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1 ave reached amplitudes of 50 m and destroyed harbours.
3 ound that outcrossing populations on average harbour 5 to 9 S-locus receptor kinase (SRK) alleles, bu
4 1139 patients with SFN, 132 (11.6%) patients harboured 73 different (potentially) pathogenic VGSC var
8 he non-coding regions of tumour cell genomes harbour a considerable fraction of total DNA sequence va
9 criptional heterogeneity but micrometastases harbour a distinct transcriptome program conserved acros
10 ent techniques have shown that healthy lungs harbour a diverse and dynamic ecosystem of bacteria, cha
13 ng evidence that macro-organisms microbiomes harbour a high functional potential and are integral com
15 ons, overall revealing that all six patients harbour a missense mutation in the subdomain of TLDc bet
16 neral, and Theonella swinhoei in particular, harbour a multitude of associated microorganisms that co
17 nts with X-linked trichothiodystrophy, which harbour a mutation in RNF113A, are defective in ASCC foc
21 ies have shown that BRCA2-mutant tumours can harbour a subpopulation of cancer cells that can tolerat
23 e with toxic metals, sponges lack organs but harbour a symbiotic microbiome performing various functi
24 w physics and devices as half-Heusler phases harbour a variety of electronic ground states, including
25 ovo producing a cohort of HSPCs in situ that harbour a very specific molecular signature close to tha
26 transducing units per ml when vector genomes harboured a 12 kb insert, approximately twice that repor
27 ncer activity in recurrent ovarian carcinoma harbouring a BRCA mutation or high percentage of genome-
28 established another Arabidopsis mutant line harbouring a different allele of gene GRIK1 (grik1-2 gri
30 dividuals in the industrialized world may be harbouring a microbial community that, while compatible
33 1 (LCD1) and generated novel transgenic mice harbouring a single amino acid substitution of arginine
36 reveal that catalytic opening of a DHT motif harbouring a toehold triggers successive branch migratio
37 r acquisition in Staphylococcus aureus cells harbouring a type II CRISPR-Cas9 system after infection
38 lated to smacoviruses but possessed a genome harbouring a unidirectionally oriented CP and Rep, assig
39 investigated the extent of MLID in a family harbouring a ZFP57 truncating variant and characterize t
40 he ageing rate across five brain regions and harbours a cis-expression quantitative trait locus for E
41 ommunity level but found that each vent site harbours a distinct microbial community with differing t
42 sequencing revealed that the coastal region harbours a hybrid form characterised by an A. gambiae-li
43 ogen III; a suppressor mutant of this strain harbours a mutation in the hemH gene encoding ferrochela
44 of hormone-receptor positive breast cancer, harbours a mutational hotspot in its promoter leading to
48 rising residues 25 to 344 revealed that WipB harbours a Ser/Thr phosphatase domain related to the euk
50 tract (FRT), similar to other mucosal sites, harbours a site-specific microbiome, which has an essent
53 increasingly clear that articular cartilage harbours a viable pool of progenitor cells and interest
54 finding therefore is that a population that harbours a virulent infection can be regulated at a simi
55 minthes) are a basally branching phylum that harbours a wealth of fascinating biology, including plan
56 in the top 100 globally invasive species and harbours a wide diversity of pathogens, including viruse
57 (CRBN) substrate and further show that ZFP91 harbours a zinc finger (ZnF) motif, related to the IKZF1
58 ng complexes, with nearly 25% of all cancers harbouring aberrations in one or more of these genes.
61 ntact zones, while Steppe Maykop individuals harbour additional Upper Palaeolithic Siberian and Nativ
63 ack-complex/perforin (MACPF)-domain protein, harbour altered endophytic phyllosphere microbiota and d
64 rnaviruses, however, are 'ambigrammatic' and harbour an additional uninterrupted open reading frame (
65 ewide, we identify over 4000 host genes that harbour an iCGI in the mammalian genome, including both
67 we report that many enterovirus genomes also harbour an upstream open reading frame (uORF) that is su
68 A monoclonal antibody isolated from this cow harboured an ultralong HCDR3 of 60 amino acids and neutr
70 es - was initially described in lung cancers harbouring an EGFR mutation, and was subsequently report
71 17 patients with myelodysplastic syndromes harbouring an IDH2 mutation (median age, 67.0 years [IQR
74 Overall, our findings indicate that ATG16L1 harbours an intrinsic ability to bind lipids that plays
78 and in identifying subgroups of patients who harbour antibodies against nodal proteins such as neurof
81 survival was 9.6% and 67% of tetrapods still harboured at least one coral colony, and overall, this a
83 For the first time we show that human tendon harbours at least five distinct COL1A1/2 expressing teno
84 CRX is one of a number of genes reported to harbour autosomal dominant (AD) and recessive (AR) causa
86 train diversity; only 10% of Finnish infants harboured Bifidobacterium longum subsp. infantis, a subs
87 caudal lateral epiblast of mammalian embryos harbours bipotent progenitors that contribute to the spi
88 alian embryo's caudal lateral epiblast (CLE) harbours bipotent progenitors, called neural mesodermal
90 mmon in two highly stable IncI1 MDR plasmids harbouring (bla(CTX-M-1),sul2, tetA) or (bla(CTX-M-1), a
91 in common with many later divergent plants, harbour both fungal groups, suggesting these fungi may c
92 ms containing f-electron elements, which can harbour both strong correlations and magnetism, are cons
94 al markers in the chromosomal region 7q21.12 harbouring both the ABCB1 and ABCB4 genes, with the most
95 metabolic diversity of the SUP05 clade that harbours both primary producers and consumers of organic
96 clinical response rates in melanoma patients harbouring BRAF mutations, but resistance is common.
97 es were obtained with a genetic construction harbouring Bs2 under the control of a pathogen-inducible
98 g cannot capture the burden of pathogenicity harboured by an individual across a given gene/pathway.
99 usive and critically endangered biodiversity harboured by current patches of the Afromontane forest.
100 arbour strains more closely related to those harboured by their familial and social contacts than men
101 N2A transcript p16 where myoepithelial cells harbour cancer-like gene expression but do not exhibit a
102 l region for specific local eQTLs that could harbour candidate genes for phenotypic QTLs, or detect g
106 y a small number of clones, which frequently harbour co-occurring mutations in epigenetic regulators.
107 actory, or progressive pilocytic astrocytoma harbouring common BRAF aberrations and NF1-associated pa
108 Results indicate that older restorations harboured communities statistically distinct from newer
111 RM reconstructions of Escherichia coli cells harbouring CpcA-labelled cytochrome bd 1 ubiquinol oxida
113 These findings demonstrate that culture RM harbours different populations responsible for anaerobic
115 iogeochemical conditions, and diverse niches harboured distinct communities of bacteria, fungi and ar
117 show that the colipterins are antioxidants, harbour diverse immunological activities in primary huma
121 ients with WHO grade I pilocytic astrocytoma harbouring either one of the two most common BRAF aberra
122 six tau isoforms from the human MAPT locus, harbouring either the wild-type sequence or the disease-
130 nto taurine cattle under positive selection, harbouring genes with functions related to body size and
132 , IKZF1 and ETV6) are the same as those that harbour germline mutations in children and adolescents w
134 comes and Coprococcus catus strains did not harbour GH9 genes and were not able to grow on beta-gluc
135 tinct models of brain cancer, including mice harbouring GL261 glioma, B16 melanoma, and in a spontane
137 evolutionary responses (mixed invasions may harbour greater genetic diversity and thus elevated evol
138 Vertical walls in marine environments can harbour high biodiversity and provide natural protection
140 pic spectrum of 16 patients from 11 kinships harbouring homozygous or heteroallelic mutations in COL1
143 ment between established human IAVs and IAVs harboured in the animal reservoir can lead to the emerge
144 Here we compared the intestinal microbiota harboured in the distal digesta of Atlantic salmon fresh
145 mplex in the eukaryotic replisome, Timeless, harbours in its C-terminal region a previously unappreci
148 e we describe the mutational signatures they harbour, including a deficiency in G:C > T:A base excisi
152 oximal promoter regions uncovered >250 genes harbouring intermediately methylated (IM) promoters (ave
154 ost species-rich terrestrial biome on Earth, harbouring just under half of the world's plant species
156 s of whom 7 exhibited gain of chromosome 12p harbouring KRAS as well as a canonical KRAS codon 12 mut
159 tributed across all vegetated continents and harbour large functional diversity, yet most Land Surfac
160 into two groups: species with the ability to harbour large number of symbionts, Orbicella annularis a
163 ficient targeted transgene insertion at safe harbour loci (Rosa26 and AAVS1); (2) biallelic knockout
166 itive E. coli strains, including isolates co-harbouring mcr-1, have been widely detected in pigs, chi
170 Recent work has suggested that the placenta harbours microbial communities, however the location and
173 h African ancestry proportions at locus 2q14 harbour more IL1B-CGTC copies and are consequently at an
174 We further show that mammal species that harbour more pathogens overall (either human-shared or n
176 pathway dominated the DMSP gene pool and was harboured mostly by members of the alphaproteobacterial
179 n flowers (for example, Lychnis flos-cuculi) harboured multiple parasite species whilst others (for e
180 te GenePy scores < 0.01 although individuals harbouring multiple rare highly deleterious mutations ca
181 SHP2 inhibitors for the treatment of cancers harbouring mutant KRAS, the mechanism underlying SHP2 ac
182 ricted our study to candidate genes known to harbour mutations for Mendelian small vessel disease: NO
183 2OGDDs in cancer extends beyond cancers that harbour mutations in the genes encoding members of the 2
185 p of patients with myelodysplastic syndromes harbouring mutations in IDH2 from the AG221-C-001 trial.
187 mtDNA in unaffected and affected individuals harbouring mutations in PRKN/PINK1 and idiopathic Parkin
188 ulating variant of C. difficile ribotype 078 harbouring mutations leading to premature stop codons wi
191 ximately 10 l water from Yangshan Deep-Water Harbour near the Yangtze River estuary in China and iden
192 Experimental systems that are predicted to harbour non-Abelian anyons include p-wave superfluids, s
193 Notably, compared with wild-type mice, mice harbouring non-methylated mutant Akt1 not only exhibited
194 l for the treatment of patients with tumours harbouring NTRK fusions and MMR deficiencies, respective
195 and larotrectinib and entrectinib for those harbouring NTRK fusions, a regulatory pathway has been c
199 metastatic or locally advanced solid tumours harbouring oncogenic NTRK1, NTRK2, and NTRK3 gene fusion
201 trary to the long-held view that most humans harbour only identical mitochondrial genomes, deep reseq
203 omerger deficient myocytes differentiate and harbour organized sarcomeres but are fusion-incompetent.
204 itional cell lines obtained from individuals harbouring other UPF3B mutations, permitting us to inter
205 e that the eukaryote-specific RpL4 extension harbours overlapping binding sites for Acl4 and the nucl
208 ciprofloxacin were obtained, among which 14 harboured PMQR genes aac(6')-Ib-cr (4 isolates), qnrB19
209 s selected in vitro for resistance to AN3661 harboured point mutations in pfcpsf3, which encodes a ho
211 ansfer to the lungs and other tissues of the harbour porpoises may suggest a potential to do likewise
216 varepsilon2 and varepsilon4 alleles of APOE harbouring protective and risk increasing effects, respe
225 t Nations communities from the Prince Rupert Harbour region of the Pacific Northwest region of Britis
226 ecies Aegilops peregrina (U(p)U(p)S(p)S(p)), harbours resistance to various diseases including leaf r
231 Around Orkney, northern Scotland, UK, the harbour seal (Phoca vitulina) population has decreased b
232 PrimPol suppresses R-loop formation in genes harbouring secondary structure-forming sequences, exempl
234 grading approach is of prognostic value, it harbours shortcomings such as ill-defined parameters for
235 s study is to identify genetic variants that harbour signatures of recent positive selection and may
237 association studies identified numerous loci harbouring single nucleotide polymorphisms (SNPs) associ
247 iments suggest that Clade IV populations may harbour stress-tolerant subgroups, and thus fitness trad
248 The largely unexplored marine environment harbours substantial diversity and is a large resource t
249 atients with pancreatic cancer whose tumours harboured such actionable molecular alterations and who
250 cells that comprised these maps collectively harboured sufficient coding capacity to approximately re
255 imestone tombstones from the same cemeteries harbouring taxonomically distinct microbial communities.
257 y, these primary atypical meningiomas do not harbour TERT promoter mutations, which have been reporte
260 to identify which host species are likely to harbour the next human virus, or which viruses can cross
262 All six socially polymorphic species studied harbour the same three inversions, with the single origi
265 maps of RD locations showed that areas that harboured the RDs were much smaller than the entire fibr
267 90% but where the sextuple-mutant parasite (harbouring the additional dhps Ala581Gly mutation) is un
268 s of IHCs from early-onset hearing loss mice harbouring the allele Cdh23(ahl) (C57BL/6J and C57BL/6NT
269 HCs decreased significantly with age in mice harbouring the Cdh23(ahl) allele but not in C57BL/6NTac(
270 transduction (MET) current from OHCs of mice harbouring the Cdh23(ahl) allele is reduced with age, hi
272 derived alveolar rhabdomyosarcoma cell line, harbouring the diagnostic t(2;13)(q35;q14) translocation
273 tant p53 mouse model of Li-Fraumeni syndrome harbouring the hot-spot p53R172H mutation described an e
274 trical transducer current is smaller in mice harbouring the hypomorphic Cdh23 allele Cdh23(ahl) (C57B
275 shallow underwater cave in Corsica (France) harbouring the largest biomass (by more than 100-fold) r
276 yos lacking endosymbionts (control) to those harbouring the male-killing Spiroplasma poulsonii strain
277 pe has played a major role in dog evolution, harbouring the oldest uncontested Palaeolithic remains a
279 types and human embryonic stem cells (hESCs) harbouring the same disease mutation are also lacking.
280 both common and divergent responses in cells harbouring the same genetic lesion and pathways of drug
281 6B8, we isolated three resistant clones, all harbouring the same mutation (Ser301Phe) in HA that abol
282 Inhibition of ROS production in strains harbouring the SEP4 gene resulted in disordered assembly
284 re translated as inactive precursor proteins harbouring the ubiquitin-fold domain linked through an i
285 y, we made the unexpected finding that ST615 harbours the expression of two haemolytic variants of Pl
286 a single quantitative trait locus (QTL) that harbours the FGR gene responsible for the production of
287 s (Stal) is a globally invasive species that harbours the primary bacterial symbiont 'Candidatus Pant
288 Analyses of mice genetically engineered to harbour these human TPM1 and VCL variants show that stre
290 e and the northern Eurasian taiga and tundra-harbour tremendous diversity in their genes, cultures an
294 otential for treating haematological cancers harbouring U2AF1 mutations with pre-mRNA splicing modula
296 resistance (aacA-aphD) (n = 179) genes, none harboured vancomycin resistance genes while mupirocin re
297 voles that are not exposed to radionuclides harbour variable (increased inter-individual differences
299 ing superior killing of bacterial reservoirs harboured within bladder cells compared with unencapsula
300 almost no data exist on the fungal community harboured within other Hevea species or its sister genus