ライフサイエンスコーパス: healthy adult

1 istributed across all lobes in stroke versus healthy adults.

2 prefusion SARS-CoV-2 spike protein (S-2P) in healthy adults.

3 -cell level in human gut microbiota from two healthy adults.

4 s unaware of trial-group assignments) in 131 healthy adults.

5 nimal models and attenuate fear responses in healthy adults.

6 , birth cohort studies, or vaccine trials in healthy adults.

7 rebral blood flow (CBF) impairs cognition in healthy adults.

8 tor control or planning capacity deficits in healthy adults.

9 the GLS-5300 MERS coronavirus DNA vaccine in healthy adults.

10 togenicity, and immunogenicity of ExPEC4V in healthy adults.

11 udy the central component of fatigability in healthy adults.

12 cteristics and corticospinal excitability in healthy adults.

13 ance imaging (MRI) data in a large cohort of healthy adults.

14 eater than/equal to plasma concentrations in healthy adults.

15 nts but not in any of 159 skin samples of 98 healthy adults.

16 pendent dilation was impaired, compared with healthy adults.

17 n those with CMC, and 71% (95%CI:-77,-64) in healthy adults.

18 rmance (P=0.0003) in 3,346 young and elderly healthy adults.

19 for 12 clinical conditions, when compared to healthy adults.

20 mponent AR structure in 90% of a group of 29 healthy adults.

21 cited robust neutralising antibody titres in healthy adults.

22 nit of blood close to the storage limit into healthy adults.

23 e common in over-the-counter supplements for healthy adults.

24 han wild type embryos, they can develop into healthy adults.

25 Videofluoroscopy was performed in 31 healthy adults.

26 cells has not been explored, particularly in healthy adults.

27 degree of interference remains undefined in healthy adults.

28 literacy and numeracy in the same sample of healthy adults.

29 nectivity to the temporopolar seed region in healthy adults.

30 somatic mutations in the blood of otherwise healthy adults.

31 ic stroke and left hemiplegia/paresis and 22 healthy adults.

32 left hemisphere (LH) in most neurologically healthy adults.

33 eparate nights of ad libitum sleep from five healthy adults.

34 rm outcomes exists among obese but otherwise healthy adults.

35 re System (IAPS) in a population (n = 50) of healthy adults.

36 participants initially recruited in ADNI as healthy adults.

37 hypothesis by performing two experiments in healthy adults.

38 apoptotic cells and commensal bacteria from healthy adults.

39 nuary 2020 for myocardial T2 measurements in healthy adults.

40 4 years) and older (n = 12; 58 +/- 6 years) healthy adults.

41 A 2-part, phase 1 trial was conducted in healthy adults.

42 n) would impair cognition in young and older healthy adults.

43 with CMCs, and 71% (95% CI, -77% to -64%) in healthy adults.

44 tor adaptation are also context dependent in healthy adults.

45 only four areas had decreased FC compared to healthy adults.

46 uring an auditory oddball roving paradigm in healthy adults.

47 cted saliva, mucosal, and fecal samples from healthy adults (10 men and 11 women; mean age, 59 +/- 12

48 ults with MDD (14 women; 18-23 years) and 20 healthy adults (10 women; 19-30 years) participated.

49 d in the United States, we randomly assigned healthy adults 18 to 55 years of age and those 65 to 85

50 lTrials.gov identifier NCT04368728) among 45 healthy adults (18-55 years of age), who were randomized

51 se-escalation, open-label trial including 45 healthy adults, 18 to 55 years of age, who received two

52 on-randomized open-label phase I/II trial in healthy adults, 18-55 years of age.

53 Monocytes sorted from nonfrail healthy adults (21-40 y) and old (>/=65 y) individuals w

54 peripheral blood mononuclear cells from 172 healthy adults 22-93 years of age using ATAC-seq, RNA-se

55 objects in a population-derived sample of 85 healthy adults (24-87 years old) by relating measures of

56 42), transplant recipients 6.5% (8/124), and healthy adults 3.8% (3/78).

57 88 healthy adults (44.6 +/- 18.0 years old, 49% male), with

58 differences in RNFL thickness are present in healthy adults 50 years of age or older from different r

59 ith two 8-d laboratory protocols in 14 young healthy adults (6 females)-that circadian misalignment h

60 In healthy adults, a 2-dose (2 x 0.1 mL) single-visit ID PE

61 In healthy adults, adding 3 or 7 g ITF to snack bars increa

62 le-site study in 103 previously unvaccinated healthy adults age >=18 to <=60 years old to evaluate th

63 Between February 2018 and March 2018, 60 healthy adults (age 18-35 years) in Melbourne, Australia

64 Seventeen healthy adults (age 35-65 years) without sleep disorders

65 index (BMI) of 19-27 kg/m(2).(10-18) Twelve healthy adults (age: 26.3 +/- 3.4 years; BMI: 21.9 +/- 1

66 This phase 1 clinical trial was performed in healthy adults aged >=60 years.

67 qNIV (in 5 different doses/formulations) in healthy adults aged >=65 years.

68 A total of 400 healthy adults aged 18 through 60 years were enrolled af

69 mised, controlled, phase 2/3 trial (COV002), healthy adults aged 18 years and older were enrolled at

70 ble-blind, placebo-controlled phase 2 trial, healthy adults aged 18-31 years were randomly assigned (

71 Eligible participants were healthy adults aged 18-50 years with documented history

72 a30, was shown to be safe and immunogenic in healthy adults aged 18-50 years.

73 We enrolled healthy adults aged 18-50 years; exclusion criteria incl

74 ded phase 1/2 randomized controlled trial of healthy adults aged 18-55 years ( NCT04324606 ).

75 Healthy adults aged 18-55 years with no history of labor

76 h (NIH) Clinical Center (Bethesda, MD, USA), healthy adults aged 18-60 years were sequentially enroll

77 Healthy adults aged 21-50 y completed graded dosages of

78 Participants were 1,007 healthy adults aged 40 to 74 years eligible for an NHS H

79 ucted from July 2015 through March 2017, 855 healthy adults aged 65-85 years from 15 US centers were

80 had limited impact on cognitive function, in healthy adults aged approximately 70 years.

81 onse study we enrolled and randomly assigned healthy adults (aged 18-61 years) at eight study sites i

82 d 15-18 years [six boys, five girls]) and 10 healthy adults (aged 22-36 years [five men, five women])

83 Participants were eligible if they were healthy adults, aged 18-50 years with no history of seve

84 In the DIETFITS trial, 609 generally healthy adults, aged 18-50 years, with body mass indices

85 rt the outcomes of colonization screening in healthy adults (all were nonsmokers without major comorb

86 haplotype; (iii) a replication cohort of 32 healthy adults also stratified by LIMK1 haplotype; and (

87 hed cellular and humoral immune responses in healthy adults and asthmatic patients.

88 walking speed effects on gait variability in healthy adults and in adults with bilateral vestibulopat

89 312 datasets inclusive of healthy adults and patients were analysed.

90 HMPV can cause severe respiratory illness in healthy adults and should be considered as a potential c

91 e, neuromagnetic signals were recorded while healthy adults and typically developing 6- to 9-year-old

92 ation, and clinical response in a rat model, healthy adults, and children with relapsing CD.

93 These findings mirror those in healthy adults, and encourage replications using larger

94 can be identified in H7N9-infected patients, healthy adults, and newborn babies.

95 ized, cross-over nutritional intervention in healthy adults, and observed that MA and OA increased in

96 amygdala lesion patients, neuroimaging of 19 healthy adults, and single-neuron recordings in 9 neuros

97 The left and right hemi pelvis of healthy adults are symmetrical enough.

98 gested under standardized GI conditions of a healthy adult as a control.

99 to the presence of protective antibodies in healthy adults as a mechanism governing protection again

100 negative effect on the future performance of healthy adults as well as people with a neurodegenerativ

101 uenza virus infections cause mild illness in healthy adults, as timely viral clearance is mediated by

102 In conclusion, lower nephron number in healthy adults associates with characteristics reflectiv

103 set of the "normal" human microbiome of 242 healthy adults at 5 major body sites.

104 otal of 250 overweight [BMI (in kg/m2) >=27] healthy adults attended an individualized dietary educat

105 h sampled from the daily interactions of 143 healthy adults, both total language output and patterns

106 Overall, in healthy adult C57BL/6 mice we could not detect male/fema

107 Young healthy adults can hear tones up to at least 20 kHz.

108 For healthy adults, CD-TREAT was easier to comply with and m

109 In the healthy, adult CNS, Sonic hedgehog (Shh) signaling is ac

110 hy and functional linear modeling (FLM), for healthy, adult companion dogs.

111 We conducted a noninferiority trial in 500 healthy adults comparing the safety and immunogenicity o

112 Here, 41 healthy adults completed a challenging working memory ta

113 Twenty healthy adults consumed only vegetable/fruit juices for

114 unctionally and phenotypically compared with healthy adult control granulocytes.

115 young patients, 932 adult patients, and 932 healthy adult controls.

116 that in adult patients with melanoma and in healthy adult controls.

117 levels found in epithelial lining fluid from healthy adults, did not induce IL-1beta release from BAL

118 In healthy adults, dietary barley beta-glucans (Bbetaglucan

119 est that trait differences in discounting in healthy adults do not appear to be strongly associated w

120 used to describe normal sleep-wake cycles of healthy adult dogs and the effects of physiologic traits

121 d-JAK signalling as a metabolic regulator in healthy adult Drosophila muscle.

122 wSMI connectivity in hd-EEG recordings of 12 healthy adults during wakefulness and deep (N3-)sleep, c

123 iffening with advancing age is attenuated in healthy adults engaged in aerobic exercise training, and

124 Methods: Twenty-seven healthy adults enrolled in this study.

125 face receptor that is low or undetectable in healthy adult epithelium but upregulated in select injur

126 t 24 h, participants with MetS compared with healthy adults excreted 41% less alpha-CEHC (all values

127 Twenty-one healthy adults executed and observed two hand actions th

128 a double-blind, placebo-controlled study in healthy adults experimentally infected with RSV (Memphis

129 A sequencing on circulating neutrophils from healthy adult females and males.

130 blind placebo-controlled study, we recruited healthy adults (>=18 years with a body-mass index of 35

131 on The pooled mean of T2 relaxation times in healthy adults had marked heterogeneity across studies w

132 , these cells make up <40% of cells within a healthy adult heart.

133 Our findings suggest that in healthy adults, higher levels of trait anxiety may arise

134 the number of peripheral blood B cells in a healthy adult human is on the order of 5 x 10(9), the ci

135 nectivity (RSFC) analyses, with data from 33 healthy adult human participants, we demonstrate that (1

136 icrobiota and single immune cells across the healthy, adult human colon, with paired characterization

137 aphy to evaluate how cortical activity in 28 healthy adult humans (17 females) entrained to the audit

138 (SM1) cortex and the contraction force of 17 healthy adult humans (7 females, 10 males).

139 gen in a mixed meal (320 mmol N) consumed by healthy adult humans equipped with a triple-lumen sampli

140 Eleven healthy adult humans performed a joystick visuomotor ada

141 Recent studies demonstrate PGN in blood of healthy adult humans.

142 In healthy adults, ID administration of a double dose of 0.

143 and GCIRAB1, from pooled serum samples from healthy adults immunised with licensed rabies vaccine, w

144 Among healthy adults in a chikungunya endemic population, a vi

145 night of total sleep deprivation (TSD) in 39 healthy adults in a controlled in-laboratory protocol.

146 HB-101 was tested in cytomegalovirus-naive, healthy adults in a randomized, double-blind, placebo-co

147 choice, we administered 150 mg L-DOPA to 87 healthy adults in a randomized, placebo-controlled, doub

148 netic resonance imaging (fMRI) data from 783 healthy adults in the Human Connectome Project (HCP) dat

149 We recruited n = 1,002 twins and unrelated healthy adults in the United Kingdom to the PREDICT 1 st

150 ndomised, observer-blinded, phase 1 study in healthy adults in two centres in the USA.

151 Twenty healthy adults, in sequentially enrolled groups of 10 ea

152 noma diagnosed at age 35 years or older, and healthy adult individuals as controls.

153 el changes in the human immune system of 135 healthy adult individuals of different ages sampled long

154 ing high-density EEG recordings collected in healthy adult individuals, we show that REM sleep is cha

155 e left hemisphere in both callosotomized and healthy adult individuals.

156 sly that alpha-tocopherol bioavailability in healthy adults is higher than in those with MetS, thereb

157 Among healthy adult kidney donors, the single-nephron GFR was

158 re, and function of lymphatic vessels in the healthy adult kidney.

159 able structure-function relationship for the healthy adult lung that can potentially be exploited as

160 Healthy, adult malaria-naive volunteers were immunized w

161 maging (fMRI), and trait anxiety measures in healthy adult male and female humans.

162 DNL in overweight and/or obese but otherwise healthy adult male subjects.

163 Healthy adult male Wistar rats underwent irradiation wit

164 re generated from one thoracic CT image of a healthy adult male.

165 Six healthy adult males were randomized to receive either si

166 a range of pull forces over 160 trials in 12 healthy adults (mean +/- SD = 31 +/- 5.8 years).

167 retrieved, 42 studies were included with 954 healthy adults (mean age, 42.4 years +/- 10.5 [standard

168 placebo-controlled, between-subject design, healthy adult men (n = 121) were administered either T o

169 Healthy adult men and women with low habitual fish consu

170 the whole-body distribution of (52)Mn(2+) in healthy adult mice by dynamic and static PET imaging.

171 l transplant (HCT) recipients and Triplex in healthy adults motivated the initiation of a placebo-con

172 By transiently depleting microglia from the healthy adult mouse brain, we show that microglia are ne

173 attenuated neurotropism and were safe in the healthy adult mouse brain.

174 Healthy adults (N = 1197) were randomized 2:2:2:2:1 to r

175 Healthy adults (n = 11; 10 males/one female; 26 +/- 4 ye

176 A in humans after consumption of raw carrots.Healthy adults (n = 12) consumed a meal containing 300 g

177 Healthy adults (N = 123; 20-21/group) received one immun

178 In a laboratory, healthy adults (n = 160, aged 18-30 years) completed a 1

179 refrontal, parietal and temporal cortices of healthy adults (n = 19) during memory encoding and retri

180 g diffusion-weighted and structural MRI from healthy adults (n = 195).

181 n = 19) or P vivax (n = 21) parasitemia; and healthy adults (n = 23) without parasitemia.

182 d, randomized crossover experiments in which healthy adults (N = 23, 23) performed a reliable and val

183 Compared to healthy adults (n = 34, 28 female, 49.7 +/- 9.9 years ol

184 Normative data from healthy adults (n = 4,187) were obtained from the Joint

185 behavioral and electrocortical markers while healthy adults (n = 40) performed a continuous monitorin

186 Healthy adults (n = 64) participated in a randomized, do

187 , successive pneumococcal challenge, and the healthy adult nasal microbiota and mucosal immunity usin

188 Similarly, in 24 healthy adults, neurobehavioral vulnerability to SR expo

189 In 23 healthy adults, neurobehavioral vulnerability to TSD exp

190 n experimental infectious challenge model in healthy adults, norovirus infection elicited a time-limi

191 -in-human proof-of-concept clinical trial in healthy adults of a prophylactic mRNA-based vaccine enco

192 ctive and objective sleep was measured in 22 healthy adults on three nights (Nights 0-2) in a sleep l

193 f glucose, sucrose, or both with fructose in healthy adults or children with or without diabetes.

194 ared with predictive equations developed for healthy adults or predictive equations based on "static"

195 In healthy adult organs, robust feedback mechanisms control

196 In this preliminary study of 6 healthy adult participants and 11 hormone and nonhormone

197 ellular volume and native T1 measurements in healthy adult participants are summarized in this analys

198 entric distance of conspecific threats while healthy adult participants navigated virtual worlds duri

199 , 2017, we enrolled and randomly assigned 49 healthy adult participants to the adjuvanted vaccine (n=

200 Healthy adult participants were recruited and randomized

201 Twenty-three healthy adults performed two sessions of a navigation ta

202 On the basis of studies in healthy adults, physicians tend to assume that oral dose

203 FMRI analysis in healthy adult population suggested that: (i) Pearson's c

204 with cardiac dilatation and hypertrophy in a healthy adult population.

205 olerance to graded dosages of histidine in a healthy adult population.

206 and psychological well-being in nonclinical, healthy adult populations.

207 Apparently healthy adults presented with a median (range) MYDGF con

208 We analyse resting-state fMRI data from 98 healthy adults previously categorized as being among the

209 e administered broad-spectrum antibiotics to healthy adults prior and subsequent to seasonal influenz

210 rus, little is known about how antibodies in healthy adults protect them against reinfection.

211 s, considered alongside our previous work in healthy adults, provides novel support for the role gamm

212 = 2.5x10-7) in brain images from 1,738 young healthy adults, providing insight into the lifetime impa

213 Twenty-five healthy adults randomly received EEN or CD-TREAT for 7 d

214 cilitate non-noxious tactile activity in the healthy adult rat spinal dorsal horn via activation of s

215 In a comparative trial, 303 healthy adults received a primary vaccination that consi

216 Ten healthy adults received two-hour controlled-exposure-exp

217 9-2012) by computed tomography (CT) in 6,619 healthy adults, recruited at age 45-84 y without cardiov

218 Ebola vaccine regimens are well tolerated in healthy adults, regardless of interval or dose level.

219 (AD) affect brain function and cognition in healthy adult samples may help to identify the biomarker

220 In healthy adults, seasonal influenza virus infections resu

221 Application of this algorithm to the EEGs of healthy adults showed that fE/I is balanced at the popul

222 In healthy adult skeletal muscle fibers microtubules form a

223 emodeling and homeostasis are unclear in the healthy adult skeleton.

224 In 115 healthy adults, social, emotional, and behavioral factor

225 ping children; (ii) a discovery cohort of 99 healthy adults stratified by LIMK1 haplotype; (iii) a re

226 ts (NPs; two females), and in a sample of 24 healthy adult subjects (HSs; 13 females).

227 efficacious in a phase 2a challenge study in healthy adult subjects and that is currently being evalu

228 Skin swabs from atopic and healthy adult subjects were analyzed for the presence of

229 fferences in NP levels are evident in young, healthy adults suggesting a state of NP deficiency exist

230 Here, we show that even healthy adults systematically misattribute touch to othe

231 l to highlight the variability in drug PK in healthy adults, taking lamotrigine as a model drug.

232 Our randomized crossover design included 27 healthy adults that underwent three separate sessions of

233 involved in embryogenesis and homeostasis of healthy adult tissues, but also in human pathologies suc

234 Here we used PET imaging in 40 healthy adults to compare, within individuals, the estim

235 , dose-escalation trial was conducted in 230 healthy adults to evaluate 4 EBOV GP antigen doses as si

236 early pharmacological interventions in older healthy adults to improve broader cognitive functions by

237 eral populations and interventions, spanning healthy adults to patients with clinical deficits and co

238 We randomized 100 healthy adults to receive morphine versus placebo after

239 l connectivity (FC) at rest in stroke versus healthy adults to then explore whether CMR affects OP1/O

240 Here, we asked 100 healthy adults to vividly imagine themselves in a novel

241 Among healthy adults, treatment with vitamin D for 3 years at

242 In healthy adults, two-hour PM2.5 exposure substantially in

243 t speech) in an age-varying sample of n = 49 healthy adults undergoing resting-state and task fMRI.

244 Fifteen healthy adults underwent three repeat sessions of an ele

245 Healthy adults underwent whole-body 3DO and DXA scans, b

246 i were added to anticoagulated blood from 12 healthy adults vaccinated with meningococcal serogroup B

247 human typhoid infection model, we recruited healthy adult volunteers aged between 18 and 60 years, w

248 PfSPZ ('PfSPZ Challenge') to malaria-naive, healthy adult volunteers taking chloroquine for antimala

249 In a between-subjects design, healthy adult volunteers underwent threat (fear) conditi

250 iva, plaque and tongue samples from dentally-healthy adult volunteers using growth media that simulat

251 Sixty healthy adult volunteers were randomized to a single sta

252 Healthy adult volunteers were randomized to receive one

253 etween Aug 23, 2012, and April 18, 2013, 148 healthy adult volunteers were screened for the trial, of

254 imental influenza challenge of 52 previously-healthy adult volunteers with influenza A/Wisconsin/67/2

255 s are isolated from blood freshly drawn from healthy adult volunteers, exposed to gel containing embe

256 In healthy adult volunteers, the scanner can generate T1-we

257 1 year post-KD, 70 adult KD patients, and 86 healthy adult volunteers.

258 e 1, randomised, open-label trials involving healthy adult volunteers.

259 We vaccinated 50 healthy, adult volunteers with lifelong exposure to Pf 3

260 f saliva, mucosal, and fecal samples from 21 healthy adults, we found each individual, and each GI re

261 In a cohort of clinically healthy adults, we show that the angular information in

262 Even in healthy adults, weeks of cognitive training alone led to

263 assessment of the safety data, a further 150 healthy adults were enrolled and randomly assigned to 1

264 Fifty-two healthy adults were enrolled into challenge studies in a

265 - 5 years) and ten older (O: 69 +/- 3 years) healthy adults were passively heated until core temperat

266 cebo-controlled experimental medicine study, healthy adults were randomized to an FAAH inhibitor (PF-

267 Thirty healthy adults were randomized to receive 600, 4,000 or

268 placebo-controlled interventional trial, 20 healthy adults were randomized to receive either placebo

269 In all three studies, healthy adults were randomly assigned by a computer-gene

270 Healthy adults were recruited for swallowing neurophysio

271 nity-based sample of 181 cognitively intact, healthy adults were recruited from the Dallas-Fort Worth

272 Systemically healthy adults were recruited.

273 In this study, 51 healthy adults were vaccinated with seasonal influenza v

274 ain rye intake decreases plasma serotonin in healthy adults when compared with refined wheat.

275 n pre- and postsynaptic dopamine function in healthy adults, which may serve as a template from which

276 s, gut microbiota, and microbial products in healthy adults while maintaining subject body weights.Af

277 Here we assessed ToM abilities in 55 healthy adults while performing a naturalistic ToM task,

278 netic resonance imaging was performed on 107 healthy adults who completed a differential cued fear co

279 In another cohort of healthy adults who received BCG at birth, 53% of mycobac

280 We recruited 18-35-year-old healthy adults who were randomly assigned (1:1) in a dou

281 Nonrandomized crossover trial involving 6 healthy adults who were treated at an academic medical c

282 t comprised within-participants data from 31 healthy adults who, over four sessions, were administere

283 ess in well-characterized, younger and older healthy adults, who were pre-selected on the basis of ha

284 We challenged 30 healthy adults with an unattenuated ETEC strain, and col

285 in-type fructans (ITF), on gut microbiota in healthy adults with habitual low dietary fiber intake us

286 ntrolled, double-blind, crossover trials, 50 healthy adults with low dietary fiber intake were random

287 samples were collected from 31 systemically healthy adults with naturally occurring plaque-induced g

288 with low or medium risk of bias, 6 enrolled healthy adults with normal cognition and 5 enrolled adul

289 This trial in healthy adults with WHO category III exposure from suspe

290 emotional faces during functional MRI in 28 healthy adults, with final analyses based on 20 individu

291 ical evaluation of the Triplex vaccine in 24 healthy adults, with or without immunity to CMV and vacc

292 ion and gargling (HSNIG) vs standard care on healthy adults within 48 hours of URTI onset to assess r

293 e cognitive training and transfer effects in healthy adults without harmful effects.

294 In part 1, healthy adults without hepatitis B aged 18-65 years at o

295 ember 2017, including 311 community-dwelling healthy adults without osteoporosis, aged 55 to 70 years

296 utozygous human populations, we identified a healthy adult woman with lifelong complete knockout of H

297 e pregnancy cohort study included apparently healthy adult women (n = 179) from Rio de Janeiro, Brazi

298 controlled trial, we randomly assigned (1:1) healthy adult women with a history of recurrent urinary

299 mmunity, which were within normal ranges for healthy adult women.

300 S) can be found to colonize about 25% of all healthy, adult women and is the leading infectious cause