178 l RdRps that contain similar regulatory beta-hairpin loops, including bovine viral diarrhea virus, de
179 that lentiviral constructs containing short hairpin loop inhibitory RNAs for human YY1 (shYY1) and i
181 To reveal mechanism, we tested different hairpin loop intermediates expected to form and facilita
183 ry interactions involves the docking of GNRA hairpin loops into stem-loop structures on other regions
186 ment at this position indicates that the DNA hairpin loop is not opened at the position adjacent to t
192 (gp4), the product of gene 4, has basic beta-hairpin loops lining its central core where they are pos
194 ions of proNGF are mostly disordered and two hairpin loops (loop 2) at the top of the NGF dimer have
195 intron of the human gene, suggesting that a hairpin loop may be involved in this intronic polyadenyl
198 of an experimentally well-characterized RNA hairpin-loop motif (sequence 5'-GGGC[GCAA]GCCU-3') via e
199 selected variants (30) had W79 in the second hairpin-loop motif, but there was diversity for hydropho
200 nding and inhibition appears to be a 40-base hairpin/loop motif with an asymmetrical internal loop.
203 y developed to predict the stability for RNA hairpin loops (n > 3) includes contributions from the si
205 he newly selected structure is a terminal or hairpin loop of 20 nucleotides, 15 being invariant.
206 of the coat protein (CP) gene, with a bulged hairpin loop of 28 nt as its most essential element, was
207 s reveal new functions for the alpha5-alpha6 hairpin loop of Bax: (i) regulation of mitochondrial tar
208 ntaining the hif-2 genes with termini in the hairpin loop of flanking intergenic dyad sequences.
210 rvation, we hypothesized that the disordered hairpin loop of sNRE facilitates conformational rearrang
211 ed with the MGDW motif located in a putative hairpin loop of the B subunit and that the expression of
212 f the inhibitor's linker segment with the 99-hairpin loop of trypsin, which is absent in plasmin.
214 We used structure-based mutations on the hairpin loops of myotrophin to determine the effect of t
218 recent model that predicts the stability of hairpin loops of six nucleotides on the basis of the clo
222 tire length, initial N-portion residues, and hairpin-loop of three Pro and one Ser residues, as well
224 he insert of interest, and a single-stranded hairpin loop on either end, which provides a site for pr
225 FKBP51 mutation L119P, which is located in a hairpin loop overhanging the catalytic pocket and introd
226 These results strongly suggest that the hairpin loop participates in the binding of substrate an
227 tted DNA sequences as input and identify the hairpin looping patterns, and (ii) exploit the consensus
228 e the motifs that each ligand binds, and the hairpin loop preferences for 1 and 2 were computed.
231 s were observed, such as small inversions in hairpin-loop regions and indels, which were common in in
233 ults define residues in the first and second hairpin-loop regions which are essential for optimal int
235 Analysis of the structures of these three hairpin loops reveals a network of heterogeneous hydroge
237 ct palindromic sequences that could produce "hairpin-loop" secondary structures with relatively high
238 ng recurrent 3D motifs from RNA internal and hairpin loop sequences extracted from secondary structur
241 revealed that residues 175-185 assume a beta-hairpin loop similar to a putative ankyrin-binding motif
242 ally incorporated into the cruciform arms as hairpin loops, single unpaired bases, and complex local
244 D (1)H-NMR structure of HB10 revealed a beta-hairpin loop stabilized by the disulfide bond and cross-
245 motifs, such as asymmetric internal loops or hairpin loop-stem junctions, by aminoglycoside antibioti
246 sequence (U/G)CCCG(A/G) in the context of a hairpin loop structure (nucleolin recognition element; N
247 ined the B52-binding site on these RNAs as a hairpin loop structure covering about 20 nucleotides, wh
248 embrane distal tip of the short helix of the hairpin loop structure, and HA2 position 112, located in
249 ine-binding RNAs have a common internal loop-hairpin loop structure, based on a conserved RAAGUGGGKKN
250 deletions occurred within the same potential hairpin loop structure, which had the lowest free energy
251 ructure analyses indicate a single conserved hairpin-loop structure towards the 5' end of the transcr
252 aptamer truncation study indicated that the hairpin-loop structure with 23 nucleotides length contai
254 anhandle structure and the presence of local hairpin loop structures in both the 5' and 3' ends of vR
255 oducts allowed precise identification of the hairpin loop structures involved in termination/antiterm
257 umerous complex mutation patterns, including hairpin loop structures, and explains multinucleotide mu
263 solution and solid-state structures of this hairpin loop suggests that formation of this hairpin may
266 activated by the addition, in trans, of a ds hairpin loop that contains only the binding region of th
267 UIM forms an alpha-helix with an unexpected hairpin loop that contributes to the binding interface w
268 mational changes in EF-Tu, displacing a beta-hairpin loop that forms a critical salt-bridge contact w
269 ers solved the structure of a hexanucleotide hairpin loop that is conserved in large subunit ribosoma
270 contacts, many that are made by a long beta-hairpin loop that reaches into the major groove of the D
271 Herein, we report the identification of RNA hairpin loops that bind derivatives of kanamycin A, tobr
272 expand the information available on the RNA hairpin loops that bind small molecules and could prove
273 araplegia encode proteins with intramembrane hairpin loops that contribute to the curvature of the en
274 le bimolecular structure containing two GTTT hairpin loops that interact through a novel T : G : G :
275 at TNR expansion can be prevented via BER in hairpin loops that is coupled with the removal of TNR ha
276 th the RNA polymerase involve a portion of a hairpin loop (the specificity loop) that makes specific
277 ps revealed that consecutive ANK repeat beta-hairpin loop tips (repeats 22-24) are required for InsP(
278 e ankyrin-B ANK (ankyrin repeat) repeat beta-hairpin loop tips revealed that consecutive ANK repeat b
279 ve altered multiple residues within the beta-hairpin loop to determine their role during dTTPase-driv
280 oices for loop, neck, and toehold length for hairpin loops to be used as fuel for autonomous DNA devi
281 e helix-turn-helix motif and within the beta hairpin loop, two putative DNA binding domains within th
284 A folding transition taking place in the RNA hairpin loop was shown to have a negligible dependence o
286 GCGU4U5A6A7G8U9CGCA), which has an r(UUAAGU) hairpin loop, was determined by NMR and molecular modeli
287 and the conformation of the active site beta-hairpin loop were characterized by the MD analyses.
289 s mRNA, including the potential formation of hairpin loops which might be important in its intracellu
290 ant E. coli strains; the in vivo cleavage of hairpin loops, which are an obligate consequence of slip
291 graminearum preferentially targets A's in hairpin loops, which is similar to the anticodon loop of
293 il dimerization of two symmetry-related stem-hairpin loops with adjacent strands antiparallel to each
294 or CTG triplets in DNA can form intrastrand hairpin loops with combinations of normal and mismatched
295 triplet, in accordance with our finding that hairpin loops with even numbers of triplets are 1-2 kcal
297 dy of the hybridization of complementary DNA hairpin loops, with particular reference to their use as
299 tion factor by site-specific cleavage of two hairpin loops within its mRNA to facilitate its nonconve