ライフサイエンスコーパス: heat-shock protein 27

1 h equivalent substitutions in the homologous heat shock protein 27.

2 protein kinase-2 and the phosphorylation of heat shock protein 27.

3 expression of a phosphorylation site mutant heat shock protein 27.

4 ), NADH-ubiquinone oxidoreductase (46+/-6%), heat shock protein 27 (18+/-3%), alphaB-crystallin (20+/

5 o be secreted (glutathione-S-transferase and heat shock protein 27/28 kDa).

6 ubstrate of p38), and the phosphorylation of heat shock protein 27 (a downstream substrate of MAP kin

7 K(4) and SCF also induced phosphorylation of heat shock protein 27, a known substrate of PKD1, which

8 Nine RCS rats were treated with adenovirus-heat shock protein 27 (Ad-HSP27) and examined for protec

9 ross-linking also induced phosphorylation of heat shock protein 27, an actin-binding protein that may

10 ssay, phosphorylated and acetylated forms of heat shock protein 27 and superoxide dismutase 2 were de

11 We saw a dramatic reduction in binding to heat shock proteins 27 and 40 following combined correct

12 Expression of heat shock proteins 27 and 70 was significantly increase

13 of c-Jun, Activating transcription factor 3, Heat shock protein 27, and Timp1 were observed.

14 actors 1alpha and 2, stress proteins such as heat shock protein 27, and vascular endothelial growth f

15 ge conferred by antiapoptotic protein Bcl-2, heat shock protein-27, and nuclear factor-kappaB; and bl

16 icated by semi-tryptic peptides derived from heat-shock-protein 27, and troponin T fast skeletal musc

17 annexin II/p36, stratifin/14-3-3 sigma, and heat shock protein 27, bind to the N-terminal domain of

18 synthase beta, protein disulfide isomerase, heat shock protein 27, cathepsin D, triose-phosphate iso

19 Heat shock protein-27 delays allograft rejection, by inh

20 (7 x 10(-10) M) and bound to both EcRE1 and heat shock protein 27 EcRE.

21 transcription factors known to transactivate heat shock protein 27 expression, these findings support

22 of p38 mitogen-activated protein kinase and heat shock protein 27, followed by a rapid down-regulati

23 lpha-crystallin domain of alphaA-crystallin, heat-shock protein 27 (HSP 27), and Mycobacterium tuberc

24 144 in the alpha-crystallin domain of human heat-shock protein 27 (HSP 27).

25 Heat shock protein 27 (HSP27) (or HSPB1) exerts cytoprot

26 in activated the MAPK p38, which resulted in heat shock protein 27 (Hsp27) activation, IL-6 release,

27 two siRNAs targeting tumor-promoting genes (heat shock protein 27 (Hsp27) and human epidermal growth

28 scriptome and functional analyses identified heat shock protein 27 (HSP27) and Mcl-1, two known regul

29 , MAPK-activated protein kinase-2 (MK2), and heat shock protein 27 (Hsp27) and MK2 phosphorylates Akt

30 Heat shock protein 27 (HSP27) and p38MAPK were identifie

31 -binding complex indicated that it contained heat shock protein 27 (Hsp27) and the regulator of mRNA

32 In the present study, we identified heat shock protein 27 (HSP27) as a suppressor of poly(Q)

33 study was to evaluate the potential of serum heat shock protein 27 (HSP27) as a therapeutic target in

34 ein array, we detected phospho-activation of heat shock protein 27 (Hsp27) as the most up-regulated e

35 Here we show that the small heat shock protein 27 (Hsp27) associates with caspase-3

36 or cells not only express elevated levels of heat shock protein 27 (Hsp27) at the intracellular level

37 Activated PRAK in turn phosphorylated small heat shock protein 27 (HSP27) at the physiologically rel

38 ing a proteomic approach, we identified that heat shock protein 27 (Hsp27) binds to a motif in estrog

39 uantified alphasynuclein, tau, ubiquitin and Heat Shock Protein 27 (HSP27) containing neurons in the

40 The small heat shock protein 27 (hsp27) increases in expression wi

41 Heat shock protein 27 (Hsp27) is a chaperone protein, an

42 Heat shock protein 27 (Hsp27) is a regeneration-associat

43 Heat shock protein 27 (Hsp27) is a ubiquitously expresse

44 Mammalian heat shock protein 27 (hsp27) is believed to function un

45 we describe how the expression of the small heat shock protein 27 (HSP27) is correlated with neurona

46 Heat shock protein 27 (Hsp27) negatively regulates anoth

47 p38 mitogen-activated protein kinase (MAPK)-heat shock protein 27 (HSP27) pathway has been shown by

48 Here we show that heat shock protein 27 (Hsp27) preferentially binds patho

49 Here we demonstrate that heat shock protein 27 (Hsp27) prevents oxidative stress-

50 and activator of transcription-1 (STAT1) and heat shock protein 27 (HSP27) than the A387 variant.

51 events revealed phosphorylation of the small heat shock protein 27 (HSP27) that was abolished by incu

52 ent studies showed that serine 82 residue in heat shock protein 27 (Hsp27) undergoes substrate phosph

53 Specifically, SFN-induced expression of heat shock protein 27 (Hsp27) underlies SFN-stimulated p

54 5 wherein a 14 amino acid peptide from human heat shock protein 27 (Hsp27) was inserted at the juncti

55 differentially expressed genes revealed that heat shock protein 27 (HSP27) was significantly up-regul

56 show for the first time that phosphorylated Heat shock protein 27 (Hsp27), a key regulator of actin

57 Heat shock protein 27 (Hsp27), a recently discovered mem

58 Phosphorylation of heat shock protein 27 (HSP27), a substrate for MAPKAPK-2

59 K2 is a prominent kinase that phosphorylates heat shock protein 27 (Hsp27), an intensively investigat

60 the probe were identified to be tubulin and heat shock protein 27 (Hsp27), and the compound inhibite

61 ed ischemia, excitotoxicity, and antibody to heat shock protein 27 (hsp27), and to assess whether the

62 ins, myeloid leukemia sequence 1 (Mcl-1) and heat shock protein 27 (HSP27), to block the two proteoly

63 ated the ability of one of these chaperones, heat shock protein 27 (Hsp27), to modulate tau dynamics.

64 pectrometry phosphoproteomics, we identified heat shock protein 27 (HSP27), which exists as a large o

65 ded on p38 MAPK activity and the presence of heat shock protein 27 (HSP27), which is phosphorylated d

66 n early dissemination is mediated by MK2 and heat shock protein 27 (Hsp27).

67 lar signal-regulated kinase-1/2 (ERK1/2) and heat shock protein 27 (HSP27).

68 l IRI by upregulation and phosphorylation of heat shock protein 27 (HSP27).

69 f this pathway is the actin-binding protein, heat shock protein 27 (Hsp27).

70 phosphorylation of its downstream substrate, heat shock protein 27 (Hsp27).

71 gase Cbl-c and the ubiquitin-binding protein heat shock protein 27 (HSP27).

72 and expression of the downstream MK2 target, heat shock protein 27 (HSP27); and markers of epithelial

73 e effects of antiapoptotic proteins Bcl2 and heat shock protein-27 (Hsp27) as well as nuclear factor-

74 Microarray analysis shows high RNA levels of heat shock protein-27 (Hsp27) in DHL4 versus DHL6 cells,

75 -activated protein kinase-2 (MAPKAPK-2), and heat shock protein-27 (Hsp27); and Hsp27 dissociates fro

76 Previous studies have proposed that heat shock proteins 27 (HSP27) and its anti-HSP27 antibo

77 Here we demonstrate that heat-shock protein 27 (Hsp27) inhibits cytochrome c (cyt

78 n of p38 MAPKalpha and its downstream target heat-shock protein 27 (Hsp27) involved in cytoskeletal r

79 Heat-shock protein 27 (Hsp27) is a member of the small H

80 urthermore, we found that phosphorylation of heat-shock protein 27 (HSP27) was necessary for ouabain

81 nown substrate of p38 MAP kinase, as well as heat-shock protein 27 (HSP27), a known substrate of MAPK

82 In cell culture systems, heat-shock protein 27 (Hsp27), a small molecular chapero

83 ncreased the phosphorylation of p38 MAPK and heat shock protein 27 in melanoma cells but not in norma

84 the phosphorylation of MAPKs, caldesmon, and heat shock protein 27 in the spastic cerebral arteries a

85 Levels of heat shock protein 27 increased 2-fold with IL-4, 3-fold

86 0S acidic ribosomal protein P2, and a second heat shock protein 27 isoform.

87 horylation of one of these sites, S82 of the heat shock protein 27 kDa (HSP27), was especially abunda

88 n kinase 2 (MK2)-mediated phosphorylation of heat-shock protein 27 kDa (HSP27) promotes actin filamen

89 duced proteins were identified: tropomyosin, heat shock protein 27, manganese superoxide dismutase, g

90 ed by a transient increase of phosphorylated heat shock protein 27, p38 mitogen-activated protein kin

91 The time course of heat shock protein 27 phosphorylation paralleled that of

92 activity was accompanied by up-regulation of heat shock protein 27 phosphorylation.

93 ncreased its transcriptional activity on the heat shock protein 27 promoter, indicating a negative ef

94 can be achieved in mice by overexpression of heat shock protein 27, providing hope for enhanced funct

95 A p38/MAPK-activated protein kinase/heat shock protein 27 signaling signature was unveiled a

96 hosphorylation of pRb and phosphorylation of heat shock protein 27, suggesting that p38 activation is

97 of oxidative stress and DNA damage including heat shock protein-27, super oxide dismutase catalase, a

98 ible nitric oxide synthase (iNOS) as well as heat-shock protein 27 synthesis, and the renal protectiv

99 tioning, inducible nitric oxide synthase and heat shock protein 27, were found to be markedly induced

100 K) resulted in the phosphorylation of HSP27 (heat shock protein 27), which may modulate F-actin polym

101 The small heat shock protein 27, which interacts with Rpp20 in the