ライフサイエンスコーパス: helical bundle

1 ane segments, S1-S4, forming an antiparallel helical bundle.

2 ee anti-parallel alpha-helices arranged in a helical bundle.

3 endence of the recovery of the transmembrane helical bundle.

4 brane helix TM1a away from the transmembrane helical bundle.

5 tructural or dynamic perturbations through a helical bundle.

6 stranded beta-sheet, and a second five alpha-helical bundle.

7 coiled-coil tower domain to create a triple-helical bundle.

8 ar to the well studied Escherichia coli four-helical bundle.

9 eral Val and Leu residues in this tetrameric helical bundle.

10 ound and bind in different groves of the MIT helical bundle.

11 al tail, rather than being inserted into the helical bundle.

12 assemble into a proton-conducting tetrameric helical bundle.

13 orientation for the N-terminal six-TM domain helical bundle.

14 a Vps9 domain stabilized by an indispensable helical bundle.

15 complement factor 5a (C5a), a 74-amino acid helical bundle.

16 sed in maquette construction is a four-alpha-helical bundle.

17 identify the most plausible model of the TM helical bundle.

18 amphipathic helices, A-G, creating a unique helical bundle.

19 ith the identical helix from the second four-helical bundle.

20 inds to a remote allosteric site outside the helical bundle.

21 the long shared helix doubles back onto the helical bundle.

22 H3 of Cenp-K to create a compact three alpha-helical bundle.

23 GPCR) ligand located entirely outside of the helical bundle.

24 ses five linear repeats of an unusual triple helical bundle.

25 ization helices and the nearby actin-binding helical bundle.

26 e in complex native systems containing alpha-helical bundles.

27 metal ion exchange into proteins, especially helical bundles.

28 ants for the special case of homo-oligomeric helical bundles.

29 s of the talin rod include a series of alpha-helical bundles.

30 organizes FtsZ protofilaments into striking helical bundles.

31 -body movements in two sets of transmembrane helical bundles.

32 formation, although they occur rarely in TM helical bundles.

33 her tethering complexes, is constructed from helical bundles.

34 multiple 15mers together, they might fold as helical bundles.

35 nsists of a central beta-sheet and two alpha-helical bundles.

36 r membrane proteins containing transmembrane helical bundles.

37 Es from opposite membranes into stable alpha-helical bundles.

38 ormation for membrane proteins consisting of helical bundles.

39 with four helical domains organized into two helical bundles.

40 curving protein FzlA to promote formation of helical bundles.

41 dipeptides, cyclic peptides, and lock-washer helical bundles.

42 ise from unzipping, as well as unwinding, of helical bundles.

43 d molecule of a complex architecture rich in helical bundles.

44 n through the formation of cytoplasmic alpha-helical bundles.

45 a multi-domain protein with an N-terminal 4 helical bundle (4HB) and a pseudokinase domain (PsK) con

46 ed from two separate fragments consisting of helical bundles A and B and C, D, E, F, and G via a spli

47 cturally, DAXX is modular with an N-terminal helical bundle, a docking site for many DAXX interactors

48 -terminal WDN sequence and the region of the helical bundle above transmembrane segment six.

49 explicit lipid bilayer and of its C-terminal helical bundle alone in aqueous solvent were performed.

50 are joined together by an antiparallel alpha helical bundle, alpha domain.

51 ng into three distinct regions: a five alpha-helical bundle, an eight-stranded beta-sheet, and a seco

52 reveals two distinct domains: an N-terminal helical bundle and a C-terminal cyclophilin beta-barrel,

53 ection giving rise to a short distorted four helical bundle and a C-terminal helical structure wedged

54 13) entry domain is composed of a C-terminal helical bundle and a dynamic N-terminal region containin

55 and an insertion consisting of a four alpha-helical bundle and a short alpha-helical hairpin.

56 Like TraM, TraM2 folds into a helical bundle and exists as homodimer.

57 6) at positions 94, 102, 204, and 341 in the helical bundle and first, second, and third extracellula

58 r, which for the first time includes refined helical bundle and loop regions and reflects a peptide-b

59 acement that is largest perpendicular to the helical bundle and not along the direction of apparent m

60 rn and functional studies do not support the helical bundle and second-gate hypothesis but correlate

61 cytoplasmic half of the S1-S4 transmembrane helical bundle and shifts open-closed channel equilibriu

62 at the allosteric coupling between the inner helical bundle and the selectivity filter might rely on

63 y contribute to the binding of this fourfold helical bundle and this evolutionary requirement may tra

64 Natural alpha-helical assemblies, such as helical bundles and coiled coils, consist of multiple ri

65 peptide motifs that are flanked by two alpha-helical bundles and covered by a beta-sheet motif.

66 olecular dynamics simulations, tends to form helical bundles and crosses based on its 8-4-2-2 hydroph

67 ns of many viral fusion proteins form stable helical bundles and inhibit fusion specifically.

68 overed by alpha-helical lids, to multi-alpha-helical bundles and layers.

69 served site at the interface between the two helical bundles and restraining their relative position

70 alanine core residues fold into stable alpha-helical bundles and that these self-sort from similar pe

71 tains both a unique interdomain insertion (4-helical bundle) and a C-terminal extension (3-helical bu

72 elical bundle) and a C-terminal extension (3-helical bundle) and it packs as a tetramer in the asymme

73 protein, namely, glycophorin (a simple alpha-helical bundle) and OmpA (a beta-barrel).

74 leotide MRS2500 (orthosteric, contacting the helical bundle) and urea BPTU (allosteric, on the extern

75 near the water-filled central cavity of the helical bundle, and (3) influences the dynamics and magn

76 The third domain, a five-helical bundle, and the C-terminal beta-sandwich domain

77 r complex, SNARE proteins which can form a 4-helical bundle, and the SNARE disassembly chaperones Sec

78 olved structures of transmembrane (TM) alpha-helical bundles, and we use this contact potential to in

79 ure that interactions within the tetra-alpha-helical bundle are such that only the heterotetramer is

80 These results suggest that some loops in helical bundles are stabilized by short-range interactio

81 ns, four-helix bundles, or membrane-spanning helical bundles, are important to the structural organiz

82 t uniaxial rotational diffusion of the M2TMP helical bundle around the membrane normal is characteriz

83 ow that the C terminus consists of two alpha-helical bundles arranged in tandem, and we identify a hi

84 ement of five alpha-helices that fold into a helical bundle arrangement.

85 dicted that STAND NTPases use the C-terminal helical bundle as a "lever" to transmit the conformation

86 he quaternary structure of the transmembrane helical bundle as a dimer-of-dimers structure.

87 s are located in the hydrophobic core of the helical bundle as characterized by various biophysical t

88 ion of the thereby connected helices and the helical bundles as a whole.

89 loops) assemble in detergent into four-alpha-helical bundles as observed by analytical ultracentrifug

90 al and systematic, and uses a set of de novo helical bundles as standards.

91 inal helical extensions that form an unusual helical bundle at its dimer interface with some resembla

92 oiled-coil motif, predictably forming a four-helical bundle at the center of the protein and emulatin

93 Each SLH domain contributes to a three-helical bundle at the spindle base, whereas another alph

94 A previously engineered tetrameric helical bundle binds C60 in solution, rendering it water

95 flexible globular ensemble to a rather rigid helical bundle, blocking access to the nuclear localizat

96 backbone structure of a transmembrane alpha-helical bundle by infrared spectroscopy.

97 The immobilization of the M2 helical bundle by the membrane composition change indica

98 plex, odd-stranded braids, but can also form helical bundles by undergoing inversions of chirality.

99 resolution, reveals a tandem pair of triple helical bundles closely related to spectrin repeats.

100 PfRH5 adopts a novel fold in which two three-helical bundles come together in a kite-like architectur

101 fusion is driven by the formation of a four-helical bundle composed of soluble N-ethylmaleimide sens

102 mbrane fusion requires the formation of four-helical bundles comprised of the SNARE proteins syntaxin

103 sistant form of gp41 akin to the postfusion, helical bundle conformation and appear to lack specific

104 t this region is helical and adopts an alpha-helical bundle conformation similar to that observed in

105 ned to prevent Env from folding into a final helical-bundle conformation abolished virus-cell fusion

106 at can adopt two very different homotrimeric helical bundle conformations-one short (~66 angstrom hei

107 rchitecture, involving three-helical and two-helical bundles connected by a compact five-helical junc

108 The structure showed two helical bundles connected by a long, curved pair of swap

109 Both helical bundles contain vinculin-binding sites but that

110 rthermore, the non-Leucine zipper N-terminal helical bundle contains several new elements for protein

111 y, talin's effects on Vh structure establish helical bundle conversion as a signalling mechanism by w

112 Thus, helical bundle conversion is a structurally conserved re

113 of talin VBSs activate vinculin by provoking helical bundle conversion of the Vh domain, which displa

114 ows the cooperative relaxation of the native helical bundle core that is monitored by both solvated (

115 to the kinetics of other members of the four-helical bundle cytokine family, erythropoietin folding a

116 ted by a disulphide bridge in the long-chain helical bundle cytokine leptin.

117 udies of erythropoietin, a glycosylated four-helical bundle cytokine responsible for the regulation o

118 Interleukin (IL)-2 is a type I four-alpha-helical bundle cytokine that plays vital roles in antige

119 NLRP12 PYD adopts a typical six-helical bundle death domain fold.

120 are uniquely arranged in a left-handed alpha-helical bundle, directly interacting with the amino-term

121 cules that self-assemble into highly ordered helical bundles displaying hexagonal close packing.

122 ng motif, which together with the downstream helical bundle domain (residues 135-230) forms an early

123 al rod domain to vinculin's N-terminal seven-helical bundle domain (Vh1).

124 A helical bundle domain connects the endonuclease and meth

125 hway in which unfolding of Zuo1's C-terminal helical bundle domain results in ribosome dissociation f

126 receptor amino terminus relative to the core helical bundle domain.

127 domain that may be similar to the N-terminal helical bundle domains of apoA-I and apoE but that apoA-

128 ns of the peptide-binding amino terminus and helical bundle domains of this receptor.

129 atenin are homologs that contain a series of helical bundle domains, D1-D5.

130 ntricate pattern of interactions within this helical bundle ensures the stable assembly of the head s

131 that low-pH induced unfolding of the RAP-D3 helical bundle facilitates dissociation of RAP-receptor

132 complexity of knot-like proteins within the helical bundle family comprises a completely new class w

133 annel-like region at the center of the S1-S4 helical bundle fills rapidly with water, reminiscent of

134 En2HD adopts a well-defined three-helical bundle fold in aqueous solution.

135 e FBXL5 N terminus, a hemerythrin-like alpha-helical bundle fold not previously observed in mammalian

136 nst SpA(KKAA) that, by binding to the triple-helical bundle fold of its immunoglobulin binding domain

137 lant pathogen Pseudomonas syringae, adopts a helical bundle fold of low stability (DeltaG(F-->U) = 2

138 ain of the homeodomain-like superfamily of 3-helical-bundle-fold proteins, (b) a central region with

139 Often, four-helical bundles form tube-like structures, with binding

140 fusion-mediating glycoproteins couple alpha-helical bundle formation to membrane merger, but have di

141 s a dimer with a characteristic central four-helical bundle formed by association of the two longest

142 t elucidated the structure of a tetrapeptide helical bundle formed by interaction of the cytosolic do

143 Strikingly, alpha-helical bundles formed from the extended C-termini of ca

144 We combine an alpha-helical bundle-forming peptide with self-assembling dend

145 sfully validated on a set of non-coiled-coil helical bundles, frequent in channels and transporter pr

146 iction of the configuration of transmembrane helical bundles (GpA).

147 , namely the direct recognition of the three-helical bundle H(abc) domain of the mouse SNARE Vti1b by

148 core polymerase, while the C-terminal, three-helical bundle has a strongly positive patch that could

149 The hypothetical N-terminal S1 helical bundle has been confirmed to form the hydrophobi

150 onstrate this we first modified the designed helical bundle hemoprotein H4, creating a highly charged

151 sequence from a structured diheme-four-alpha-helical bundle (HP1), with 24 residues of a membrane-spa

152 c site outside the seven transmembrane (7TM) helical bundle in a position between TM6 and TM7 extendi

153 he maize nsLTP, implying the importance of a helical bundle in accommodating the non-specific binding

154 For example, a transmembrane four-helical bundle in cytochrome bc(1) binds a pair of porph

155 that bind a diiron site within a four alpha-helical bundle in general and ferritins in particular.

156 tochondria ruling out a possible role of the helical bundle in mitochondrial targeting.

157 lasmic end of helix 4 lies outside the inner helical bundle in the exofacial configuration of Glut1.

158 en IKK is resting, HLX2, CCR2, and LZ form a helical bundle in which HLX2 is sequestered.

159 it interactions maintain the gp41 ectodomain helical bundles in a "spring-loaded" conformation distin

160 cture, the large entropic cost of organizing helical bundles in the absence of the constraining bilay

161 e peptides are thought to form transmembrane helical bundles in which the more hydrophilic residues l

162 ined fatty acid bound down the center of the helical bundle, in agreement with the location of the fa

163 1 and 12 packed against the predicted alpha-helical bundle, in the apparent absence of ligand.

164 merization occurs through the formation of a helical bundle, including a coiled-coil interaction moti

165 cture of the Fs peptide is predicted to be a helical bundle instead of a single helix; and (iii) the

166 generates near-native models of large alpha-helical bundles, interlocking beta sandwiches, and inter

167 In particular, the DH helical bundle is coupled to the structurally dependent

168 magnetic resonance indicate that the overall helical bundle is formed from two tightly interacting pa

169 system for the study of coiled-coil 4-alpha-helical bundles, is characterized by a remarkable struct

170 wn as the talin head domain, and a series of helical bundles known as the rod domain.

171 nus of the ligand interacting with the seven-helical bundle (leading to receptor activation).

172 thesized that lipid-free apoA-IV exists in a helical bundle, like other apolipoprotein family members

173 nits has a major domain composed of an alpha-helical bundle-like structure.

174 onditions, the C-terminus is indeed an alpha-helical bundle, located near the five-fold symmetry axis

175 t has been proposed for the folding of alpha-helical bundle membrane proteins.

176 nt with theoretical values calculated from a helical bundle model but not from a helical hairpin.

177 sulfide bonds, and a common multiamphipathic helical bundle motif.

178 pothesis that pentamers containing a central helical bundle, observed in different nonenveloped virus

179 antiparallel beta-sheet, followed by a three-helical bundle of alpha-helices, and then a C-terminal b

180 The five-helical bundle of granulysin resembles other "saposin fo

181 the wild type TM topology of the N-terminal helical bundle of LacY.

182 f NLRP3 requires (i) the death effector four-helical bundle of MLKL, (ii) oligomerization and associa

183 ucture of the tetramerization site, a triple helical bundle of partial domain helices, show that muta

184 The seven-helical bundle of rhodopsin and other G-protein coupled

185 nal H(abc) domain of syntaxin-1 and the four-helical bundle of the assembled SNARE complex.

186 d with the detailed structural analyses, the helical bundle of the CB(1) receptor appears to be fully

187 distributed over the surface and within the helical bundle of the cholecystokinin receptor to the am

188 ine N-terminal region into the transmembrane helical bundle of the receptor concurrent with receptor

189 e III PKS architecture along with an unusual helical bundle of unknown function that appears to exten

190 vel conformational changes in the N-terminal helical bundle of Vh1, which disrupt its intramolecular

191 tes were identified within the transmembrane helical bundles of both the alpha1 (labeled residues alp

192 The backbone geometries of the helical bundles of cytochrome bc(1), TolC, and DSD are w

193 A, to activate ring constriction by inducing helical bundles of FtsZ filaments.

194 of these polymers are homotetrameric, alpha-helical bundles of low-molecular-weight peptides.

195 ll with the size found in solution for alpha-helical bundles of peptides with a similar amino acid se

196 stability and transition kinetics of the 13 helical bundles of talin are utilized in the diverse tal

197 tions starting from tetrameric transmembrane helical bundles of these two peptides, as well as their

198 als a ~180-degree rotation of the C-terminal helical bundle on the "large" Cas8f subunit.

199 s, reveals that Vps54 has a continuous alpha-helical bundle organization similar to that of other mul

200 mune responses further suggested that packed helical bundles partially inserted into the lipid bilaye

201 Its C-terminal rod domain, which contains 13 helical bundles, plays important roles in mechanosensing

202 Like alpha-helical bundles possessing fluorous cores, fluorous beta

203 lays an outer stabilizing role for the inner helical bundle predicted to form the exofacial substrate

204 of talin and alpha-actinin are buried within helical bundles present in their central rod domains.

205 n and allosteric regulation in a tetra-alpha-helical bundle protein composed of two identical di-heli

206 DBPA is determined to be a helical bundle protein consisting of five helices held t

207 pathic alpha helices in water leads to alpha-helical-bundle protein structures.

208 on of the talin rod, and show that the three helical bundles R1-R3 in this region unfold in three dis

209 ctural characterization of the talin rod: 13 helical bundles (R1-R13) organized into a compact cluste

210 nd supports external contact dimerization of helical bundles, rather than domain-swapped dimerization

211 achments, it is likely that the tetrapeptide helical bundle reflects the lowest energy state, such as

212 xtreme plasticity in the assembly of 4-alpha-helical bundles reflects the capacity of the Rop sequenc

213 conformational changes in a C-terminal four-helical bundle region of ExoU as it interacts with lipid

214 ceptor amino-terminal domain relative to its helical bundle region.

215 , which form antiparallel 12-helical and six-helical bundles, respectively.

216 biophysical analyses of the C-terminal alpha-helical bundle reveal critical roles for the conserved r

217 ted a red copper protein site within a three helical bundle scaffold which we later revisited and det

218 The helical bundle sequentially folded in an N-terminal doma

219 Der p 5 is a three-helical bundle similar to Blo t 5, but the interactions

220 The rDer f 21 protein consists of a three helical bundle, similar to available structures of group

221 ment trimer, has a central coiled-coil alpha-helical bundle, similar to the fusion proteins of many e

222 The four-helical bundle soluble N-ethylmaleimide-sensitive fusion

223 exposed HR1 grooves, lack of binding to hexa-helical bundle-specific NC-1 mAb, and inhibition of viru

224 Widely-shared, helical-bundle spectrin repeats are known to melt at tem

225 Vpx is made up of a three-helical bundle stabilized by a zinc finger motif, and wr

226 ch eight transmembrane domains form an inner helical bundle stabilized by four outer helices.

227 h eight transmembrane segments form an inner helical bundle stabilized by four outer helices.

228 The model describes how primordial alpha-helical bundles stabilized membranes, how these were dec

229 re-hairpin intermediate to its post-fusion 6-helical bundle state.

230 lices (helices A1, B1, and C1) form a triple helical bundle structural domain that is similar, but no

231 It depicts a helical bundle structure in which the N- and C-termini a

232 The results reveal that the helical bundle structure of the CB(1) receptor maintains

233 mutation (Leu-1034 to Ser) that weakens the helical bundle structure of the FAK FAT domain.

234 es revealed that SYCE3 adopts a dimeric four-helical bundle structure that acts as the building block

235 ptad repeat to induce an extended MPER alpha-helical bundle structure yielded an antigenicity profile

236 helical conformations (as in the postfusion helical bundle structure) and beta-turn conformations (a

237 nformational changes in Vh, creating a novel helical bundle structure, and this alteration actively d

238 by disulfide and oxime linkages to mimic the helical bundle structures commonly found in proteins.

239 Thus, SMN tetramers do not form symmetric helical bundles such as those found in glycine zipper tr

240 h eight transmembrane segments form an inner helical bundle surrounded by four outer helices.

241 Specifically, we investigated homooligomeric helical bundle systems consisting of synthetic alpha-hel

242 ble junction between helix C' and the triple helical bundle that allows multiple orientations between

243 editing applications, contains an ancestral helical bundle that blocks AcrVA4 binding and allows it

244 e fusion by forming a four-stranded parallel helical bundle that brings the membranes into close prox

245 ur elongated S6 segments form a right-handed helical bundle that closes the pore at the cytoplasmic b

246 f four outer helices that surround the inner helical bundle that comprises the aqueous substrate-bind

247 y its D3 domain, a relatively unstable three-helical bundle that denatures at pH <6.2 due to protonat

248 s were found in the motions of the inner TM2 helical bundle that directly modulate the size of the ce

249 e t-SNARE and controls the rate at which the helical bundle that forms the SNAREpin can zip up to dri

250 peratively generate a heterotetrameric alpha-helical bundle that functions in conjunction with its ne

251 olvase RuvC but Ydc2 contains a small triple helical bundle that has no equivalent in RuvC.

252 d the core strand-4, as well as a C-terminal helical bundle that is fused to the NTPase domain.

253 sion conformation indicates a trimeric alpha-helical bundle that is highly similar to those of Ebola

254 The novel C-terminal domain forms an alpha-helical bundle that is positioned perpendicular to the t

255 are produced and are organized in a vertical helical bundle that is projected toward the particle sur

256 segment and show that it forms a tetrameric, helical bundle that is structurally "conditioned" for in

257 lized SNARE proteins zipper up into an alpha-helical bundle that pulls the two membranes tightly toge

258 port the design of a membrane-spanning, four-helical bundle that transports first-row transition meta

259 mino terminal GTPase domain and two extended helical bundles that are connected by flexible regions.

260 lar membrane fusion through the formation of helical bundles that span opposing membranes.

261 nd consist of a series of four-transmembrane helical bundles that we term Piezo repeats.

262 that leucine-967 is buried within the alpha-helical bundle through predominantly hydrophobic interac

263 ng residues (70 amino acids total) of the TM helical bundle (TM1-7) of the M3R to systematic alanine

264 strap" and helix 1 are displaced from the Vt helical bundle to mediate actin bundling.

265 ng from complete inversion of the N-terminal helical bundle to mixed topology and then to completely

266 ring SNARE proteins to zipper up in an alpha-helical bundle to pull two membranes together.

267 es that assemble into amphiphilic (AP) alpha-helical bundles to reproduce key structure characteristi

268 , prolactin adopts an "up-up-down-down" four-helical bundle topology and resembles other members of t

269 has been proposed that the assembly of this helical bundle transduces force through the entire bilay

270 IL-21), a potent immunomodulatory four-alpha-helical-bundle type I cytokine, is produced by NKT and C

271 ic residues that would destabilize the alpha-helical bundle under conditions where the side chains ar

272 e of integral membrane proteins built from a helical bundle (up to seven transmembrane segments).

273 ition from an unstructured monomer to a four-helical bundle upon phosphorylation by the enzyme cyclic

274 two membrane protein architectures (an alpha-helical bundle versus a beta-barrel) and two different d

275 A homodimeric helical bundle was reconnected into a monomeric building

276 tended apolar interface to form a four-alpha-helical bundle, where two of the alpha-helices are contr

277 tifying the ligand binding pocket within the helical bundle, whereas the role of the extracellular lo

278 HR1-54Q reveals a trimeric, coiled-coil six-helical bundle, which probably represents a postfusion f

279 gather behind the cell body and form a close helical bundle, which propels the cell forward during a

280 ecognizes CD81 through a dynamic loop on the helical bundle, which was shown by nuclear magnetic reso

281 es (MIT) domains comprising asymmetric three-helical bundles, which interact with helical MIT-interac

282 erminal interactions and (2) the surrounding helical bundle whose contributions to protein stability

283 pts a novel fold consisting of an orthogonal helical bundle with a beta hairpin along one side.

284 Crystal structures have revealed a compact helical bundle with a buried active site, which requires

285 The crystal structure reveals a six-helical bundle with a prominent loop, which among IRAKs

286 n solved, revealing an elongated three alpha-helical bundle with a small membrane distal head.

287 (NMR) spectroscopy that the protein forms a helical bundle with a surprisingly polar lipid-facing su

288 tion phenomena and demonstrated a rigid four-helical bundle with relatively mobile interconnecting lo

289 whereas the KdpD TM domain comprises a four-helical bundle with shorter second and third helices.

290 owed by a long helix that forms a four-helix helical bundle with the C-terminal domain.

291 -free apoA-IV does indeed exist as a complex helical bundle with the N and C termini in close proximi

292 g structure consists of a right handed alpha-helical bundle with the residues Ile659, Val663, Leu667,

293 the membrane-associated region forms a three-helical bundle with two cysteine residues located at pos

294 the predicted secondary structure of 4 alpha-helical bundles with an up-up-down-down topology, and tw

295 he relative orientation of the transmembrane helical bundles with respect to one another has been det

296 Each MLD contains a four-helical bundle, with the conserved arginine exposed at i

297 ated several strategies to stabilize minimal helical bundles, with the dimer motif as the initial foc

298 stitutions indicates the F TM trimer forms a helical bundle within the membrane.

299 e of domain III at one end, and an elongated helical bundle within the portion corresponding to domai

300 o acid residues on the exterior of the alpha-helical bundle yields monodisperse macromolecules with p