ライフサイエンスコーパス: hemolysin

1 ody with a remarkably high affinity to alpha-hemolysin.

2 uctural homology to the staphylococcal alpha-hemolysin.

3 so known as LukAB), leukotoxin DE, and gamma-hemolysin.

4 rally occurring toxin channels such as alpha-hemolysin.

5 tivity when they are forced to express alpha-hemolysin.

6 macrophages, in response to Escherichia coli hemolysin.

7 y two protein nanopores: aerolysin and alpha-hemolysin.

8 rulence factors, such as coagulase and alpha-hemolysin.

9 he expression pattern of coagulase and alpha-hemolysin.

10 of ADAM10 as the cellular receptor for alpha-hemolysin.

11 ion channel nanopore methods employing alpha-hemolysin.

12 o solved the first x-ray structure of a TpsA hemolysin.

13 using a bacterial pore-forming toxin, alpha-hemolysin.

14 ), and bacterial channel-forming toxin alpha-hemolysin.

15 d ASC due to the secreted pore-forming toxin hemolysin.

16 teins classically consists of cytolysins and hemolysins.

17 lonal group positive for sepA and a putative hemolysin; (2) a group harboring the EAST-1 enterotoxin

18 tructure and function of a truncated form of hemolysin A (HpmA265) from Proteus mirabilis using a ser

19 Hemolysin A belongs to the two-partner secretion pathway

20 The truncated hemolysin A formed a right-handed parallel beta-helix wi

21 between HpmA265 and neighboring full-length hemolysin A molecules, facilitated in part by the highly

22 The Escherichia coli hemolysin A secretion system was used to promote the sec

23 activity profile after full-length, inactive hemolysin A was seeded with truncated hemolysin A.

24 aride, toxin coregulated pilus A, sialidase, hemolysin A, flagellins (FlaB, FlaC, and FlaD), phosphoe

25 active hemolysin A was seeded with truncated hemolysin A.

26 nidirectional interconversion of full-length hemolysin A.

27 peptide is facilitated by alpha-toxin (alpha-hemolysin), a pore-forming toxin and virulence factor of

28 This pathogen secretes alpha-hemolysin, a pore-forming cytotoxin that contributes to

29 S. aureus alpha-hemolysin, a pore-forming cytotoxin, is an essential vir

30 We show herein that staphylococcal alpha-hemolysin, a pore-forming cytotoxin, is required for ful

31 li that produce the pore-forming toxin alpha-hemolysin, a response that is markedly attenuated when t

32 oles of two established cytotoxins, the HpmA hemolysin, a secreted cytotoxin, and proteus toxic agglu

33 leukocidins, Leukocidin ED (LukED) and gamma-Hemolysin AB (HlgAB), are necessary and sufficient to ki

34 We show that alpha-hemolysin activates the NLRP3 inflammasome during S. aur

35 Screening by means of assays to detect delta-hemolysin activity and agr autoinducing peptide producti

36 dated via measurement of reconstituted alpha-hemolysin activity and the voltage-gated channel activit

37 h strong blood agar hemolysis and high alpha-hemolysin activity are markers for VAP, but not VAT, and

38 us Sequence Typing and spa-typing, and alpha-hemolysin activity by semiquantitative analysis of hemol

39 cheal aspirates (ETA) for genotype and alpha-hemolysin activity in relation to the development of VAT

40 alpha-Hemolysin activity of S. aureus isolates was predictive

41 patients exhibited significantly lower alpha-hemolysin activity than those from VAP cases; however, n

42 on and in vitro killing, agr function (delta-hemolysin activity), agr group, SCCmec type, and surviva

43 for appropriate regulation of Stk1 function, hemolysin activity, autolysis, and GBS virulence.

44 e barrier, Staphylococcus aureus toxin alpha-hemolysin (aHL) channels have been incorporated into the

45 Mechanistically, alpha- and beta-hemolysins alone did not trigger caspase-1 activation, b

46 ution of operative ion channels (e.g., alpha-hemolysin (alpha-HL) and gramicidin) in the bilayer is o

47 ntact DNA strands with the ion channel alpha-hemolysin (alpha-HL) are limited to single-stranded DNA

48 h region of the wild-type protein pore alpha-hemolysin (alpha-HL) constitutes a sensing zone for indi

49 ough the bacterial protein ion channel alpha-hemolysin (alpha-HL) embedded in a lipid bilayer.

50 taining DNA duplexes was studied in an alpha-hemolysin (alpha-HL) nanopore.

51 translocation of proteins through the alpha-hemolysin (alpha-HL) pore using the AAA+ unfoldase ClpX.

52 he presence of an applied voltage, the alpha-hemolysin (alpha-HL) protein ion channel can produce uni

53 e for capture in the nanocavity of the alpha-hemolysin (alpha-HL) protein pore under an electrophoret

54 e prototypic transmembrane beta-barrel alpha-hemolysin (alpha-HL) reconstituted on immobilized single

55 n) and one static biological nanopore (alpha-hemolysin (alpha-HL)) were successfully incorporated int

56 old NPs using the biological nanopores alpha-hemolysin (alphaHL) and its M113N mutant equipped with a

57 This paper reports on the use of alpha-hemolysin (alphaHL) for detecting a variety of thiolate-

58 Alpha-hemolysin (alphaHL) from Staphylococcus aureus is a symm

59 alently coupled a DNA polymerase to an alpha-hemolysin (alphaHL) heptamer using the SpyCatcher/SpyTag

60 ecule resolution with the protein pore alpha-hemolysin (alphaHL) is presented.

61 ctric field applied across a wild-type alpha-hemolysin (alphaHL) nanopore provides structural informa

62 (SG)18 metallic cluster is bound to an alpha-hemolysin (alphaHL) nanopore, the mean residence time of

63 lyethylene glycol (PEG) molecules with alpha-hemolysin (alphaHL) nanopores.

64 means to monitor the conductance of an alpha-hemolysin (alphaHL) pore as a DNA hairpin with a polydeo

65 rated an unnatural amino acid into the alpha-hemolysin (alphaHL) pore by using solid-phase peptide sy

66 ilize the well-studied protein channel alpha-hemolysin (alphaHL) to map the presence of beta-cyclodex

67 ed of phosphocholine using the protein alpha-hemolysin (alphaHL), to demonstrate osmotically-driven m

68 inflammasome required GBS expression of beta-hemolysin, an important virulence factor.

69 f this conjecture by using two toxins, alpha-hemolysin and aerolysin, which differ in their shape, si

70 sion of many virulence factors such as alpha-hemolysin and coagulase; however, the molecular mechanis

71 nal reporters, direct protein outputs (alpha-hemolysin and delta-toxin), and an in vivo skin challeng

72 Many interactions between alpha-hemolysin and host cells have been identified that promo

73 nalysis using the biological nanopores alpha-hemolysin and its E111A mutant is presented here as a pr

74 secretory virulence factors (S. aureus beta-hemolysin and P. acnes CAMP (Christie, Atkins, Munch-Pet

75 uppress production of key MRSA toxins (alpha-hemolysin and Panton-Valentine leucocidin) that impair h

76 alpha-Hemolysin and protein A were maximally expressed 4 h aft

77 ody response that neutralized not only alpha-hemolysin and PVL, but also other related toxins, produc

78 thoadaptation, we measured the rate of alpha-hemolysin and staphyloxanthin inactivation during serial

79 Detection of increased rates of alpha-hemolysin and staphyloxanthin inactivation in GO and MMR

80 CV with heme, but not iron, restored growth, hemolysin and staphyloxanthin production, and sensitivit

81 In particular, S. aureus produces potent hemolysins and leukotoxins.

82 coccus aureus, controlling the production of hemolysins and other virulence factors.

83 ted genes encoding virulence factors such as hemolysins and proteases were lowered in the presence of

84 S. aureus required alpha-, beta-, and gamma-hemolysins and the host Nlrp3 inflammasome.

85 phasis on Panton-Valentine leukocidin, alpha-hemolysin, and the recently discovered alpha-type phenol

86 putative roles in virulence (e.g., ctx, tcp, hemolysin, and type VI secretion genes) were upregulated

87 ce genes for the biosynthesis of O antigens, hemolysins, and exonucleases as well as others for sugar

88 ncluded those for enterotoxins, leukocidins, hemolysins, and surface proteins and several newly ident

89 odels, the therapeutic efficacy of the alpha-hemolysin antibody appeared additive to the antibiotic l

90 otection against dermonecrosis by anti-alpha-hemolysin antibody.

91 we solved the crystal structure of the alpha-hemolysin:antibody complex.

92 ovide insights into the application of alpha-hemolysin as a molecular sieve to differentiate nanostru

93 tion and reintroduce the pore-forming toxin, hemolysin, as an effector that surprisingly targets mult

94 complex shows that the antibody binds alpha-hemolysin between the cap and the rim domains.

95 The alpha-hemolysin binding to its receptor A-disintegrin and meta

96 ple is the highly potent pore-forming toxin, hemolysin BL (HBL), produced by the gram-positive pathog

97 s to elevated expression of PAP fimbriae and hemolysin by an unknown mechanism.

98 The observation that alpha-hemolysin can usurp the metalloprotease activity of its

99 alentine leukocidin LukSF-PV (PVL) and gamma-hemolysin CB (HlgCB) target human phagocytes through int

100 ution to the alpha-hemolysin pore, the alpha-hemolysin channel can be controlled open or closed by ad

101 eported earlier for OmpF porin and the alpha-Hemolysin channel, we estimate the radii of cis and tran

102 scopy shows that Staphylococcus aureus alpha-hemolysin channels in membranes tethered to gold have th

103 These results indicate that S. aureus hemolysins circumvent the requirement of ATP and the P2X

104 en, genetic fusion of GFP with the bacterial hemolysin ClyA resulted in a chimeric protein that elici

105 Hemolysin co-regulated protein 1 (Hcp1) and O-polysaccha

106 the secretion of the T6SS hallmark protein, hemolysin-coregulated protein (Hcp).

107 d are defective for T6SS-dependent export of hemolysin-coregulated protein (Hcp).

108 secretion signal sequences but are linked to hemolysin-coregulated protein and valine-glycine repeat

109 roduction of its associated effectors, e.g., hemolysin-coregulated protein.

110 The Bordetella adenylate cyclase toxin-hemolysin (CyaA) and the alpha-hemolysin (HlyA) of Esche

111 The adenylate cyclase toxin-hemolysin (CyaA) plays a key role in immune evasion and

112 The adenylate cyclase toxin-hemolysin (CyaA) plays a key role in the virulence of Bo

113 erial invasion and the GBS pore-forming beta-hemolysin/cytolysin (beta-h/c) trigger autophagic activa

114 in covR and related factors, including beta-hemolysin/cytolysin (beta-h/c), surface-anchored adhesin

115 he contribution of the pore-forming GBS beta-hemolysin/cytolysin (betaH/C) to vaginal colonization, a

116 systemic infections, exhibit decreased beta-hemolysin/cytolysin activity, and show increased sensiti

117 gh transcription of genes important for beta-hemolysin/cytolysin expression and export is similar to

118 ponse with serine hydroxamate increased beta-hemolysin/cytolysin expression.

119 ns demonstrated decreased expression of beta-hemolysin/cytolysin, an important cytotoxin implicated i

120 tivated when BMDCs were infected with a live hemolysin deficient (Deltahly) strain.

121 flamed skin and indicate that S. aureus uses hemolysin-dependent killing of these cells as an immune

122 ved in GBS-infected human PMNs in vitro in a hemolysin-dependent manner, appeared to be part of this

123 and penetrate chorioamniotic membranes in a hemolysin-dependent manner.

124 ossible inclusion in a new diagnostic assay: hemolysin E (HlyE), cytolethal distending toxin, S. Typh

125 One such protein is the hemolysin encoded by hlyA.

126 ermines the presence of both the tdh and trh hemolysin-encoding genes, which are also present in ST36

127 Hemolysin expressing UPEC strains have been associated w

128 However, sAIP did not promote hemolysin expression in hemB mutant strains or S. aureus

129 after infection, with higher levels of alpha-hemolysin expression in mice infected with bacteria alon

130 sion of type I and P fimbriae, modulation of hemolysin expression, and expression of a novel pathogen

131 tein nanopores, such as those based on alpha-hemolysin from Staphylococcus aureus have shown great pr

132 ndomly fragmented and separately ligated the hemolysin gamma A (HlgA) and LukS genes into a custom-bu

133 he region of the chromosome that encodes the hemolysin gene cfb, the region targeted by the Xpert GBS

134 emonstrating that the rtx operon is a second hemolysin gene cluster in V. anguillarum M93Sm.

135 The two hemolysin gene clusters previously identified in Vibrio

136 Previously, two hemolysin gene clusters responsible for the hemolysis an

137 IL-1beta production dependent on CT when the hemolysin gene was deleted.

138 fector EspT gene, an autotransporter gene, a hemolysin gene, and putative fimbrial genes are all carr

139 A probe designed for the virulence hemolysin gene, hlyA, was immobilized on the gold-coated

140 One hemolysin gene, vah1, has been previously identified but

141 The expression of Klebsiella hemolysin gene; TNF-alpha; IFN-beta; nucleotide-binding

142 -PCR) were used to examine expression of the hemolysin genes under exponential and stationary-phase c

143 rries genes associated with virulence (e.g., hemolysin genes) and conjugation (tra and trb genes) but

144 2) conjugated to a non-toxic mutant of alpha-hemolysin (Hla H35L), CP5 conjugated to clumping factor

145 a is a disease driven in large part by alpha-hemolysin (Hla) and Panton-Valentine leukocidin (PVL), w

146 sponses to 2 staphylococcal exotoxins, alpha-hemolysin (Hla) and Panton-Valentine leukocidin (PVL; Lu

147 We tested the hypothesis that alpha-hemolysin (Hla) contributes to the severity of USA300 sk

148 nactivation of fakA leads to decreased alpha-hemolysin (Hla) production but increased expression of t

149 Alpha-hemolysin (Hla), a pore-forming cytotoxin of S. aureus,

150 alpha-Hemolysin (Hla), a pore-forming toxin secreted by S. aur

151 Staphylococcus aureus alpha-hemolysin (Hla), a potent cytotoxin, plays an important

152 Panton-Valentine leukocidin (PVL) and alpha-hemolysin (Hla), although supporting evidence is lacking

153 ents with higher levels of IgG against alpha-hemolysin (Hla), delta-hemolysin (Hld), Panton Valentine

154 They include the secreted factors alpha-hemolysin (Hla), ess extracellular A (EsxA), and ess ext

155 ors, including the abundantly produced alpha-hemolysin (Hla), failed to induce eosinophil death.

156 establishment in immunocompetent hosts-alpha-hemolysin (Hla), iron-regulated surface determinants (Is

157 ll-established virulence determinants: alpha-hemolysin (Hla), phenol-soluble modulin-alpha peptides (

158 e factors, including protein A and the alpha-hemolysin (Hla), which cause pathology by activating hos

159 accessory gene regulator C (agrC) and alpha-hemolysin (hla)--molecules important for S. aureus virul

160 Panton-Valentine leukocidin (PVL)- and alpha-hemolysin (Hla)-negative isogenic derivatives (LACDeltap

161 as well as the gene encoding the toxin alpha-hemolysin (hla).

162 s dependent on S. aureus expression of alpha-hemolysin (Hla).

163 eus secretion of the virulence factor, alpha-hemolysin (Hla).

164 he S. aureus-secreted virulence factor alpha-hemolysin (Hla).

165 of IgG against alpha-hemolysin (Hla), delta-hemolysin (Hld), Panton Valentine leukocidin (PVL), stap

166 The gamma-hemolysins (HlgAB and HlgCB) and Panton-Valentine leukoc

167 Escherichia coli (UPEC) strains produce both hemolysin (Hly) and cytotoxic necrotizing factor type 1

168 Cytotoxic necrotizing factor 1 (CNF1) and hemolysin (Hly) are toxins made by approximately 50% of

169 al toxins including the two RTX toxins alpha-hemolysin (HlyA) from Escherichia coli and leukotoxin A

170 It was observed that active alpha-hemolysin (HlyA) induced cleavage of caspase-1 leading t

171 We show that UPEC alpha-hemolysin (HlyA) induces Caspase-1/Caspase-4-dependent i

172 m-negative bacteria such as Escherichia coli hemolysin (HlyA) insert into host-cell membranes to subv

173 cyclase toxin-hemolysin (CyaA) and the alpha-hemolysin (HlyA) of Escherichia coli belong to the famil

174 cyclase toxin (CyaA), Escherichia coli alpha-hemolysin (HlyA), and Kingella kingae cytotoxin (RtxA).

175 ract infections are commonly caused by alpha-hemolysin (HlyA)-producing Escherichia coli.

176 e a labile pore-forming toxin known as alpha-hemolysin (HlyA).

177 ting the pore-forming virulence factor alpha-hemolysin (HlyA).

178 ve hemagglutinin (MSHA), and enterotoxigenic hemolysin (HlyA); C-II encodes a variant of Vibrio patho

179 Cytotoxic necrotizing factor 1 (CNF1) and hemolysin (HlyA1) are toxins produced by uropathogenic E

180 infections, secretes the pore-forming toxin hemolysin II (HlyII).

181 ation of CAMP factor neutralization and beta-hemolysin immunization cooperatively suppressed the skin

182 reus strains secrete an extensive arsenal of hemolysins, immunomodulators, and exoenzymes to cause di

183 crobe, Elsen and colleagues identify a novel hemolysin in a highly virulent Pseudomonas aeruginosa st

184 There was a higher abundance of alpha-hemolysin in culture supernatants among ACME-positive is

185 udied the role of purified recombinant alpha-hemolysin in inducing inflammatory responses and cell de

186 eexisting antibodies against S. aureus alpha-hemolysin in the serum of human individuals by isolating

187 The activity of an ion channel, alpha-hemolysin, incorporated into bis-DenPC BLMs prior to pol

188 creased production of cholera toxin (CT) and hemolysin, increased motility, and a reduced ability to

189 ll help to understand the mechanism of alpha-hemolysin induced inflammatory response and cell death.

190 inhibition as a strategy to attenuate alpha-hemolysin-induced disease.

191 findings suggest a role for S. aureus alpha-hemolysin-induced PNA formation in alveolar capillary de

192 not driven by this mechanism; rather, alpha-hemolysin-induced PNA formation was solely platelet P-se

193 alpha-hemolysin injures epithelial cells in vitro by interacti

194 this report, we demonstrate use of the alpha-hemolysin ion channel to analyze these subtle topologica

195 inkage and capturing the DNA inside an alpha-hemolysin ion channel.

196 ne glycol) (PEG) molecules in a single alpha-hemolysin ion channel.

197 astic detection using between 1 and 26 alpha-hemolysin ion channels reconstituted in a lipid bilayer,

198 Staphylococcal alpha-hemolysin is an essential virulence factor in severe S.

199 The staphylococcal alpha-hemolysin is critical for the pathogenesis of Staphyloco

200 The wild-type protein nanopore alpha-hemolysin is used to capture individual DNA duplexes con

201 This large, hemolysin-like protein was found in the supernatant of a

202 GBS expression of the cytolytic toxin, beta-hemolysin, lysosomal acidification, and leakage.

203 We sought to determine the role of alpha-hemolysin-mediated activation of NLRP3 in the pathogenes

204 the mechanism of action for the two-partner hemolysin members is not fully understood.

205 Upon interaction of its C-terminal hemolysin moiety with the cell surface receptor alphaMbe

206 rt the generation of two distinct anti-alpha-hemolysin monoclonal antibodies that antagonize toxin ac

207 report of the crystal structure of the alpha-hemolysin monomer.

208 DNA-PNA duplexes unzipping inside the alpha-hemolysin nanopore (alpha-HL) are presented.

209 polymers to perform nanopore SBS on an alpha-hemolysin nanopore array platform.

210 The blocking of the alpha-hemolysin nanopore by rhodamines could be utilized in DN

211 atcheting of DNA templates through the alpha-hemolysin nanopore controlled by phi29 DNA polymerase wi

212 ecules are initially pulled through an alpha-hemolysin nanopore from the cis to the trans side of a l

213 vidual complexes are captured atop the alpha-hemolysin nanopore in an applied electric field.

214 mplitude states when captured atop the alpha-hemolysin nanopore in an applied field.

215 vidual complexes are captured atop the alpha-hemolysin nanopore in an electric field.

216 Detection using the alpha-hemolysin nanopore is also developed to analyse the mark

217 Using an alpha-hemolysin nanopore, we measured the dwell time for compl

218 Utilizing the alpha-hemolysin nanopore, we show that in the presence of Ag(+

219 captured in an electric field atop the alpha-hemolysin nanopore.

220 e concentration gradients applied over alpha-hemolysin nanopores.

221 and a mutation in an rtx gene resulted in a hemolysin-negative mutant, demonstrating that the rtx op

222 s performed with a vah1 mutant resulted in a hemolysin-negative mutant.

223 P. acnes CAMP factor was neutralized or beta-hemolysin of S. aureus was mutated.

224 Hemolysins of V. anguillarum have been considered virule

225 and blocked the formation of a stable alpha-hemolysin oligomer on the target cell surface.

226 oltage-driven translocation via either alpha-Hemolysin or a solid-state nanopore.

227 Pulmonary injury induced by isolated alpha-hemolysin or live S. aureus is independent of interleuki

228 biotype strains, which do not produce either hemolysin or the MARTX toxin, activated low-level IL-1be

229 cific bacterial clone, (iii) levels of alpha-hemolysin, or (iv) delta-hemolysin production were ident

230 oduce virulence factors such as leukocidins, hemolysins, or the antioxidant staphyloxanthin.

231 hly-encoded alpha hemolysin partially accounted for these effects by eleva

232 Because all strains had a similar beta-hemolysin phenotype, we surmise that thermostable direct

233 in mutualistic or hostile interactions (i.e. hemolysins, pilins, adhesins), and exoenzymes with a pot

234 es within the lumen of the stem of the alpha-hemolysin pore for the C4R1 dimer, but only one binding

235 les include purified proteins from the alpha-hemolysin pore from Staphylococcus aureus, the anthrax t

236 The transmembrane protein alpha-hemolysin pore has been used to develop ultrasensitive b

237 easurements of ion conductance through alpha-hemolysin pore in a bilayer lipid membrane revealed bloc

238 tion of the chelating agent through an alpha-hemolysin pore in the absence and presence of target ana

239 examined mutants of the staphylococcal alpha-hemolysin pore so severely truncated that the protein ca

240 ed sensors based on the staphylococcal alpha-hemolysin pore to allow the single-molecule detection an

241 -stranded DNA movement through a model alpha-hemolysin pore under an applied electric field.

242 EG copolymer threaded through a single alpha-hemolysin pore was induced by a combination of DNA stran

243 es of the temperature in and around an alpha-hemolysin pore, and we use this to explore melting prope

244 e protein unfolds and moves through an alpha-hemolysin pore, enables the distinction between unphosph

245 l)phosphonium chloride solution to the alpha-hemolysin pore, the alpha-hemolysin channel can be contr

246 s of polynucleotide folding: 1), Using alpha-hemolysin pores and a diverse set of different DNA hairp

247 gether, backward translocation through alpha-hemolysin pores combined with mesoscopic theoretical mod

248 ngs, we detect the insertion of single alpha-hemolysin pores into the bilayer membrane, demonstrating

249 Two heptameric staphylococcal alpha-hemolysin pores were covalently linked in an aligned cap

250 il antibody also recognizes heptameric alpha-hemolysin pores, but not monomers, suggesting that the a

251 anslocation of polynucleotides through alpha-hemolysin pores.

252 yclodextrin in multiple staphylococcal alpha-hemolysin pores.

253 Here we report evidence that alpha-hemolysin-positive (hly(+)) type I Escherichia coli (E.

254 The virulence factor alpha-hemolysin produced by S. aureus lyses perivascular macro

255 Hemolysins produced by Vibrio anguillarum have been impl

256 bated with pathogenic E coli including alpha-hemolysin producing strains.

257 bronectin binding in SCVs, it cannot promote hemolysin production in the absence of a functional elec

258 her pvl presence nor in vitro level of alpha-hemolysin production is the primary determinant of outco

259 In vivo alpha-hemolysin production was reduced in both L and V-treated

260 ii) levels of alpha-hemolysin, or (iv) delta-hemolysin production were identified.

261 n-binding protein (FnBP) and greatly reduced hemolysin production, although the basis for this is unc

262 ell walls, significantly reduced capsule and hemolysin production, and restoration of the phenotypes

263 maturation of IL-1beta, while inactive alpha-hemolysin (proHlyA) failed to do so in THP-1 derived mac

264 Furthermore, these studies revealed that hemolysins promote in the presence of lipoproteins the a

265 l for the binding of the enzyme to the alpha-hemolysin promoter.

266 cretion signal of the Escherichia coli alpha-hemolysin protein (HlyA) on a low-copy-number plasmid.

267 strate how peptide passage through the alpha-hemolysin protein can be sufficiently slowed down to obs

268 Here, a wild-type alpha-hemolysin protein nanopore was used to monitor DNA repai

269 of DNA through different mutations of alpha-hemolysin protein nanopores.

270 The sensing element is a wild-type alpha-hemolysin protein pore with boromycin as a molecular ada

271 strand of DNA-PEG copolymer inside an alpha-hemolysin protein pore.

272 The severe deficiency in alpha-hemolysin protein secretion in DeltafakA and DeltafakB1

273 Like alpha-hemolysin, purified alpha-toxin readily degrades Bcl-x(L

274 20-mer) through a protein ion channel (alpha-hemolysin) reconstituted in a DPhPC bilayer suspended ac

275 , we use a robust beta-barrel channel, alpha-hemolysin, reconstituted into planar lipid bilayers.

276 e used degenerate PCR to identify a positive hemolysin regulatory gene, hlyU, from the unsequenced V.

277 at GBS invades hAECs and strains lacking the hemolysin repressor CovR/S accelerate amniotic barrier f

278 reviously unrecognized sensing zone in alpha-hemolysin specific for dsDNA structure.

279 Vaccine and infection-elicited alpha-hemolysin-specific antibodies protect against S. aureus-

280 also regulates virulence genes, including a hemolysin, superantigen-like protein, and phenol-soluble

281 Among them are the thermostable direct hemolysin (TDH) and the TDH-related hemolysin (TRH), whi

282 enotype, we surmise that thermostable direct hemolysin (TDH) plays a limited role in these models.

283 increased transcription of the thermolabile hemolysin (tlh).

284 we identified in all a homologue of the beta-hemolysin toxin gene shared by Brachyspira hyodysenteria

285 riptional regulatory RNA important for alpha-hemolysin translation, suggesting that VfrB may function

286 e direct hemolysin (TDH) and the TDH-related hemolysin (TRH), which share amino acid similarities to

287 enes known to affect the production of alpha-hemolysin, two of them were associated with an apparent

288 e expression patterns of coagulase and alpha-hemolysin, two well-known sae target genes.

289 opore and the transmembrane pore of an alpha-hemolysin-under both equilibrium and nonequilibrium cond

290 toxin-receptor function revealed that alpha-hemolysin upregulates ADAM10 metalloprotease activity in

291 Vibrio cholerae cytolysin/hemolysin (VCC) is an amphipathic 65-kDa beta-pore-formi

292 humans, secretes a PFT called V. vulnificus hemolysin (VVH), which contains a single C-terminal targ

293 during intracellular infection, while alpha-hemolysin was produced but was not hemolytic, suggesting

294 y phase but not log phase CA-MRSA, and alpha-hemolysin was singularly identified as the mediator of t

295 vidual cells to the pore-forming agent alpha-hemolysin, we have controlled the membrane permeability,

296 hemolysis and cytolysis of recombinant beta-hemolysin were markedly enhanced by recombinant CAMP fac

297 ich dominated the response to S aureus alpha-hemolysin, were of low concentration or absent.

298 ranscription of the hla gene, encoding alpha-hemolysin, when grown in broth, as well as on RNAIII, a

299 h is held at the latch constriction of alpha-hemolysin, which is used to monitor the kinetics of base

300 upon intestinal injury via the production of hemolysin, which required NLRP3 and IL-1 receptor signal