ライフサイエンスコーパス: helices

1 nt with bending of a GGxGG motif in the pore helices.

2 ne breaks in two corresponding transmembrane helices.

3 acts with the Fabs through its extracellular helices.

4 ing, as they require insertion of downstream helices.

5 membrane by going between the transmembrane helices.

6 rly identical to those of DNA and RNA double helices.

7 erol molecules to the receptor transmembrane helices.

8 s, which stack within each helix and between helices.

9 e helix, analogous to A-RNA and B-DNA double helices.

10 an azimuthal angular shift between apposing helices.

11 zing the open-state position of the GluN1 M3 helices.

12 osolic ends of 5 of SERCA's 10 transmembrane helices.

13 ove formed by BAK alpha4, alpha6, and alpha7 helices.

14 ter leaflet coordinate between two E protein helices.

15 logs with different numbers of transmembrane helices.

16 e multi-specific DNA-binding proteins prefer helices.

17 on the structural differences between their helices.

18 formation of gels containing only homochiral helices.

19 pseudokinase domain (PsK) connected by brace helices.

20 atic residues F557 and F656 in the S5 and S6 helices.

21 e antiparallel and mixed arrangements of the helices.

22 2D nanosheets assembled from collagen triple helices.

23 r dynamic helical polymers or supramolecular helices.

24 emaining positive basepairs into alternative helices.

25 between the intracellular segments of these helices.

26 flexible loop conformations that connect the helices.

27 eteromerization are controlled by C-terminal helices.

28 ficant rotational movement of the associated helices.

29 e receptor extracellular loops (ECLs) and TM helices.

30 is mediated by small connecting segments of helices.

31 r formation, promoting supramolecular double helices.

32 d at the tip of two amphipathic dimerization helices.

33 hly flexible loop surrounded by more ordered helices.

34 ks of a-BTA and dictate the chirality of the helices.

35 terface of the amphipathic and transmembrane helices.

36 ve contacts between the C-termini of the two helices.

37 lined by the side chains of the pore-lining helices.

38 n of poly(methyl methacrylate) (PMMA) triple-helices.

39 izes the open-state position of the GluN1 M3 helices.

40 L/ChREBP bind LDs via C-terminal amphipathic helices.

41 ching geometry and the number of interacting helices.

42 f the gating ring and bending of pore-lining helices.

43 bundle with a long unstructured loop between helices 1 and 2.

44 s adjacent to Leu(63) in the loop connecting helices 1 and 2.

45 nding pocket that is formed by transmembrane helices 1, 6, and 10 and conserved among SLC7 transporte

46 nserved fingers subdomain, and a bundle of 3 helices: 1 from the palm subdomain and 2 from the N-term

47 Helices 152-163 (alpha5) and 183-193 (alpha7) of SCARB2

48 artially cross-reactive regions around alpha-helices 2 and 4 as well as a novel Art v 3-specific epit

49 truct derived from CFTR's transmembrane (TM) helices 3 and 4 (TM3/4) and their intervening loop, we i

50 heterodimer interface between transmembrane helices 3 and 5 of both subunits, which serves as a sign

51 pyrrole adducts with lysine residues in the helices 3-4 of another apoA-I or in the central domain o

52 that the beta2 and beta3 strands as well as helices 4 and 5 of the GTPase G-domain bind to PIP2 and

53 We found that five histidine residues in helices 5-8 of apoA-I are preferably cross-linked by oxP

54 on of extracellular loop 3 and transmembrane helices 6 and 7 manifests independently of direct ligand

55 e of the cytoplasmic region of transmembrane helices 6 and 7 of the beta(1)-adrenergic receptor to ag

56 ellular loop 3 and the tops of transmembrane helices 6 and 7, an inward movement of transmembrane hel

57 e uncovered NTD residues in the loop between helices A1 and A2 that can be substituted to enhance dis

58 ing "switch" at the loop between the A and B helices (AB loop).

59 disulfide bond between the alpha(1)/alpha(2) helices abrogates TAPBPR binding, both in solution and o

60 orescence experiments to show that a kink in helices affects the formation of membrane pores by stabi

61 ns of LDs, and most of them bear amphipathic helices (AH), which can selectively target to LDs, or to

62 al dynamics, and the role of the amphipathic helices (AHs) on proton conductance remain elusive.

63 We have also shown that the helices align TANGO1 around an ER exit site.

64 ophobic packing of the conserved amphipathic helices alpha1 and alpha3.

65 The sequence segments spanning helices alpha2 and alpha3 underwent a compaction during

66 ue pairs within the DNA binding N-termini of helices alpha2 and alpha3; and gamma/delta'-residues ass

67 e interface between alphaM4 and the adjacent helices, alphaM1 and alphaM3, had little effect, althoug

68 d for several naturally occurring RNA triple helices, although all are limited to six or fewer consec

69 forms with each monomer composed of 12 alpha-helices and 9 beta-sheets.

70 It further accelerates the unfolding of helices and a complete collapse of structure.

71 that each subunit contains 11 transmembrane helices and a lumenal beta-trefoil fold termed the MIR d

72 The epitopes of Pin p 1 were found in alpha-helices and coils in the 3D protein structure.

73 he bundle dissociates and the remaining four helices and connecting loops rearrange to form the inter

74 onstrate that PaaR2 mainly consists of alpha-helices and displays a concentration-dependent octameric

75 ton transfer dynamics, and how transmembrane helices and gating residues control the hydration proces

76 , lipids penetrate as far as the pore-lining helices and lipid molecules can align along TM3b perpend

77 cating a strong topological coupling between helices and loops in RNA tertiary motifs.

78 DNA tertiary structures involving juxtaposed helices and might modulate DNA topology by plectoneme st

79 e, pitch, and polarity between peptide alpha-helices and oligourea 2.5-helices suggest that a tertiar

80 sely defined as containing membrane-spanning helices and processing an isoprenoid-linked carbohydrate

81 rough an opening between the F/G-, H-, and I-helices and requires a number of cooperative multiresidu

82 to two rings, which subsequently expand into helices and spirals that narrow down to the incipient si

83 assembles before ESCRT-III rings expand into helices and spirals.

84 the CD loop to furl, which moves the E and F-helices and switches an electron transfer gate formed by

85 ng of incipient 2D layers of collagen triple helices and that the scrolling direction determines the

86 gating involves lysine protonation on inner helices and the formation of a protein seal between the

87 ional ensemble that are controlled by the AI helices and their displacement upon membrane binding.

88 of intermediates, including filaments, rods, helices, and 2D rectangular plates, before transforming

89 Heating led to a decrease in alpha- helices, and an increase in aggregated strands, random c

90 catalytic loci of kinases: the alphaB-alphaC helices, and HRD-motif loop, and DFG-motif.

91 es, dynamics, variable topologies, accessory helices, and malleability and abetted by adaptability of

92 sidues from the SF, outer-mouth vestibule, P-helices, and S5-P segments.

93 ore is made of multiple connected DNA double helices, and the outer shell is composed of regularly ar

94 Heparin binding stabilizes LPL helices, and the presence of substrate triggers helix di

95 e shape of tetrahedral containers, of double helices, and, supreme wonder, of the Borromean rings.

96 orce to initiate folding while transmembrane helices are aligned in a zigzag manner within the bilaye

97 ix formation is concentration-dependent, and helices are composed of inactive dihedral LPL dimers.

98 ceed via global unfolding, whereas the alpha-helices are free to swap locally in the native basin.

99 These helices are important for gating and sensing in MscS but

100 of FVIIIa-specific changes indicated that 3 helices are involved in FIXa-FVIIIa assembly.

101 Some of these transient helices are known to interact with partners, whereas oth

102 ped dimer in which the central alpha5-alpha7 helices are mutually crossed over, resulting in chimeric

103 oil assemblies formed between or among alpha-helices are the most regular feature of tertiary and qua

104 Short RNA helices are unwound in a single ATPase cycle, but the AT

105 L402C/L403C, at the cytosolic ends of the MA-helices, are conducive for disulfide bond formation.

106 Numerical models that treat the DNA helices as elastic rods are used to evaluate the local l

107 whereas toluene results in the formation of helices as intermediates during the course of crystalliz

108 This work showcases the versatility of alpha helices as scaffolds for metalloprotein design and the p

109 lementation of functional chirally amplified helices as switchable asymmetric catalysts, chiral senso

110 rged residues on predicted amphipathic alpha-helices, as shown for murine gasdermin-D.

111 Mixed-chirality helices assemble into relatively complex, odd-stranded b

112 nning K61 to I72 and flanked by longer alpha-helices at the outer edges, and basic side grooves near

113 the two crossed C-terminal M4 transmembrane helices at the vestibule entrance.

114 Molecular helices based on self-organized aromatic oligoamide fold

115 ansition, the intracellular halves of the S6 helices bend and rotate by about 100 deg, exposing diffe

116 ar peptides, peptide macrocycles, stabilized helices, beta-hairpin peptides, and cross-linked helix d

117 omains then template the formation of triple helices between appropriate partner strands.

118 A network of connecting helices between neighboring CNBs contributes to maintain

119 TM1 and TM6 helices break alpha-helical geometry halfway across the

120 ino groups onto robustly folded beta-peptoid helices by construction and incorporation of novel chira

121 anically robust intermediate located between helices C and B that, with our enhanced resolution, is n

122 The alternative helices can be compatible with the nested structure such

123 These three helices cannot insert stably when ribosome-bound during

124 operties of cationic amphiphilic polyproline helices (CAPHs) with modifications to the hydrophobic mo

125 s of SERPINA1 identified 3 amphipathic alpha-helices clustered in the N-terminal domain of the protei

126 ts support the hypothesis that transmembrane helices co-evolve with membranes, suggesting that, on th

127 We focus our investigation on supramolecular helices composed of an achiral benzene-1,3,5-tricarboxam

128 Collagen triple helices, comprising collagen-mimetic peptides (CMPs), ar

129 ve long-range allosteric changes in flanking helices consistent with winding/unwinding in helical pro

130 uctural rearrangements between transmembrane helices control ligand binding, receptor activation, and

131 (DeltaDeltaG(asc)) caused by mutations in TM helices correlated with experimental changes in the stab

132 The unusual topology of the FlhB/SctU helices creates a loop wrapped around the bottom of the

133 red thermostability and disruptions to alpha helices, disulfide bonds, or the permeation pore.

134 , with each subunit forming 12 transmembrane helices divided into structurally similar amino (N) and

135 ly developed enzymatic-cleavage site between helices E and F and pulled from the top of the E helix u

136 ven-subunit protomers with 50 trans-membrane helices each.

137 Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold

138 our beta4, each containing two transmembrane helices, encircle Slo1, contacting it through helical in

139 sting of a ring of seven transmembrane alpha-helices enclosing a large (>12,000 angstrom(3)) interior

140 e crystal structure of the Hb tetramer, with helices exhibiting no or minor HDX and loops undergoing

141 ,3,5-tricarboxamides (BTAs) that form double helices, fibers that were long thought to be chains of s

142 Pase could dislocate misinserted hydrophobic helices flanked by short basic segments from the ER.

143 nge of chaperoning hydrophobic transmembrane helices for faithful membrane insertion.

144 ne protein that contains eight transmembrane helices form a complex that may function as a peptidogly

145 n ATP molecule is not bound to the two alpha-helices forming its C-terminal domain, probably because

146 pling between movements of the transmembrane helices forming the two Ca(2+)-binding sites and the cyt

147 Novel peptides designed to mimic helices found in nature employ a variety of methods to c

148 The MA-helices from all five subunits form the extension of the

149 to-tail" homodimer, formed between two alpha-helices from each monomer, with three Zn(II)-binding sit

150 nding and release of its two most N-terminal helices from the catalytic core.

151 s a cluster of serine residues linking alpha-helices G and H of the Wee1 kinase domain.

152 The results revealed that amphipathic alpha-helices h1 and h3 comprise a lipid-binding site that is

153 formed by the N terminus, the transmembrane helices H1, H2 and H7, and the first extracellular loop

154 -344 mutation affects proper folding of rRNA helices H68-70 during anchoring of the Rpf2 subcomplex.

155 dimer, with the first ten transmembrane (TM) helices harboring the transport core and TM11-TM12 helic

156 eptides (CMPs) that form sticky-ended triple helices has allowed the production of surprisingly stabl

157 taple strands into parallel arrays of double helices, has proven a powerful method for custom nanofab

158 We show that 92% of all transmembrane helices have at least one non-canonical H-bond formed by

159 Although CMPs and their triple helices have been studied extensively, the structure of

160 However, stalling after the first three helices have exited the ribosome cannot be successfully

161 binding domains (NBDs) contact intracellular helices (ICHs).

162 C] linker region, and the alpha1 and alpha'1 helices in BRCT-[N] and -[C].

163 the importance of including the amphipathic helices in future experimental and theoretical studies o

164 tering either LPS structure or transmembrane helices in LptG.

165 Rough mapping implicated CT C-terminal helices in MA binding, in agreement with cell culture st

166 We have reconstituted these membrane helices in model membranes and shown that TM and IM toge

167 he binding affinity and specificity of alpha-helices in proteins, resist proteolytic degradation, and

168 ticle stabilizes functionally important rRNA helices in the A and P-sites, prior to the completion of

169 6, the long alpha-helix binds to other alpha-helices in the C-terminal region of predominantly one of

170 ranslocate their substrates occluded between helices in the center of the transmembrane part of the p

171 se mutants demonstrated that (i) four of the helices in the CVSC helix bundle can be attributed to tw

172 he structure and dynamics of CA-SP1 junction helices in the immature lattice.

173 ton of each wedge is provided by three alpha-helices in the membrane domains of the b-subunit to whic

174 s in the acid unfolded and presence of alpha-helices in the molten globule state lead to internal fri

175 nsing in MscS but the role of the additional helices in the paralogs is not understood.

176 and revealed that with the exception of key helices in the platform domain, all other 16S rRNA domai

177 To investigate the role of these helices in the transport function of P-gp, we substitute

178 The identification of transmembrane helices in transmembrane proteins is crucial, not only t

179 The association of amphipathic alpha helices in water leads to alpha-helical-bundle protein s

180 Upon activation, the transmembrane helices increase the tilt angle by 6 degrees and the ave

181 3D structure is predicted to have four alpha-helices interlinked by three loops and a long C-terminal

182 how novel assembly of the four transmembrane helices into channels of octamers and undecamers, respec

183 , and the palmitoleate protrudes between two helices into the bilayer.

184 e insertion of its hydrophobic transmembrane helices into the lipid bilayer.

185 iated through a collective motion of channel helices, involving hydrophobic contacts between an isole

186 ition of pyrimidine motif RNA*DNA-DNA triple helices is not well understood beyond the canonical U*A-

187 otein with subunits packed into well-defined helices, is a key component of the iron regulatory syste

188 d-induced oblique orientation of cholesteric helices, is comprised of a chiral dopant, a conventional

189 only a narrow channel between transmembrane helices IV and V that connects it to the lipid bilayer.

190 s harboring the transport core and TM11-TM12 helices lining the dimer interface.

191 abilized by one or both of the transmembrane helices linked by the loop.

192 417, and beta3Thr-418) and M3 (beta3Arg-309) helices located at the base of a pocket in the beta(+)-a

193 rface formed between the VSDs and the alphaB helices located at the top of the CTDs.

194 situated above and a gate with four parallel helices located below; however, the K(2P) channels studi

195 ructures like those (strands, sheets, turns, helices, loops, or distorted variations) found at protei

196 ete group of residues at the GluN2B membrane helices M1 and M4 and the GluN1 helix M3, and that PES p

197 es from differences within the transmembrane helices (M1 and M2) of both channel families, we turned

198 l PLB-binding site (comprising transmembrane helices M2, M4, and M9) is the preferred site.

199 tive base triples and that longer RNA triple helices may exist in nature.

200 proximity and mobility of segments of the MA-helices most distal to the membrane bilayer.

201 ed p110beta peptides that overlap with these helices; no interactions were detected between Rab5 and

202 We identified two residues in consecutive helices occurring in the mRNA entry pore, whose mutation

203 octanoyl-CoA establishes with the four alpha-helices of ACBP and showed that the unfolding pathway is

204 In the presence of PES, the M1 and M4 helices of agonist-activated receptor rearrange, forming

205 ICU1-MICU2 oligomeric complex the C-terminal helices of both proteins form a central semiautonomous a

206 binding pocket formed by seven transmembrane helices of CCR5, and the N terminus of CCR5 contacts the

207 creases with pressure but they assemble into helices of conserved wavelength in response linked to gr

208 1 intermediates during the unfolding of five helices of EF-cleaved bR.

209 the interactions that establish the relaxed helices of IHMs: one in invertebrates, by either regulat

210 ing the crossing angle between transmembrane helices of integrin alphaIIbbeta3, which eventually resu

211 tations in a turn that connects the two main helices of Rev have different effects in different conte

212 sing nearly planar arrays of sequential half-helices of similar size and alternating handedness, acco

213 Rab33B molecules bind to the diverging alpha-helices of the dimeric Atg16L1 coiled-coil domain.

214 ue-long truncations of the N- and C-terminal helices of the gamma subunit, respectively, to identify

215 lalanine residues in the transmembrane alpha-helices of the GPCR CXCR4.

216 formed by the C-terminal anti-parallel alpha-helices of the histone fold extension (HFE) of the Cenp-

217 1.8 angstrom resolution, revealing that the helices of the WT globin dimer are under tension and sug

218 The chirality of these helices offers a basis for asymmetric catalysis.

219 l amino acid residues allow close-packing of helices on the matrix side.

220 truct, revealing the role of the amphipathic helices on this transition and shedding light on the pro

221 state for complex formation, except for two helices, one from each domain, that display a native-lik

222 esized, correctly oriented, membrane protein helices, or even small bundles of helices, to emerge fro

223 a novel fold comprised of ten transmembrane helices organized into two subdomains and bisected by a

224 eight distinct subunits and 26 transmembrane helices per monomer, catalyzes proton-coupled electron t

225 The linkage between the helices plays an essential role in determining the struc

226 pathway near the intracellular end of the S6 helices, pointing to a conserved cytoplasmic gate and su

227 red for antigen fusion, featuring N-terminal helices positioned to match the C termini of the viral g

228 TAM comprises amphipathic alpha-helices predicted to form a protein-binding pocket and o

229 f AimR that approximates the DNA-recognition helices, preventing AimR binding to the aimX promoter re

230 tein targets with 7, 11 and 16 transmembrane helices provided measures of success.

231 ggers disassembly of fully assembled dynamin helices, releasing free dynamin dimers/tetramers and fac

232 n with the phosphate backbone of neighboring helices, resulting in an azimuthal angular shift between

233 structures with elementary shapes including helices, S-turns and U-turns, which are synthesized in 5

234 Comparisons between ligated and nicked helices show that the latter exhibit nearly a two-fold d

235 y different from those in RNA*DNA-DNA triple helices, showing that base triplet stability depends on

236 at Panx1 protomers harbor four transmembrane helices similar in arrangement to other large-pore formi

237 nal (3D) structure is composed of four alpha-helices stabilized by four disulfide bonds, and a long C

238 ween peptide alpha-helices and oligourea 2.5-helices suggest that a tertiary structure could be retai

239 s with sequence-randomized and truncated-CEH helices suggest that this binding interaction with TERT

240 pendages provide hyperstable collagen triple helices ( T(m) = 70 degrees C).

241 Moreover, the alpha-helices tend to hybridize and to promote protein associa

242 nanodiscs reveal large-amplitude movement of helices that alter the orientation of a putative substra

243 region contains two predicted transmembrane helices that appear to reoccur in a wide range of plant

244 ores formed by two concentric rings of alpha-helices that are stable and monodisperse in both their w

245 eric binding sites outside the transmembrane helices that can only be reached via lipid pathways.

246 alpha helices that carry information through long distances, t

247 INA1 contains a cluster of amphipathic alpha-helices that enable apolipoproteins to bind phospholipid

248 RTF1 also forms four alpha-helices that extend from the Plus3 domain along the Pol

249 phobic residues of the M and E transmembrane helices that form a binding pocket not previously charac

250 Two of the four helices that form the coiled-coil tetramerization domain

251 rm a switch in the central region of the two helices that governs whether a given substrate is pumped

252 t forms a pseudo-hexagonal network of triple helices that have a pitch variation consistent with the

253 ly to moderately conserved sites on distinct helices that line a central negatively charged cavity, i

254 cific roles to particular residues and alpha helices that mediate individual steps of the BAX activat

255 architecture and reveal a cleft between two helices that provides accommodation in the membrane for

256 ses, including the preferential formation of helices that solvate charged labels through interactions

257 e reveals that the CT folds into amphipathic helices that wrap around the C-terminal end of the TMD,

258 istic combinations of beta-strands and alpha-helices, the actual properties and functions of these se

259 s Rhs that contains N-terminal transmembrane helices, the PAAR domain, and an intact beta-cage.

260 ough interactions between both transmembrane helices, the turret, selectivity filter loop, and the po

261 units but were caused by the presence of the helices themselves.

262 s faced each other through the F and G alpha-helices, thus blocking the substrate access channel.

263 ess conformational defects in supramolecular helices, thus leading to the emergence of homochirality

264 e DcuS of Escherichia coli is anchored by TM helices TM1 and TM2 in the membrane.

265 embrane domain (TMD), which is formed of two helices (TM1 and TM2), and an extracellular domain (ECD)

266 Homologous transmembrane helices (TMHs) 6 and 12 of human P-gp connect the transm

267 volves rigid body movements of transmembrane helices (TMs) 2-6 and 8-12 to form an inverted V, facili

268 C1), a lysosomal protein of 13 transmembrane helices (TMs) and three lumenal domains, exports low-den

269 unreported fold involving five transmembrane-helices (TMs) that creates a membrane cavity presenting

270 ding LeuT-have shown how their transmembrane helices (TMs) undergo conformational changes during the

271 Each monomer contains nine transmembrane helices (TMs), six of which (TM4-TM9) form a cavity that

272 es various mechanisms employed by CMP triple helices to alleviate the elastic strain associated with

273 ehavior of individual beta-strands and alpha-helices to be targeted selectively by stopped-flow kinet

274 se from the footprint shifting away from the helices to engage more variable residues.

275 structure predictions for the transmembrane helices to the amino acid sequence we identified a linke

276 ne protein helices, or even small bundles of helices, to emerge from the HTL.

277 nput domain of PA1396 has five transmembrane helices, two of which are required for DSF sensing.

278 otein, each forming three well-defined alpha-helices upon binding.

279 k that cross-links the extracellular ends of helices V and VI.

280 iplets in DNA*DNA-DNA and RNA*RNA-RNA triple helices was distinctly different from those in RNA*DNA-D

281 ver the curvature, torsion and the number of helices, we have constructed 16 different linear and cir

282 The first halonium-ion-based helices were designed and synthesized using oligo-aryl/p

283 Constraints for orientation of individual helices were obtained in a previous study from continuou

284 d was quite capable of forming several alpha-helices which was correlated with CD spectroscopic analy

285 SH4UD adopts transient helices, which are found away from known phosphorylation

286 the periodic trend expected for coiled coil helices, which disagree with the presence of a coiled co

287 stereoselective attachment to protein alpha-helices, which permits accurate measurements of orientat

288 brane protein containing seven transmembrane helices with an extracytoplasmically located N terminus

289 s the micelle by a dynamic assembly of three helices with many residues of hATMfatc located in the he

290 plementary 'meta-base pairs' can form double helices with programmed handedness and helical pitches.

291 kwise rotational motion of interlinked alpha-helices with specific tilted helical extension.

292 st gating charge, the S4 breaks into two sub-helices with the lower sub-helix becoming parallel to th

293 y of proteins containing seven transmembrane helices, with the N- and C-terminus of the protein locat

294 to the repositioning of tethered pore-lining helices within a surrounding protein shell that dramatic

295 By permuting the topology of the four helices within FRB, we have created cpFRB-FKBP pairs tha

296 change of all Orai transmembrane domain (TM) helices within the channel complex.

297 rom inactivation involve movements of the S4 helices within the DIII and DIV voltage sensors in respo

298 the distance between the two DNA-recognizing helices within the EmhR dimer, leading to diminished Emh

299 erminal extensions projecting from these two helices, wrap around the L protein in a manner similar t

300 t gate with its four predicted transmembrane helices wrapped around FliPQR/SctRST.