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1 ) Compared with the unmethylated duplex, the hemimethylated 20mer specific duplex had a slightly incr
2 poly(dI-dC).poly(dI-dC) and unmethylated and hemimethylated 36- and 75-mer oligonucleotides.
3  SeqA, OxyR and Dam may compete for the same hemimethylated agn43 DNA that is formed after DNA replic
4                                              Hemimethylated agn43 DNA was also a binding substrate fo
5                                   OxyR bound hemimethylated agn43 DNA, but the affinity was severalfo
6 f the ON phase, however, Dam must access the hemimethylated agn43 region after DNA replication, and O
7 f the N7 and O6 positions of guanines within hemimethylated and fully methylated CG dinucleotides tow
8                The demethylase targeted both hemimethylated and fully methylated substrates.
9 ak (MB) is a 22-mer oligonucleotide with one hemimethylated and two unmethylated CpG sites, which are
10 ir altered noncognate DNA sequence, and both hemimethylated and unmethylated cognate DNA sequences.
11                                              Hemimethylated and unmethylated double-stranded DNA show
12 rt crystal structures of MutH complexed with hemimethylated and unmethylated GATC substrates.
13 (Dnmt3a and Dnmt3b) in mouse which methylate hemimethylated and unmethylated templates with equal eff
14  replication fork, the dnaA promoter becomes hemimethylated, and DnaA accumulation drops.
15 n interact differentially with unmethylated, hemimethylated, and homomethylated TIR substrates.
16 thin a CpG context and showed preference for hemimethylated base mismatches.
17 to 5mC-containing DNA in either the fully or hemimethylated CG context or the methylated CHH context
18 ther report the structure of AtMET1 bound to hemimethylated CG DNA, unveiling the molecular basis for
19 n, that shows strong preferential binding to hemimethylated CG sites, the physiological substrate for
20                      CDCA7 recruits HELLS to hemimethylated chromatin and facilitates UHRF1-mediated
21  Furthermore, switching from unmethylated to hemimethylated cognate DNA involves detectable protein c
22                                       In the hemimethylated complexes, the active site is more compac
23 n IGF2/H19 imprint regulation, including two hemimethylated consensus binding sites for the vertebrat
24 5-methylcytosines (5mC) in CpG, non-CpG, and hemimethylated contexts, measured via high-throughput pr
25 through the ctrA P1 promoter, generating two hemimethylated copies of ctrA.
26                   Maintenance methylation of hemimethylated CpG dinucleotides at DNA replication fork
27 ded from the active site to ensure that only hemimethylated CpG dinucleotides undergo methylation.
28 pe zinc finger domain contributes to CpG and hemimethylated CpG DNA preference for DNA-dependent HELL
29 NA methyltransferases (DNMTs) that recognize hemimethylated CpG DNA produced by replication.
30 x reveals that the HMZF domain can recognize hemimethylated CpG in the outward-facing DNA major groov
31                Additional proteins recognize hemimethylated CpG or fully methylated CpG-containing mo
32 igh specificity the unmethylated strand of a hemimethylated CpG sequence following DNA replication.
33 ssion due to the digestion of SacII when the hemimethylated CpG site is methylated, which inhibits Sa
34 1(731-1602)-DNA complex containing a central hemimethylated CpG site.
35 mouse UHRF1 in complex with DNA containing a hemimethylated CpG site.
36 plication is initiated by the recognition of hemimethylated CpG sites and further flipping of methyla
37  the specificity of DNMT1 for methylation of hemimethylated CpG sites.
38                  The DNA is distorted at the hemimethylated CpG step, with side chains from catalytic
39 e of DNA methylation on chromatin by sensing hemimethylated CpG that is otherwise inaccessible to UHR
40 studies show that UHRF1 binds selectively to hemimethylated CpG via its conserved SRA (SET- and RING
41 howed a binding preference to DNA containing hemimethylated CpG, and replication-dependent pericentro
42  the maintenance methyltransferase, and with hemimethylated CpG, the substrate for DNMT1 (refs 1 and
43 s not as high as the rates of methylation of hemimethylated CpGs in otherwise identical oligonucleoti
44                                          The hemimethylated d(GATC) sequence that directs Escherichia
45 fied M.RSR:I were performed on unmethylated, hemimethylated, dimethylated or non-specific target DNA
46  elucidated by using defined unmethylated or hemimethylated DNA (DNAHM) substrates.
47 NMT1 has been shown to have a preference for hemimethylated DNA and has therefore been termed the mai
48 finity of the enzyme for its two substrates, hemimethylated DNA and S-adenosyl-l-methionine.
49 eal an elaborate allosteric cascade in which hemimethylated DNA binding first activates the SNF2 ATPa
50 Here, we demonstrate that UHRF1 histone- and hemimethylated DNA binding functions, but not E3 ligase
51 d upon stoichiometric addition of M.RSR:I to hemimethylated DNA containing the fluorescent analog 2-a
52  the enzyme that is highly active on a 26-bp hemimethylated DNA duplex substrate, the introduction of
53 , which catalyzes maintenance methylation of hemimethylated DNA during DNA replication, is overexpres
54 nd RING finger domains, 1) recruits DNMT1 to hemimethylated DNA during replication and is essential f
55 onsequence of the inefficient replication of hemimethylated DNA in B. anthracis.
56 Since GADD45alpha binds with high avidity to hemimethylated DNA intermediates, it may also provide a
57 ence of its cofactor, and the preference for hemimethylated DNA is increased to 12-fold over unmethyl
58 tosine at CpG sites in fully methylated DNA; hemimethylated DNA is not a significant substrate.
59                  The preference of DNMT1 for hemimethylated DNA may be the result of positive coopera
60 suggested that binding cooperativity targets hemimethylated DNA preferentially over unmethylated DNA.
61                                              Hemimethylated DNA preferentially stimulates ATPase acti
62 li cells lose their ability to interact with hemimethylated DNA sequences of oriC, the chromosomal or
63 ivity; methylase activity can be detected on hemimethylated DNA substrates and residual endonuclease
64 ltransferase and an inactive endonuclease on hemimethylated DNA substrates.
65 tivity measurements on both unmethylated and hemimethylated DNA substrates.
66 ethyltransferase (DNMT1) on unmethylated and hemimethylated DNA templates in order to assess the mech
67 ger affinities of DNA methyltransferases for hemimethylated DNA than for unmethylated or fully methyl
68 -1 (DNMT1) has a higher specific activity on hemimethylated DNA than on unmethylated DNA, but this pr
69 ecular basis for the enzyme's preference for hemimethylated DNA to be the methyl transfer step.
70 suggest that UHRF1 may help recruit DNMT1 to hemimethylated DNA to facilitate faithful maintenance of
71 sence of DNMT1, prolonged binding of NP95 to hemimethylated DNA transiently disrupts SETDB1-dependent
72                                In our study, hemimethylated DNA was detected at both origins of V. ch
73 cells these sequences contain high levels of hemimethylated DNA, suggestive of poor maintenance methy
74                                           In hemimethylated DNA, this motif consists of a 5-methylcyt
75  and RING-associated (SRA) domain to bind to hemimethylated DNA.
76 ism of DNMT1 and its specific recognition of hemimethylated DNA.
77 n or during homologous recombination between hemimethylated DNA.
78 antly decreased the processivity of DNMT1 on hemimethylated DNA.
79 transferases that recognize newly replicated hemimethylated DNA.
80 ethylated DNA substrates more than 3-fold to hemimethylated DNA.
81 t 501 amino acids retains its preference for hemimethylated DNA.
82  parallel with a higher binding affinity for hemimethylated DNA.
83 -1) on unmethylated DNA, and 8.3-49 h(-1) on hemimethylated DNA.
84                      The values of k(cat) on hemimethylated DNAs showed a 2-3-fold difference, depend
85                                 In contrast, hemimethylated double-stranded substrates show burst kin
86 es for single-stranded, double-stranded, and hemimethylated double-stranded substrates.
87                        Methylated strands in hemimethylated duplexes were cleaved at a higher rate th
88 ict the relative abundances of unmethylated, hemimethylated, fully methylated, and hydroxymethylated
89 transferase (CcrM) methylates the adenine of hemimethylated GANTC after replication.
90 on when it rapidly methylates the adenine in hemimethylated GANTC sequences.
91 mosome (oriC) and the P1 plasmid (P1oriR) at hemimethylated GATC adenine methylation sites.
92 both DNA strands in a discrete patch at each hemimethylated GATC sequence.
93 chia coli SeqA binds clusters of transiently hemimethylated GATC sequences and sequesters the origin
94 ch, the MMR machinery searches for the first hemimethylated GATC site located on its origin-distal si
95                 Enzymatic methylation of the hemimethylated GATC site resulted in destabilisation of
96  and extent of mismatch-provoked cleavage at hemimethylated GATC sites by MutH in the presence of Mut
97 eplication origins: different fragments with hemimethylated GATC sites can bind SeqA in vitro when ce
98 esis that PapI-dependent binding of Lrp to a hemimethylated GATC(dist) site generated by DNA replicat
99 ferences in mutation frequency observed when hemimethylated genomes containing PdG on the (-)-strand
100 ce of sinefungin with decreasing affinities: hemimethylated > unmethylated > dimethylated >> non-spec
101 G), incorporated at different positions into hemimethylated (HM) and nonmethylated (NM) DNA duplexes.
102 hing between a methyltransferase function on hemimethylated host DNA and an endonuclease function on
103  DNA, rMcrA-S binds DNA containing a single, hemimethylated HpaII site; however, it does not bind if
104 inucleotides on both DNA strands, generating hemimethylated intermediates and eventually fully methyl
105 lly methylated oligonucleotide product and a hemimethylated oligonucleotide substrate using a 13-bp d
106 g poly(dG-dC).poly (dG-dC), unmethylated and hemimethylated oligonucleotides as substrates.
107  DNA methyltransferase were also observed in hemimethylated oligonucleotides, suggesting that this is
108 at methylation spreading can be initiated by hemimethylated or duplex methylated CpGs indicating that
109 lex molecules that were either unmethylated, hemimethylated or fully methylated at CpG sequences and
110 ex deoxyoligonucleotides containing cytosine hemimethylated or fully methylated at N-4 in BslI sites
111  BPDE preferentially modified the guanine in hemimethylated or fully methylated CpG sequences, produc
112 o unmethylated DNA with higher affinity than hemimethylated or methylated DNA.
113 lower affinity for fully methylated than for hemimethylated or unmethylated DNA fragments derived fro
114 ossible because SeqA blocked DnaA binding to hemimethylated oriC only at low-affinity recognition sit
115                               The binding of hemimethylated oriC to Escherichia coli membranes has be
116              After initiation, SeqA binds to hemimethylated oriC, sequestering oriC while levels of a
117 re required for the high-affinity binding of hemimethylated oriC.
118 questration by the SeqA protein, which binds hemimethylated origin DNA.
119                   Selectivity/preference for hemimethylated over fully methylated DNA may thus reflec
120             Thus, selectivity/preference for hemimethylated over unmethylated DNA appears to result l
121             The preference of the enzyme for hemimethylated, over unmethylated, DNA was 7-21-fold.
122 demonstrated that OxyR is capable of binding hemimethylated P mom , although its affinity is reduced
123 lls can be attributed to its ability to bind hemimethylated P mom DNA, the product of DNA replication
124 te with Dam for assembly on unmethylated and hemimethylated pap DNA.
125 am, Lrp, and the local regulator PapI onto a hemimethylated pap intermediate is a critical step of th
126 lease DpnI, which digests the methylated and hemimethylated parental DNA template.
127 rA gene is preferentially transcribed from a hemimethylated promoter.
128 ith non-palindromic duplex DNA, containing a hemimethylated recognition sequence, and with the cofact
129            In mammals, Dnmt1 is recruited to hemimethylated replication foci by Uhrf1 (Ubiquitin-like
130 ently induces DNA methylation, especially at hemimethylated replication sites.
131  DNMT1, either inhibiting the methylation of hemimethylated sites or triggering the inappropriate met
132  The protein appears to recognize individual hemimethylated sites, but must undergo an obligate coope
133 n active demethylase then demethylates these hemimethylated sites.
134 strong binding of several TFs to non-CpG and hemimethylated sites.
135 gest that TnpA binds to the postreplicative, hemimethylated Spm sequence and promotes demethylation e
136 ogressively from the fully methylated to the hemimethylated state during DNA replication.
137 rmer and stalked cells serves to protect the hemimethylated state of DNA during chromosome replicatio
138 cle, thereby allowing the maintenance of the hemimethylated state of the chromosome during the progre
139 n of the ctrA promoter from the fully to the hemimethylated state until late in the cell cycle, inhib
140 ry of a DNA methyltransferase that prefers a hemimethylated substrate, Dnmt1 (4), suggested a mechani
141 mt1 (encoded by Dnmt) shows a preference for hemimethylated substrates in vitro, making the enzyme a
142                                              Hemimethylated substrates partition toward product forma
143 ibits 3-fold higher catalytic efficiency for hemimethylated substrates.
144 yotes by enzymes that specifically methylate hemimethylated symmetrical sites (e.g., (5')CpGGpC(5') o
145 ne methyltransferase-catalyzed conversion of hemimethylated to fully methylated DNA through a simple,
146 ases, methylated CG sequences, and preferred hemimethylated to unmethylated DNA, as did the full-leng
147 H3K9me to an increase in the specificity for hemimethylated versus unmethylated DNA.
148 roportionately reduces ATPase stimulation by hemimethylated versus unmethylated substrates.

 
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