ライフサイエンスコーパス: hem

1 from helicopter emergency medical services (HEMS).

2 igration of CR cells arising in the cortical hem.

3 even prior to the formation of the cortical hem.

4 r rhombic lip and the telencephalic cortical hem.

5 Cux2 expression specifically in the cortical hem.

6 eocortical CR cells arises from the cortical hem.

7 cells, we therefore genetically ablated the hem.

8 ium hydroxide concentration and milled using HEM.

9 Cux2 enhancer activity outside the cortical hem.

10 d these fibers may remain within the blanket hem.

11 x in mice genetically engineered to lack the hem.

12 muV; and a hemin degradation/storage enzyme, HemS.

13 teria had a survival benefit associated with HEMS.

14 s an ultra-stable organic cation for polymer HEMs.

15 IV) state without direct contact between the hemes.

16 e redox and chemical properties of the SoxAX hemes.

17 dioxygenation (NOD) reaction similar to oxy-hemes.

18 hodovulum sulfidophilum SoxAX contains three hemes.

19 ation state of the proximal histidine to the hemes.

20 extends to the electronic properties of the hemes.

21 uction potentials for the high- and low-spin hemes.

22 Q, while being totally inactive, retains the hemes.

23 heme degradation and do not bind additional hemes.

24 n of MauG, the electron equilibrates between hemes.

25 ains one high-spin and three low-spin c-type hemes.

26 spectral contamination from changes in the b hemes.

27 s, arginines, and associated water above the hemes.

28 tions of a diheme system with two equivalent hemes.

29 re a natural consequence of thiolate-ligated hemes.

30 the heme nitrogens than for high-spin ferric hemes.

31 on of hydrogen-bonded water chains above the hemes.

32 ndicated by interactions typical of adjacent hemes.

33 c interaction of the active site with nearby hemes.

34 N-based nucleophiles on synthetic ferric-NO hemes.

35 nd intermonomer Coulombic effects between bL hemes.

36 hose of closely related compounds containing hemes.

37 ling oxidation states of the His/His ligated hemes.

38 His/Cys (heme 2), and two His/His ligations (hemes 3 and 4).

39 The closeness of hemes 3 and 8 from different enzyme subunits allows redi

40 In particular, the cortical hem, a region of high bone morphogenetic proteins (BMPs)

41 The cortical hem, a source of Wingless-related (WNT) and bone morphog

42 that neocortical layers would be inverted in hem-ablated animals, as in reeler mice, deficient in ree

43 anizer, yet the FGF8 source was unchanged in hem-ablated brains.

44 neocortex, was reduced in size in late-stage hem-ablated embryos, whereas cortex ventrolateral to the

45 n control mice, but were virtually absent in hem-ablated mice from embryonic day (E) 10.5 until birth

46 Unexpectedly, hem ablation also perturbed regional patterning along th

47 10-heme cytochrome, MtrC, which presents its hemes across a large surface area for electrical contact

48 Estimating the health effects of mitigation (HEM) actions can help policy makers prioritize investmen

49 In subjects triaged to HEMS, actual transport by HEMS was associated with an in

50 ows separate monitoring of the alpha or beta hemes along the allosteric pathway.

51 r path, with respect to the distance between hemes, along the polypeptide chain is exactly the same i

52 e course at 3 mus for beta but not for alpha hemes, an interval previously shown to be the first step

53 ed Wnt3a and Lef1 expression in the cortical hem and adjacent hippocampal promordium and consequent i

54 rain signalling centres-the septum, cortical hem and the pallial-subpallial boundary-known to generat

55 Since Hem and WAVE normally form a complex, our data argues th

56 affects RP2 migration in a similar manner as Hem and WAVE, and appears to operate via WAVE.

57 diencephalic signaling centers, the cortical hem and zona limitans intrathalamica (ZLI), are merged,

58 tions between (i) the propionates of the two hemes and (ii) the heme of each protein with the polypep

59 ments such as inter-subunit parallel-stacked hemes and axial coordination of heme by histidines from

60 family, including rearrangement of high-spin hemes and conformational adaption of a transmembrane hel

61 s as a mixture of populations with nonplanar hemes and electronic structures that place significant s

62 ified cytochrome was confirmed to contain 10 hemes and exhibited Fe(III)-NTA reductase activity.

63 ma2Delta cells synthesized WT levels of ISCs/hemes and had normal aconitase activity.

64 which pairs of conserved histidine-chelating hemes and one experimentally determined salt bridge were

65 operties: availability of unliganded ferrous hemes and R-state character of the hemoglobin tetramer.

66 CymA is limited by electron transfer to the hemes and that complex formation with Fcc3 facilitates t

67 to change the EPR spectra of both the cyt b hemes and the [2Fe-2S] cluster of the Fe/S protein.

68 oscopic properties of each of the two c-type hemes and the overall redox properties of MauG are descr

69 We hypothesize that the two hemes and their axial ligands in cyt b561 are integral p

70 photopigment rhodopsin [11] is expressed in HEMs and contributes to UVR phototransduction.

71 analysis of lightly versus darkly pigmented HEMs and found 16 genes differentially expressed in the

72 1.5 cm were created in the assessed lesions (HEM) and in the uninvolved liver parenchyma (liv).

73 ncephalon Lmx1a is expressed in the cortical hem, and in its absence cortical hem progenitors contrib

74 ce due to a migratory defect in the cortical hem, and is accompanied by upregulation of Ebf3 in this

75 p a dorsal telencephalic midline, a cortical hem, and two cortical hemispheres.

76 In oxygenic phototrophs, chlorophylls, hemes, and bilins are synthesized by a common branched p

77 lls exhibited WT levels of Fe/S clusters and hemes, and they did not hyperaccumulate Fe.

78 ver, this treatment led to secondary corneal hem- and lymphangiogenesis associated with significant u

79 neovascularisation model was used to induce hem- and lymphangiogenesis.

80 Furthermore, our findings reveal that the hem- and lymphangiogenic potential of corneal wound macr

81 Yet, molecular regulators of the hem- and lymphangiogenic potential of corneal wound macr

82 acement provoked wound macrophages with both hem- and lymphangiogenic potential.

83 s to repress the generation of both cortical hem- and PSB-derived CR cells.

84 line signaling in the production of cortical hem- and PSB-derived CR cells.

85 ping studies, as a novel marker for cortical hem- and septum-derived CR cells.

86 mal expression is restricted to the cortical hem are completely absent in Gli3(Xt/Xt) embryos, but so

87 ellar rhombic lip and telencephalic cortical hem are dorsally located germinal zones which contribute

88 the Soret peaks of the oxidized and reduced hemes are 403 and 418 nm for the low-spin heme and 389 a

89 In MV.CO the spectra of both hemes are almost independent of pH between 5.7 and 11.0.

90 be markedly decreased to the point that two hemes are almost isopotential, yet the enzyme retains ca

91 Typically, c hemes are bound to the protein through two thioether bon

92 Our work shows that cobalt hemes are chemically competent to engage in the NO-to-N(

93 The reduction potentials of the hemes are different and are cross-assigned to fast and s

94 supporting the idea that ferric-hydroperoxo hemes are indeed the precursors of the reactive ferryl i

95 Cysteine-bound hemes are key components of many enzymes and biological

96 e(III) oxidation state, the nuclear receptor hemes are low spin and 6-coordinate with cysteine(thiola

97 ical globins to the parent red Lbs but their hemes are nitrated.

98 As the two hemes are physically separated by 14.5 A, a hole-hopping

99 heme, and four low-spin, bis-his coordinated hemes are positioned to facilitate intra- and intermolec

100 lts as well as more complex siderophores and hemes are potential carriers to deliver Ga(III) to the m

101 Hemes are prosthetic groups that participate in diverse

102 HEMS are resource intensive, and the most efficient geog

103 Hydroxide (OH(-))-exchange membranes (HEMs) are important polymer electrolytes enabling the us

104 d Boundary and Homogenous Equilibrium Model (HEM), are employed to describe the claw motion and cavit

105 revealed that these proteins bind 10 c-type hemes arranged in the peculiar shape of a staggered cros

106 olves laser flash-quench oxidation of ferric hemes, as demonstrated by our work on the ferryl (compou

107 e viability, and release CO to intracellular hemes, as predicted, but their actions are more complex,

108 tivity and can result in the loss of the two hemes at the active site, hemes d and b595.

109 semble of conformations with nearly parallel hemes, at a metal-metal distance approximately 18-19 A.

110 c-type cytochrome domains wrapped around two hemes axially coordinated by His(53)/Cys(96) and His(164

111 ase activity, indicating that the cofactors (hemes b and copper for CcoN and cytochromes c for CcoO a

112 tral signals characteristic of the high-spin hemes b and d of these oxidases.

113 g an electron transfer complex consisting of hemes b(n), c(n), and PQ, and the pathway of n-side redu

114 Hemes b, o, o+16, and heme a, those involved in the bios

115 orate intramonomer Coulombic effects between hemes bL and bH and intermonomer Coulombic effects betwe

116 udo first-order reduction rate constants for hemes bL and bH in H111N and H198N, by ubiquiniol, are 1

117 The Em values for hemes bL and bH in the H111N and H198N complexes are -95

118 ibrium with facile electron transfer between hemes but with only one binding nitric oxide.

119 do not describe redox properties of distinct hemes, but the first and second one-electron reductions

120 R spectrum attributed to interaction between hemes c(n) and b(n).

121 eased, and the redox potential of one of the hemes can stay above the level of quinone pool, or Delta

122 Many HEM cations exist, featuring desirable properties, but n

123 the telencephalon (for example, the cortical hem (CH)) to populate the entire cortical surface.

124 maquette demonstrate the tight affinity for hemes containing the C-2 hydroxyethylfarnesyl group in b

125 HEM could be a faster, non-pollutant, energy-saving, alt

126 he loss of the two hemes at the active site, hemes d and b595.

127 that, although the specification of cortical hem-derived CR cells is dependent on signaling from the

128 mutants results in the loss of the cortical hem-derived CR character but does not affect the specifi

129 often involves an assembly of two hemesb The hemes display a large difference in redox midpoint poten

130 n pattern of Frizzled10 mRNA in the cortical hem, dorsal thalamus and dorsal neural tube.

131 lineage marker for CR cells derived from the hem during embryonic life.

132 primary sterol Delta(14)-reductase and that HEM dysplasia and ichthyosis are inborn errors of choles

133 th respect to cholesterol synthesis and that HEM dysplasia and ichthyosis are laminopathies rather th

134 in B receptor (LBR) have been shown to cause HEM dysplasia in humans and ichthyosis in mice.

135 tion may be useful in designing more durable HEM electrochemical devices.

136 y-conversion devices such as HEM fuel cells, HEM electrolyzers, and HEM solar hydrogen generators.

137 que has been used to study copper complexes, hemes, enzyme mechanisms, micellar water content, and wa

138 tions that are unknown for histidine-ligated hemes enzymes.

139 approaches taken to developing and reporting HEM estimates has limited their comparability and useful

140 Harmonization of HEM estimates has the potential to lead to advances in a

141 ovides guidance for conducting and reporting HEM estimates to make them more comparable and useful fo

142 ise to identify areas of consensus regarding HEM estimation.

143 oxidation of bis-ferric MauG, the two c-type hemes exist as a spin-uncoupled bis-Fe(IV) species with

144 In the cortical hem, expression of LacZ mRNA was confined to the ventric

145 a hematopoietic cell-specific member of the Hem family of cytoplasmic adaptor proteins.

146 ESEM analysis showed smaller particles of HEM flours compared to those of the control.

147 hromes contain a number of His/His ligated c-hemes for electron transfer and a structurally different

148 the MhuD-diheme complex reveals two stacked hemes forming extensive contacts with residues in the ac

149 rochemical energy-conversion devices such as HEM fuel cells, HEM electrolyzers, and HEM solar hydroge

150 so show that during the degradation of WAVE, Hem function is opposite to that of and downstream of Ab

151 igh-copy suppressor screen for regulators of hem gene expression resulted in the identification of an

152 We demonstrate that the expression of hem genes in Rhodobacter capsulatus is transcriptionally

153 ons in LBR result in Pelger-Huet anomaly and HEM-Greenberg skeletal dysplasia, whereas in mice Lbr mu

154 set to determine whether subjects triaged to HEMS had a survival benefit when actually transported by

155 positioned between the D-propionates of the hemes, had been mutated in vivo to lysine and showed to

156 In addition, one of the hemes has an atypical His-Tyr axial ligation.

157 The hemes have positive reduction potentials that allow down

158 This indicates that the high- and low-spin hemes have similar intrinsic E(m) values but exhibit neg

159 and redox reactivity of the model Cys-bound hemes highlight the critical role of the protein scaffol

160 In the absence of Nf2, NPCs of the cortical hem, hippocampal primordium and neocortical primordium o

161 orsal midline structures, including cortical hem, hippocampus and choroid plexus, either failed to fo

162 ng PFGE and MLST of seven genes, aroC, dnaN, hemD, hisD, purE, sucA, and thrA.

163 a a single cytoplasmic YxxL motif known as a hem immunoreceptor tyrosine-based activation motif (hemI

164 anule release in response to stimulation of (hem) immunoreceptor tyrosine-based activation motif (ITA

165 elets prevent inflammatory bleeding through (hem) immunoreceptor tyrosine-based activation motif-depe

166 gered by 2 receptors that signal through an (hem)immunoreceptor tyrosine-based activation motif (ITAM

167 nflammatory disease, which signal through a (hem)immunoreceptor tyrosine-based activation motif (ITAM

168 reveal an important contribution of Grb2 in (hem)immunoreceptor tyrosine-based activation motif signa

169 s that Grb2 is a crucial adapter protein in (hem)immunoreceptor tyrosine-based activation motif signa

170 In vivo, this selective (hem)immunoreceptor tyrosine-based activation motif signa

171 LEC-2 mediates platelet activation through a hem-immunoreceptor tyrosine-based activation motif (hemI

172 findings reveal a much broader role for the hem in cortical development than previously recognized,

173 quired for enhancer activity in the cortical hem in vivo Mis-expression of Lmx1a in hippocampal proge

174 he interprotein ET across 6 angstrom between hemes in adjacent proteins was about 10(5) s(-1), about

175 ditions, carbon monoxide binds to the Fe(II)-hemes in approximately 15 ms.

176 of reversible electron transfer between the hemes in bis-Fe(IV) MauG.

177 We identified the axial ligands to hemes in cyt b561 by mutating four conserved histidines

178 mine that the midpoint potentials of the two hemes in cytochrome c(4) are 240 and 340 mV (vs standard

179 cuit comprising seven His/His-ligated c-type hemes in each subunit.

180 In vitro, ferrous deoxy-hemes in hemoglobin (Hb) react with nitrite to generate

181 , CO-inhibited (carboxy), and O2-bound (oxy) hemes in myoglobin (MB) and hemoglobin (HB) solutions an

182 do the Soret peaks of the low- and high-spin hemes in the absorption spectrum.

183 electron equilibration between the two b(H) hemes in the dimer through the two b(L) hemes is possibl

184 the stability of the Chl a and one or both b hemes in the monomer of the b 6 f complex, and (b) Phe r

185 The electronic properties of the hemes in the reduced state of TDO change significantly u

186 Hemes (iron porphyrins) are involved in a range of funct

187 Whether the hem is a major regulator of cortical patterning outside

188 When the hem is ablated a necessary balance is perturbed, and cer

189 The cortical hem is an embryonic signaling center that generates bone

190 ious finding that in these mice the cortical hem is expanded leading to increased production of CR ce

191 b(H) hemes in the dimer through the two b(L) hemes is possible upon reduction through one center N de

192 lation of five coordinated histidine-ligated hemes is present in the ferrous state at a physiological

193 ich a tryptophan residue located between the hemes is reversibly oxidized and reduced to increase the

194 nd SLAP2 as critical inhibitors of platelet (hem)ITAM signaling in the setting of arterial thrombosis

195 ity, and thrombin generation in response to (hem)ITAM-coupled, but not G protein-coupled, receptor ac

196 e PIG3V and the normal human melanocyte line HEM-l by RNA sequencing, targeted metabolomics, and shot

197 Two lesions with HEM/liv 1.42 and 1.46 were classified as benign foci oth

198 The HEM/liv quotients were calculated for each mass.

199 One lesion with HEM/liv ratio equal to 1.21 was classified as metastasis

200 adiologically typical for hemangiomas, their HEM/liv ratios were at least 1.6 (smaller masses) or 1.8

201 hemangiomas and in normal liver parenchyma (HEM/liv), and to verify, whether the quotient could be p

202 about 45 residues at the N terminus with the hemes located between the two monomers.

203 the neocortical primordium to compensate for hem loss.

204 e calculated from the oxidation state of the hemes measured with multi-wavelength cell spectroscopy.

205 t be a consequence of growth in the cortical hem (medial patterning center), which produces morphogen

206 mendations regarding stakeholder engagement: HEM modeling, including model structure, scope and scale

207 to [Fe4S4](2+) clusters and low-spin Fe(II) hemes, most of which were associated with mitochondrial

208 The Hem-o-lok and other surgical clips must not be used to c

209 in 2006, have continued due to postoperative Hem-o-lok clip failure with sudden, massive bleeding.

210 hile the FDA issued a Class II recall of the Hem-o-lok clip for laparoscopic donor nephrectomies in 2

211 e plan, funded by oversight agencies and the Hem-o-lok manufacturer, is proposed.

212 A February 2011 survey disclosed that Hem-o-lok or other clips are still used by some surgeons

213 re found to represent the only two authentic hemes of cyt b561; models that propose smaller or greate

214 ly ordered for a favorable reaction with the hemes of DHC showing potentials of -310 and -240 mV, res

215 ms a trimer or tetramer in solution; the two hemes of each monomer are hexacoordinated by histidine a

216 The iron hemes of MtrA are bound to its polypeptide chain via pro

217 ns to compute the redox potentials of the 10 hemes of MtrF in aqueous solution.

218 real-time oxidation state of NAD(H) and the hemes of the electron transport chain and oxygen consump

219 The redox potentials of the hemes of the mitochondrial bc(1) complex are dependent o

220 TGFbeta signaling in explants from cortical hems of wild-type mice altered p21 expression and the pr

221 Here, we show that in HEMs, OPN3 acts as a negative regulator of melanin produ

222 In Hem or WAVE mutants, RP2 neuron either abnormally migrat

223 ower heme redox potential of R-state ferrous hemes or could reflect the high ligand affinity geometry

224 with established HNO targets such as Fe(III) hemes or Ph3P.

225 ve cohort study of subjects undergoing scene HEMS or ground emergency medical services (GEMS) in the

226 zation of the hexaheme cytochrome OmcS, with hemes packed within ~3.5-6 angstrom of each other.

227 ption factor (TF)-binding sites for cortical hem-patterning TFs.

228 A), a dimeric enzyme that houses five c-type hemes per protomer, conducts the six-electron reduction

229 antially lower than that of the 5-coordinate hemes present in myoglobin and hemoglobin.

230 e flours and corn masas were affected by the HEM process.

231 he cortical hem, and in its absence cortical hem progenitors contribute excessively to the adjacent h

232 ional regulator, called HbrL, that regulates hem promoters in response to the availability of heme.

233 Here, we show that the Hem protein, via the WAVE complex, regulates migration o

234 herol quinone (aTQ), and other constituents (hemes, proteins, DNA, and surfactant lipids).

235 Because human epidermal melanocytes (HEMs) provide critical protection against skin cancer, s

236 Human and DmCBS Fe(II) hemes react relatively slowly with CO and NO, and the ra

237 HEM reduced the gelatinization enthalpy compared to cont

238 Indicating that the hem regulates dorsoventral patterning in the cortical he

239 We report that Hem regulates neuronal migration through stabilizing WAV

240 underlying the higher reactivity of R-state hemes remains elusive.

241 An expert panel of HEM researchers was recruited to participate in developi

242 mpared several human enhancers with cortical hem-restricted activity and found that recurrent Lmx1a-b

243 n of the promoter regions of hutA, tonB, and hemS reveals consensus sequence promoters that encompass

244 [Fe(4)S(4)](2+) clusters, low- and high-spin hemes, S = (1)/(2) [Fe(2)S(2)](+) clusters, NHHS Fe(II)

245 Hemes sequester NO, whereas thiols deploy NO bioactivity

246 and Ahualulco creole grains nixtamalized by HEM showed similar viscosity profiles as a control.

247 ed midpoint potentials (E(m,7)) of the two b hemes similar to those in the wild type.

248 modified tetrapyrroles include chlorophylls, hemes, siroheme, corrins (including vitamin B(12)), coen

249 in previous spectroscopic studies, the four hemes sites have been presumed to be equivalent.

250 tion magnitudes were analyzed using NOTOCORD-hem software.

251 ch as HEM fuel cells, HEM electrolyzers, and HEM solar hydrogen generators.

252 The primary literature and a synthesis of HEM studies were provided to the panel.

253 , and generate guidance regarding conducting HEM studies.

254 cipate in developing guidance for conducting HEM studies.

255 Nitrite is reduced by deoxygenated ferrous hemes, such that heme deoxygenation increases the rate o

256 ajal-Retzius cells derived from the cortical hem that guide migration of progenitors and neurons to t

257 hromes of c-type contain covalently attached hemes that are formed via thioether bonds between the vi

258 plitting of the redox potentials of adjacent hemes that leads to differential heme binding affinities

259 t from those normally observed for {FeNO}(7) hemes, that may indicate magnetic interaction of the act

260 analogs, diacetyl, monoformyl, and diformyl hemes, that posses electron-withdrawing groups, resulted

261 rizzled10 gene in order to mark the cortical hem (the most caudomedial edge of the telencephalic neur

262 ly expressed in human epidermal melanocytes (HEMs)-the skin cells that produce melanin.

263 her links to the porphyrin typical of c-type hemes, there is a third proteinaceous link involving a c

264 on transfer from the cytochrome b(L) to b(H) hemes, thereby promoting the formation of a ubisemiquino

265 protolytic residue that interacts with both hemes through a hydrogen-bonding network.

266 an also trigger the spin state transition of hemes through deprotonated histidine (e.g. Cytochrome c)

267 strated that MsrQ is able to bind two b-type hemes through the histidine residues conserved between t

268 GF8 coordinates with Wnt3a from the cortical hem to regulate graded expression of transcription facto

269 e remaining proton is transferred toward the hemes to a so-called "pump site." Thus, this proton may

270 me that utilizes two covalently bound c-type hemes to catalyze the biosynthesis of the protein-derive

271 lead from E286 through the region above the hemes to the Mg(2+), and from E286 to the heme a(3) D-pr

272 the repulsion between propionates of partner hemes to the reactive binding free energy to be surprisi

273 y we performed high throughput sequencing of HEMs to obtain a complete data set of transcript sizes,

274 sure of primary human epidermal melanocytes (HEMs) to UVA causes calcium mobilization and early melan

275 es patients with improved survival following HEMS transport and should be considered in air medical t

276 tion of patients most likely to benefit from HEMS transport is imperative to justify the risks and co

277 rns demonstrating NO and nitrite with ferric hemes under near physiological conditions yield an inter

278 ld be measured from the redox poise of the b-hemes under physiological conditions assuming the redox

279 e movement of protons to the vicinity of the hemes upon reduction, to favor charge neutrality.

280 ully oxidized enzyme and its transfer to the hemes using time-resolved absorption spectroscopy and pH

281 The optimal cutoff for triage to HEMS was >/=2 points.

282 ubjects triaged to HEMS, actual transport by HEMS was associated with an increased odds of survival (

283 High-energy milling (HEM) was used to produce nixtamalized corn flours, the t

284 plex, our data argues that in the absence of Hem, WAVE, which is presumably no longer in a complex, b

285 of diminished BMP signaling on the cortical hem were at least partly responsible for these defects i

286 the region between and above the a and a(3) hemes where well-defined water chains have not been iden

287 h expresses Fgf8 and Fgf17, and the cortical hem, which expresses Bmps and Wnts.

288 fibroblast growth factors, and the cortical hem, which expresses bone morphogenetic proteins and ver

289 aling profile of the dorsal midline cortical hem, which in turn causes gyrification of the distal neo

290 ncephalic structures, including the cortical hem, which normally expresses a number of Wnt molecules

291 ructures, including hippocampus and cortical hem, while the ventral telencephalon appears to expand.

292 with a subpopulation of beta-subunit ferric hemes whose population is influenced by quaternary state

293 , this tetraheme cytochrome c contains three hemes with axial His/Met ligation, whereas heme 3 exhibi

294 e interaction between five-coordinate ferric hemes with bound axial imidazole ligands and nitric oxid

295 Thus, the two hemes with distinct spectral properties are reduced and

296 otein harbors four low-spin hexa-coordinated hemes with His/Lys (heme 1), His/Cys (heme 2), and two H

297 utes to the high reactivity of R-state deoxy-hemes with nitrite.

298 Equilibrium binding studies of the hemes with the maquette demonstrate the tight affinity f

299 the protein evolved to harbor low-potential hemes without slowing down electron flow.

300 Rather we found that hem WNT or BMP signals, or both, have opposite effects t