ライフサイエンスコーパス: headgroup

1 pin progressing to the completely deacylated headgroup.

2 ge with the negative charge on the phosphate headgroup.

3 by the functional group grafted at the lipid headgroup.

4 ophobic core and the hydrophilic carboxylate headgroup.

5 h the negatively charged GD2-pentasaccharide headgroup.

6 ming oligonucleotide extensions as the lipid headgroup.

7 r to CD1d than do counterparts with the same headgroup.

8 beyond the first few carbons adjacent to the headgroup.

9 moiety anchored to the phosphatidylglycerol headgroup.

10 y focused on the special properties of their headgroup.

11 ence of phosphate or net charge on the lipid headgroup.

12 yl hydrophobic domain and a polar or charged headgroup.

13 nitroxide tag attached to the lipids' polar headgroup.

14 or with a small molecule bearing a pyridine headgroup.

15 sitioning of the 3-O-sulfated beta-galactose headgroup.

16 plex pores, which become stabilized by lipid headgroups.

17 osyl, phosphohexose and hexose-phosphohexose headgroups.

18 rs, using natural phospholipids with various headgroups.

19 sitive to the surface curvature of the lipid headgroups.

20 ming salt bridges to the phosphates of lipid headgroups.

21 nge of the methylation level of phospholipid headgroups.

22 and further processed by addition of various headgroups.

23 the JM region, and negatively charged lipid headgroups.

24 nolamine) over neutral (glycerol and serine) headgroups.

25 between charged amino acids and lipid polar headgroups.

26 bonding of the polyol species to the bilayer headgroups.

27 uggests a correlation among the phospholipid headgroups.

28 at is promoted by protonation of cardiolipin headgroups.

29 ivatives that have been grafted to the lipid headgroups.

30 incorporating acidic, basic, or zwitterionic headgroups.

31 c interactions with negatively charged lipid headgroups.

32 g of Ca(2+) cations to the exposed phosphate headgroups.

33 by differential recognition of phospholipid headgroups.

34 phospholipids with phosphatidyl-ethanolamine headgroups.

35 dimethylsiloxanes covalently attached to the headgroups.

36 These arise primarily from phospholipid headgroups.

37 ules with negatively charged oligosaccharide headgroups.

38 s derivatized with polyethylene glycol (PEG) headgroups.

39 ide weak interactions with the anionic lipid headgroups.

40 eraction with unsaturated PLs with different headgroups.

41 but not charged interactions with the lipid headgroups.

42 ding of E7 to phosphatidylethanolamine lipid headgroups.

43 dipalmitoylphospatidyl-tempo-choline (on the headgroup), 5PC and 14PC (5-C and 14-C positions on the

44 osed of a zwitterionic headgroup, a negative headgroup, a headgroup that is composed only from the ne

45 and polyphilicity of the aminocyclopropenium headgroup, a lamellar phase was formed.

46 of lipid vesicles composed of a zwitterionic headgroup, a negative headgroup, a headgroup that is com

47 s glycodendrimers (GDs) with d-mannose (Man) headgroups, a known routing signal for lectin-mediated t

48 We implicate changes in lipid headgroup accessibility to small molecules (physical mem

49 dified GMs show that the structure of the GM headgroup affects the phase separation, whereas the natu

50 eometry of DPPC and monosialoganglioside GM1 headgroups affects their close molecular packing, induci

51 These structurally much simpler headgroups again furnished potent and selective S1P1 ago

52 the impact of peptide incorporation on lipid headgroup alignment.

53 bonding, and properties of the phospholipid headgroup all influence cholesterol/phospholipid interac

54 ester phosphate attached to its myo-inositol headgroup, also supported enhanced enzymatic activity of

55 a salt bridge between the ligand carboxylate headgroup and a conserved arginine side chain.

56 atures that include a heteroaryl sulfonamide headgroup and a lipophilic aromatic tail group.

57 with a succinimidyl ester as amine-reactive headgroup and a matrix-silane with an unreactive ethylen

58 when surfactants with a tripropargylammonium headgroup and a methacrylate-functionalized hydrophobic

59 ) of bovine mincle that encompasses both the headgroup and a portion of the attached acyl chains.

60 The relative hydration of the headgroup and alkyl chain correlates with detergent hars

61 s reveal how Ca(2+) binding to the PI(4,5)P2 headgroup and carbonyl regions leads to confined lipid h

62 In this work, we explore the impact of headgroup and chain length on the performance of this tw

63 nimization of local deviations in surfactant headgroup and counterion solvation to maintain a nearly

64 used phosphocholine spin labels on the lipid headgroup and different positions on the acyl chain to d

65 the native conformation of P7, and the lipid headgroup and fatty acid composition.

66 nt of the Sec17 effect varied with the lipid headgroup and fatty acyl composition of the proteoliposo

67 ions arising from the combined loss of polar headgroup and HNO2, [NO2-FA + H](+) and [NO2-FA - H](-)

68 ply that the specific chemistry of the lipid headgroup and its selective location in either monolayer

69 ated by systematically changing the aromatic headgroup and linker amino acid leading to compounds wit

70 e proton interacted strongly with both lipid headgroup and linker carbonyl oxygens.

71 e same structural elements of a zwitterionic headgroup and lipophilic tail, a variety of chemotypes h

72 rties of a range of lipids, varying both the headgroup and the chain length.

73 Therefore, the headgroup and the fatty acid composition of lipids are i

74 OxPCs yielded product ions related to the PC headgroup and the fatty acid substituents.

75 fferent lipid species, combining 14 types of headgroups and 11 types of tails asymmetrically distribu

76 rane configuration by shielding phospholipid headgroups and affecting curvature.

77 ds between the 5-HT hydroxyl group and lipid headgroups and allows 5-HT to intercept reactive oxygen

78 d, local partition coefficients at the lipid headgroups and at the lipid tails are modulated opposite

79 line and sphingomyeline which have identical headgroups and cannot be easily distinguished from anoth

80 ely charged sites on the cationic surfactant headgroups and deprotonated silanol sites on the pore wa

81 ntact polar lipids with phosphatidylglycerol headgroups and glycerol dibiphytanyl glycerol tetraether

82 essibility observed for smaller phospholipid headgroups and long Gb3 acyl chains.

83 etacyt is peripherally associated with lipid headgroups and one in which it penetrates deeply into th

84 ion-pairing interactions between the sulfate headgroups and oxidized ferrocenium species, forming an

85 of cation-pi interactions between PC choline headgroups and protein tyrosines vary as a function of P

86 of spacer length (between mannose-mimicking headgroups and quaternary nitrogen centers) in modulatin

87 asuring the fractional dissociation of lipid headgroups and the monolayer surface potential.

88 the vicinity of the negatively charged lipid headgroups and the very first carbon atoms of the acyl c

89 s are induced by looser packing at the lipid headgroups and tighter packing at the tails upon the add

90 bonding, and 2 cation-pi (between PC choline headgroups and Tyr residues) transient interactions with

91 g a coordination complex involving the lipid headgroups and water.

92 lar interactions with ionic and zwitterionic headgroups and, presumably, the interfacial dipole poten

93 RB-005, in which the lipophilic tail, polar headgroup, and linker region were modified to extend the

94 ation of the phospholipid carbon chains, the headgroup, and the composition of the liposome did not a

95 ractions between water, the ionic surfactant headgroups, and counterions.

96 een water and adhesion of water to the lipid headgroups, and so mitigating the stress induced by the

97 ogous molecule without the charged sulfonate headgroup are investigated by observing spectral diffusi

98 hiles containing mannose-mimicking shikimoyl headgroup are promising DNA vaccine carriers for dendrit

99 eadgroups of bound ligands suggests that the headgroups are saturated on the ligand shell as the size

100 ght the immune reactivity of novel synthetic headgroups as a key design consideration.

101 corresponds with the location of their lipid headgroups at the border and also inside of the unit cel

102 muM preferentially interacts with the polar headgroups at the membrane-electrolyte interface, leadin

103 he nucleation is the initial merger of lipid headgroups at the nascent pore center.

104 ses three sections: a 2-substituted 5-phenyl headgroup attached to the benzo[d]imidazole platform, wh

105 ures were identified as follows: a phosphate headgroup binding site, a hydrophobic cleft to accommoda

106 The quinone headgroup binds at the deep end of this chamber, near ir

107 l diglyceride chain as well as the remaining headgroup bound to {LGa2}(5+) as the most abundant peaks

108 penic hydrophobic backbone and a hydrophilic headgroup built from two sugar molecules.

109 interstitial space between the phospholipid headgroups but do not penetrate into the acyl tail regio

110 ers hydrogen bonding between water and lipid headgroups by forming a coordination complex involving t

111 -pi interaction between Tyr-33 and the lipid headgroups can influence conformational flexibility of t

112 non that lipids with highly charged or bulky headgroups can promote highly curved membrane architectu

113 used to determine the effect of ganglioside headgroup charge and geometry on its interactions with t

114 ratios can be explained by global effects of headgroup charge and resultant dipole moments within the

115 The headgroup charge is thought to contribute to both the st

116 ms studied, despite differences in detergent headgroup charge or dipole orientation.

117 ation of solubilized benzene is sensitive to headgroup charge).

118 econstituted in liposomes with different net headgroup charges and equilibrated in buffer with differ

119 vestigated to determine the effects of lipid headgroup chemistry on Nanodisc dissociation mechanisms.

120 tinuum models of lipids with large and small headgroups (choline and ethanolamine, respectively), and

121 en by the need of ceramide to obtain a large-headgroup co-lipid, and saturated lyso-PLs were preferre

122 vides glycerophospholipid (GPL) class (i.e., headgroup composition) and fatty acyl composition.

123 One of them is the lipid headgroup composition, which defines the electrostatic p

124 (i) different thermal regulations and polar headgroup compositions of membrane lipids between the ep

125 abilized oil/aqueous interface, in which the headgroups consist of positively charged methylimidazoli

126 This FPR2/Fpr2 agonist contains a headgroup consisting of a 2-aminooctanoic acid (Aoc) res

127 d preferentially to nanobilayers in which PS headgroups contained l-serine versus d-serine.

128 teins disrupt both the L(beta) phase and the headgroup correlation.

129 nitroxide moiety directly to the lipid polar headgroup defines the location of the measured potential

130 ts of DMSO on the membrane structure and the headgroup dehydration have been extensively studied, the

131 It is found that the headgroup densities of these "supersaturated" heterogene

132 of salt concentrations, exhibit slight lipid headgroup dependence, and show significant stimulation b

133 tive, while decreasing the penalty for lipid headgroup desolvation.

134 ch28/11 Fab complexes with the SSEA-4 glycan headgroup, determined at 1.5-2.7 angstrom resolutions, d

135 shown to fragment predominantly via a novel headgroup dication transfer to the reagent anion.

136 The cytoplasmic site nucleates headgroup-dipole stacking interactions that form a chain

137 raction with GlnK, and lipids with different headgroups display a range of allosteric modulation.

138 Tyr-33) that we propose interacts with lipid headgroups during the transport cycle.

139 We find that headgroup dynamics are sensitive to the position of the

140 relaxation data indicated a change in lipid headgroup dynamics induced by kalata B1.

141 Here, we demonstrate that the headgroup dynamics of polymerized monolayers of function

142 he assumption of negligible influence of the headgroup-electrode contact on the molecular resistance

143 ction between the fluorophores and the lipid headgroups facilitates the initial, fast membrane associ

144 iment thus facilitates assignment of the GPL headgroup, fatty acyl composition, carbon-carbon double

145 e attachment of aryl layer bearing an acidic headgroup, followed by chemical coupling leading to immo

146 rs contain an essential threonyl-hydroxamate headgroup for high-affinity interaction with LpxC.

147 To elucidate the role of SM headgroup for SM/ceramide interactions, we explored the

148 pendent of the number of water molecules per headgroup for the lamellae, but they slow somewhat in th

149 itation to the use of other engineered lipid headgroups for drug delivery.

150 of the dimerization interface; the cationic headgroups form multiple hydrogen bonds, thus crosslinki

151 differentiates between the two primary lipid headgroups found in mitochondrial membranes, phosphatidy

152 the intact lipid ion and the characteristic headgroup fragment, the regioisomer composition from fra

153 class identification by forming distinctive headgroup fragments based on the number of (13)C atoms i

154 form one or two strong, characteristic polar headgroup fragments.

155 catalyzes the transfer of the phosphocholine headgroup from PC to DAG.

156 ctant carrying a zwitterionic phosphocholine headgroup gives rise to two coexisting micelle populatio

157 rol tetraether lipids with phosphatidic acid headgroups (GMGTPA) occur without liposome content relea

158 ribution, differences in hydration, specific headgroup/H-bonding interactions, or a difference in the

159 ncreased with acyl chain length, whereas the headgroup had little effect on activation.

160 ectroscopy, we found that the size of the SM headgroup had no marked effect on the thermal stability

161 h the phosphate moiety of the phosphocholine headgroups had a condensing effect on our model bilayer.

162 oups in combination with an acyl sulfonamide headgroup have emerged, with the acyl sulfonamide bestow

163 molecules that interact with the surfactant headgroups have hydrogen-bonding properties different fr

164 have been identified: those close to the SDS headgroup having fairly isolated O-H groups, i.e., local

165 pids that contain phosphomonoesters in their headgroups having pK(a) values in the physiological rang

166 ium to the inactive state, whereas the small-headgroup, highly unsaturated DOPE lipids favored the ac

167 inner leaflet, a difference in transmembrane headgroup hydration, and a different headgroup orientati

168 nd micelles plausibly originating from their headgroup hydrogen bonding capabilities.

169 ands depending on the stereochemistry of the headgroup, illustrating the complex structure-functional

170 Comprehensive profiling of GSL headgroups in biological samples requires the use of end

171 omote anion-pi interactions with carboxylate headgroups in fatty acids.

172 olar furrow that becomes accessible to lipid headgroups in the Ca(2+)-bound state.

173 raction of formins with multiple PI(4,5)P(2) headgroups in the membrane to initiate actin nucleation.

174 ons with divalent ions can be used to tether headgroups in-plane, decreasing surface hydrophilicity.

175 ular determinants of specificity for several headgroups, including phosphatidylserine and phosphoinos

176 nsertion of alpha-Syn into the region of the headgroups, inducing a lateral expansion of lipid molecu

177 rating the necessity of a negatively charged headgroup interaction with Lys-436 for transport.

178 Atomic simulations uncover two lipid headgroup-interaction sites flanking the groove.

179 provide evidence for the role of protein-DDM headgroup interactions in stabilizing membrane protein s

180 Even though butanethiol SAMs manifest strong headgroup interactions, steric interactions are shown to

181 lecule remaining attached to the protein via headgroup interactions.

182 tch extensively to avoid unfavorable peptide/headgroup interactions.

183 control cable residues at the membrane core-headgroup interface, causing a break in the control cabl

184 he binding site for its redox-active quinone headgroup is approximately 20 A above the membrane surfa

185 residue of the trehalose Glcalpha1-1Glcalpha headgroup is liganded to a Ca(2+) in a manner common to

186 ating that either a glycerol or ethanolamine headgroup is the chemical determinant for substrate reco

187 the error arises from the fact that a lipid headgroup is typically smaller than the Debye length of

188 lating the methylation level of phospholipid headgroups is a simple way to control the specificity of

189 a detailed spectral characterization of its headgroup, is also presented.

190 se primarily choline as a positively charged headgroup; it may also be relevant for sicariid predator

191 tions are shown to dictate the nature of the headgroup itself, whether it takes on the adatom-bound m

192 ed conformation in a deep groove, the glycan headgroup likely sits flat against the membrane to allow

193 comprised of a substituted resorcylaldehyde headgroup linked to a 15-carbon tail that harbors two co

194 focus on recently described synthetic lipid headgroups, linkers and hydrophobic domains that can pro

195 ward water is mediated by unsaturated, small-headgroup lipids and couples directly to GPCR activation

196 estabilize chain-chain interactions near the headgroups, making the headgroups more solvent-accessibl

197 t T(2) relaxation dynamics data suggest that headgroup mobility depends on aspect ratio and absolute

198 unconfined lipid vesicle surfaces, the lipid headgroup mobility, and the repeat distances in multilam

199 ons, differentially affecting lipid chain or headgroup moieties of PI(3,4,5)P3.

200 (GSLs) is largely determined by their glycan headgroup moiety.

201 interactions near the headgroups, making the headgroups more solvent-accessible and increasing surfac

202 greater hydrocarbon chain ordering and less headgroup motion as the diameter of the particles increa

203 the lipid interface and restricts the lipid headgroup motion.

204 d transport, whereby polar and charged lipid headgroups move through the low-dielectric environment o

205 nding among signalling lipids with phosphate headgroups, namely C1P, phosphatidic acid or their lyso-

206 An increase in headgroup negative charge through the addition of phosph

207 d picosecond orientational relaxation of the headgroup occurring at the monolayer-air interface by em

208 the interfaces between individual oleophobic headgroup of AOT molecules and their surrounding non-pol

209 widely in their preference for choline, the headgroup of both sphingomyelin and lysophosphatidylchol

210 ler number of hydrogen bonds that the planar headgroup of FMN can form with this protein compared to

211 The phosphomonoester headgroup of phosphatidic acid enables this lipid to act

212 D superfamily catalyzes the cleavage of the headgroup of phosphatidylcholine to produce phosphatidic

213 The headgroup of PIP2 is highly negatively charged, and this

214 s(1,4,5)P3 or PtdIns(4,5)P2 The Ins(1,4,5)P3 headgroup of PtdIns(4,5)P2 binds in precisely the same o

215 biquitous ubiquinone, and the naphthoquinone headgroup of the former furnishes stronger binding inter

216 ng and an aromatic moiety in the hydrophobic headgroup of the molecule demonstrate exceptional potenc

217 re well defined, specific recognition of the headgroup of the zwitterionic phosphatidylcholine (PC) i

218 nging the acyl chain length, saturation, and headgroup of these LPA analogs, we established strict re

219 work the mechanism for binding of the sugar headgroup of trehalose dimycolate to mincle has been elu

220 of NaD1 that cooperatively bind the anionic headgroups of 14 PIP2 molecules through a unique 'cation

221 Because of their high density, the headgroups of anionic lipids experience electrostatic re

222 the proton signals from the solvent-exposed headgroups of bound ligands suggests that the headgroups

223 f 0.5 mM at 1 T and 0.2 mM at 2 T, while the headgroups of phosphatidylcholine (PC), phosphatidyl-eth

224 ain and interact with the negatively charged headgroups of PIP molecules.

225 es with PtdSer to form nanodomains where the headgroups of PtdSer are maintained sufficiently separat

226 dration forces due to the highly hydrophilic headgroups of SLBs.

227 d membranes via interaction with hydrophilic headgroups of surface lipids.

228 within the bilayer, positioned closer to the headgroups of the lipids than to the middle of the tail

229 functionalized with a rhenium metal carbonyl headgroup on an SiO2 surface.

230 to establish the deterministic role of lipid headgroup on gating.

231 embrane headgroup hydration, and a different headgroup orientation for the interacting phosphate grou

232 ilayer curvature, accompanied by a change of headgroup orientation relative to the membrane normal an

233 dies and MD simulations, we suggest that the headgroup packing limits the ligand density, rather than

234 ition of phosphoethanolamine to the 1 and 4' headgroup positions by phosphoethanolamine transferases.

235 domains in close proximity to anionic lipid headgroups, "prime" Syt1 for cooperative binding of a fu

236 Reversible phosphorylation of its headgroup produces seven distinct phosphoinositides.

237 throughput glyco-analytical platform for GSL headgroup profiling.

238 highly sensitive to the nature of the lipid headgroup, ranging from a fast lateral diffusion at some

239 through a novel surface-localized, phosphate headgroup recognition centre connected to an interior hy

240 The patches form grooves for specific lipid headgroup recognition or flat surfaces for non-specific

241 the aqueous buffer, solvated in the vesicle headgroup region and solvated in the acyl chain bilayer

242 relocation of the peptides within the lipid headgroup region as compared to the individual peptides.

243 with the membranes and penetrates below the headgroup region into the upper part of the fatty acyl c

244 ults demonstrate that VSTx1 localizes to the headgroup region of lipid membranes and produces a thinn

245 th its strong preference to be buried in the headgroup region of membrane bilayers.

246 A location in the amphiphilic headgroup region of the bilayer was supported by (15)N-N

247 s by decreasing the negative pressure in the headgroup region of the outer leaflet and increasing the

248 peptides aggregate in the lipopolysaccharide headgroup region of the outer membrane with limited tend

249 nd suggest a large contribution of the polar headgroup region to the dielectric response of the lipid

250 e inclusion will soften the bilayer near the headgroup region, an effect that may weaken curvature in

251 duces solvent accessibility around the lipid headgroup region.

252 of the peptidic moiety from the phospholipid headgroup region.

253 s located at the interface beneath the lipid headgroup region.

254 ith many residues of hATMfatc located in the headgroup region.

255 s of reducing the size of the phosphocholine headgroup (removing one, two, or three methyls on the ch

256 EN-like domain with negatively charged lipid headgroups results in nanoclustering of PIP2 molecules i

257 tatics, specific recognition of phospholipid headgroups, sensitivity to phospholipid acyl chain compo

258 ding a GSL with a monosaccharide sialic acid headgroup (sGSL); for all 11 E. huxleyi strains we teste

259 water-soluble version of the metal carbonyl headgroup shows that water hydrogen bond rearrangement d

260 Increasing unsaturation and decreasing headgroup size have similar effects that combine to yiel

261 ment ability had different origins, with the headgroup size primarily influencing tN-Ras binding to p

262 degree of acyl chain unsaturation and polar headgroup size using 1-palmitoyl-2-oleoyl-sn-glycero- an

263 ers of lipids, namely acyl chain saturation, headgroup size, and acyl chain length, modulate the capa

264 to methane starvation, including changes in headgroup-specific fatty acid saturation levels, and red

265 phospholipase Cdelta1 (PHPLCdelta1), mediate headgroup-specific interactions with corresponding phosp

266 st evidence for a potential phosphoglyceride headgroup-specific regulatory interaction site(s) existi

267 fy more than a dozen residues that determine headgroup specificity for phospholipid transport.

268 Negatively charged lipid headgroups stably anchored P2 on the myelin-like bilayer

269 as placed a renewed emphasis on detailed GSL headgroup structural analysis.

270 cal/mol relative to zwitterionic lipids in a headgroup structure-dependent manner.

271 ure of the fatty acid chains, as well as the headgroup structure.

272 ing from acyl chain hydroxyl groups to novel headgroup structures.

273 es and phospholipids with negatively charged headgroups, such as the late endosomal phospholipid bis(

274 tterionic headgroup, a negative headgroup, a headgroup that is composed only from the negative phosph

275 novel bromodomain binding mode of a phenolic headgroup that led to the unusual displacement of water

276 azobenzene and a quaternary ammonium bromide headgroup that self-assembles into highly charged nanofi

277 e discovered that individual monolayers with headgroups that coat the bilayer-aqueous interface with

278 riginate from strong binding to phospholipid headgroups that hampers the diffusion of the free transp

279 ical SNARE levels, neutral lipids with small headgroups that tend to form non-bilayer structures (pho

280 terfacial hydroxylation, the identity of the headgroup, the length of the N-acyl chain, and the posit

281 urfactants containing an amide bond near the headgroup, the MINPs had a layer of hydrogen-bonding gro

282 al pore opens laterally to accommodate lipid headgroups, thereby enabling lipids to flip.

283 and carbonyl regions leads to confined lipid headgroup tilting and conformational rearrangements.

284 ted across the bilayer to expose a catalytic headgroup to the internal vesicle solution.

285 ne was identified among several heterocyclic headgroups to have the best potency.

286 proximity of the peptides allows fewer lipid headgroups to line the pores than in previous simulation

287 components such as the acyl chain length and headgroup type and is further amplified by the presence

288 Some of the saccharide headgroup types investigated are able to bind adjacent m

289 Both recognize basic substrate headgroups via Asp189 at the bottom of the S1 pocket.

290 ongly indicate that PI-PLC interacts with PC headgroups via cation-pi interactions with tyrosine resi

291 The fatty acid headgroups were located at the unit cell boundary with t

292 nalogous to AOT but has no charged sulfonate headgroup, were also studied.

293 ss of the exact chemical nature of the lipid headgroup, whereas GlpF was not sensitive to changes in

294 a contact ion pairing, dehydrating the lipid headgroup, whereas Mg(2+) and Cu(2+) were bound without

295 sponsible for interaction with the sulfatide headgroup, whereas the C-terminal polybasic region contr

296 While the combination of small headgroups with linear p-alkoxyphenyl units led to bilay

297 id mixing, binding peripherally to the lipid headgroups with minimal perturbation to the bilayer stru

298 hain packing order and saturation of charged headgroups within the same spherical ligand shell at lar

299 the negative phosphate group, or a positive headgroup without the phosphate group.

300 rier for penetration through the hydrophilic headgroup zone of the lipid A leaflet, which was confirm