ライフサイエンスコーパス: helix

1 ted in the DNA major groove (the recognition helix).

2 spatial organization at the DNA recognition helix.

3 cur to allow formation of the U2-branch-site helix.

4 lly sequestering the canonical eIF4E-binding helix.

5 nterface straddle a conserved peripheral NBD helix.

6 ) cohort who underwent Exome + sequencing at Helix.

7 the corresponding value of the intact double-helix.

8 eroid sensitivity determinant in the alphaM1 helix.

9 ng C-terminal end of the pHLIP transmembrane helix.

10 in vitro enzymatic degradation of the triple helix.

11 r-leaflet, as a consequence of a rotated TM2 helix.

12 lter the exact positioning of the activation helix.

13 urret, selectivity filter loop, and the pore helix.

14 o subdomains and bisected by a long diagonal helix.

15 effect, at least in part, through the alphaB helix.

16 tion through the acquisition of the I2 alpha-helix.

17 ns through a single transmembrane (TM) alpha-helix.

18 rt trigger heme release by contacting Hb's F-helix.

19 2-16 actin filaments on the outer rim of the helix.

20 y rearrangement of the CcP heme-coordinating helix.

21 horizontally" grab the protruding MHC alpha2-helix.

22 We observe two dynamical modes for the helix.

23 s in the linker between cap helix 2 and pore helix 1, markedly reduced the inhibitory effect of IBMX.

24 vation loop (a-loop) and an IN kinase domain helix 11 (kalpha11).

25 ing mass spectrometry confirm the repressive helix 12 conformation.

26 Helix 12 is displaced from the solvent-exposed active co

27 use a conserved activation function-2 (AF-2) helix 12 mechanism for agonist-induced coactivator inter

28 ition 92, which is in the linker between cap helix 2 and pore helix 1, markedly reduced the inhibitor

29 Local unfolding of either betaB-betaD or helix 2 can generate an opening large enough for ligands

30 cavity, but only the fast local unfolding of helix 2 is relevant to the ligand entry process.

31 gulatory region, comprising loop-3 and alpha-helix-2, contributes to this interaction.

32 cluster surrounded Arg(101) on a surface of helix 3.

33 itch variation consistent with the model 7/2 helix (3.5 residues per turn).

34 We show that deletion of the conserved alpha-helix 30 interferes with the integrity of the cell wall,

35 Additionally, deletion of alpha-helix 30 results in hyperacetylated PG, suggesting this

36 est homologs of ILR3 (i.e., basic-helix-loop-helix 34 [bHLH34], bHLH104, and bHLH115).

37 cle, conformational changes in transmembrane helix 6 (TM6) alter the glutathione-binding site and the

38 ment (ca. 6 to 14 angstrom) of transmembrane helix 6 (TM6) to a conformation which binds and activate

39 mains into close contact along transmembrane helix 6 and ultimately inducing conformational rearrange

40 to two intracellular loops and transmembrane helix 6 of the kappaOR.

41 two consecutive Gly substitutions break the helix ~65% of the time.

42 oximately 10 angstrom shift of transmembrane helix 7 that exposes a large membrane-accessible cavity.

43 cluding an aberrantly flexible ribosomal RNA helix 74, resulting in at least three different blocks i

44 together in the maturation of ribosomal RNA helix 74, which is required to ensure proper constructio

45 to the membrane-embedded complex, including helix 8 burial in the inner leaflet, ordered lysine and

46 GPCR cargoes, must release their amphipathic helix 8 from the membrane to be recognized by the BBSome

47 ttle movement in the receptor core; however, helix 8 showed considerable flexibility.

48 a 'latch' that reaches the end of the bridge helix, a flexible element of the Pol II active site.

49 re biomimetic analogs of the collagen triple helix, a fold that is a hallmark of collagen-like sequen

50 two consecutive reactions and the DNA double helix adopts drastically different structures.

51 hat KCNE3 tucks its single-membrane-spanning helix against KCNQ1, at a location that appears to lock

52 acting network involving Gln59 in the alpha1-helix, Ala352 in the beta6-alpha5 loop, and Thr355 in th

53 g studies suggested that the transient alpha-helix aligns multiple polar residues to interact with po

54 nteraction between the auto-inhibitory brace helix alpha6 and the four-helix bundle by stacking to Ph

55 However, the C-terminal helix alphaN, implicated in assembly of synaptic complex

56 A binding mechanisms of the N-terminal alpha-helix and AP2/ERF domain.

57 ic information on dynamics for both an alpha-helix and beta-sheet site of GB1, the immunoglobulin bin

58 ein structure and the presence of both alpha-helix and beta-sheet was observed, with higher beta-shee

59 ause of the presence of the N-terminal 3(10)-helix and beta-turn type III.

60 oportion of beta sheets, random coils, alpha-helix and beta-turns for all fractions of RB of both cul

61 onformationally disordered state to an alpha-helix and develops contacts with the C-terminal domain o

62 ase hOGG1 locates the lesions inside the DNA helix and facilitates their extrusion for repair.

63 BSA lost the alpha-helix and gain beta-sheets in the secondary structure du

64 its target site by unwinding the DNA double helix and hybridizing a 20-nucleotide section of its ass

65 In contrast, the IFITM3 amphipathic helix and its amphipathic properties were required for v

66 d highly dynamic with one four-residue alpha-helix and one three-residue antiparallel beta-sheet stab

67 he transiently forming interface, both the F-helix and receptor bridge are in motion, dynamically sam

68 CdiB pore is occluded by an N-terminal alpha-helix and the conserved extracellular loop 6; these two

69 regions through the SMARCB1 C-terminal alpha-helix and the SMARCA4/2 C-terminal SnAc/post-SnAc region

70 and normal bases when extruded from the DNA helix and their associated free energy profiles.

71 ng from different interactions with the pore helix and water behind the SF.

72 oprotein with an ectodomain, a transmembrane helix, and a short carboxyl-terminal tail, or as a solub

73 ses an extracellular region, a transmembrane helix, and two tandem intracellular catalytic domains re

74 n that oligomerizes as a right-handed double helix around microtubules, which are left-handed.

75 tify the positively charged alpha1-extension helix as essential for RNF168-mediated ubiquitination of

76 proposed tentative paths of cotranslational helix assembly of several polytopic proteins were consis

77 ization, K552T and R553L mutations at distal helix B decrease calmodulin-binding and axonal enrichmen

78 he rigid-body coupling, with LptF's coupling helix being important in coordinating cavity collapse wi

79 ) cofactors and DNA-binding basic helix-loop-helix (bHLH) and GATA transcription factors.

80 transcription factor of the basic helix-loop-helix (bHLH) family.

81 ANSCRIPTION FACTOR (FIT), a basic helix-loop-helix (bHLH) transcription factor (TF), regulates root F

82 Here, we showed that the basic Helix-Loop-Helix (bHLH) transcription factor Cucumis sativus Irregu

83 RACTING FACTORs, a group of basic helix-loop-helix (bHLH) transcription factors.

84 e mutation, Mlkl(D139V), that alters the two-helix 'brace' that connects the killer four-helix bundle

85 t fraction of helix disruption, in which the helix breakage increases from 26% at pH 7.5 to 53% at pH

86 ches (e.g., repair and stabilize and glycine-helix breaking) yields well-behaved clade C-Env trimers

87 ding proteins, that bind the N-terminal four-helix bundle (4HB) "killer" domain and neighboring first

88 led a novel fold primarily consisting of a 3-helix bundle and a beta-sandwich.

89 -helix 'brace' that connects the killer four-helix bundle and regulatory pseudokinase domains.

90 cate that the M8R mutation disrupts the four-helix bundle at the head-to-tail junction, leading to we

91 o-inhibitory brace helix alpha6 and the four-helix bundle by stacking to Phe148.

92 xocytosis, SNARE assembly into a stable four-helix bundle drives membrane fusion.

93 onfirms that in solution leptin forms a four-helix bundle including a pierced lasso topology.

94 cally simple and highly conserved four-alpha-helix bundle protein that acts as an intracellular trans

95 interaction with BVM does not alter the six-helix bundle structure appreciably.

96 mpartment (ERGIC) membrane, ETM forms a five-helix bundle surrounding a narrow pore.

97 elical structure to form an intermolecular 4-helix bundle with the E6AP AZUL, which is unique to this

98 try axis, and forming a basket-like pentamer helix bundle.

99 n residing on synaptic vesicles (SVs), forms helix bundles with syntaxin-1 and SNAP25 for the SNARE a

100 segment 2 of ArkA (C-terminal) adopts a 310 helix, but is far less structured than segment 1.

101 site, including the translation of an alpha-helix by 1 angstrom.

102 xtending studies on the role of the H2 alpha-helix C terminus of PrP, we found that deletion of the h

103 ir at the groove (C55) and C-terminal alpha9 helix (C175) of BFL-1 operates as a redox switch to cont

104 At its full capacity, each dynamin helix captures 12-16 actin filaments on the outer rim of

105 undary helix, pseudoknot, and core-enclosing helix (CEH).

106 e mitochondrial paralogs coiled-helix-coiled-helix (CHCHD) domain 2 (C2) and CHCHD10 (C10) were recen

107 tations in the mitochondrial paralogs coiled-helix-coiled-helix (CHCHD) domain 2 (C2) and CHCHD10 (C1

108 l monomers bound each other in a short-pitch helix complex in addition to other configurations, with

109 eviously-unseen compact fold, the helix-turn-helix conformation of pUL51 resembles the cellular endos

110 and simulations indicate that the helix-turn-helix conformation of the MPER-TMD is responsible for se

111 be collagen losing its original triple alpha-helix conformation, further confirming the diagenetic de

112 and ions, as well as discrete alterations in helix conformations.

113 crystallinity along with the loss of double helix content was supported by size exclusion chromatogr

114 e of the UCS domain (by decreasing the alpha-helix content), leading to a significant change in its s

115 profiling, here we show that the Orc4 alpha-helix contributes to the DNA sequence-specificity of ori

116 strongly with the polymer-stabilizing alphaF-helix could potentially weaken the polymer.

117 In addition to outward movement of the B'-helix, DEER-constrained Rosetta structural models sugges

118 ices, and the presence of substrate triggers helix disassembly.

119 rmational change in which residues of the B'-helix displayed outward movement with respect to the sym

120 D27H/E28H causes a pH-dependent fraction of helix disruption, in which the helix breakage increases

121 The module is bifurcated by the alpha2 helix dividing two distinct regulatory sites: Na(+) and

122 positively charged cleft and a helix-hairpin-helix DNA-binding motif found in other DNA repair enzyme

123 s in Uaf30 that include an N-terminal winged helix domain and a disordered tethering domain as well a

124 Furthermore, the winged-helix domain of LEM2 activates the ESCRT-II/ESCRT-III hy

125 rved aromatic residue in the extended winged-helix domain of TFEalpha interacts with promoter DNA to

126 Here, we truncated the C-terminal winged-helix-domain (WHD) of Mcm6 to slow down the loading reac

127 n the ORC ring and cooperate with the winged-helix domains to stabilize DNA bending.

128 central pore and radially arrayed helix-turn-helix domains.

129 Substitution to helix-enhancing alanine at either of these positions dra

130 lternate structure with an elongated central helix, exposed splice donor residues, and an accessible

131 Recently, we revealed that basic helix-loop-helix factors, HECATEs (HECs), function as positive regu

132 ed Galalpha1-3Gal revealed the parallel beta-helix fold of the enzyme and the structural basis of its

133 yP regions within the PRD stay in a polyP II helix for most of the simulation, whereas occasional kin

134 ed after SARRAH silencing via RNA-DNA triple helix formation and cardiomyocytes lacking the triple he

135 mation and cardiomyocytes lacking the triple helix forming domain of Sarrah show an increase in apopt

136 a highly evolutionary conserved amphipathic helix-forming (AH) motif encoded by exon 5.

137 Proline mutations in the alphaB helix greatly decreased voltage activation while having

138 elucidated, although a predicted helix-loop-helix (H-L-H) was suggested to form pores by virtue of i

139 logy to class A GPCRs, but the transmembrane helix H4 is shifted by more than 20 angstrom and the G-p

140 YaaA has a positively charged cleft and a helix-hairpin-helix DNA-binding motif found in other DNA

141 hin the aromatic oligomers, depending on the helix handedness and on the extent of electronic polariz

142 lication origins, mediated by the Orc4 alpha-helix, has co-evolved with the gain of ORC-Sir4-mediated

143 otein TraK, a predicted member of the Ribbon-Helix-Helix (RHH) family of DNA-binding proteins, to tra

144 g behavior stemming from an additional GXXXG helix-helix interaction motif created in the mutant hair

145 e potent inhibitors of helical extension and helix-helix interaction, which are removed in part by va

146 ), N(55)) sideways along TMD2, available for helix-helix interactions.

147 site tunnel, and an insert within the alpha3 helix helps to stabilize this energetically unfavorable

148 e this possibility using two randomly chosen helix-heterotetramers, showing that their mechanical pro

149 amphipathic structures: A classic horizontal helix (horine) and a novel vertical spiral structure (ve

150 redicted to contain an N-terminal helix-turn-helix (HTH) domain.

151 ation loop from cracking and keep the alphaC helix in an active-like conformation, whereas phosphoryl

152 ds to DNA and unwinds ~2 turns of the double helix in an ATP-independent fashion.

153 ed intrastrand disruption of collagen triple helix in pigmented AKU human cartilage, and in cartilage

154 ssible helix transition from alpha- to 3(10)-helix in S4 during the activation process is still unres

155 MR structural determination indicated a bent helix in solution and bound to MDM2.

156 Small molecule-based modulation of a triple helix in the long non-coding RNA metastasis-associated l

157 rresponding to a predicted amphipathic alpha-helix in the prodomain N terminus adopt helical structur

158 ed contacts provided by residues in an alpha-helix inserted in the DNA major groove (the recognition

159 The alpha-clamp-helix interactions exhibit structural plasticity when co

160 ch I of EF-Tu rapidly converts from an alpha-helix into a beta-hairpin and moves to interact with the

161 ribosomes by inserting its C-terminal alpha-helix into the vacant mRNA tunnel.

162 c module fibrillarin for the substrate-guide helix is dependent on the RNA sequence outside the methy

163 Interestingly, the alphaC helix is destabilized when the activation loop is fully

164 The double helix portion of the RNA triple helix is more similar to both the helical and base step

165 is structure demonstrates that an RNA triple helix is not limited in length to six consecutive base t

166 Here, we show that 4 bp of core-enclosing helix is required for telomerase to be active in vitro a

167 1C, and His52) rigidly arranged on one alpha-helix is responsible for chelating the first Cu(II) and

168 e alternative rotamer within the recognition helix itself as an important determinant of DNA specific

169 We showed that there is an optimal helix-like motif sequence (RLLRLLR) and polyarginine tai

170 Through near-exhaustive sampling of loop-helix-loop elements, LUCS generates highly diverse geome

171 tiviral substructure through which its 18-nt helix-loop intimately contacts multiple EZH2 sites surro

172 present a computational design method, loop-helix-loop unit combinatorial sampling (LUCS), that mimi

173 otein (SSBP) cofactors and DNA-binding basic helix-loop-helix (bHLH) and GATA transcription factors.

174 MXD family transcription factor of the basic helix-loop-helix (bHLH) family.

175 -INDUCED TRANSCRIPTION FACTOR (FIT), a basic helix-loop-helix (bHLH) transcription factor (TF), regul

176 Here, we showed that the basic Helix-Loop-Helix (bHLH) transcription factor Cucumis sat

177 CHROME INTERACTING FACTORs, a group of basic helix-loop-helix (bHLH) transcription factors.

178 e yet to be elucidated, although a predicted helix-loop-helix (H-L-H) was suggested to form pores by

179 three closest homologs of ILR3 (i.e., basic-helix-loop-helix 34 [bHLH34], bHLH104, and bHLH115).

180 Recently, we revealed that basic helix-loop-helix factors, HECATEs (HECs), function as po

181 In both cases, the dimer is stabilized by a helix-loop-helix motif at the C terminus and interaction

182 increasing altitude is controlled by a basic/helix-loop-helix transcription factor (bHLH TF), MdbHLH3

183 PP2A substrates is MYC proto-oncogene basic helix-loop-helix transcription factor (MYC), whose overe

184 cribed to nuclear translocation of the basic helix-loop-helix transcription factor Transcription Fact

185 The basic helix-loop-helix transcription factors collectively call

186 ERACTING FACTORS (PIFs) are a group of basic helix-loop-helix transcription factors that can physical

187 ffects the protein dynamics of Her6, a basic helix-loop-helix transcriptional repressor.

188 zebrafish ortholog of human HES4, is a basic helix-loop-helix-orange transcriptional repressor that r

189 iption factors including a central MYB-basic helix-loop-helix-WD40 complex containing WEREWOLF (WER),

190 ites on M3 and with the outside of the SERCA helix M9.

191 disrupt a rigid IS6-alpha-interaction domain helix markedly reduced basal open probability despite in

192 e transduction pathways involving the alphaB helix may be involved.

193 larger, aromatic side chains in the ENaC M2 helix may contribute to the constitutive activity of the

194 We speculate that the nascent H2 helix may provide conformational flexibility to initiate

195 The DsbD functional homolog CcdA is a six-TM-helix membrane protein that provides reducing equivalent

196 m self-assembled nanocarriers known as three-helix micelles (3HM).

197 ses, the dimer is stabilized by a helix-loop-helix motif at the C terminus and interactions between t

198 s to functionally map the determinants of S4 helix motion during voltage-dependent transition from th

199 IFITM3 restriction and converted amphipathic helix mutants into infection enhancers.

200 y of origins in S. cerevisiae and Orc4 alpha-helix mutations change genome-wide origin firing pattern

201 Different constructs of two-helix nanobeams with specified densities of nicks and Ho

202 to the N130 GlcNAc and the N-terminal alpha-helix near the peptide-binding site while increasing fle

203 ed a mutation in, or adjacent to, the alpha2 helix of 2C.

204 ere that the strongly amphipathic N-terminal helix of CPn0678 mediates binding to phospholipids in bo

205 GRK5 via ordering of the amphipathic alphaN-helix of GRK5 and allosteric disruption of kinase-RH dom

206 "killer" domain and neighboring first brace helix of human MLKL with nanomolar affinity.

207 is a domain swap of the conserved C-terminal helix of Ku80.

208 ace groove to capture the critical BH3 alpha-helix of pro-apoptotic members.

209 In the actin-bound structure, the first helix of the bundle dissociates and the remaining four h

210 n the PHDs are conserved, but the C-terminal helix of the PHDs is strikingly absent.

211 pomyosin under the influence of a 64-residue helix of TnT located at the overlap of adjacent tropomyo

212 d that binding and release of the C-terminal helix of transducin is coupled to hydration changes as m

213 n complexes reveal a disruption in the alpha-helix of transmembrane segment 6 (TM6) not observed in f

214 CaM binds to the rib helix of TRPC4, which results in the ordering of a previ

215 rtholog of human HES4, is a basic helix-loop-helix-orange transcriptional repressor that regulates ne

216 TANGO1 has an unusual membrane helix organisation, composed of one membrane-spanning he

217 global fold can be described at the level of helix orientations and relatively flexible loop conforma

218 space, in particular, on the distribution of helix orientations, for pseudoknots and loop-loop kissin

219 r the catalytic lysine (K745) in the "alphaC-helix out" inactive state.

220 As revealed that the second internal loop of helix P3 in the transcriptional RNA usually contains an

221 nce motifs that are known to be important in helix packing.

222 sect cells, the transmembrane form of the 12-helix pore enables the passage of ions across the membra

223 The double helix portion of the RNA triple helix is more similar to

224 Rev1 evicts the templating base from the DNA helix prior to binding the incoming nucleotide.

225 The eight-TM-helix protein DsbD reduces DsbC and is itself reduced by

226 LOTUS domains are helix-turn-helix protein folds identified in essential germline pro

227 GFP and ONE HELIX PROTEIN1 transcript levels were downregulated by u

228 light-inducible protein homologs, called ONE-HELIX PROTEINS (OHPs), is lacking.

229 , containing the template, template-boundary helix, pseudoknot, and core-enclosing helix (CEH).

230 ght-handed with a 1.3 mum pitch and 0.14 mum helix radius, which is consistent with the feature of a

231 A helix-refinement algorithm made further improvements to

232 press high levels of Cthrc1 (collagen triple helix repeat containing 1), and localize into the scar.

233 zed by expression of Cthrc1 (collagen triple helix repeat containing 1), emerges in fibrotic lungs an

234 M1 helix residue W559 interacts with the M4 helix residue M824.

235 s that, in the absence of PES, the GluN2B M1 helix residue W559 interacts with the M4 helix residue M

236 ming a tighter interaction with the GluN1 M3 helix residues G638 and I642.

237 The C-terminal 'fastener' helix retains PAF and is followed by a 'latch' that reac

238 This variant causes substitution F302L, in helix S4 of the K(V) 1.2 voltage-sensing domain (VSD).

239 sy, causing amino acid substitution F302L at helix S4, in the K(V) 1.2 voltage-sensing domain.

240 transition in the pore-lining transmembrane helix S6.

241 MA) polymer-OP conjugate (PDOP) adopts alpha-helix secondary structure and induces robust immunogenic

242 beta(1-40) was less prone to adopt the alpha-helix secondary structure.

243 jacent pyrrolidine units mimics natural PPII helix secondary structure.

244 nal assay observing the conformation of this helix showed that the F148A mutant is unresponsive to th

245 ammer, which locally alters the twist of the helix, significantly increases copper-catalyzed nitrite

246 olypeptides that bound phospho-ligands via N-helix sites.

247 predominantly determined by the motif type, helix size, and loop size, indicating a strong topologic

248 boswitch is largely unfolded, lacking the PK helix so that translation can be initiated at the riboso

249 Due to helical unwinding, the RNA triple helix spans an average of 12 base triples per turn.

250 rithm made further improvements to the alpha-helix SSEs of the backbone trace.

251 small-molecule corrector Lumacaftor exerts a helix stabilization effect not only on the E217G mutant

252 The alpha-helix structure was observed for amyloid-beta(1-42) frag

253 ed ferritin at the interface between the two-helix subunits and proximal to the ferroxidase center.

254 cracked" activation loop and with the alphaC helix swung away from the active site.

255 ad is a pH sensor in the center of the M2 TM helix that activates the channel in response to the low

256 Intriguingly, mutations in the activation helix that are frequently found in cancers do not dimini

257 protein sequence features in the recognition helix that could be used to predict the specificity of o

258 ansition upon nucleosome binding: it forms a helix that enhances its DNA binding ability.

259 We identify a Get2/CAML cytoplasmic helix that forms a "gating" interaction with Get3/TRC40

260 The critical Set1 RxxxRR motif adopts a helix that mediates bridging contacts between the nucleo

261 beta6-alpha5 loop, and Thr355 in the alpha5-helix, these conformational changes might lead to the de

262 anisation, composed of one membrane-spanning helix (TM) and another that penetrates the inner leaflet

263 aptotagmin-1 contains a single transmembrane helix (TM) and two tandem C2 domains (C2A and C2B).

264 to co-translationally insert a transmembrane helix (TMH) of many multi-pass integral membrane protein

265 econdary structure transformation from alpha-helix to beta-sheets.

266 ate, as if transitioning from one end of the helix to the other.

267 on of the fingers subdomain-especially the O helix-to engage the primer-template and dNTP triphosphat

268 conducted an in-depth analysis of the alpha-helix-to-beta-strand and beta-strand-to-alpha-helix tran

269 altitude is controlled by a basic/helix-loop-helix transcription factor (bHLH TF), MdbHLH3.

270 rates is MYC proto-oncogene basic helix-loop-helix transcription factor (MYC), whose overexpression i

271 ox C1 (FOXC1) gene encodes a forkhead/winged helix transcription factor involved in embryonic develop

272 uclear translocation of the basic helix-loop-helix transcription factor Transcription Factor E3 (TFE3

273 The basic helix-loop-helix transcription factors collectively called E protei

274 CTORS (PIFs) are a group of basic helix-loop-helix transcription factors that can physically interact

275 protein dynamics of Her6, a basic helix-loop-helix transcriptional repressor.

276 obic plug upon voltage changes, the possible helix transition from alpha- to 3(10)-helix in S4 during

277 An analogous coil-to-helix transition in the bridging helix, which connects t

278 elix-to-beta-strand and beta-strand-to-alpha-helix transitions and domain motions displayed by the es

279 cryo-electron microscopy structure of the 16-helix transmembrane pore closely matches the design mode

280 el (ICab) immunized against a bacterial 14TM helix transporter, NorC, from Staphylococcus aureus We i

281 (IMCT) of both muscles, a decrease in alpha- helix, turn and unordered structures was complemented wi

282 n that is predicted to contain an N-terminal helix-turn-helix (HTH) domain.

283 adopts a previously-unseen compact fold, the helix-turn-helix conformation of pUL51 resembles the cel

284 ental data and simulations indicate that the helix-turn-helix conformation of the MPER-TMD is respons

285 ith a wide central pore and radially arrayed helix-turn-helix domains.

286 LOTUS domains are helix-turn-helix protein folds identified in essential g

287 five-beta palm-like fold that wrapped over a helix, typical of an FK506-binding domain.

288 teins, the H-segment of the leader peptidase helix used in the von Heijne and White biological scale

289 ces E and F and pulled from the top of the E helix using a site-specific, covalent attachment.

290 hese findings indicate that an intact alphaB helix/VSD interface is required for effective coupling o

291 ors including a central MYB-basic helix-loop-helix-WD40 complex containing WEREWOLF (WER), GLABRA3 (G

292 ous coil-to-helix transition in the bridging helix, which connects the ankyrin repeat motifs to the c

293 econdary structure change of the pore-lining helix, which contains a pai-helical segment in the close

294 -induced thermal stabilization of the triple helix, which correlated with decreased in vitro degradat

295 t bridge with a glutamate (Glu130) of alphaC helix, which is conserved across all kinases.

296 ues in proximity to the H2A alpha1-extension helix, which plays an important role in the DDR pathway.

297 tic information is encoded in the DNA double helix, which, in its physiological milieu, is characteri

298 ion connecting the head to the transmembrane helix while still not disrupting the ACE2 homodimer or A

299 s pre-structured and adopts a polyproline II helix, while segment 2 of ArkA (C-terminal) adopts a 310

300 different surface contacts to bind the LIC1 helix with affinities ranging from 1.5 to 15.0 muM.