ライフサイエンスコーパス: hemiasterlin

1 Hemiasterlin, a tripeptide isolated from marine sponges,

2 idity development, and the morphology of the hemiasterlin aggregate (as opposed to the dolastatin 10

3 However, the hemiasterlin aggregate differed from the dolastatin 10 a

4 independent mutants resistant to a synthetic hemiasterlin analog.

5 r cryptophycin and 44.6 nm mean diameter for hemiasterlin and dolastatin, as revealed by electron mic

6 a synthetic analogue of the natural product hemiasterlin and is a potent antimitotic agent.

7 oduct, facilitating further investigation of hemiasterlin and its analogues as potential payloads in

8 Total synthesis of hemiasterlin and its analogues has been accomplished, an

9 nhibitors from rescuing wild-type worms from hemiasterlin and sensitized mutants to the toxin, sugges

10 hetic sequence enabled investigation of both hemiasterlin and taltobulin as cytotoxic payloads in ant

11 ishing a structural relationship between the hemiasterlins and the dolastatins.

12 gate the structural relationship between the hemiasterlins and the more complex dolastatins, hybrid c

13 nca domain-binding peptides--cryptophycin 1, hemiasterlin, and dolastatin 10.

14 ch include the cryptophycins, dolastatin 10, hemiasterlin, and phomopsin A have been found to be pote

15 ptophycin 1, cryptophycin 52, dolastatin 10, hemiasterlin, and phomopsin A on beta-tubulin has been i

16 sponding oligomers formed in the presence of hemiasterlin are stable.

17 Since hemiasterlins are poor substrates for P-glycoprotein, th

18 Hemiasterlins are sponge-derived tripeptides that inhibi

19 ulin-dolastatin 10 mixtures was inhibited by hemiasterlin at 22 degrees C and stimulated at 0 degrees

20 Both HTI-286 and hemiasterlin bind tubulin with nearly equal potency.

21 2 fused to diphtheria toxin or conjugated to hemiasterlin compounds strongly inhibits in vivo tumor c

22 zing effects of paclitaxel, both HTI-286 and hemiasterlin depolymerize preassembled microtubules at m

23 A synthetic analogue of the tripeptide hemiasterlin, designated HTI-286, depolymerizes microtub

24 e describe an expeditious total synthesis of hemiasterlin featuring a four-component Ugi reaction (Ug

25 A total synthesis of (-)-hemiasterlin has been accomplished in nine steps from 25

26 sis of resistance to a synthetic analogue of hemiasterlin, HTI-286 (HTI), was examined in cell popula

27 a means to understand the mode of action of hemiasterlin, HTI-286, and other closely related molecul

28 Like dolastatin 10, hemiasterlin induced formation of a tubulin aggregate th

29 Hemiasterlin is a natural product derived from marine sp

30 Hemiasterlin is a potent antimitotic peptide that interf

31 Hemiasterlin is an antimitotic marine natural product wi

32 These results suggest that hemiasterlin is in close contact with alpha-tubulin and

33 86, an analogue from an initial study of the hemiasterlins, is presently in clinical trials.

34 are observed with dolastatin 10 but not with hemiasterlin or cryptophycin 1).

35 We have now demonstrated that hemiasterlin resembles most other antimitotic peptides i

36 alogue of the naturally occurring tripeptide hemiasterlin, taltobulin (HTI-286, 3), has advanced to c

37 Data indicate that direct binding of hemiasterlin to prohibitin 2 is unlikely.

38 c analogue of the peptidic antimitotic agent hemiasterlin, to tubulin is proposed.

39 , paraquat, all rescued wild-type worms from hemiasterlin toxicity.

40 ubulin concentration as low as 1 nM, whereas hemiasterlin-tubulin rings are the least, depolymerizing

41 tubulin oligomerization reaction induced by hemiasterlin was compared to the reactions induced by do

42 The sponge-derived antimitotic tripeptide hemiasterlin was previously shown to inhibit tubulin pol

43 vive in the presence of an antimitotic drug, hemiasterlin, we identified eight strong mutants.