ライフサイエンスコーパス: halt

1 here were no early hemodynamic predictors of HALT.

2 nificantly reduced in patients who developed HALT.

3 computed tomographies, of whom 27 (16%) had HALT.

4 he LRTC of brain dynamics when comprehension halts.

5 eurodegeneration characteristic of FD can be halted.

6 the majority were disappointed when play was halted.

7 r decline of the tuberculosis burden will be halted.

8 control groups - tumor growth was completely halted.

9 ration is reduced and when it is temporarily halted.

10 duals grade 3 ISR occurred and the study was halted.

11 >0.05) suggesting that the reinnervation has halted.

12 ls and the observed loss in islet volume was halted.

13 que mechanism by which the fusion process is halted.

14 Of 558 adults with ADPKD in the HALT-A study, we identified 25 patients of class 2A with

15 el therapeutic opportunities for treating or halting AD.

16 The domain was halted after results from another trial were released.

17 MV causes epithelial cell death and halts alveolar development.

18 ion of a single epitope is not sufficient to halt an ongoing autoimmune response.

19 he global community has agreed on targets to halt and reverse these declines, and the restoration sec

20 , and hemodynamic and clinical correlates of HALT and RLM after aortic bioprosthetic replacement.

21 The rates of HALT and RLM were similar after the implantation of supr

22 conservation success show that losses can be halted and even reversed.

23 Furthermore, halting and resuming proliferation results in the synchr

24 nd offer our and others' recommendations for halting and then reversing the continuing increases in t

25 growth in the number of infected individuals halts and starts decreasing cannot be calculated with ce

26 d hemodynamic outcomes were compared between HALT (+) and (-) patients.

27 maging by hypoattenuated leaflet thickening (HALT) and reduced leaflet motion (RLM).

28 erized by hypoattenuated leaflet thickening (HALT) and reduced leaflet motion observed on 4-dimension

29 ugh the trial, production of BCG-Denmark was halted, and the trial continued comparing BCG-Japan (3,1

30 ugh the trial, production of BCG-Denmark was halted, and the trial continued comparing BCG-Japan (319

31 fuels to renewable energy is fundamental for halting anthropogenic climate change.

32 ed in 54% of patients at 1 year, whereas new HALT appeared in 21% of patients at 1 year.

33 ors, making them a promising alternative for halting AR signaling in progressed disease.

34 The primary endpoint was the frequency of HALT at 30 days and 1 year, analyzed by an independent c

35 days and 1 year, compared with those with no HALT at 30 days and 1 year, had significantly increased

36 ersus 0.5+/-0.1; P=0.003) than those without HALT at 30 days but not at 1 year.

37 ntrast-enhanced computed tomography assessed HALT at 30 days.

38 charge valve hemodynamics and development of HALT at 30 days.

39 Patients with HALT at both 30 days and 1 year, compared with those wit

40 oxidative stress, which supports elongation halt at pretranslocation.

41 ous malformations (ARUBA), randomisation was halted at a mean follow-up of 33.3 months after a prespe

42 Glycogen accumulation was halted at the 4-month level, while LB formation and neur

43 y the cytoplasmic 5'-3' exoribonuclease Xrn1 halted at the Xrn1-resistant RNA (xrRNA) structures with

44 tracellular arrest was interaction-specific, halting at various stages of the infection cycle.

45 l is more easily protonated in a manner that halts ATPase-driven rotation by blocking ATPase-dependen

46 tation, pharmaceutical therapy that slows or halts ATTR-CM progression and favorably affects clinical

47 nned 1600 events), the trial was prematurely halted based on an interim analysis that indicated a low

48 Recruitment was halted before the trial reached the planned sample size

49 d T1D interventions tested to date failed to halt beta cell demise.

50 m preclinical efforts capable of delaying or halting beta-cell destruction has been limited.

51 Sex chromosomes evolve once recombination is halted between a homologous pair of chromosomes.

52 Once recombination is halted between the X and Y chromosomes, sex chromosomes

53 tabolic activity and cell division typically halts between 0.700 and 0.640 water activity (approximat

54 , a step-change is needed to not just simply halt biodiversity loss, but to bend the curve of biodive

55 s likely to fall short of its commitments to halting biodiversity loss unless more considerable inves

56 Many global environmental agendas, including halting biodiversity loss, reversing land degradation, a

57 to lengthen, whereas in Dendronotus, curare halted bursting altogether.

58 worse valve hemodynamics than those without HALT, but hemodynamic and clinical outcomes at 1 year we

59 HALT by computed tomography may be associated with early

60 of pulmonary emboli, thrombus dissolution is halted by alpha2-antiplasmin.

61 t MOFs can be powered by various engines and halted by different brakes, resulting in a high degree o

62 supported accelerated tumor growth which was halted by PMP transfusion.

63 We demonstrate that these processes are halted by the disruption of microtubules and inhibition

64 Because this pathway is normally halted by the pro-apoptotic protease caspase-8 and the I

65 eant ion; (ii) that Cs(+) or Rb(+), known to halt C-inactivation, prevented mode-shift of gating; and

66 ng and closing in conditions that promote or halt C-type inactivation, we have found (i) that KcsA un

67 ic cell state, but is nevertheless unable to halt cancer cell proliferation and tumour growth due to

68 The growing recognition that metallodrugs halt cancer cell proliferation through mechanisms other

69 s that can break immunological tolerance and halt cancer progression, whereas on the contrary allerge

70 ) in CD4(+) T cells, but not CD8(+) T cells, halts cancer progression as a result of tissue healing a

71 Here, we investigate how neural progenitors halt cell division in response to nutrient restriction a

72 ear because these severe stressors typically halt cell growth and/or cause substantial cell deaths.

73 endent decrease of Notch signaling activity, halted cell cycle progression and induced apoptosis, thu

74 /cyclin-dependent kinase (CDK) complexes and halts cell cycle progression.

75 Microscopy analysis revealed that SosA halts cell division and synchronizes the cell population

76 Nutrient starvation usually halts cell growth rather than causing death.

77 ains of ER to suppress activation of SREBPs, halting cholesterol uptake and synthesis; and (3) determ

78 Although the NWFP halted clearcutting on federal land, this has so far bee

79 Renewable energy production is necessary to halt climate change and reverse associated biodiversity

80 development of phage-resistant bacteria will halt clinical phage therapy.

81 CTCF, which in turn results in a failure to halt cohesin-mediated extrusion.

82 KT signaling caused leader cell collapse and halted collective invasion.

83 emonstrate a novel mechanism for bacteria to halt costly motility when nutrients become scarce.

84 Transient dwells can halt counterclockwise rotation powered by the F1-ATPase

85 co-essential isoforms that when co-inhibited halt CR transcription, making CR TF sites hyper-accessib

86 We find that hyperacetylation selectively halts CR TF transcription.

87 ccess to medication for opioid use disorder, halt critical research, and prevent exacting legal repar

88 en if fossil fuel emissions were immediately halted, current trends in global food systems would prev

89 IL-33 also boosted luminal NETosis and halted cytolytic antiviral activities but did not affect

90 oil production or consumption is unlikely to halt deforestation in M&I in the absence of active fores

91 ly needed alongside current efforts aimed at halting deforestation and restoring the integrity of for

92 ency of slow waves restores slow wave power, halts deposition of amyloid plaques and prevents neurona

93 This will have a major impact on inhibiting/halting diabetic retinopathy and preventing the loss of

94 ing indicated that, while the increase in pH halts dichloramine formation, it converts amine-based ND

95 The presence of HALT did not significantly affect aortic valve mean grad

96 ent is prudent in such neoplasms not only to halt disease progression but also to prevent circulatory

97 A single agent or approach seems unlikely to halt disease progression in all people with or at risk o

98 ctively neutral intervention (at 2 years) to halt disease progression in keratoconus.

99 model, and that targeting these factors may halt disease progression in PD patients.

100 Because current therapies often fail to halt disease progression, there is an unmet need for nov

101 prevent the formation of these inclusions to halt disease progression.

102 t OPCs to overcome remyelination failure and halt disease progression.

103 ffering survival benefits, are not enough to halt disease progression.

104 targets can provide potential treatments to halt disease progression.

105 hereby correcting the biochemical defect and halting disease progression.

106 ively promoting remyelination are pivotal in halting disease progression.

107 A strategy to halt dissolution of particle-coated air bubbles in water

108 e virus, disrupts the cell cycle of hNPCs by halting DNA replication during S phase and inducing DNA

109 tions as the best prospect for preventing or halting DPN and its devastating sequelae.

110 T19 product whose commercial development was halted due to cerebral edema deaths during a separate ph

111 acting CB1 inverse agonist otenabant (1) was halted due to its potential of producing adverse effects

112 in a bottom-up freeze front that eventually halts due to poor conduction along the bubble.

113 tegravir in healthy, HIV-negative adults was halted early after two of the four patients developed se

114 However, the trial was halted early because of rejection in the belatacept trea

115 l evidence suggests that cells can be stably halted en route to EMT in a hybrid E/M phenotype.

116 lly reduce SARS-CoV-2 transmission rates and halt endogenous transmission in the target population.

117 ion, but preferences for local assortativity halt epidemics by disconnecting the infected from the su

118 Ablation halted epilepsy progression relative to untreated epilep

119 ofoundly alters proximal-distal identity and halts epithelial differentiation.

120 '-deoxyadenosine base efficiently and stably halts Escherichia coli RNAP transcription.

121 e, we define the role of PrP(C) to rescue or halt established AD endophenotypes in a therapeutic dise

122 eutically exploited as an alternative way to halt fasting hyperinsulinemia and the progression of typ

123 EZH2 inhibitor DZNep halted fibrosis both in vitro and in vivo.

124 ought traditional in-person conferences to a halt for the foreseeable future, the growth of virtual c

125 itiation of new disc formation is completely halted, forcing all newly synthesized membrane material

126 ntial in facilitating effective treatment to halt further chronic liver disease progression.

127 Interestingly, after halting GCV at 14 d postinjury, scar elements and vessel

128 which may offer an unanticipated strategy to halt glioma progression.

129 Halting global biodiversity loss is central to the Conve

130 RNase L executes regulated RNA decay and halts global translation.

131 Patients with HALT had smaller aortic valve areas (1.4+/-0.4 versus 1.

132 At 30 days, patients with HALT had worse valve hemodynamics than those without HAL

133 n cohort, prognosis worsened with increasing HALT-HCC score (5-year overall survival of 78.7% [95% CI

134 + (1.85 x lnAFP) + (0.26 x MELD-Na) and the HALT-HCC score ranged from 2.40 to 46.42 in the CCF coho

135 fter transplantation after stratification by HALT-HCC score with a cutoff of 17; conversely, among th

136 Multivariate Cox modelling showed that HALT-HCC was significantly associated with overall survi

137 ransplantation for Hepatocellular Carcinoma; HALT-HCC) assessed the association of the following prev

138 Currently, there is no effective vaccine to halt HIV transmission.

139 The recently halted HVTN702 clinical trial not only further stresses

140 rrence in the absence of the drug, therefore halting imatinib during pregnancy endangers the mother.

141 Chlamydial persistence is characterized by a halt in the division cycle, aberrant morphology, and, in

142 on, where the distribution of ivermectin was halted in 1999 after the occurrence of fatal events rela

143 Neonatal expansion was halted in mice conditionally deficient in STAT5, and its

144 disease onset to determine whether LD can be halted in midcourse, or even reversed.

145 ictors of hypoattenuated leaflet thickening (HALT) in low-risk patients undergoing transcatheter aort

146 The incidence of HALT increased from 10% at 30 days to 24% at 1 year.

147 2i) peptide for intra-articular injection to halt inflammation that contributes to the advancement of

148 elusive with reliance on therapies aimed at halting inflammation in its tracks.

149 at the growing aster periphery, then mostly halted inside the aster, while dynein-coated beads moved

150 aring age with weight management in order to halt intergenerational obesity.

151 atment with the SERCA-inhibitor Thapsigargin halted intracellular MRSA survival.

152 The HALT-IT Trial Collaborators.

153 tients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, pla

154 ntervention of cognitive impairment that may halt its progression.

155 d currently no effective treatment exists to halt its progression.

156 s focused on the development of a vaccine to halt its spread throughout the world.

157 owever, degassing the sample with helium gas halted its oxidation.

158 in human beings, and vector control has not halted its spread worldwide.

159 demonstrates that organ transplantation can halt life-threating recurrent liver failure episodes and

160 ch transports citrate across cell membranes, halts liver cancer cell growth by altering both energy p

161 cted macrophages with LVS-immune lymphocytes halted LVS replication and inhibited the spread of LVS i

162 e the World Health Organization criteria for halting mass treatment and move on to surveillance, ther

163 ce can be maintained for a long period after halting mass treatment and that true elimination (0% pre

164 en future uncertainty, specific responses to halt MDR-TB transmission should be prioritized.

165 terial cells known as persisters survives by halting metabolism.

166 y to clinical approaches aimed ultimately to halt metastasis.

167 in TIMP targeting that could be exploited to halt metastatic renal carcinoma progression.

168 bition of tumor-secreted factors effectively halts microtumor migration despite tumor-to-tumor variat

169 Ca2+ binding to Miro1 halts mitochondrial transport by modifying its interacti

170 ions revealed that heating could effectively halt modeled upslope range expansion except when combine

171 al amplitude, an external electric field can halt morphogenesis in Hydra regeneration.

172 lasmic E2f4, deuterosomes are not assembled, halting multiciliogenesis.

173 etic cell transplant (HCT) has been shown to halt neurologic progression, although the mechanism of d

174 In response to stresses, cells often halt normal cellular processes, yet stress-specific path

175 pi expression in dose-dependent fashion, and halted Nrf2 dysregulation of these antioxidants.

176 Spontaneous resolution of 30-day HALT occurred in 54% of patients at 1 year, whereas new

177 Enrollment halted October 2, 2017, after publication of ART (Alveol

178 on by CRISPR-Cas9 gene editing resulted in a halt of cell proliferation, severely impaired EGFR signa

179 l of warming above the present for an abrupt halt of emissions.

180 est practice guidelines recommend offering a halt of endogenous puberty for patients with early gende

181 f ABA-induced monomerization, which leads to halt of quenching and recovery of fluorescence of Cy5.5

182 The impact of HALT on thromboembolic complications and structural valv

183 Enrolment began on April 4, 2007, and was halted on April 15, 2013, after which follow-up continue

184 locomotion in the lamprey: their activation halts ongoing locomotion and their inactivation slows do

185 Prevention trials of measures to halt or delay cognitive decline are increasingly recruit

186 ppropriate interventions can be initiated to halt or even reverse the progression of cardiac dysfunct

187 cells employ diverse adaptive mechanisms to halt or exit the cell cycle temporarily or permanently.

188 of intense research, therapeutic options to halt or reverse renal disease are rather limited.

189 Effective measures to halt or reverse the decline of terrestrial biodiversity

190 o at month 18, suggesting that patisiran may halt or reverse the progression of the cardiac manifesta

191 ot influenced by the presence or severity of HALT or RLM at either time point.

192 refore crucial to identify methods that will halt or slow the progression to arthritis, starting with

193 mbination precluded determination of disease halting or reversal in this tissue.

194 mostly limited to treat symptoms rather than halting or reversing disease progression.

195 l exists for successful medical therapy that halts or reduces aneurysm progression and hence alleviat

196 There is currently no treatment to delay, halt, or reverse the progression of Wolfram syndrome, ra

197 lipoprotein cholesterol level of <70 mg/dl) halts plaque progression.

198 ing challenges(4,5), because disruptions can halt power production and damage key components.

199 n a univariable regression model to identify HALT predictors.

200 Trial recruitment was halted prematurely on the advice of the Trial Steering C

201 romal targets for interventions that seek to halt progression and improve therapy outcomes.

202 preventive measures before disease onset and halt progression.Objectives: To investigate the prevalen

203 NSI-189 also halted progression of established peripheral and central

204 therapy upon detection of T(2) prolongation halted progression to LV motion deterioration and resolv

205 Halting progression of myopia is critical, as high myopi

206 Treatment of periodontitis aims to halt progressive bone and attachment loss and regenerate

207 acutely by the Toll-like receptors (TLRs) to halt proliferation and activate an immune response.

208 ons through regulating nucleotide levels and halting proliferation.

209 In endothelial cells, TFEB depletion halts proliferation at the G1-S transition by inhibiting

210 3,) an inhibitor of many ATPases) completely halted recovery from drought-induced embolism for up to

211 ies have focused on developing treatments to halt renal microvascular (MV) rarefaction in RVD, a majo

212 ed mechanism of action (MOA), which involves halting retrograde vesicle transport to the endoplasmic

213 that MeCP2 binding to methylated miRNA loci halts RNA polymerase II elongation, leading to enhanced

214 polymerases (RNAPs) from bacteria to mammals halts RNAP in an elemental paused state from which longe

215 s there is currently no treatment to slow or halt SCAs (many SCAs lead to premature death), the clini

216 COVID-19 abruptly halted scientific conferences and seminars in mid-March,

217 vity in epilepsy may inform new therapies to halt seizure spread, and pave the way for targeted patie

218 targets to reverse biodiversity declines and halt species extinctions are not being met despite decad

219 for development of novel approaches aimed at halting synapse failure and cognitive loss in AD.

220 e female reproductive tract (FRT) mucosa, it halts systemic Chlamydia dissemination.

221 t we discover underscores the urgent need to halt the advance of pathogenic chytrids and prevent inci

222 hich is offered a maximum temporal window to halt the assembly at the point of C9 insertion.

223 eplication with nutrient availability and to halt the cell cycle during acute stress.

224 Therefore, developing an effective method to halt the disease process, as well as restore and regener

225 he BM environment is a promising strategy to halt the disease-inducing and relapse potential of LSCs.

226 ferase inhibitors provides another avenue to halt the exacerbation of the inflammatory response in pe

227 Whether avoidance of further use will halt the extension of related cross-allergies remains un

228 , suggestive that this may be a mechanism to halt the growth and other age-related programs supported

229 recently reported two sulfonylpyridines that halt the growth of the pathogen.

230 effective, and scalable vaccine is needed to halt the ongoing SARS-CoV-2 pandemic.

231 icking as a feasible therapeutic strategy to halt the onset and progression of renal inflammation and

232 immediately after a kindling protocol could halt the proepileptogenic plasticity observed in AS mode

233 toring, suggests that antireflux surgery may halt the progression of Barrett's esophagus, and this mi

234 Novel strategies that minimize AKI and halt the progression of CKD are urgently needed.

235 could be a potential therapeutic strategy to halt the progression of Parkinson's disease and related

236 There is currently no treatment to halt the progression of scarring trachoma due to an inco

237 ease resilience and potentially slow-down or halt the progression of the neurodegenerative process.

238 h to allow for renewal during development or halt the spread of a life-threatening crisis.

239 els for studying localized cell suicide that halt the spread of pathogen infection and immune respons

240 An effective vaccine is needed to halt the spread of the severe acute respiratory syndrome

241 . pneumoniae; and present strategies used to halt the striking spread of these deadly pathogens.

242 On July 3, 2017, the FDA decided to halt the study because of the imbalance in the proportio

243 tworks, in combination with BRAF inhibition, halted the adaptive transition and led to prolonged grow

244 pic expression of catalase, a ROS scavenger, halted the in vitro-induced differentiation.

245 OR inhibitor) treatment of patients with BRR halted the in vivo proliferation of TEM cells and their

246 e triple combination outweighed benefits and halted the study.

247 The data and safety monitoring board halted the trial when the numbers of clinical events wer

248 Current strategies for halting the antiapoptotic properties of MCL1 revolve aro

249 Thus, halting the disproportionate loss of ecological strategi

250 enting person-to-person spread is central to halting the epidemic and, consequently, tuberculosis tra

251 ines to meet UNAIDS-defined targets aimed at halting the global HIV epidemic.

252 r Paris 1.5 and 0.34% under Paris 2, thereby halting the global population decline.

253 ions for PWID remains a crucial priority for halting the HIV and HCV epidemics.

254 strictor angiotensin II while simultaneously halting the NEP-dependent degradation of vasodilator atr

255 Our results offer insight into halting the ongoing wave of vertebrate extinctions by re

256 ion could guide the development of therapies halting the progression of Alzheimer's disease.

257 target aging processes may be beneficial for halting the progression of disease and improving quality

258 days 1, 4, 8, and 11) prevent GFR decline by halting the progression of late donor-specific antibody

259 rs of PDE6 with therapeutic implications for halting the progression of several retinal degenerative

260 benefit of scaling up DTG-based regimens for halting the rise of NNRTI resistance.

261 e is a terminal differentiation program that halts the growth of damaged cells and must be circumvent

262 e we show that trans-cleavage of transcripts halts the growth of the host cell and is sufficient to a

263 monensin, a Na(+)/H(+) exchanger, completely halts the infection.

264 troesophageal reflux with antireflux surgery halts the progression of BE, often because of difficulti

265 Glucose control effectively halts the progression of diabetic neuropathy in patients

266 lipophilic radical-trapping antioxidant that halts the propagation of lipid peroxides.

267 n of the eukaryotic initiation factor 2alpha halts the transcription of uPA mRNA, leaving unopposed t

268 If activities are halted, the malaria burden in 2020 could be more than do

269 proliferate by suppressing p21 expression to halt their differentiation program.

270 any living organisms track light sources and halt their movement when alignment is achieved.

271 Initiation of antiangiogenic treatment halted their growth.

272 However, the mechanisms that halt this response of HSCs, which is critical to restore

273 Here we assess possible interventions to halt this seeding, using biochemical and EM assays.

274 It has long been debated how Aurora B halts this action when bi-orientation is established and

275 s work, we developed a chemical approach for halting transcription by Escherichia coli RNAP.

276 actor eIF2B to block eIF2 recycling, thereby halting translation initiation and reducing global prote

277 mine the minimal antibody titers required to halt transmission in different settings.

278 ign and rigorously evaluate interventions to halt transmission, prioritizing those interventions most

279 ch focused on understanding and, ultimately, halting transmission.

280 gh to support intrinsic localized modes that halt transport.

281 his process is well-informed, as prematurely halting treatment and surveillance programs could pose a

282 at effective public health interventions can halt tuberculosis transmission, but an evidence-based ap

283 e useful to define effective treatments that halt tumor growth and tumor progression in NF1.

284 creted factors during tumor progression, can halt tumor migration.

285 ignaling through the reciprocal arm, thereby halting tumor growth and survival.

286 cell phenotypes is a promising strategy for halting tumor migration.

287 ith the neddylation inhibitor, pevonedistat, halts tumor growth in a panel of patient-derived xenogra

288 t genetic or chemical inhibition of p38alpha halts tumor growth in lung cancer mouse models.

289 nostat inhibits cancer cell self-renewal and halts tumor maintenance without affecting normal stem ce

290 Analysis of a recent prematurely halted vaccine trial revealed increased mortality rates

291 major impact on the ability of antibodies to halt viral replication.

292 (RTA), a key KSHV lytic switch protein, and halted viral lytic replication.

293 such as VRC01 could promote HIV remission by halting viral replication and clearing infected cells.

294 Success is defined by halting viral transmission and by continuous viral restr

295 ed success in generating treatments that can halt vision loss.

296 At 30 days, the frequency of HALT was 31 of 179 (17.3%) for TAVR and 23 of 139 (16.5%

297 At 1 year, the frequency of HALT was 47 of 152 (30.9%) for TAVR and 33 of 116 (28.4%

298 HALT was more frequent in transcatheter versus surgical

299 r, all nonessential research activities were halted when the pandemic started, forcing those involved

300 For instance, Xrn1-resistant RNAs (xrRNAs) halt Xrn1 digestion, leading to the production of subgen