ライフサイエンスコーパス: heparan sulfate

1 red by addition of heparin, a GAG similar to heparan sulfate.

2 degradation pathway of dermatan sulfate and heparan sulfate.

3 al glycocalyx coverage, with preservation of heparan sulfate.

4 blocks binding to scavenger receptor B1 and heparan sulfate.

5 minal AgRP, not the N-terminal domain, binds heparan sulfate.

6 peptides with glycosaminoglycans, including heparan sulfate.

7 Hpa2 function does not rely on heparanase or heparan sulfate.

8 glycosaminoglycans, particularly heparin and heparan sulfate.

9 glycan (GAG) adhesion molecules and binds to heparan sulfate.

10 ls, binding of FH is generally attributed to heparan sulfate.

11 alloproteinase, ADAM-10, in combination with heparan sulfate.

12 strongly to longer GAG chains of heparin and heparan sulfate.

13 of the sulfate groups to the sugar moiety of heparan sulfate.

14 nchored and extracellular proteins that bind heparan sulfate.

15 gate for the extracellular matrix component, heparan sulfate.

16 heparin or enzymatic removal of cell surface heparan sulfates.

17 Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) is one o

18 ction in HS2ST1 mRNA and decreased or absent heparan sulfate 2-O-sulfotransferase 1 in two of three f

19 of twenty-three experimental measurements on heparan sulfate, a mixture of linear chains of disacchar

20 lysosomal enzymes that specifically degrade heparan sulfate, a sulfated glycosaminoglycan.

21 Heparan sulfate, a sulfated linear polysaccharide modifi

22 Heparan sulfate accelerated AL-12, AL-09, kappaI Y87H, a

23 ntration of thrombomodulin and the degree of heparan-sulfate accelerated antithrombin activity on tho

24 r the activity of major inhibitors including heparan-sulfate-accelerated antithrombin and activated p

25 st a model in which FN matrix and associated heparan sulfate act as a scaffold to organize enzyme and

26 strategy based on modifying the activity of heparan sulfate, an important regulator of a wide range

27 ule that masks sGAGs, by GM-1111, a sulfated heparan sulfate analogue, and by sulfated cyclodextrin,

28 We observed a 3-fold elevation in CSF heparan sulfate and a 3-8 fold increase in MPS-IH specif

29 cells, spike protein binding depends on both heparan sulfate and ACE2.

30 2 spike protein interacts with both cellular heparan sulfate and angiotensin-converting enzyme 2 (ACE

31 normal levels of attachment to cell surface heparan sulfate and binding to nectin-1 receptor.

32 er glycosaminoglycans, including endothelial heparan sulfate and chondroitin sulfate E, but not with

33 Binding was reduced after the removal of heparan sulfate and following the inhibition of glycosam

34 es corresponded with augmented extracellular heparan sulfate and glypican 4 levels.

35 Heparan sulfate and heparin are highly acidic polysaccha

36 ral pieces of evidence that demonstrate that heparan sulfate and other closely related glycosaminogly

37 ween the alpha-synuclein amyloid fibrils and heparan sulfate and show that overall sulfation of the h

38 tors/attachment factors such as neuropilins, heparan sulfate and sialic acids and the putative altern

39 trometry-based toolkit for the sequencing of heparan sulfate and structurally related biomolecules.

40 plasma levels of its principal constituents, heparan sulfate and syndecan-1.

41 E is likely responsible for virus binding to heparan sulfate and that N- and 6-O-sulfation of the hep

42 Our data also implicate NCX-9 in a LON-2/heparan sulfate and UNC-6/netrin-mediated, RAC-dependent

43 Secreted and furin-processed ADAMTS9 bound heparan sulfate and was internalized by LRP1, LRP2 and c

44 Here, we identify heparins/heparan sulfates and Lewis antigens as receptors for dif

45 t requires sulfated polysaccharides, such as heparan sulfates and/or chondroitin sulfates, for initia

46 ted two native GAGs (chondroitin sulfate and heparan sulfate) and compared our results to chemically

47 Syndecan-1, heparan sulfate, and HA are the main components whose sh

48 Heparin and heparan sulfate antagonize the binding of these pathogen

49 Heparan sulfates are structurally diverse sulfated polys

50 ter regions of all genes involved in heparin/heparan sulfate assembly uncovered a transcription facto

51 Heparan sulfate belongs to the group of glycosaminoglyca

52 cause fibroblast growth factor 22 (FGF22), a heparan sulfate binding growth factor, has been shown to

53 Despite the large number of heparin and heparan sulfate binding proteins, the molecular mechanis

54 tructurally equivalent residues from AAV2, a heparan sulfate binding serotype, followed by cell bindi

55 otective antibody that binds adjacent to the heparan sulfate binding site of A27, likely affecting li

56 proach specifically designed to identify HEP/heparan sulfate binding sites in proteins were first car

57 s, we identify exosomal fibronectin as a key heparan sulfate-binding ligand and mediator of exosome-c

58 a provide compelling evidence that AgRP is a heparan sulfate-binding protein and localizes critical r

59 The identification of membrane heparan sulfate-binding proteins is challenging because

60 Docking studies suggest a heparin/heparan sulfate-binding site adjacent to the ACE2-bindin

61 man hepatocytes, CRISPR/Cas9 manipulation of heparan sulfate biosynthesis in human hepatoma cells, or

62 cts, although some distinct pathways such as heparan sulfate biosynthesis showed differences.

63 Moreover inactivation of the heparan sulfate biosynthetic gene N-deacetylase and N-su

64 teins in the liver are commonly decorated by heparan sulfate, but the potential role of hepatic hepar

65 in/dermatan sulfate by approximately 50-60%, heparan sulfate by approximately 35%), N-acetyl-d-glucos

66 recruitment of FGF2 at the inner leaflet and heparan sulfates capturing FGF2 at the outer plasma memb

67 e + laminin (CHL) or collagen IV + gelatin + heparan sulfate (CGH) demonstrated significantly higher

68 we further investigated the role of EXTL2 in heparan sulfate chain elongation by gene silencing and o

69 stimulates elongation resulting in increased heparan sulfate chain length.

70 he same cell line had little or no effect on heparan sulfate chain length.

71 ent interactions between LPL and SDC1-linked heparan sulfate chains and between LPL and the Golgi mem

72 in sodium chlorate, indicating that sulfated heparan sulfate chains are required for nuclear transloc

73 the balance between chondroitin sulfate and heparan sulfate chains in dictating ligand responses wit

74 lfate and show that overall sulfation of the heparan sulfate chains is more important than sulfation

75 ing that Wnt interactions with the TbetaRIII heparan sulfate chains result in inhibition of Wnt signa

76 er affinity for endothelial-derived perlecan heparan sulfate chains than serglycin GAG chains.

77 the core LON-2/glypican protein, lacking its heparan sulfate chains, and secreted forms of LON-2/glyp

78 ransferase activity related to elongation of heparan sulfate chains.

79 ctrometry on urine samples to determine GAG (heparan sulfate, chondroitin sulfate, and hyaluronic aci

80 acid) concentrations as well as patterns of heparan sulfate/chondroitin sulfate disaccharide sulfati

81 f ions and proteins with the chondroitin and heparan sulfate components of the extracellular matrix;

82 data support the idea that abnormalities in heparan sulfate content and distribution contribute to a

83 lfate synthesized was confirmed by analyzing heparan sulfate content in tissues isolated from Ndst2(-

84 sing cells alone could explain the increased heparan sulfate content.

85 ular domain of LRRTM4 was found to engage in heparan-sulfate dependent binding with pikachurin.

86 hich viral attachment and infection involves heparan sulfate-dependent enhancement of binding to ACE2

87 Heparin is a fractionated form of heparan sulfate derived from animal sources, predominant

88 chondroitin sulfate/dermatan sulfate nor the heparan sulfate derived from CCD-1095Sk cells primed on

89 paranase expression, consequent reduction in heparan sulfate expression and endothelial glycocalyx th

90 AFM pulling on glypican-1 and heparan sulfate for 10 min caused significantly increase

91 approaches demonstrated that the avidity of heparan sulfate for BDNF increased with sulfation at the

92 mmunosorbent assays (ELISAs) and depended on heparan sulfate for efficient cell binding and infection

93 fever virus, highlighting the importance of heparan sulfate for host cell infection by bunyaviruses.

94 ion of the endothelial glycocalyx, releasing heparan sulfate fragments (of sufficient size and sulfat

95 ndicate that circulating 2-O- and N-sulfated heparan sulfate fragments contribute to septic cognitive

96 Heparan sulfate fragments penetrated the hippocampal blo

97 howed no major structural difference between heparan sulfate from control and Ndst2(-/-) tissues, wit

98 d in vivo Specifically, enzymatic removal of heparan sulfate from primary human hepatocytes, CRISPR/C

99 nd Ndst2(-/-) tissues, with the exception of heparan sulfate from spleen where the relative amount of

100 Heparan sulfate from the cerebral cortex of MPS IIIA mic

101 Removal of heparan sulfate from the exosome surface releases fibron

102 ration-dependent manner by the XylNap-primed heparan sulfate GAGs.

103 -Delta20, binds to heparin and brain-derived heparan sulfate glycosaminoglycans (GAGs) but not to the

104 ns that couple a membrane-docking peptide to heparan sulfate glycosaminoglycans (GAGs) with a PTD.

105 The complex sulfation motifs of heparan sulfate glycosaminoglycans (HS GAGs) play critic

106 affinities in the following order: heparin > heparan sulfate > chondroitin sulfate = dermatan sulfate

107 Manipulation of heparan sulfate had a similar effect on IL6-dependent he

108 ncluding cello-oligosaccharides, hyaluronan, heparan sulfate, heparin, and chondroitin sulfate, and c

109 s of the glycosaminoglycans-hyaluronan (HA), heparan sulfate/heparin (HS/HP), chondroitin/dermatan su

110 omputational strategy on a library of 46 656 heparan sulfate hexasaccharides we identified a rare seq

111 Heparin and heparan sulfate (Hp/HS) are linear complex glycosaminogl

112 Heparan sulfate (HS) 3-O-sulfation determines the bindin

113 attachment of the PCV2 icosahedral capsid to heparan sulfate (HS) and chondroitin sulfate B (CSB) gly

114 ne circovirus 2 (PCV2) attaches to cells via heparan sulfate (HS) and chondroitin sulfate B (CSB) gly

115 Heparan sulfate (HS) and dermatan sulfate (DS) are l-idu

116 he host glycosaminoglycans heparin (Hep) and heparan sulfate (HS) are high-priority carbohydrates for

117 Heparin and heparan sulfate (HS) are linear polysaccharides that are

118 scribed to establish ligand requirements for heparan sulfate (HS) binding proteins based on a workflo

119 3 (EXTL3), a glycosyltransferase involved in heparan sulfate (HS) biosynthesis.

120 Heparin and heparan sulfate (HS) by nature contain multiple isomeric

121 ly replaced with an antibody that recognizes heparan sulfate (HS) chains attached to multiple HSPGs w

122 various tissue injury factors through their heparan sulfate (HS) chains, but the importance of HSPGs

123 gher 6-O sulfation level in Sdc2 versus Sdc4 heparan sulfate (HS) chains, leading to an increase in V

124 , and overexpression approaches identified a heparan sulfate (HS) component of proteoglycans as an im

125 ortant reason lies in its ability to exploit heparan sulfate (HS) for attachment to cells.

126 marine sponges, chondroitin sulfate (CS) and heparan sulfate (HS) have been identified in Cnidarians,

127 are correlated with the expression level of heparan sulfate (HS) in human skin.

128 osulfatases removing 6-O-sulfate groups from heparan sulfate (HS) in the extracellular space, thus el

129 Heparan sulfate (HS) is a cell surface and extracellular

130 Heparan sulfate (HS) is a linear sulfated polysaccharide

131 Heparan sulfate (HS) is a linear, complex polysaccharide

132 Heparan sulfate (HS) is a polysaccharide known to modula

133 Heparan sulfate (HS) is a sulfated glycosaminoglycan abu

134 Heparan sulfate (HS) is an essential component of the ex

135 Heparan sulfate (HS) mediates a wide range of protein bi

136 Heparanase cleaves polymeric heparan sulfate (HS) molecules into smaller oligosacchar

137 ional entity composed of a complex synthetic heparan sulfate (HS) oligosaccharide and biotin.

138 cell surface and extracellular carbohydrate heparan sulfate (HS) performed by Hs2st suppresses the s

139 Heparan sulfate (HS) polysaccharides are ubiquitous in a

140 A small library of well defined heparan sulfate (HS) polysaccharides was chemoenzymatica

141 rface of host cells and specifically bind to heparan sulfate (HS) present on host cell surface proteo

142 Heparan sulfate (HS) proteoglycan chains are key compone

143 mics, we identified the extracellular matrix heparan sulfate (HS) proteoglycan perlecan as a G6b-B bi

144 Expression of the heparan sulfate (HS) proteoglycan syndecan-1 is a hallma

145 membrane (ILM), a basement membrane rich in heparan sulfate (HS) proteoglycan.

146 Heparan sulfate (HS) proteoglycans bind to many proteins

147 action of the viral envelope protein E2 with heparan sulfate (HS) proteoglycans from the host's plasm

148 Despite evident regulatory roles of heparan sulfate (HS) saccharides in numerous biological

149 cosidase heparanase specifically cleaves the heparan sulfate (HS) side chains on proteoglycans, an ac

150 Here we show that heparan sulfate (HS), a class of glycosaminoglycan chain

151 These contain lower sulfated Hp-like and heparan sulfate (HS), as well as other glycosaminoglycan

152 minal domains of OPG is to bind cell surface heparan sulfate (HS), but the in vivo evidence was lacki

153 to binding tissue glycosaminoglycans (GAGs), heparan sulfate (HS), chondroitin sulfate (CS), and derm

154 ect of ZIKV NS1 on expression and release of heparan sulfate (HS), hyaluronic acid (HA), and sialic a

155 EXTL3 regulates the biosynthesis of heparan sulfate (HS), important for both skeletal develo

156 particular highly sulfated heparin (Hep) and heparan sulfate (HS), is challenging because of their st

157 saminoglycans (GAGs), especially heparin and heparan sulfate (HS), modulate the functions of numerous

158 isaccharides of chondroitin sulfate (CS) and heparan sulfate (HS), which are representatives of two m

159 Heparanase, a heparan sulfate (HS)--specific endoglucuronidase, mediat

160 OPG is known to be a high-affinity heparan sulfate (HS)-binding protein.

161 al delivery of AAV serotype 2 (AAV2) and its heparan sulfate (HS)-binding-deficient capsid led to sim

162 a multitude of cell-signaling events through heparan sulfate (HS)-protein interactions and are associ

163 es highly enriched in ADAM10-cleaved PrP and heparan sulfate (HS).

164 ) is mediated by tau binding to cell surface heparan sulfate (HS).

165 tein domains 19 and 20, which also recognize heparan sulfate (HS).

166 the highly sulfated cell signalling molecule heparan sulfate (HS).

167 , leading to increased levels of nondegraded heparan sulfate (HS).

168 Heparan sulfates (HS) are linear sulfated polysaccharide

169 g the lesion express Ndst1, a key enzyme for heparan sulfates (HS) synthesis.

170 Accumulation of heparan sulfate in cultured astrocytes corresponded with

171 ole mammalian endoglucuronidase that cleaves heparan sulfate in ECM, is preferentially expressed in c

172 Circulating heparan sulfate in endotoxemic mice and septic humans wa

173 n sulfate, but the potential role of hepatic heparan sulfate in hepcidin expression and iron homeosta

174 ndrome and emphasize a role for 2-O-sulfated heparan sulfate in human neuronal, skeletal, and renal d

175 Specifically, altered sulfation of heparan sulfate in mutant neutrophils affected formation

176 ntent are capable of competing with the PCV2-heparan sulfate interaction and, thus, have the potentia

177 y that therapeutic disruption of fibronectin-heparan sulfate interactions will negatively impact myel

178 , PAPST1-triggered synthesis of cell surface heparan sulfate is required for the efficient replicatio

179 Combinatorial ECMs composed of collagen IV + heparan sulfate + laminin (CHL) or collagen IV + gelatin

180 Surface expression of CD138 increased heparan sulfate levels on ASCs, which are known to bind

181 tility for the assembly of both heparin- and heparan sulfate-like oligosaccharides.

182 M genes (Collagens, Galectin-1, Fibronectin, Heparan Sulfate, LOX, FAK1), cell cycle genes (USP16, S1

183 e first evidence that fibronectin binding to heparan sulfate mediates exosome-cell interactions, reve

184 odels, we utilized sulfated polysaccharides, heparan sulfate mimetics, and occluding compounds.

185 y features of this binding interaction using heparan sulfate mimetics, identify an important sulfate

186 ngs demonstrate a novel regulatory factor in heparan sulfate modification that could further advance

187 neurexin O-glycosylation and suppressed its heparan sulfate modification, suggesting that FAM19As re

188 As heparan sulfate modulates FGF-mediated signaling, we fou

189 Heparan sulfate modulates the activity and distribution

190 ations in Raman peaks arising from different heparan sulfate moieties, indicating that protein-hepari

191 Through heparan sulfate moieties, syndecans are thought to ancho

192 In fibroblasts, ligand interactions with heparan sulfate of syndecan-4 recruit cytoplasmic protei

193 ic methodology that can provide libraries of heparan sulfate oligosaccharides that have glucosamine r

194 First, we used short heparan sulfate oligosaccharides to remove lipoproteins

195 the synthetic difficulties to access diverse heparan sulfate oligosaccharides with well-defined sulfa

196 ays a dual role in exosome-cell interaction; heparan sulfate on exosomes captures fibronectin, and on

197 ptors for exosome uptake, but the ligand for heparan sulfate on exosomes has not been identified.

198 eviously shown that HMPV requires binding to heparan sulfate on the surfaces of target cells for atta

199 ly exclusive interactions with PI(4,5)P2 and heparan sulfates on opposing sides of the membrane.

200 Heparan sulfates on target cell surfaces can act as rece

201 Manipulation of heparan sulfate or inhibition of viral adhesion by exoge

202 We discovered that heparan sulfate plays a dual role in exosome-cell intera

203 provide compelling evidence that hepatocyte heparan sulfate plays a key role in regulating hepcidin

204 minished infection with SBV, confirming that heparan sulfate plays an important role in cell attachme

205 In vivo transcript expression levels of the heparan sulfate-polymerizing enzymes Ext1 and Ext2 were

206 Size estimation of heparan sulfate polysaccharide chains indicated that inc

207 icoagulant heparin, heparin lyases, and lung heparan sulfate potently block spike protein binding and

208 ability to transfer N-acetylgalactosamine to heparan sulfate precursor molecules but also, that EXTL2

209 blocked by addition of exogenous heparin or heparan sulfate, pretreatment of conditioned medium with

210 ply the number of sulfates, is important for heparan sulfate protein binding.

211 ma cells, or pharmacological manipulation of heparan sulfate-protein interactions using sodium chlora

212 many important cellular functions by way of heparan sulfate-protein interactions.

213 tate to produce Acetyl-CoA, and secretion of heparan sulfate proteoglycan (component of syndecan-1).

214 Binding of AAV to heparan sulfate proteoglycan (HSPG) at the ILM may allow

215 We show that SLC35B2, as a key regulator of heparan sulfate proteoglycan (HSPG) biosynthesis, is ess

216 ce lacking lipoprotein lipase (LPL), hepatic heparan sulfate proteoglycan (HSPG) receptors, LDLR, or

217 l synaptogenesis, including the GPI-anchored heparan sulfate proteoglycan (HSPG) Wnt co-receptor Dall

218 To confirm this finding, we prepared heparan sulfate proteoglycan (HSPG)-knockout (KO) cells

219 atases (Sulf-1 and Sulf-2) are extracellular heparan sulfate proteoglycan (HSPG)-specific 6-O-endosul

220 at reduce its expression and ability to bind heparan sulfate proteoglycan and LRP4 coreceptors involv

221 Here, we identified heparan sulfate proteoglycan as a major cellular attachm

222 activity, GAG incorporation of (35)SO4, and heparan sulfate proteoglycan assembly.

223 Syndecan-1 is a common heparan sulfate proteoglycan expressed by many natural t

224 ayed comprehension of the molecular basis of heparan sulfate proteoglycan functions.

225 vate EGL-mediated NO production and that the heparan sulfate proteoglycan glypican-1 is a primary mec

226 Glypican-3 (GPC3) is a cell-surface heparan sulfate proteoglycan highly expressed in hepatoc

227 Endorepellin, the C-terminal fragment of the heparan sulfate proteoglycan perlecan, influences variou

228 Syndecan-1 is a cell surface heparan sulfate proteoglycan primarily expressed in the

229 The heparan sulfate proteoglycan syndecan-1 is proteolytical

230 s have shown that postsynaptic expression of heparan sulfate proteoglycan syndecan-2 (SDC2) induces d

231 PAPST1 is a sulfotransferase involved in heparan sulfate proteoglycan synthesis encoded by the so

232 a patients express dendritic cell-associated heparan sulfate proteoglycan-dependent integrin ligand,

233 Here, we provide evidence of a novel role of heparan sulfate proteoglycans (HSPG) in the adaptive res

234 step of virus-cell interaction by mimicking heparan sulfate proteoglycans (HSPG), the highly conserv

235 3 spreads extracellularly and interacts with heparan sulfate proteoglycans (HSPG).

236 We now show that heparan sulfate proteoglycans (HSPGs) act as alternative

237 We previously showed that HMPV binds heparan sulfate proteoglycans (HSPGs) and that HMPV bind

238 Heparan sulfate proteoglycans (HSPGs) are cell surface r

239 Heparan sulfate proteoglycans (HSPGs) bind to and regula

240 f DIDS-resistant virus became independent of heparan sulfate proteoglycans (HSPGs) but, concomitantly

241 Heparan sulfate proteoglycans (HSPGs) critically modulat

242 matosensory neurons as a model, we show that heparan sulfate proteoglycans (HSPGs) Dally and Syndecan

243 Heparan sulfate proteoglycans (HSPGs) have long been imp

244 we identify that four genes associated with heparan sulfate proteoglycans (HSPGs) metabolism, specif

245 transferases, a class of enzymes that modify heparan sulfate proteoglycans (HSPGs), are essential to

246 We found levels of mRNAs encoding heparan sulfate proteoglycans (HSPGs), particularly SDC1

247 DS-resistant HCMV also became independent of heparan sulfate proteoglycans (HSPGs), suggesting that e

248 Heparan sulfate proteoglycans and heparin derivatives fu

249 inoglycans, we analyzed the role of membrane heparan sulfate proteoglycans in the adhesion and migrat

250 ed groups on their glycosaminoglycan chains, heparan sulfate proteoglycans interact with growth facto

251 sulfate and that N- and 6-O-sulfation of the heparan sulfate proteoglycans is required for HCV infect

252 d ones bind heparin - a structural analog of heparan sulfate proteoglycans known to mediate exosome e

253 and Tec kinase, as well as membrane-proximal heparan sulfate proteoglycans on cell surfaces.

254 ) extracellular trapping of FGF2 mediated by heparan sulfate proteoglycans on cell surfaces.

255 "seeding." We have previously observed that heparan sulfate proteoglycans on the cell surface mediat

256 t or dynamin activity or remove cell surface heparan sulfate proteoglycans reduced infection efficien

257 Heparan sulfate proteoglycans take part in crucial event

258 Heparin, an analog of the heparan sulfate proteoglycans that are receptors for den

259 Animal cells express heparan sulfate proteoglycans that perform many importan

260 Glypicans are a family of cell-surface heparan sulfate proteoglycans that regulate growth-facto

261 led at the cell surface level via binding to heparan sulfate proteoglycans, such as syndecans.

262 cells requires its interaction with surface heparan sulfate proteoglycans.

263 lular trapping mediated by membrane-proximal heparan sulfate proteoglycans.

264 ude laminins, type IV collagen, nidogens and heparan sulfate proteoglycans.

265 ifferentiated ligand binding and activity of heparan sulfate proteoglycans.

266 by glycosaminoglycans and were reduced after heparan sulfate removal or inhibition of glycosaminoglyc

267 We found that the binding of HS20 to heparan sulfate required sulfation at both the C2 positi

268 The accumulation of heparan sulfate results in neurological symptoms, culmin

269 s address the difficult challenge of heparin/heparan sulfate saccharide separation and will enhance s

270 The complexity of heparin and heparan sulfate saccharides makes their purification, in

271 eparanase is an endoglycosidase that cleaves heparan sulfate side chains of proteoglycans, resulting

272 Here, we show that modulation of hepatic heparan sulfate significantly alters hepcidin expression

273 red spectra of a systematic set of synthetic heparan sulfate stereoisomers were recorded in the finge

274 UVPD spectra for both dermatan and heparan sulfate structures display extensive fragmentati

275 n biochemical activity of binding to surface heparan sulfate, suggesting the possible involvement of

276 of several specialized enzymes required for heparan sulfate synthesis and catalyzes the transfer of

277 Our data demonstrate that a heparan sulfate synthesis deficit causes a recognizable

278 Analysis of heparan sulfate synthesized by HEK 293 cells overexpress

279 The heparan sulfate synthesized by the individual 1 cell lin

280 he role of NDST2 in regulating the amount of heparan sulfate synthesized was confirmed by analyzing h

281 st sequencing method of a complex mixture of heparan sulfate tetrasaccharides by LC-MS/MS.

282 come this challenge and distinguish isomeric heparan sulfate tetrasaccharides that differ only in the

283 arin biosynthesis are identical to those for heparan sulfate, the factors regulating these enzymes ar

284 does not involve its binding to cell surface heparan sulfate, the only known biochemical activity of

285 ularly SDC1 mRNA, and cell surface levels of heparan sulfate to be reduced in cells after SMAD6 knock

286 High-affinity binding of heparin/heparan sulfate to the Ig-like domain may proceed from s

287 The pre-binding of heparan sulfate to VLPs inhibited the binding of both N-

288 en the PCV2 capsid and heparin, an analog of heparan sulfate, to better than 3.6- angstrom resolution

289 abdus nematophila XptA1 reveal that heparins/heparan sulfates unexpectedly bind to different regions

290 Inactivation of heparan sulfate uronyl 2-O-sulfotransferase (Hs2st) in n

291 Accumulation of heparan sulfate was also detected in primary cultures of

292 ment and entry, although to various degrees, heparan sulfate was also found to be important to initia

293 A comparable dependency on heparan sulfate was also observed for La Crosse virus an

294 and/or NDST2 demonstrated that the amount of heparan sulfate was increased in NDST2- but not in NDST1

295 Using heparin, a routinely used analog of heparan sulfate, we demonstrate that increasing lengths

296 Consistent with its role in the synthesis of heparan sulfate, we show that this activity is required

297 brils in neuroblastoma cells is dependent on heparan sulfate, whereas internalization of smaller non-

298 ocyte-like cell line is equally dependent on heparan sulfate, while astrocyte- and microglia-like cel

299 These changes coincide with accumulation of heparan sulfate with characteristic non-reducing ends, w

300 applicable to the modular assembly of other heparan sulfates with regiodefined sulfation pattern for