ライフサイエンスコーパス: heavy chain

1 cMLCK), located at the neck region of myosin heavy chain.

2 CAV-1) and dynamin-2 (DNM2) but not clathrin heavy chain.

3 d and somatically mutated residues on the Ab heavy chain.

4 ctin and its C-terminal lobe with the myosin heavy chain.

5 performing immunostaining of neonatal myosin heavy chain.

6 d His231 in the hinge region of the IgG1 mAb heavy chain.

7 potential paratope at the N-terminus of the heavy chain.

8 ing muscle biopsies for developmental myosin heavy chain.

9 e was resolved using the mass signature of a heavy chain.

10 w and troponin T and carbonylation of myosin heavy chains.

11 efficient heterodimerization of the antibody heavy chains.

12 ences onto suitable human variable light and heavy chains.

13 les, and antibodies with mispaired light and heavy chains.

14 , which express a slow fiber-specific myosin heavy chain 1 (Smyhc1), are the first group of muscle fi

15 zeta/delta, annexin A1/A3/A4/A5/A6, clathrin heavy chain 1, glyceraldehyde-3-phosphate dehydrogenase,

16 ation status of the pivotal VSMC gene myosin heavy chain 11 (Myh11).

17 rs such as alpha smooth muscle actin, myosin heavy chain 11, and smooth muscle 22 alpha.

18 t citations are as follows: MHC class I free heavy chain(22); HLA-B5802(34); I-E(k) (ref.

19 The germline immunoglobulin (Ig) variable heavy chain 4-34 (VH4-34) gene segment encodes in humans

20 56 and rs1354187) within the dynein axonemal heavy chain 5 (DNAH5) gene (Pmeta-int = 3.6 x 10(-5) and

21 rum levels of ANP fell sharply in PAM myosin heavy chain 6 conditional knockout mice, and RNA sequenc

22 domains under the control of the Myh (myosin heavy chain) 6 promoter was generated.

23 In parallel, mRNA expression of myosin heavy chain 7 and natriuretic peptide B is up-regulated

24 Elevated myosin heavy chain 7 mRNA expression is detected in left ventri

25 riants in the MYH7-encoded MYH7 (beta myosin heavy chain 7) represent a leading cause of hypertrophic

26 vel correlates with that of embryonic myosin heavy chain, a regeneration marker.

27 omodimer theory, which proposes that HLA-B27 heavy chains aberrantly form homodimers, is a central hy

28 They showed that myosin heavy chain alpha (MYHCA) is a dominant cardiac autoanti

29 II-restricted epitopes, we found that myosin heavy chain alpha (MYHCA) was a dominant cardiac antigen

30 ns expressing the structural proteins myosin heavy chain alpha and myosin light chain 2a in real-time

31 by thrombin, yielding an N terminus-derived heavy chain and a C terminus-derived light chain.

32 ed heart-to-body weight ratios, alpha myosin heavy chain and cardiac isoprostane levels, suggesting t

33 We characterized the heavy chain and kappa light chain antibody repertoires o

34 nteraction for hRSV90 on RSV F, in which the heavy chain and light chain both have specific interacti

35 e of two interacting proteins, including the heavy chain and light chain of an antibody Fab.

36 3 sequence coverage enabled determination of heavy chain and light chain pairing from a single experi

37 y (mAb) therapeutics is the determination of heavy chain and light chain pairing.

38 MYH7 and MYBPC3, encoding beta-myosin heavy chain and myosin-binding protein C, respectively,

39 rks and did not show up-regulation of myosin heavy chain and myotube formation when grown in differen

40 o, SOD1 myotubes had loosely arranged myosin heavy chain and reduced acetylcholine receptor expressio

41 represented by the expression of the myosin heavy chain and the oxidative markers PGC1-alpha and COX

42 ion generates a covalent complex between the heavy chains and hyaluronan that can promote leukocyte i

43 mains requires heterodimerization of the two heavy chains and pairing of each heavy chain with its co

44 c cardiomyopathy (HCM) are MYH7 (beta-myosin heavy chain) and MYBPC3 (beta-myosin-binding protein C).

45 ntraction-related genes, such as MYH (myosin heavy chain) and troponin I, consistent with its depress

46 d function among wild type, Dnchc2 (dynein 2 heavy chain), and Wdr34 mutant cells demonstrates that c

47 the upper 50 kDa sub-domain of the myosin II heavy chain, and cells carrying this lethal mutation are

48 ed myogenic markers such as Myogenin, myosin heavy chains, and myogenic differentiation 1 (MyoD).

49 eavy domains derived from the unconventional heavy chain antibodies found in camelids, provide stable

50 The two identical copies of the dynein-2 heavy chain are contorted into different conformations b

51 In contrast, NMII heavy chains are mostly positioned along the longitudina

52 We previously reported efficient heavy-chain assembly of heterodimeric bispecific antibod

53 e clathrin lattice, namely, between adjacent heavy chains, at the light chain-heavy chain interface a

54 vels of different immunoglobulins (light and heavy chains) based on Ig alpha, Ig lambda, Ig kappa, Ig

55 homologous protein (chop) and immunoglobulin heavy chain binding protein (bip) levels.

56 rotein homologous protein and immunoglobulin heavy chain binding protein UPR-response genes.

57 light chain-binding domain nor the clathrin heavy chain-binding motif were needed for virus infectio

58 t, the Caenorhabditis elegans immunoglobulin heavy chain-binding protein (BiP) homologue Heat-Shock P

59 entarity-determining regions (CDRs) from the heavy chain but no drug conjugation near CDRs of light c

60 rms a disulfide-linked heterodimer with CD98 heavy chain (CD98hc, 4F2hc or SLC3A2), but the mechanism

61 all tryptophan residues including one in the heavy chain CDR1 and a tryptophan in close proximity to

62 er oxidation susceptibility of tryptophan in heavy chain CDR3 did not linearly correlate to higher so

63 or surrounding structure elements around the heavy chain CDR3 may also be involved.

64 solvent accessibility is a prerequisite for heavy chain CDR3 tryptophan oxidation.

65 CDR1 and a tryptophan in close proximity to heavy chain CDR3 were not susceptible to oxidation.

66 omprised of designed heavy and light or just heavy chain CDRs were synthesized and screened for pepti

67 athrin adaptor interaction sites on clathrin heavy chain (CHC) are repurposed during mitosis to direc

68 s (PreB cells) is dictated by immunoglobulin heavy chain checkpoint (IgHCC), where the IgHC encoded b

69 We examined clathrin heavy chain (ClaH-GFP) which localized to three distinct

70 Immunoglobulin heavy chain class switch recombination (CSR) requires ta

71 otypes, including between 1 and 6% of B cell heavy-chain clonotypes shared between two subjects (0.3%

72 iously shown that mESCs lacking the clathrin heavy chain (Cltc), an essential component for clathrin-

73 ncer hub that regulates the essential myosin heavy chain cluster during skeletal muscle cell differen

74 myosin light chain 2 (MLC2), and myosin IIA heavy chain coimmunoprecipitated from EC lysates with en

75 ting of substitutions L351D and L368E in one heavy chain combined with L351K and T366K in the other.

76 ion (PTM), namely O-sulfated tyrosine in the heavy chain complementarity determining region (CDR) H3

77 to be a conserved tryptophan residue in the heavy chain complementarity determining region 3 (CDR3)

78 additions and a greater frequency of unique heavy chain complementarity determining region 3 sequenc

79 ) differing by only three amino acids in the heavy chain complementarity determining regions (CDRs),

80 the formation of numerous interactions with heavy chain complementarity domain regions (CDRs) of HM1

81 The lineage Abs bore an anionic heavy chain complementarity-determining region 3 (CDRH3)

82 most bnAbs, a strong dependence on antibody heavy chain complementarity-determining region 3 (HCDR3)

83 by germline encoded and immunoglobulin (Ig) heavy-chain complementarity determining region 3 (HCDR3)

84 Eight Ab heavy-chain complementarity determining region 3 (HCDR3)

85 igh somatic mutation frequencies, long third heavy-chain complementarity determining regions, and/or

86 ain (hROR2-Kr) guided affinity maturation by heavy-chain complementarity-determining region 3 (HCDR3)

87 o HIV often have unusual sequences with long heavy-chain complementarity-determining region loops, hi

88 ibody repertoire of cows contains long third heavy chain complementary determining regions (HCDR3) wi

89 tion of both chimeric and full-length native heavy chain-containing Abs provided structural insights

90 overage of 100% for light chains and 85% for heavy chains, demonstrating the practical utility of mic

91 The most abundant Ig heavy chains detected in both control individuals and KC

92 A mutation in the cytoplasmic dynein heavy chain (DHC) gene was discovered to cause an autoso

93 Neurofilament light chain and phosphorylated heavy chain), DNA oxidation (8-oxo-2'-desoxyguanosine),

94 osure; p=1.1x10-06), was annotated to Dynein Heavy Chain Domain 1 gene (DNHD1) which is highly expres

95 arental antibodies, each containing a single heavy chain domain mutation, are mixed and subjected to

96 Myosin heavy chain-embryonic (MyHC-emb) is a skeletal muscle-sp

97 We then tested a full-length native Ab heavy chain encoding the same 17-residue-long HCDR3 loop

98 Tuning heavy chain expression of an IgG with the RgEs to variou

99 Fiber type (myosin heavy chain expression) and 2DG accumulation were measur

100 on was confirmed by uniform NCAM1 and myosin heavy chain expression.

101 The contact surfaces between the heavy-chain ferritin and CD71 largely overlap with arena

102 s a novel biomarker along with smooth myosin heavy chain for the pacemaker cells (previously termed '

103 al development of recombinant tetanus toxoid heavy chain fragment (rTTHC) linked to FP8 (FP8-rTTHC) a

104 y engraft a new paratope, i.e., the extended heavy-chain framework region 3 (FR3) loop of VRC03, whic

105 ocyte function, we have deleted the ferritin heavy chain (Fth) specifically in the oligodendrocyte li

106 ent metal transporter 1 (DMT1), the ferritin heavy chain (Fth), and the transferrin receptor 1 (Tfr1)

107 Mutations in the beta-cardiac myosin heavy chain gene (beta-MyHC) are a major cause of HCM, b

108 Nonmuscle myosin IIA (NMIIA) heavy chain gene (MYH9) mutations cause macrothrombocyto

109 We show that myo-sex, a myosin heavy-chain gene also in the M-locus, was required for m

110 kinetics bat and songbird SFM express myosin heavy chain genes that are evolutionarily and ontologica

111 nd in patients with unmutated immunoglobulin heavy-chain genes.

112 Methods: Since the heavy chain glycans influence the affinity of FcgammaR f

113 pment of novel antibody-based therapies, and heavy chain (Hc) heterodimers represent a major class of

114 We traced all lineages in high-throughput heavy chain (HC) repertoire (Rep-seq) data generated fro

115 nked glycosylation sites: one present on the heavy chain (HC) variable region (Fab) and the other pre

116 ogy directed repair strategy, to replace the heavy chain (HC) variable region in B cell lines with th

117 n (LC) disulfide bond linked to a C-terminal heavy chain (HC) which includes a translocation domain (

118 c) without drug (Lc0), Lc with 1 drug (Lc1), heavy chain (Hc) without drug (Hc0), and Hc with 1-3 dru

119 light chain, an essential light chain, and a heavy chain (HC), were screened for inhibition of myosin

120 ype FXII is bound by an antibody to the FXII heavy chain (HC; 15H8).

121 s required to transfer inter-alpha-inhibitor heavy chains (HC) to hyaluronan (HA), facilitating HA re

122 teinase inhibitor bikunin and two homologous heavy chains (HC1 and HC2) covalently linked through cho

123 It comprises two homologous "heavy chains" (HC1 and HC2) covalently attached to chond

124 e-deposits of monoclonal light chain (LCDD), heavy chain (HCDD), or both (LHCDD).

125 hypothesis for this phenotype is that myosin heavy chain HCM mutations increase muscle contractility.

126 BCR with the combination of IGHV3-21-derived heavy chains (HCs) with IGLV3-21-derived light chains (L

127 Heavy chain-Hyaluronan/Pentraxin 3 (HC-HA/PTX3) is a com

128 Because heavy chain-hyaluronic acid/pentraxin 3 (HC-HA/PTX3) pur

129 pyogenes (IdeS), cleaves the hinge region of heavy-chain IgG, abolishing its ability to bind FcgammaR

130 list scaffold generated from camelid-derived heavy-chain IgGs, are one such example.

131 Bs) serve as obligatory intermediates for Ig heavy chain (Igh) class switch recombination (CSR).

132 or functions, B cells undergo Immunoglobulin Heavy Chain (IgH) class switch recombination (CSR).

133 f switch regions, located upstream of the Ig heavy chain (IgH) constant genes.

134 determining region 3 sequences of the B cell heavy chain (IgH) from The Cancer Genome Atlas.

135 ontraction of the 2.8-Mb-long immunoglobulin heavy chain (Igh) locus by Pax5(17,18).

136 susceptibility signal in the immunoglobulin heavy chain (IGH) locus centring on a haplotype of nonsy

137 We identify the immunoglobulin heavy chain (IGH) locus to be associated with anti-PEG I

138 of CTCF binding at the murine immunoglobulin heavy chain (IgH) locus, we utilized a computational app

139 rrangements at the endogenous immunoglobulin heavy chain (Igh) locus.

140 e germline variable sequences of both the Ig heavy-chain (IgH) and Ig kappa (IgK) loci with the human

141 MYH9 gene that encodes the nonmuscle myosin heavy chain IIA are associated with diabetic nephropathy

142 lipase, glutathione peroxidase-1, and myosin heavy chain IIa in quadriceps of control mice but not in

143 NA loop, are formed in switch regions on the heavy-chain immunoglobulin locus.

144 determining region 3 of each B cell receptor heavy chain in every patient repertoire as input to a de

145 the transferrin receptor 1, and the ferritin heavy chain in Schwann cell (SC) maturation and myelinat

146 nsgenic murine B cells expressing the iglb12 heavy chain in vivo, despite the presence of deletion an

147 equired for the stability of axonemal dynein heavy chains in cytoplasm and suggest that cytoplasmic/I

148 suggested a cooperative assembly process of heavy chains in heterodimers.

149 tural details of the interaction between two heavy chains in the Fc domain.

150 y one head bound to one of the two identical heavy-chains in the asymmetrically bent IgE-Fc.

151 fied a role for DHC-1, the C. elegans dynein heavy chain, in maintaining neuronal cargo distribution.

152 characteristics are likely facilitated by a heavy-chain insertion and increased inter-protomer conta

153 en adjacent heavy chains, at the light chain-heavy chain interface and within the trimerization domai

154 One heavy chain is steered into a zig-zag conformation, whic

155 as shown by the expression profile of myosin heavy chain isoforms, as well as the upregulation of gen

156 utated and appeared relatively stable as per heavy chain isotype, somatic hypermutations, and clonal

157 -10, chemokine receptors, and immunoglobulin heavy-chain isotypes, was measured.

158 t-1, CHI3L1 and phosphorylated neurofilament heavy chain levels in longitudinal CSF and matching plas

159 t difference in Ig kappa/Ig lambda ratios or heavy chain levels.

160 SR) in B lymphocytes replaces immunoglobulin heavy chain locus (Igh) Cmu constant region exons (C(H)s

161 strand DNA mutagenesis at the immunoglobulin heavy chain locus and some other regions of the B cell g

162 Quantitative deep sequencing of the Ig heavy chain locus from B220(+)CD43(+) populations identi

163 HLA-DQB1 region, but also the immunoglobulin heavy chain locus, including the IGHV4-61 gene segment,

164 ssed a Pax5 minigene from the immunoglobulin heavy-chain locus.

165 odification (+162.1 Da), partially processed heavy chain lysine residues (+128.1 Da), and loss of N-a

166 Locus B of immunoglobulin heavy chain mapped to an area containing multiple SNPs w

167 For the analyzed heavy chain marker peptides deuterium uptake differences

168 onstitutes the transport subunit whereas the heavy chain mediates trafficking to the plasma membrane

169 n adult mice using an alphaMHC (alpha-myosin heavy chain)-MerCreMer system.

170 new transgenic mouse, alphaMHC (alpha myosin heavy chain)-MerDreMer-Ki67p-RoxedCre (denoted alphaDKRC

171 ng velocities, and/or a difference in myosin heavy chain (MHC) isoform content in chimpanzee relative

172 e outstanding question is whether the myosin heavy chain (MHC) isoforms alone account for these disti

173 Myosin heavy chain (MHC) isoforms in goat muscles and their pos

174 To investigate myosin heavy chain (MHC) phosphorylation roles in 3D migration,

175 samples made without salt (Lot A), no myosin heavy chain (MHC) polymerization was observed, only aggr

176 sis that inhibit transcription of the myosin heavy chain (MHC) protein family.

177 system for recombinant expression of myosin heavy chain (MHC) proteins in whole transgenic flies, we

178 ensions and caused a shift from alpha-myosin heavy chain (MHC) to beta-MHC gene expression.

179 Gel electrophoresis showed loss in myosin heavy chain (MHC), and a resulting increase in cross-lin

180 associated with an increased ratio of myosin heavy chain (MHC)-beta to MHC-alpha and upregulated card

181 metric complex of 2 identical membrane-bound heavy chains (mHC) and 2 identical light chains.

182 vents the interaction of RLC with the myosin heavy chain (MHCII) to form functional NMII units.

183 generate BsAbs without heavy/heavy and light/heavy chain mispairing.

184 ulk expression of secretory immunoglobulin M heavy chain (mu(s)) thanks to the unfolded protein respo

185 although they do not express cell surface mu-heavy chain (muHC).

186 karyotype, or immunoglobulin variable region heavy chain mutation status).

187 utralizing VRC34.01 branch required the rare heavy-chain mutation Y33P to bind FP, whereas the early

188 logically related biomarkers, immunoglobulin heavy chain mutational status, and ZAP70 expression, as

189 ol in Longissimus dorsi muscle, where myosin heavy chain (MYH) was significantly up-regulated.

190 x and myotube diameter; likewise, the myosin heavy chain (MyHC)-IIB isoform (encoded by Myh4) is an i

191 Proteins, among which heavy chain myosin, underwent denaturation and aggregati

192 evel profiling of proteoforms with regard to heavy chain N-glycosylation.

193 amic of neurons expressing nonphosphorylated heavy-chain neurofilaments (labeled by SMI-32 antibody)

194 Accumulation of the heavy-chain neurofilaments reflects the maturation statu

195 ecific knockout (KO) mice using alpha-Myosin Heavy Chain-nuclear Cre (ZO-1cKO) and investigated physi

196 Involvement of IgG was studied using IgG mu heavy chain-null mice deficient in mature B cells and by

197 DYNC1H1 encodes the heavy chain of cytoplasmic dynein-1, a 1.4-MDa motor com

198 ed by persistent expression of the secretory heavy chain of immunoglobulin M (micros), is well-tolera

199 S100A4 binds to the heavy chain of non-muscle (NM) myosin II and can regulat

200 osome pull-down screen identifies KIF5B, the heavy chain of the motor protein kinesin-1, as a new PA-

201 n mim6 was appended to the C terminus of the heavy chains of bNAbs, this sulfopeptide improved the po

202 ectively cover the sequence of the light and heavy chains of mAbs at increased sensitivity.

203 eoside-modified mRNAs encoding the light and heavy chains of the broadly neutralizing anti-HIV-1 anti

204 rbors four glycans per molecule, two on each heavy chain, of which the Fab glycans have been reported

205 stimulates phosphorylation of the NM myosin heavy chain on Ser1943 and causes NM myosin filament ass

206 stimulated the phosphorylation of NM myosin heavy chain on Ser1943 in tracheal SM tissues, which can

207 applications, nanobodies (VHH) derived from heavy chain only antibodies from Camelidae, may be bette

208 Ly-6G-specific variable fragments of camelid heavy chain-only antibodies (VHH) conjugated to Pseudomo

209 Heavy chain-only antibodies, discovered in camelids, hav

210 omain antigen binding fragments from camelid heavy chain-only antibodies.

211 Our results indicate that heavy-chain-only anti-BCMA CARs are suitable for evaluat

212 duction, the recombinant variable domains of heavy-chain-only antibodies (VHHs) are becoming a salien

213 oNT/A1 termed ciA-C2, derived from a camelid heavy-chain-only antibody (VHH).

214 ploys fusion of the enzyme to either the IgG heavy chain or light chain using a long flexible linker.

215 ractions mediating binding to site VIII, the heavy chain overlaps with site O, and the light chain in

216 ow that PfMyoA motor properties are tuned by heavy chain phosphorylation (Ser19), with unphosphorylat

217 In HeLa and NIH 3T3 cells, heavy chain phosphorylation of NMIIB by PKCzeta, as well

218 CHI3L1, CHI3L2, phosphorylated neurofilament heavy chain (pNFH) and C-reactive protein were measured

219 that levels of phosphorylated neurofilament heavy chain (pNFH) in cerebrospinal fluid (CSF) predict

220 Phosphorylated neurofilament heavy chain (pNfH) levels are elevated in cerebrospinal

221 ress the effect of absence of NaCl on myosin heavy chain polymerization during two-step surimi gelati

222 sed PC differentiation and no immunoglobulin heavy chain production.

223 ocytes under the control of the alpha-myosin heavy chain promoter.

224 n by the cardiomyocyte-specific alpha-myosin heavy chain promoter.

225 ion of JunD via the alpha MHC (alpha- myosin heavy chain) promoter (alpha MHC JunD(tg)) were protecte

226 TSG-6 and heavy-chain protein-hyaluronan are constitutively expres

227 lpha-trypsin inhibitor to hyaluronan to form heavy-chain protein-hyaluronan complexes.

228 nctions, including the enzymatic transfer of heavy-chain proteins from inter-alpha-trypsin inhibitor

229 ictions were not found in the immunoglobulin heavy chain repertoire.

230 Diversity estimates of the OmniRat heavy chain repertoires almost reached that of humans, a

231 We sequenced antibody heavy-chain repertoires in a large cohort of HIV-infecte

232 g emphasizes the importance of the Pg latent heavy chain (residues 1-561) in PAM binding and shows th

233 mino acid mutations in the CDR region of the heavy chain resulted in significantly different labeling

234 ducible short hairpin RNA targeting clathrin heavy chain, resulting in approximately 85% protein loss

235 the beta-cardiac/slow skeletal muscle myosin heavy chain rod.

236 d we found changes in the loop region of the heavy chain's constant domain; this corresponds well wit

237 sts of residues Pro238 to Lys340 of the IgG1 heavy chain sequence.

238 smablast/plasma cells with highly similar Ig heavy-chain sequences across MS subjects, similarities w

239 o date, comprising almost 3 billion antibody heavy-chain sequences.

240 myosin RLC phosphorylation and by NM myosin heavy chain Ser1943 phosphorylation.

241 w demonstrate that co-expressing an anti-RAS heavy chain single VH domain, that binds to mutant RAS s

242 in the PKJ co-expressed smooth muscle myosin heavy chain (smMHC) and several other smooth muscle gene

243 l pelvis do not express smooth muscle myosin heavy chain (smMHC) but are in close apposition to nerve

244 (ASM) against a loss of smooth muscle myosin heavy chain (SMMHC) expression.

245 raction between CBFbeta-smooth muscle myosin heavy chain (SMMHC; encoded by CBFB-MYH11) and RUNX1 pla

246 end-diastolic flow contained reduced myosin heavy chain, smooth muscle actin, and desmin, and increa

247 eight correlated positively with CSE, myosin heavy chain, smooth muscle actin, and desmin, and negati

248 CSE correlated positively with myosin heavy chain, smooth muscle actin, and desmin.

249 HC796-835 comprising residues 796-835 of the heavy chain strongly inhibited myosin-enhanced prothromb

250 ned by expression of distinct immunoglobulin heavy chain subclasses.

251 ain subunit from an SLC7 family member and a heavy chain subunit from the SLC3 family.

252 AT units is mediated via dimerization of the heavy chain subunits and does not include participation

253 Ig alpha, Ig lambda, Ig kappa, Ig u, and Ig heavy chain subunits in non-KC tears (n = 7 control indi

254 eracts with the neuronal (non-muscle) myosin heavy chain subunits, motors of nucleokinesis during neu

255 eased alpha myosin and increased beta myosin heavy chains, suggesting an alpha-to-beta conversion wit

256 we found that the same domain of the kinesin heavy chain tail is involved in keratin and vimentin IF

257 tures reveal two IgAs conjoined through four heavy-chain tailpieces and the JC that together form a b

258 We showed that the axonemal inner-arm dynein heavy chain TbIAD5-1 and TbCentrin3 form a complex, loca

259 n have canonical CDR3s in the immunoglobulin heavy chain that, owing to junctional biases during V(D)

260 , but residues in the N-terminal part of the heavy chain, the gamma-loop, and anion-binding exosite 1

261 When bound to HA, the heavy-chain third complementarity determining region (HC

262 art failure via targeting the cardiac myosin heavy chain to increase myocardial contractility.

263 ted apoptosis-inducing ligand receptor 2, as heavy chains to form antibody dimers and Fab heavy chain

264 heavy chains to form antibody dimers and Fab heavy chains to form Fab tetramers.

265 h TSG-6, is able to catalyze the transfer of heavy chains to hyaluronan.

266 merization, which covalently linked antibody heavy chains together.

267 a phylogenetic distance metric to analyze Ig heavy-chain transcript sequences in both young and elder

268 lasm and suggest that cytoplasmic/IFT dynein heavy chains use a distinct folding pathway.

269 l user-defined human immunoglobulin variable heavy-chain (V(H)) genes, including IGHV1-69, which show

270 be a novel primer set, covering the full rat heavy chain variable and kappa light chain variable regi

271 ody trastuzumab, which are fused through the heavy chain variable domain to either cutinase or SnapTa

272 ultivariate modeling revealed immunoglobulin heavy chain variable gene (IGHV) mutation status and tri

273 Combining heavy chain variable gene repertoire sequencing and sing

274 sorted B cells, and nasal biopsy samples for heavy chain variable gene repertoire sequencing.

275 p sequencing, we analyzed the immunoglobulin heavy chain variable region repertoire in both graft and

276 neDB, a system for analyzing vast amounts of heavy chain variable region sequences and exploring the

277 mutational status of the immunoglobulin (Ig) heavy-chain variable (IGHV) gene.

278 ignated FHVH33-CD8BBZ contains a fully human heavy-chain variable domain (FHVH) plus 4-1BB and CD3zet

279 ltiple individuals, including one encoded by heavy-chain variable domain V(H)6-1.

280 ion domains consisting of only a fully human heavy-chain variable domain without a light-chain domain

281 alysing BCR clonality, use of immunoglobulin heavy-chain variable region (IGHV) genes and-in particul

282 is involving patients without immunoglobulin heavy-chain variable region (IGHV) mutation, ibrutinib-r

283 2 antibodies and found that immunoglobulin G heavy-chain variable region 3-53 (IGHV3-53) is the most

284 the mutational status of the immunoglobulin heavy-chain variable region are important in clinical ma

285 Ig heavy-chain variable region exons are assembled developm

286 high-throughput sequencing of immunoglobulin heavy chain VDJ rearrangements of naive, mature CD5(+),

287 Variable heavy chain (VH) family frameworks (FWRs) have been repo

288 ared the effect of a seed-expressed nanobody-heavy chain (VHH-Fc) antibody against the highly abundan

289 Nanobody-heavy chain (VHH-Fc) antibody formats have the potential

290 coli (eNISTmAb), a truncated variant of its heavy chain was observed.

291 outer arm heavy chains, while the IFT dynein heavy chain was present in normal amounts.

292 s sequence identity with beta-cardiac myosin-heavy chain, was used because of its stability in vitro.

293 The monoclonal immunoglobulin heavy chains were also classified into specific germline

294 ld lower the denaturation of crayfish myosin heavy chain when compared to the control.

295 ICH3 interacting proteins including clathrin heavy chain which are known to play a role in vesicular

296 lated the binding of S100A4 to the NM myosin heavy chain, which was catalysed by RhoA GTPase via the

297 almost completely lacked all three outer arm heavy chains, while the IFT dynein heavy chain was prese

298 of the two heavy chains and pairing of each heavy chain with its cognate light chain.

299 he VRC26UCA and poor pairing of the VRC26UCA heavy chain with the mouse surrogate light chain may con

300 e fragment crystallizable (Fc) region of the heavy chain, with a net mass increase of 14 Da.