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1 and synergistically in the presence of Sonic Hedgehog protein.
2 oss membrane protein that binds the secreted Hedgehog protein.
3 ence documenting the in vivo source of Sonic hedgehog protein.
4  beta-turn from the autoprocessing domain of Hedgehog protein.
5 atched gene required for release of secreted Hedgehog protein.
6 nts treated directly with active recombinant hedgehog protein.
7 e signaling from posteriorly localized Sonic hedgehog protein.
8  direct application of the recombinant Sonic hedgehog protein.
9 rrow stripes of cells abutting the source of Hedgehog protein.
10 s for a functionally important domain of the hedgehog protein.
11  the signaling mechanisms of the Wnt and the Hedgehog proteins.
12 ting protein) because of its ability to bind Hedgehog proteins.
13 ome is associated with abnormal diffusion of Hedgehog proteins.
14 nthesis, embryonic cholesterol transport and Hedgehog proteins.
15 ment, including the covalent modification of Hedgehog proteins.
16 icroinjection of RNA encoding active Xenopus hedgehog proteins.
17 edgehog signalling as a result of binding to Hedgehog proteins: a negative regulatory feedback loop e
18                    The secreted Wingless and Hedgehog proteins activate huckebein expression in disti
19 eloping rostral central nervous system Sonic hedgehog protein also participates in ventral regionaliz
20 in an intramolecular cleavage of full-length Hedgehog protein and covalent attachment of a cholestero
21                               The Drosophila Hedgehog protein and its vertebrate counterpart Sonic he
22 re consistent with a functional link between hedgehog proteins and COUP-TFII, factors that are vital
23                                  PTCH1 binds Hedgehog proteins and inhibits signaling in the absence
24 r developmental signalling molecules such as hedgehog proteins and the bone morphogenetic proteins, W
25 bone morphogenetic proteins (BMPs) and Sonic hedgehog protein are secreted factors that regulate dors
26                       To investigate whether hedgehog proteins are also involved in the development o
27                                              Hedgehog proteins are intercellular long-range signaling
28                                              Hedgehog proteins are pivotal morphogens acting through
29                                              Hedgehog proteins are secreted from cells and undergo au
30                                              Hedgehog proteins are secreted morphogens that play crit
31  that the OLFM4 protein interacts with sonic hedgehog protein, as well as significantly inhibits GLI-
32 nvergent evolution, but in at least one case-hedgehog protein autoprocessing-there is definitely a cl
33                                              Hedgehog proteins bind to and inhibit the transmembrane
34 or endocytosis and degradation, triggered by Hedgehog protein binding, and causing reduced levels of
35 ue-patterning activity of the lipid-modified Hedgehog protein by releasing it from tightly -localized
36                      These results show that Hedgehog proteins can regulate mitogenesis and photorece
37                                              Hedgehog proteins constitute one of the major classes of
38                                              Hedgehog proteins control morphogenesis by promoting GLI
39 ing in mouse and Drosophila; in both species Hedgehog proteins define a posterior domain of the limb
40 og interacting protein, and the interference hedgehog protein family, suggesting a unique mechanism o
41  role for oxysterols in the effects of Sonic hedgehog protein focuses on their role in normal fetal d
42 ne ureas is reported as potent modulators of Hedgehog protein function.
43       The N-terminal domain (ShhNp) of Sonic hedgehog protein, generated by cholesterol-dependent aut
44                                              Hedgehog proteins govern crucial developmental steps in
45 rt a model in which GAS1 helps transform the Hedgehog protein gradient into the observed activity gra
46                         To determine whether hedgehog proteins have activities on developing retinal
47 accompanying paper, we provide evidence that Hedgehog protein (Hh), being secreted from P compartment
48 25 kDa carboxy-terminal domain of Drosophila Hedgehog protein (Hh-C) possesses an autoprocessing acti
49 nscription factors that mediate responses to Hedgehog proteins (Hh) in flies and vertebrates, respect
50 edge, these are the earliest functions for a hedgehog protein in post-implantation development in the
51  Factor (WIF), modulates the distribution of Hedgehog protein in the wing imaginal disc through a Wnt
52 ants, previously implicated in signalling by Hedgehog proteins in the zebrafish embryo.
53  Smoothened is controlled by three different hedgehog proteins, Indian, Desert, and Sonic hedgehog, t
54  acid, or fibroblast growth factor and sonic hedgehog proteins into antagonist-treated embryos.
55  that, in addition to cholesterol, the human hedgehog protein is palmitoylated.
56                                 The signal - Hedgehog protein - is modified by cholesterol and palmit
57 the endoplasmic reticulum that palmitoylates Hedgehog proteins, is a member of a small subfamily of m
58 ase D], APOE [apolipoprotein E], IHH [Indian hedgehog protein], ITIH4 [inter-alpha-trypsin inhibitor
59 n occurs during somite stages due to varying Hedgehog protein levels, while later expansion refines t
60 tion and indicate that delivery of exogenous hedgehog proteins may have therapeutic potential for the
61                                              Hedgehog proteins mediate many of the inductive interact
62                                              Hedgehog proteins modulate development and patterning of
63 nsforming growth factor beta1 (TGFbeta1) and hedgehog proteins or antagonists of the Wnt/beta-catenin
64 e were combinatorial effects of TGFbeta1 and hedgehog proteins or antagonists of the Wnt/beta-catenin
65                     Evolutionarily conserved hedgehog proteins orchestrate the patterning of embryoni
66  probably exclusive role for Disp1 is within hedgehog protein-producing cells.
67           A gene encoding a receptor for the hedgehog protein, ptc-2, is expressed by retinal neuroep
68 ls with the amino-terminal fragment of Sonic hedgehog protein results in an increase in the proportio
69                                        Sonic Hedgehog protein (SHH), secreted by retinal ganglion cel
70 neuroepithelium under the influence of sonic hedgehog protein (SHH).
71                 N-terminal recombinant Sonic Hedgehog protein (SHH-N) was added to rat retinal cultur
72 mino-terminal signalling domain of the Sonic hedgehog protein (ShhN) with DISP1 occurs via an extensi
73 e, cholesterol- and palmitate-modified Sonic hedgehog protein signal (ShhNp) when added to cultured c
74 ced but dose-dependent response to the Sonic hedgehog protein signal in vitro, demonstrating that thi
75 limit the range of signaling by sequestering Hedgehog protein signal within imaginal disc epithelium.
76 isp1 activity is only required for paracrine hedgehog protein signaling by the cholesterol modified f
77  substantially reduced mitogenic response to Hedgehog protein signaling.
78 teins mediate the transcriptional effects of Hedgehog protein signals.
79 of SZP in the culture medium, in response to hedgehog proteins (sonic hedgehog [SHH] and Indian hedge
80                                              Hedgehog proteins stimulated SZP accumulation.
81 ytic biogenesis mechanism similar to that of hedgehog proteins, the inteins, and the N-terminal nucle
82 ose product is necessary for the movement of Hedgehog protein through tissues.
83        Signalling is activated by binding of Hedgehog protein to the multipass membrane protein Patch
84 are impaired in export of the lipid-modified Hedgehog protein to the SCUBE2 acceptor.
85  in the HI+cyclopamine (an antagonist of the hedgehog protein)+UCBMC group compared with the HI+UCBMC
86                                              Hedgehog protein undergoes post-translational palmitoyla
87                                              Hedgehog proteins use an auto-processing strategy to gen
88 h PTCH molecules with respect to the various Hedgehog proteins, we have isolated the human PTCH2 gene
89 in the N-terminal domain of the murine Sonic hedgehog protein, which also exhibits an architecture fo
90 ress the selector gene engrailed and secrete Hedgehog protein whilst A compartment cells need the pat
91 ) in modulating signaling pathways involving hedgehog proteins, wingless-related proteins and fibrobl
92 ycoprotein that binds to all three mammalian Hedgehog proteins with an affinity comparable to that of