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1 ntification in domestic dogs of a nonprimate hepacivirus.
2 longing to the family flaviviridae and genus hepacivirus.
3 t on the genetic diversity and host range of hepaciviruses.
4 ce of ancient recombination with these other hepaciviruses.
5 es has resulted in escape from antagonism by hepaciviruses.
6 fected a panel of CC strains with Norway rat hepacivirus and identified several that failed to clear
7 ion was specific to orthoflaviviruses as the hepacivirus and member of the broader Flaviviridae famil
8 at share features with members of the genera Hepacivirus and Pegivirus.
9 s) of the RNA genomes of Flaviviridae of the Hepacivirus and Pestivirus genera contain internal ribos
10  four cysteine residues, conserved among the Hepacivirus and Pestivirus genera, fitting the formula o
11  data highlight the similarities between the Hepacivirus and Pestivirus NS5A proteins and suggest tha
12  on the natural history and evolution of the hepaciviruses and on the extent of structural variation
13 major and ancient natural reservoir for both hepaciviruses and pegiviruses and provide insights into
14                                              Hepaciviruses and pegiviruses constitute two closely rel
15 erse group of bat-derived viruses related to hepaciviruses and pegiviruses within the family Flavirid
16 volutionary analyses revealed that all known hepaciviruses and pegiviruses, including those previousl
17 about the origin and evolution of the animal hepaciviruses as well as their potential usage as surrog
18                                   Bald eagle hepacivirus (BeHV) belongs to a divergent clade of avian
19 tics, the IRES of hepatitis C virus (HCV), a Hepacivirus belonging to Flaviviridae, cannot as yet be
20 that facilitates the entry of an HCV-related hepacivirus but with a mechanism not described for HCV.
21    Full-genome alignments of all branches of Hepacivirus C are provided in the supplement.
22  of HCV include a recently discovered canine hepacivirus (CHV) and GB virus B (GBV-B), both viruses w
23 parative phylogenetic analysis of the canine hepacivirus (CHV) confirmed it to be the most geneticall
24 derstand the molecular mechanisms that drive hepacivirus clearance and chronicity, the virus and host
25                                   Norway rat hepacivirus, closely related to HCV, causes chronic live
26 try factors of GB virus B (GBV-B), the first hepacivirus described in an animal after hepatitis C vir
27             Here we show that an HCV-related hepacivirus discovered in Norway rats can establish high
28                                       Equine hepacivirus (EHCV; nonprimate hepacivirus) is a hepatotr
29                                       Equine hepacivirus (EqHV) is phylogenetically the closest relat
30                        Infection with rodent hepacivirus from Rattus norvegicus (RHV-rn1) in rats sha
31 gy caused by another, more rapidly resolving hepacivirus, GB virus B (GBV-B), in infections of common
32 nnate immunity in resolving infection with a hepacivirus, GBV-B, in common marmosets.
33 ars, the known phylogenetic diversity of the hepacivirus genera has absolutely exploded.
34                 We also find an EVE from the Hepacivirus genus of flaviviruses with orthology across
35  of hepatitis C virus (HCV), a member of the Hepacivirus genus of the family Flaviviridae, has been d
36 age the addition of 4 virus families and the Hepacivirus genus to the growing virus fossil record of
37  number of viral species classified into the Hepacivirus genus.
38                       The new virus, guereza hepacivirus (GHV), clusters phylogenetically with GBV-B
39 xpanded the previously mammal-only pegivirus-hepacivirus group to include a virus from the graceful c
40 B virus B (GBV-B; family Flaviviridae, genus Hepacivirus) has been studied in New World primates as a
41 ne against the hepatitis C virus (HCV; human hepacivirus) have been stymied by a lack of small animal
42  novel hepacivirus-like virus (Flaviviridae: Hepacivirus) identified during an investigation of Wisco
43 n CD4(+) and CD8(+) T cells is important for hepacivirus immunity, and that subversion of responses c
44 ry, pathogenesis, and immunity of this novel hepacivirus in its natural host.
45      The recent identification of nonprimate hepaciviruses in dogs and then in horses prompted us to
46 ow that NS3 proteases from all other primate hepaciviruses, including the highly divergent GBV-A and
47 enetically with GBV-B and recently described hepaciviruses infecting African bats and North American
48 netic and biological characterization of new hepaciviruses infecting animals contributes to our under
49 xperimental rat model of chronic HCV-related hepacivirus infection and its response to T cell immuniz
50 st that NK cell and DC mobilization in acute hepacivirus infection can dampen virus replication but a
51 virus mouse model will facilitate studies of hepacivirus infection for in-depth characterization of v
52 ese modified genomes protect against chronic hepacivirus infection, a strategy with an apparent trans
53 vention, and treatment of diseases caused by hepacivirus infection.
54  studies of humoral immune responses against hepacivirus infection.
55 and thus represents an animal model to study hepacivirus infections in their natural hosts.
56 ile GB virus B (GBV-B), another hepatotropic hepacivirus, infects small New World primates (tamarins
57                                   Norway rat hepacivirus is of particular interest, as it enables stu
58         Equine hepacivirus (EHCV; nonprimate hepacivirus) is a hepatotropic member of the Flavivirida
59                   Hepatitis C virus (HCV), a Hepacivirus, is a major cause of viral hepatitis, liver
60 tal infection of laboratory rats with rodent hepacivirus isolated from feral Rattus norvegicus (RHV-r
61 l infection of laboratory rats with a rodent hepacivirus isolated from Rattus norvegicus (RHV) is a p
62 ch primates might clear infections by extant hepaciviruses like HCV.
63                    Here, we describe a novel hepacivirus-like virus (Flaviviridae: Hepacivirus) ident
64 aled that the genetic distance between these hepaciviruses likely prevented virus morphogenesis.
65                        Similar work on other hepaciviruses may unveil a commonality of entry factors
66  reverse genetic studies, and the Norway rat hepacivirus mouse model will facilitate studies of hepac
67 h a recombinant adenovirus vector expressing hepacivirus non-structural proteins induces effective im
68                                   Nonprimate hepacivirus (NPHV) is the closest known relative of hepa
69 he natural host of the only known nonprimate hepacivirus (NPHV), CHV, which is also the closest phylo
70 sest homolog of HCV is the equine nonprimate hepacivirus (NPHV), which shares similar features with H
71    Among these novel viruses, the nonprimate hepaciviruses (NPHV) that infect horses are the closest
72                                   Norway rat hepacivirus (NrHV) infection in rats shares HCV-defining
73 l for deciphering virus-host interactions in hepacivirus pathogenesis.
74 2 glycoproteins from 60 viral species in the Hepacivirus, Pegivirus, and Pestivirus genera.
75       However, the E1E2 glycoproteins of the hepaciviruses, pegiviruses and pestiviruses are structur
76   The mechanism of translation initiation on hepacivirus/pestivirus (HP) IRESs, which involves factor
77 n the closest genetic relatives of the human hepaciviruses, providing an intriguing clue to the zoono
78 animal and primate hepaciviruses, the equine hepaciviruses remain the closest genetic relatives of th
79                                       Animal hepaciviruses represent promising surrogate models for h
80 mune-competent rats challenged with a rodent hepacivirus (RHV) develop chronic viremia characterized
81                          Discovery of rodent hepacivirus (RHV) enabled establishment of novel surroga
82   The recent discovery of an HCV-like rodent hepacivirus (RHV) enabled the development of such a mode
83  for assessing HCV vaccines; however, rodent hepacivirus (RHV) infection in laboratory rats recapitul
84  a strictly hepatotropic, HCV-related rodent hepacivirus (RHV) model circumvents many of the challeng
85                                 Using rodent hepacivirus (RHV), a homolog of HCV that shares many cha
86 l NPHV cDNA clones and other novel tools for hepacivirus studies.
87                Conserved genetic features of hepaciviruses suggest that they have undergone specific
88  is an entry factor shared between these two hepaciviruses suggests that the tight junction protein i
89 onclusion, we identified a genomic region of hepacivirus that can be synonymously mutated to attenuat
90 inants between HCV and GB virus B (GBV-B), a hepacivirus that infects small New World primates (tamar
91 ntification of these many animal and primate hepaciviruses, the equine hepaciviruses remain the close
92 yet been identified, for others, such as the hepaciviruses, the molecular mechanisms of membrane fusi
93                    Hepatitis C virus-related hepaciviruses were discovered in a number of animal spec
94                Studying the entry of related hepaciviruses will increase the knowledge of the molecul