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1 ic and highly pathogenic paramyxovirus genus Henipavirus.
2 l surface, including HIV, parainfluenza, and henipaviruses.
3 ll-genome sequence information available for henipaviruses.
4 gent for the treatment of diseases caused by henipaviruses.
5 hibits high sequence conservation across all henipaviruses.
6 transcription of minigenomes from all tested henipaviruses.
7  mechanistic understanding for the important henipaviruses.
8 h mediate cell entry for all other known bat henipaviruses.
9 al candidates for treating highly pathogenic henipaviruses.
10 stituted with analogous sequences from other henipaviruses.
11 the antibody-mediated immune response across henipaviruses.
12 lso utilized as a dissemination mechanism by henipaviruses.
13  the missing sequences with those from other henipaviruses allowed us to overcome this challenge.
14 nvelope glycoprotein of viruses in the genus Henipavirus and the family Filoviridae.
15 potential subunit vaccine immunogens against henipaviruses and also establish important tools for fur
16                    Characterization of novel henipaviruses and documentation of their pathogenic and
17  human pathogens, including Hendra and Nipah henipaviruses and Ebola and Marburg filoviruses.
18                     Surveillance efforts for henipaviruses and filoviruses have been largely restrict
19        In the current study, we screened for henipaviruses and filoviruses in New World bats collecte
20 ential circulation of viruses related to the henipaviruses and filoviruses in New World bats.
21 ggest a potentially broader distribution for henipaviruses and filoviruses than previously recognized
22 iple serological assays reveal antibodies to henipaviruses and Lagos bat virus in all locations, incl
23   Notably, this knowledge may apply to other henipaviruses and more broadly to other paramyxoviruses.
24 a new efficient vaccination strategy against henipaviruses and opens novel perspectives on the use of
25  fusion cascade, however, remain unknown for henipaviruses and paramyxoviruses.
26                           The replication of henipaviruses and the development of antiviral agents ca
27 mbrane fusion-triggering mechanism(s) of the henipaviruses and the paramyxoviruses.
28                     The broad tropism of the henipaviruses and the unavailability of therapeutics thr
29 omprehensive investigation of the biology of henipaviruses and their interaction with the host.
30  species specific ephrin receptor usage by a henipavirus, and implicates additional ephrin receptors
31 ute respiratory syndrome-like coronaviruses, henipaviruses, and Ebola virus.
32 viruses, including SARS-like corona viruses, henipaviruses, and lyssaviruses, understanding how patho
33 he discovery and characterization of a novel henipavirus, Angavokely virus (AngV), isolated from wild
34                     To this end, we followed henipavirus antibody levels of >100 individual E. helvum
35 ially be harnessed to develop universal anti-henipavirus antivirals.IMPORTANCEGiven the severity of d
36 lycoprotein pairs.IMPORTANCE The NiV and HeV henipaviruses are BSL-4 pathogens transmitted from bats.
37 phosphoprotein (P), and large protein (L) of henipaviruses are critical elements of their replication
38                                              Henipaviruses are recognized as significant global healt
39                                              Henipaviruses are zoonotic viruses that can cause severe
40 n humans and the continuous emergence of new henipaviruses as well as henipa-like viruses, it is nece
41             There is heightened concern that henipaviruses, as respiratory pathogens, could spark ano
42 sults advance our basic understanding of the henipavirus assembly process and provide a novel model f
43 for life-cycle modeling of highly pathogenic henipaviruses at low biocontainment.
44 ractions with host cell machinery.IMPORTANCE Henipaviruses can cause deadly infections of medical, ve
45  are unknown, as are the mechanisms by which henipaviruses can cause disease.
46 ruses, influenza A viruses, hantaviruses, or henipaviruses, can result in profound pathology in human
47                                              Henipaviruses cause deadly infections in humans, with a
48                In contrast to AGMs, in which henipaviruses cause severe and usually lethal disease, H
49 on of NiV, HeV, and a related non-pathogenic henipavirus, Cedar virus (CedPV).
50                        As the group of known henipaviruses continues to grow, shared protocols for co
51 lopment of effective countermeasures against henipavirus disease.
52                      A longitudinal study of henipavirus diversity and excretion dynamics identified
53 ility to understand the molecular drivers of henipavirus emergence.
54 of a changing climate on the future risk for Henipavirus emergence.
55                         Viruses in the genus Henipavirus encompass 2 highly pathogenic emerging zoono
56   After attaching to the host cell receptor, henipaviruses enter the target cell via direct viral-cel
57                To estimate the likelihood of henipaviruses entering the UK, a qualitative release ass
58  to cognate ephrinB receptors, indicate that henipavirus entry and fusion could differ mechanisticall
59 hrinB3 have been identified as receptors for henipavirus entry.
60  Emerging viruses in the paramyxovirus genus Henipavirus evade host antiviral responses via protein i
61               Here, several soluble forms of henipavirus F (sF) were engineered and characterized.
62 plicable to prefusion stabilization of other henipavirus F proteins and support the use of NiV as a p
63 ent to which substitutions transfer to other henipavirus F proteins is not known.
64 t of new cross-reactive antibodies targeting Henipavirus F proteins.
65 undation for future antigen design targeting henipavirus F proteins.
66                                    The genus Henipavirus (family Paramyxoviridae) currently comprises
67 HeV) and Nipah (NiV) are the most well-known henipaviruses, for which no effective antivirals or vacc
68  for most paramyxoviruses, activation of the henipavirus fusion protein occurs in recycling endosomal
69 hat ephrinB2 and -B3 binding determinants on henipavirus G are distinct and dissociable.
70                                              Henipavirus G chimeric protein analysis implicated resid
71                                          The henipavirus G glycoproteins lack both hemagglutinating a
72  for the highly specific interactions of the henipavirus G glycoproteins with only two members (ephri
73 ently published data for morbillivirus H and henipavirus G proteins, we extend our recently proposed
74 , recently emerged paramyxoviruses that form Henipavirus genus and are capable of causing considerabl
75 n process for NiV and likely for the related Henipavirus genus and possibly Paramyxoviridae family me
76 ruses are emerging zoonotic pathogens in the Henipavirus genus causing outbreaks of disease with very
77                     Bat-borne viruses in the Henipavirus genus have been associated with zoonotic dis
78                               IMPORTANCE The Henipavirus genus in the Paramyxoviridae family includes
79 (NiV) and Hendra virus (HeV), members of the Henipavirus genus in the Paramyxoviridae family, are rec
80 h virus (NiV) and Hendra virus belong to the Henipavirus genus in the Paramyxoviridae family.
81                               IMPORTANCE The Henipavirus genus is quickly expanding into new animal h
82 s (HeV) and Nipah virus (NiV) constitute the Henipavirus genus of paramyxoviruses, both fatal in huma
83 s one of the two prototypical members of the Henipavirus genus of paramyxoviruses, which are designat
84 sely related emerging viruses comprising the Henipavirus genus of the Paramyxovirinae, which are dist
85 sely related emerging viruses comprising the Henipavirus genus of the Paramyxovirinae.
86 s a highly pathogenic enveloped virus in the Henipavirus genus within the Paramyxoviridae family, cap
87 (NiV) and Hendra virus (HeV), members of the Henipavirus genus, are recently emerged, highly lethal z
88 angya virus (LayV) is a paramyxovirus in the Henipavirus genus, closely related to the deadly Nipah (
89                            As members of the Henipavirus genus, NiV and HeV use an attachment (G) gly
90  to a proline-rich microdomain unique to the Henipavirus genus.
91 tibodies may also bind F proteins across the Henipavirus genus. This work identifies new epitopes as
92  84 serum samples, 28 were reactive with >=1 henipavirus glycoprotein by >=1 serological method, and
93 ah virus (NiV), a paramyxovirus in the genus Henipavirus, has a mortality rate in humans of approxima
94 ximity to other countries where incidents of henipaviruses have occurred and the distribution of Pter
95 man metapneumovirus, and the deadly zoonotic henipaviruses Hendra and Nipah virus (NiV).
96                                          The henipaviruses, Hendra virus (HeV) and Nipah virus (NiV),
97                                          The henipaviruses, Hendra virus (HeV) and Nipah virus (NiV),
98                                          The henipaviruses, Hendra virus (HeV) and Nipah virus (NiV),
99 cestral to all four previously described bat henipaviruses-HeV, NiV, Cedar virus (CedV), and Ghanaian
100 ly been shown to have antiviral activity for henipaviruses highlights the validity of this new screen
101 irus (CedV) is a nonpathogenic member of the Henipavirus (HNV) genus of emerging viruses, which inclu
102 pah virus (NiV) is a highly lethal, zoonotic Henipavirus (HNV) that causes respiratory and neurologic
103 PORTANCENipah virus (NiV) is a highly lethal henipavirus (HNV) that causes severe respiratory and neu
104 Langya virus (LayV) is a recently discovered henipavirus (HNV), isolated from febrile patients in Chi
105 miners prompted the isolation of a rat-borne henipavirus (HNV), Mojiang virus (MojV).
106              Zoonotic transmission of lethal henipaviruses (HNVs) from their natural fruit bat reserv
107                     The discovery of African henipaviruses (HNVs) related to pathogenic Hendra virus
108 us (NiV) and Hendra virus (HeV) are zoonotic henipaviruses (HNVs) responsible for outbreaks of enceph
109 us (NiV) and Hendra virus (HeV) are zoonotic henipaviruses (HNVs) responsible for outbreaks of enceph
110 V) and Nipah virus (NiV) are deadly zoonotic Henipaviruses (HNVs) responsible for recurrent outbreaks
111 s and Nipah virus (NiV) are lethal, zoonotic Henipaviruses (HNVs) that cause respiratory and neurolog
112 ation among climate models to estimate where Henipavirus host distribution is most likely to expand,
113 cterize Angavokely virus (AngV), a divergent henipavirus identified in urine samples from wild, Madag
114 e immune response in bats and indicates that henipavirus IFN antagonist mechanisms are likely active
115          Nipah virus (NiV) is a zoonotic bat henipavirus in the family Paramyxoviridae NiV is deadly
116 (HeV) and Nipah virus (NiV) are in the genus Henipavirus in the family Paramyxoviridae.
117    There is new evidence for the presence of henipaviruses in African bats.
118  in geographical and species distribution of henipaviruses in Australasia which will contribute to pl
119 Rousettus madagascariensis, to Cedar-related henipaviruses in E. dupreanum and R. madagascariensis an
120 vidence of exposure to Hendra-/Nipah-related henipaviruses in Eidolon dupreanum, Pteropus rufus and R
121 his study was to determine the occurrence of henipaviruses in fruit bat (Family Pteropodidae) populat
122 ey indicate the presence of non-NiV, non-HeV henipaviruses in fruit bat populations of Sulawesi and S
123       Evidence was obtained for the presence henipaviruses in the non-Pteropid species R. amplexicaud
124                                   IMPORTANCE Henipaviruses include highly pathogenic emerging zoonoti
125                                    The genus Henipavirus includes Hendra virus (HeV) and Nipah virus
126                    The risk posed by related henipaviruses, including Hendra virus (HeV) and Nipah vi
127 digm of receptor-facilitated severe disease, henipaviruses, including Nipah and Hendra viruses, use d
128                                          The henipaviruses, including Nipah virus (NiV) and Hendra vi
129 African green monkey (AGM) best mimics human henipavirus-induced disease.
130 ns, supporting the F/G dissociation model of henipavirus-induced membrane fusion, even in the context
131 ature of paramyxoviral infections.IMPORTANCE Henipaviruses infect bats, agriculturally important anim
132 ssed in cynomolgus monkeys and compared with henipavirus-infected historical control AGMs.
133                                              Henipavirus infection causes severe respiratory illness
134                         The host response to henipavirus infection in NHBE and SAEC highlighted a dif
135 pment of diagnostics or therapeutics against henipavirus infection.
136 virus entry receptors, mice are resistant to henipavirus infection.
137 ype I interferon signaling in the control of henipavirus infection.
138 ah virus (NiV; family Paramyxoviridae, genus Henipavirus) infection can cause severe respiratory and
139                            Upon viral entry, Henipavirus infections yield the formation of multinucle
140 l entry into host cells is the first step of henipavirus infections, which ultimately cause syncytium
141 ive targets for universal and effective anti-henipavirus interventions.
142  have a Low annual probability of release of henipaviruses into the UK.
143              The emergence of this and other henipaviruses involves interactions among a suite of ant
144                                              Henipavirus is a new genus of Paramyxoviridae that uses
145 rategies to prevent lethal infections due to henipaviruses is highly desirable.
146  scope of research which may be conducted on henipaviruses is limited.
147       The role of cholesterol for NiV or the henipaviruses is unknown.
148                     Nipah virus (NiV) (Genus Henipavirus) is a recently emerged zoonotic virus that c
149  zones according to location of outbreaks of henipaviruses, isolation of henipaviruses, proximity to
150 may have some antiviral activity against the henipaviruses, its use as an effective standalone therap
151 features with the F protein from an emerging henipavirus, Langya virus (LayV).
152                   The emergence of the novel henipavirus, Langya virus, received global attention aft
153 stigations into the growing numbers of novel henipavirus-like viruses.
154 ple emerging viruses, including filoviruses, henipaviruses, lyssaviruses, and zoonotic coronaviruses.
155 y highly pathogenic human viruses, including henipaviruses, lyssaviruses, severe acute respiratory sy
156  first time, host factors that interact with henipavirus M proteins and contribute to viral particle
157 , but where this bat species is absent other henipaviruses may be present, as on Sulawesi and Sumba.
158          Cedar virus (CedV), a nonpathogenic henipavirus, may be a useful tool to gain knowledge on h
159 more recently than rodent- and shrew-derived henipaviruses, Mojiang (MojV), Gamak (GAKV), and Daeryon
160 ructs (sF(GCNt)) could elicit cross-reactive henipavirus-neutralizing antibody in mice.
161 ps, and parainfluenza viruses and the deadly henipaviruses Nipah (NiV) and Hendra (HeV) viruses.
162 re, we highlight the emergence of a zoonotic Henipavirus, Nipah virus, to demonstrate the interdiscip
163                                          The henipaviruses, Nipah virus (NiV) and Hendra virus (HeV),
164 ions within the fusion protein of the deadly henipavirus NiV.
165 usion stabilization in F proteins from three henipaviruses: NiV, HeV, and Langya virus (LayV).
166 ort the first cryoEM structure of the Hendra henipavirus nucleoprotein in complex with RNA, at 3.5 an
167                           The recognition of henipaviruses occurring across a wider geographic and ho
168 V) and Nipah virus (NiV) belong to the genus Henipavirus of the family Paramyxoviridae and are unique
169 ) and Hendra virus (HeV) are closely related henipaviruses of the Paramyxovirinae.
170                 Given the sporadic nature of henipavirus outbreaks, licensure of vaccines and therape
171 noclonal antibodies to prepare for potential henipavirus outbreaks.
172 e of a conserved mechanism of retrovirus and henipavirus parasitization of cell-to-cell recognition p
173 cted trafficking processes are important for henipavirus particle production and identify a new host
174 cial new information in the understanding of henipavirus pathogenesis in the human respiratory tract
175              In this study, we characterized henipavirus pathogenesis using primary cells derived fro
176 ore, to facilitate spatiotemporal studies on henipavirus pathogenesis, we generated a firefly lucifer
177  -B3 usage will further our understanding of henipavirus pathogenesis.
178 s newly observed promiscuous property of the henipavirus polymerase complex proteins likely attribute
179 ccine candidate in areas where both RABV and henipaviruses pose a threat to human health.
180  of outbreaks of henipaviruses, isolation of henipaviruses, proximity to other countries where incide
181            Cedar virus (CedV) is a bat-borne henipavirus related to Nipah virus (NiV) and Hendra viru
182 ptiacus) is an important viral host in which Henipavirus-related viral sequences have previously been
183  Langya virus fusion protein compares to its Henipavirus relatives and propose a mechanism for the in
184                                          All henipaviruses replicated in macaques with similar kineti
185             We show that the distribution of Henipavirus reservoirs, and therefore henipaviruses, wil
186                               This optimized henipavirus reverse genetics system will facilitate futu
187 , and tested for the presence of HeV, NiV or henipavirus RNA by PCR.
188          Recent evidence identified multiple Henipavirus species in Africa distinct from those in Sou
189 nism that is a general property of the known Henipavirus species.
190                                              Henipavirus-specific vaccines are still commercially una
191  genome of AngV, which encodes the six major henipavirus structural proteins (nucleocapsid, phosphopr
192  vaccine antigen design.IMPORTANCEPathogenic henipaviruses such as Nipah virus (NiV) and Hendra virus
193                                     Batborne henipaviruses, such as Nipah and Hendra viruses, represe
194 tures associated with pathogenicity in other henipaviruses, suggesting that AngV could be pathogenic
195  work suggests that AngV is an ancestral bat henipavirus that likely uses viral entry pathways distin
196 ogy and PCR also suggested the presence of a henipavirus that was neither HeV nor NiV in Pteropus ale
197 irus (TPMV), a relative of the morbilli- and henipaviruses that neither infects humans nor has cross-
198 (BSL-4) paramyxoviruses in the growing genus Henipavirus The attachment (G) and fusion (F) envelope g
199 cally related to highly pathogenic bat-borne henipaviruses, the absence of a conserved ephrin recepto
200  within the Paramyxovirinae subfamily called HENIPAVIRUS: These viruses are most closely related to m
201 roteins of the Nipah virus and other related henipaviruses to neutralize infection.
202 ing site is structurally distinct from other henipaviruses, underlying its capability to accommodate
203 dy was to develop candidate vaccines against henipaviruses utilizing two well-established rhabdoviral
204  findings characterize essential regions for Henipavirus V proteins that represent potential targets
205 he use of NiV as a prototypical pathogen for henipavirus vaccine antigen design.IMPORTANCEPathogenic
206                         GSL incorporation in henipaviruses was also dependent on the viral capsid (M)
207 of the highly pathogenic paramyxovirus genus Henipavirus, which can cause severe respiratory disease
208 oonotic paramyxovirus belonging to the genus Henipavirus, which infects Pteropus bat species in South
209  of the Langya virus fusion protein to other henipaviruses, which have important vaccine and therapeu
210 ion of Henipavirus reservoirs, and therefore henipaviruses, will likely change under climate change s

 
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