ライフサイエンスコーパス: hapten

1 ication to the detection of small molecules (haptens).

2 ection as well as for NK memory responses to hapten.

3 the target IgE compared with the monovalent hapten.

4 t of a monoclonal antibody to this synthetic hapten.

5 ubsequent contact immunization with the same hapten.

6 eutic advantage over mAbs targeting just one hapten.

7 -1beta and direct the T-cell fate to a given hapten.

8 contact hypersensitivity to various doses of hapten.

9 ed contact hypersensitivity (CHS) to topical hapten.

10 composed of a minimal length oligosaccharide hapten.

11 group that was immunized with dAd5 without a hapten.

12 -17 through endothelial cell presentation of hapten.

13 ked in rats vaccinated using the heroin-like hapten.

14 indiscriminately recognize each carbohydrate hapten.

15 ce utilizing 2,4-dinitrofluorobenzene as the hapten.

16 s model ligand for competitive biosensing of haptens.

17 to kill cells expressing low levels of these haptens.

18 ential for application in detection of other haptens.

19 dified to different levels with piperacillin haptens.

20 onses to a secondary challenge with specific haptens.

21 atom were designed as unique coating antigen haptens.

22 Hapten 1 was conjugated to tetanus toxoid and mixed with

23 , followed by (131)I-di-DTPA-indium bivalent hapten (1.8 GBq/m(2)) 4-6 d later.

24 y due in part to its use of racemic nicotine hapten, (+/-)-3'-AmNic.

25 gainst a coadministered T cell-dependent Ag, hapten 4-hydroxy-3-nitrophenyl acetyl (NP)-conjugated ch

26 chain and recognize a common foreign Ag (the hapten 4-hydroxy-3-nitrophenylacetyl) but differ in L ch

27 l population specific for an oxycodone-based hapten (6OXY) was analyzed by flow cytometry paired with

28 ic antibody and a small-molecule radioactive hapten, a complex of (177)Lu and S-2-(4-aminobenzyl)-1,4

29 robes consist on anabolic androgenic steroid haptens (AAS) covalently linked to specifically designed

30 N'-Disuccinimidyl carbonate was employed for hapten activation, so the resulting N-hydroxysuccinimyl

31 ients and a mouse model of CHS, we find that hapten allergens disrupt the Arginase1 (Arg1) and induci

32 Exposure of naive mice to hapten also induced an increase in the proportion of mig

33 cine containing a more hydrolytically stable hapten analogue and a Th1 adjuvant (CpG ODN).

34 ti-heroin potency, i.e., a chemically labile hapten and an exclusively Th2 humoral response elicited

35 e with (4-hydroxy-3-nitrophenyl) acetyl (NP) hapten and evaluated the binding affinity of the resulta

36 ce of regioselective deuteration of a heroin hapten and its impact upon the immune response against h

37 We show that both monovalent hapten and recombinant SPE-7 IgE Fab inhibit its cytokin

38 i, including epicutaneous sensitization with hapten and skin infection with Candida albicans.

39 f naive and sensitized mice had acquired the hapten and the ability to activate hapten-primed CD8 T c

40 e that can be activated with the beta-lactam hapten and/or an imbalance in immune regulation.

41 ht be useful to potentiate oral tolerance to haptens and alleviate ACD in human subjects.

42 Design of different haptens and coating antigens resulted in two assays with

43 n of bioconjugates from innovative synthetic haptens and monoclonal antibodies with subnanomolar affi

44 g due to both the low immunogenicity of many haptens and the cross-reactivity of the protein carriers

45 A comparison of enantiomeric haptens and the racemate elucidated the importance of em

46 NK cell memory of haptens and viruses depended on CXCR6, a chemokine recep

47 pitope peptide of influenza virus as a model hapten, and the immune complex was injected to chickens.

48 ological response in mice than previous METH haptens, and a monoclonal antibody generated from this M

49 d impaired contact hypersensitivity (CHS) to haptens, and their T cells failed to adoptively transfer

50 pport specific immobilization to fluorescein hapten- and protein A-patterned regions through antigen-

51 ive activity of EVs, after coating with anti-hapten antibody light chains, was assessed in hapten-ind

52 led with an arylamine, able to transduce the hapten-antibody association into a change in electroacti

53 can specifically recognize the formation of hapten-antibody immunocomplexes and can thus be used to

54 n of a reactant in solution; the competitive hapten/antibody transduction produces a "signal-on" (a c

55 These results indicate that hapten application to the skin of sensitized animals ini

56 uces immune cell infiltration to the site of hapten application.

57 immunochemically dynamic such that multiple haptens are simultaneously presented to the immune syste

58 Haptens are small molecules with low molecular weight th

59 itrophenylacetyl (NP), one of the most noted haptens, are gammadelta T cell antigens, recognized dire

60 eins, carbohydrates and other small molecule haptens as antigens are compared.

61 y (82, 130, and 169 nM for MH2, MH6, and MH7 hapten-based vaccines, respectively).

62 is in vivo was delayed, and strikingly fewer hapten-bearing LC subsequently accumulated in lymph node

63 igosaccharides and are used to report glycan hapten binding epitopes.

64 n synthesized and used to create multiplexed hapten-biofuncionalized plasmonic nanostructures.

65 oducible and reusable universal platform for hapten biosensors.

66 ct with cyclized and hydrolysed forms of the hapten bound to eight lysine residues was used to detect

67 bition and the use of structurally unrelated hapten-BSA adducts confirmed antigen specificity.

68 ons produced a mutant with high affinity for hapten but exceptionally low stability.

69 uced as spacer arm in all of the synthesized haptens, but it was located at different positions of th

70 mpaired contact hypersensitivity response to hapten by using a modified contact hypersensitivity prot

71 The role of hapten-carrier adducts in re-challenge reactions leading

72 ese processes has been gained by using model hapten-carrier complexes or SRBCs.

73 By contrast, upon immunization with a hapten-carrier conjugate, nitrophenyl-coupled chicken ga

74 thought to be similar to what was known for hapten-carrier conjugates: protease digestion of the car

75 and HIF-2alpha led to humoral defects after hapten-carrier immunization.

76 ing sensitization and the need of a covalent hapten-carrier link for initiation, but not for elicitat

77 y in immunization studies using proteins and hapten-carrier systems.

78 To analyze the MHC background effect on hapten/carrier immunization, we immunized DBA/2 mice (wh

79 to PAD proteins may trigger ACPAs through a hapten/carrier mechanism.

80 s to proteins bound by PADs, according to a "hapten/carrier" model.

81 that seen in control mice at 24 hours after hapten challenge but resulted in increased ear swelling

82 ized mice, DC-HIL-SAP injected i.v. prior to hapten challenge led to markedly suppressed contact hype

83 IFN-gamma, mRNA was detectable within 1 h of hapten challenge of sensitized mice and increased therea

84 he skin parenchyma to elicit the response to hapten challenge requires prior CXCL1/KC-directed neutro

85 Effector CD8 T cell recruitment into hapten challenge sites to elicit CHS requires prior CXCL

86 zed IL-1R(-/-) mice had low CHS responses to hapten challenge that were caused in part by marked decr

87 d during CS, peaking 8-24 h after an initial hapten challenge, and within 4 h of a second challenge.

88 t result in T cell activation in response to hapten challenge, indicating a need for IL-1R signaling

89 Four hours after hapten challenge, Tregs underwent adhesion with ~25% of

90 nted in the skin of DC-IL10R(-/-) mice after hapten challenge.

91 that both MRGPRA3+ and MRGPRD+ neurons from hapten-challenged mice displayed a significantly more de

92 enge site and elicit CHS when transferred to hapten-challenged naive wild-type recipients.

93 t reduction in spontaneous scratching of the hapten-challenged nape of the neck of previously sensiti

94 MRGPRA3+ and MRGPRD+ neurons innervating the hapten-challenged skin exhibited a greater incidence of

95 t Ly6G(+) (neutrophil) cell recruitment into hapten-challenged skin is required to direct effector CD

96 Hapten-challenged skin of TRPA1-deficient mice contained

97 ttractants, CCL1, CCL2, and CCL5, within the hapten-challenged skin.

98 undant in early GCs but, unlike responses to haptens, clonal diversity increased in GC B cells as ear

99 g of IgE-mediated drug allergy relies on the hapten concept, which is well established in inducing ad

100 endent Ag 4-hydroxy-3-nitrophenylacetyl (NP) hapten conjugated to chicken gamma globulin were delayed

101 nsequently, secondary IgG Ab responses to NP hapten conjugated to chicken gamma globulin were signifi

102 induced by means of intravenous injection of hapten conjugated to self-antigens of syngeneic erythroc

103 esponse to the 4-hydroxy-3-nitrophenylacetyl hapten conjugated with chicken gamma-globulin.

104 es of mice hyperimmunised with tetraconazole haptens conjugated to bovine serum albumin.

105 mulations consisting of novel fentanyl-based haptens conjugated to carrier proteins.

106 were created and immunized with nitrophenol hapten-conjugated keyhole limpet hemocyanin adsorbed to

107 red delayed-type hypersensitivity to a model hapten, consistent with recovery of immunocompetence in

108 ntiserum 1648 and a heterologous competitive hapten containing a piperidine was further characterized

109 An oxycodone hapten containing a tetraglycine linker at the C6 positi

110 A second assay utilizing a competitive hapten containing Br instead of Cl substitutions was bro

111 The assay consists of haptens covalently conjugated to fluorescence-encoded po

112 killer (NK) cells possess memory features to haptens, cytokines, and viruses.

113 c mutations that enhance binding affinity to hapten decrease the stability of the germline antibody;

114 lfhydryl nucleophile into a phosphoinositide hapten demonstrates a general strategy to reliably acces

115 can readily be equipped with tumor-targeting hapten-derivatized small molecules without causing a sys

116 Herein, we describe optimization of both hapten design and formulation, identifying a vaccine tha

117 nce of employing (S)-stereochemistry in METH hapten design for optimal protection.

118 Hapten design is largely responsible for immune recognit

119 Herein, we detail investigations into a new hapten design, which was able to elicit an antibody resp

120 cal studies, and molecular modeling assisted hapten design.

121 ort the systematic generation of a series of haptens designed to target the most stable conformations

122 tudy, we used biotin as a model molecule for hapten detection.

123 These findings suggest that regioselective hapten deuteration could be useful for the resurrection

124 itor, zanamivir, with the highly immunogenic hapten, dinitrophenyl (DNP), which specifically targets

125 induction in mice to the prototype innocuous hapten DNTB and suggest that strategies targeting LCs mi

126 ells (DCs) to draining lymph nodes following hapten elicitation of CHS.

127 incorporate this design consideration (i.e., hapten enantiopurity) in order to maximize efficacy.

128 Upon hapten exposure, AhR(-/-) mice are not able to mount an

129 und that ATP, which is released in skin upon hapten-exposure, is inducing the protease ADAM17 in LN-r

130 type contact hypersensitivity induced by the hapten FITC in combination with the sensitizing agent di

131 data suggests that not only could strategic hapten fluorination be useful for improving upon the cur

132 pt, we chemically programmed h38C2 x v9 with hapten-folate and demonstrated its selectivity and poten

133 ized antibody pellet to remove the trivalent hapten from the purified antibody.

134 nd GN5F) and one chlorine-containing cocaine hapten (GNCl) were designed and synthesized, based upon

135 A cocaine-like hapten GNE and a cocaine transition-state analogue GNT w

136 Hapten GNF was found to retain potent cocaine affinity,

137 Three fluorine-containing cocaine haptens (GNF, GNCF and GN5F) and one chlorine-containing

138 cancer of PAM4 and another Fab binding to a hapten (histamine-succinyl-glycine [HSG]) and tested thi

139 ficity, hybridoma cells are incubated with a hapten-horseradish peroxidase conjugate (hapten-HRP), wh

140 h a hapten-horseradish peroxidase conjugate (hapten-HRP), which is subsequently incubated with a fluo

141 ug hypersensitivity reactions, including the hapten hypothesis, direct binding to T-cell receptors (t

142 gn to be a versatile platform for inhibiting hapten/IgE interactions, which can potentially be applie

143 thylene glycol (PEG) coatings for subsequent hapten immobilization on glass-type silica surfaces is p

144 hat a vaccine using enantiopure (-)-3'-AmNic hapten imparts superior capacity to bind (-)-nicotine.

145 apten antibody light chains, was assessed in hapten-induced CHS in wild-type or miRNA-150(-/-) mice.

146 LA), a CD28 family coinhibitory receptor, in hapten-induced CHS, BTLA-deficient (BTLA(-/-)) mice and

147 coated with antibody light chains inhibited hapten-induced CHS.

148 either cytokine in the skin led to impaired hapten-induced contact hypersensitivity responses.

149 In contrast, severity of hapten-induced contact hypersensitivity, in which CD8 T

150 tagonists, such as aprepitant inhibited both hapten-induced cutaneous inflammation and scratching beh

151 Hapten inhibition and the use of structurally unrelated

152 first kinetic measurements of small-molecule hapten interactions with a receptor antibody.

153 S) induced in mice by high doses of reactive hapten is mediated by suppressor cells that release anti

154 mediately before conjugation, the immunizing hapten is obtained by removing the diphenylmethane prote

155 The hapten is prepared in the form of a stable prehapten thr

156 that immunopresentation with the heroin-like hapten is thought to be immunochemically dynamic such th

157 Induction of oral tolerance to haptens is an efficient way to prevent allergic contact

158 nduced liver injury (DILI) triggered by drug haptens is more prevalent in women than in men.

159 of the tailed primers obviates the need for hapten labelling and consequent use of capture and repor

160 Small molecules (haptens) like pharmaceuticals or peptides can serve as t

161 Drug allergies occur when hapten-like drug metabolites conjugated to serum protein

162 lification and detection by increasing probe-hapten linker lengths, and improving probe specificity u

163 antibody library (size, 4.4 x 10(6)) against hapten markers for petroleum contamination (phenanthrene

164 dent on proteasomal processing, suggesting a hapten mechanism.

165 and mice, respectively, as well as in acute hapten-mediated colitis and chronic, spontaneous colitis

166 6(+)DX5(-) liver-resident NK cells and their hapten memory function.

167 A novel METH-like hapten (METH-SSOO9) was synthesized and then conjugated

168 d on an electroactive and electropolymerized hapten (mimetic molecule of the pollutant to be detected

169 ars to be more relevant than presentation of hapten-modified peptides.

170 The hapten moiety of HBI enables selective targeting of a sp

171 was achieved by combining the humanized anti-hapten monoclonal antibody (mAb) h38C2 with the humanize

172 9A on dendritic cells was followed using the hapten nitrophenol (NP) conjugated to rat Ig carrier.

173 r the model Ag 4-hydroxy-3-nitrophenylacetyl hapten (NP) conjugated to chicken gamma globulin lysine

174 Confirmation in a hapten (NP) model allowed measurement of affinity, revea

175 ntibodies, and 4-hydroxy-3-nitrophenylacetyl hapten (NP)-chicken gamma-globulin (CGG) (NP-CGG)- or NP

176 conjugated to 4-hydroxy-3-nitrophenylacetyl hapten (NP-cOVA).

177 The low molecular weight hapten, Ochratoxin A (OTA), is a natural carcinogenic my

178 In this work, hapten-oligonucleotide bioconjugate probes, with sequenc

179 er the antibody binding to the corresponding hapten-oligonucleotide probes immobilized on the nanostr

180 for use in immobilizing low molecular weight haptens onto glass planar waveguides for immunosensor de

181 antibody that competitively binds either the hapten or the pollutant.

182 the skin with a protein antigen, a chemical hapten, or a non-replicating poxvirus.

183 lunted in mice challenged with an irrelevant hapten, or by inhibition of effector cell recruitment, i

184 t scratching behavior in mice exposed to the haptens, oxazolone and urushiol, the contact allergen of

185 or that binds, in addition to a self-Ag, the hapten p-azophenylarsonate (Ars).

186 Specific antibodies have been raised using hapten PC1 (a 1:1 mixture of 9-hydroxy- and 6-hydroxy-ph

187 itis, in which myeloid dendritic cells sense haptens, pDCs are primary sensors of imiquimod.

188 vitro using a fluorescent TF12 conjugate or hapten-peptide and (111)In-labeled TF12 and RS7.

189 s prepared and evaluated with a radiolabeled hapten-peptide in vitro and in vivo to determine whether

190 when the tumor was probed with a fluorescent hapten-peptide over 4 h, and microscopy showed substanti

191 High-specific-activity labeling of DOTA-hapten-peptide was obtained from the (68)Ga/(68)Ge gener

192 a pretargeting agent with an (111)In-labeled hapten-peptide were assessed in several human epithelial

193 n of a high-specific-activity (68)Ga-labeled hapten-peptide, IMP288, was evaluated.

194 y a variety of chemicals, also known as weak haptens, present in fragrances, dyes, metals, preservati

195 ed by adoptive transfer experiments, ex vivo hapten presentation, and forkhead box p3 regulatory T-ce

196 mice was associated with marked decreases in hapten-presenting dendritic cell migration from the sens

197 hil release of CG that systemically inhibits hapten-presenting dendritic cell production of IL-12 and

198 Transfer of hapten-presenting dendritic cells from wild type donors

199 The immunizing hapten preserves the most important and characteristic e

200 tized individuals proposed to be mediated by hapten-primed CD8 cytolytic T cells.

201 uired the hapten and the ability to activate hapten-primed CD8 T cell cytokine production.

202 nsitized gld/perforin-/- mice, they restored hapten-primed CD8 T cell infiltration into the challenge

203 Mechanisms directing hapten-primed CD8 T cell localization and activation in

204 initiates an inflammatory response promoting hapten-primed CD8 T cell localization to the challenge s

205 ated whether neutrophil activities directing hapten-primed CD8 T cell skin infiltration in response t

206 icate FasL/perforin-independent functions of hapten-primed CD8 T cells in CHS and identify new functi

207 ndent on IFN-gamma and IL-17 produced by the hapten-primed CD8 T cells.

208 f WT mice markedly increased IL-12-producing hapten-primed dendritic cell numbers in the skin-drainin

209 Hapten-primed wild type CD8 T cell transfer to naive IL-

210 Hapten-primed wild-type CD8 T cells, however, did not el

211 (c) The generation of covalent hapten-protein adducts requires hours, either because th

212 gs and have a similar appearance as covalent hapten-protein adducts.

213 imary immune responses to a T cell-dependent hapten-protein conjugate and the helminth Nippostrongylu

214 urther, for months after immunization with a hapten-protein conjugate, newly formed Ag-induced, IgM-s

215 class-switched high-affinity antibodies to a hapten-protein conjugate.

216 ude and duration of recall responses against hapten-protein conjugates.

217 and neutrophil-depleted WT mice induced both hapten-reactive CD4 and CD8 T cells producing IFN-gamma

218 hil serine protease cathepsin G (CG)-induced hapten-reactive CD4 and CD8 T cells producing IFN-gamma

219 l production of IL-12 and the development of hapten-reactive CD4 T cells to IFN-gamma-producing CHS e

220 Sensitization of wild-type (WT) mice induces hapten-reactive effector CD8 T cells producing IFN-gamma

221 able to mount an NK cell memory response to hapten rechallenge.

222 ntibody 93F3, which binds a relatively small hapten, reduce the melting temperature compared with its

223 opment of antibodies to low molecular weight haptens remains challenging due to both the low immunoge

224 to contain antibodies capable of binding to haptens represented in the benzylpiperidine leads identi

225 study reports the synthesis of the mercapto-hapten (S)-N-(2-(mercaptoethyl)-6-(3-(2-(methylamino)pro

226 itivity is a CD8 T cell-mediated response to hapten sensitization and challenge of the skin.

227 LC migration in the steady state, after hapten sensitization and postinfection with C. albicans,

228 IL-2/JES6-1 injection before or after hapten sensitization led to a considerable reduction of

229 TLR ligands are present in C. albicans, and hapten sensitization produces endogenous TLR ligands.

230 In hapten-sensitized mice, DC-HIL-SAP injected i.v. prior t

231 persensitivity (CHS) is a T cell response to hapten skin challenge of sensitized individuals proposed

232 y (CHS) is a CD8 T cell-mediated response to hapten skin sensitization and challenge.

233 Thus, hapten skin sensitization induces neutrophil release of

234 nanoparticles that are covalently coupled to haptens (small molecular mass compounds) activate the im

235 mab and rituximab, by synthesizing trivalent haptens specific for each antibody.

236 dy complexes created by binding to trivalent haptens specific for the antibody; and (iii) membrane fi

237 In contrast, hapten-specific Ab affinity maturation was significantly

238 BI binds the two independent sites on a drug hapten-specific Ab and covalently conjugates only to the

239 m differs distinctly from either peptide- or hapten-specific antibodies described to date.

240 techniques are still required to select rare hapten-specific antibodies from large recombinant librar

241 ered to be one of the most critical steps in hapten-specific antibody production.

242 y in the number of naive and early-activated hapten-specific B cells determines postvaccination serum

243 luorobenezene (DNFB) sensitization to induce hapten-specific CD8 effector T cells and in the traffick

244 t were caused in part by marked decreases in hapten-specific CD8 T cell development to IL-17- and IFN

245 Hapten-specific CD8 T cells and neutrophils represent th

246 raining lymph nodes and decreased priming of hapten-specific CD8 T cells compared with dendritic cell

247 ensitization of gld/perforin-/- mice induced hapten-specific CD8 T cells producing IFN-gamma and IL-1

248 ed CHS suppression, a sustained reduction of hapten-specific CD8 T cells, and a decrease in effector

249 enic CD11c(+) DCs leads to the generation of hapten-specific CD8(+) Treg cells, which protect against

250 e FACS procedure was employed to select rare hapten-specific clones.

251 o confer immunological memory in the form of hapten-specific contact hypersensitivity independent of

252 he sorted hybridoma clones revealed that all hapten-specific hybridoma clones secrete antibodies agai

253 dendritic cells, and led to lower numbers of hapten-specific IFN-gamma-producing CD8 T effector cells

254 suppression of contact hypersensitivity and hapten-specific IFN-gamma-producing effector T cells.

255 BI) was designed to specifically target drug hapten-specific IgE to prevent it from binding drug-hapt

256 to eight lysine residues was used to detect hapten-specific IgG 1-4 subclasses in patient plasma.

257 Distinct hapten-specific immune-polarizing responses to potent in

258 Our approach employs a novel hapten-specific labeling technique of hybridoma cells.

259 However, we show that long-lived hapten-specific plasma cells are readily induced without

260 generally adopted in the selection of other hapten-specific recombinant antibodies.

261 studied primarily in genetically restricted, hapten-specific responses.

262 Competitive FACS increased the frequency of hapten-specific scFvs in our yeast-displayed scFvs from

263 The presence of hapten-specific scFvs was confirmed by competitive ELISA

264 ll mice exhibited a significant reduction of hapten-specific serum Abs in response to immunization wi

265 eneic mouse red blood cells (sMRBC) leads to hapten-specific suppression of contact hypersensitivity

266 provide a pathway for the induction of drug hapten-specific T-cell responses.

267 T and B cell responses induced are primarily hapten-specific, rather than protein-specific.

268 cheek of previously sensitized mice with the hapten, squaric acid dibutyl ester, produced symptoms of

269 eveloped through comprehensive evaluation of hapten structure, carrier protein, adjuvant and dosing.

270 nst methamphetamine have focused on a single hapten structure, namely linker attachment at the aromat

271 vector coupled to a third-generation cocaine hapten, termed GNE (6-(2R,3S)-3-(benzoyloxy)-8-methyl-8-

272 based upon the chemical scaffold of the only hapten that has reached clinical trials, succinyl norcoc

273 Diphencyprone (DPCP) is a hapten that induces delayed-type hypersensitivity (DTH)

274 simple, but chemically robust, organomercury hapten that was conjugated to chicken immunoglobulin G (

275 n allergic contact dermatitis, especially at hapten threshold levels eliciting allergic reactions.

276 acid dibutylester (SADBE), a small molecule hapten, through directly promoting the excitability of p

277 lent targeting was accomplished by linking a hapten to an NBS ligand with an ethylene glycol linker.

278 Conjugation of the PI3P hapten to maleimide-activated keyhole limpet hemocyanin

279 imilar to that of melamine was employed as a hapten to raise a polyclonal antibody and as the immobil

280 that lasted 3 wk and were restricted to the hapten to which the mice were originally sensitized.

281 osteres of pArg and then use these mimics as haptens to develop the first high-affinity sequence inde

282 the possibility of using halogenated cocaine haptens to enhance the immunological properties of anti-

283 such as chicken egg ovalbumin or nitrophenyl haptens, to study immune responses in model organisms su

284 (PETN) were generated by designing suitable haptens using geometry optimization modules.

285 ltivalent antigen and then excess monovalent hapten was added to break-up cross-links.

286 A hydrolyzed piperacillin hapten was detected on four lysine residues of human ser

287 A second hapten was prepared with the intermolecular oxymercurati

288 oclonal antibodies from different immunizing haptens was obtained.

289 eagent) and fluorescein (antibody Fab domain hapten) was achieved photolithographically on commercial

290 monoclonal antibodies (mAbs) specific for a hapten were rapidly isolated and deposited from a fusion

291 (H(dAc)) and cognate protium heroin (H(Ac)) haptens were compared head to head in an inclusive vacci

292 study, oxycodone-based and hydrocodone-based haptens were conjugated to KLH to generate immunogens th

293 Novel immunizing haptens were synthesized by derivatizing at the 4-Cl pos

294 The haptens were synthesized by derivatizing the para positi

295 Two organomercury haptens were synthesized via the classical oxymercuratio

296 isplay multiple drug-like antigens; thus two haptens were synthesized, one heroin-like and another mo

297 an original approach where probe molecules (haptens) were conjugated to different carriers such as p

298 1155 and a heterologous competitive hapten, where the 2'-OH group was substituted with a Cl

299 By using a series of haptens with a linker at alternative tethering sites of

300 where specific antibodies bind to conjugated haptens with high affinity and specificity.