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1 s for nuclear receptors as key regulators of hepatic bile acid (BA)/lipid metabolism and inflammation
2                                              Hepatic bile acid and lipid content was elevated in WT m
3  acid synthetic enzymes but exhibited higher hepatic bile acid and serum bilirubin levels, suggesting
4 rate-limiting step in the classic pathway of hepatic bile acid biosynthesis from cholesterol.
5 ion of the side chain of C27 steroids in the hepatic bile acid biosynthesis pathway, which begins wit
6 testine-specific deletion of SIRT1 increased hepatic bile acid biosynthesis, reduced hepatic accumula
7 isrupts the classical homeostatic control of hepatic bile acid biosynthesis.
8 ted the effect of the C-36 serpin peptide on hepatic bile acid biosynthesis.
9 stinal bile acid carrier ASBT (SLC10A2), the hepatic bile acid carrier NTCP (SLC10A1), and the steroi
10   Lung function, indices of inflammation and hepatic bile acid enzyme expression were measured in obe
11                                 In addition, hepatic bile acid export in humans is more dependent on
12 cid intraduodenally for 24 hours so that the hepatic bile acid flux reached prefistula levels.
13 IRT1 plays a vital role in the regulation of hepatic bile acid homeostasis through the HNF1alpha/FXR
14 ter gene expression, including the principal hepatic bile acid importer, the Na(+)/taurocholate co-tr
15  rifampicin, a ligand for human PXR, reduces hepatic bile acid levels in cholestasis patients.
16  aminotransferase, alkaline phosphatase, and hepatic bile acid levels in WT mice.
17              These observations suggest that hepatic bile acid levels or therapeutic agents targeting
18 alysis detected a 4.6-fold increase in total hepatic bile acid levels, despite the coordinated repres
19 eral UPR genes, as well as genes involved in hepatic bile acid metabolism and inflammation.
20 ase levels were correlated with the level of hepatic bile acid metabolism gene expression but not liv
21     In addition, metabolites associated with hepatic bile acid metabolism were affected by oil exposu
22 cid synthetic pathways, thereby reducing the hepatic bile acid pool and blood levels of bile acids.
23 stomorphology, serum liver enzyme, serum and hepatic bile acid profiles, and hepatic bile acid synthe
24 tein that controls the rate-limiting step in hepatic bile acid secretion.
25 idaxomicin and streptomycin markedly altered hepatic bile acid signaling and lipid metabolism, while
26 Furthermore, Pon3KO mice exhibited decreased hepatic bile acid synthesis and decreased bile acid leve
27  of the dual FXR and TGR5 agonist INT-767 on hepatic bile acid synthesis and intestinal secretion of
28 vels in the serum, which caused an increased hepatic bile acid synthesis and lipogeneses.
29 ted FGF15 signaling and subsequently reduced hepatic bile acid synthesis and lipogenesis and attenuat
30 e, serum and hepatic bile acid profiles, and hepatic bile acid synthesis and transportation gene expr
31 culation to induce FGF15/19, which modulates hepatic bile acid synthesis and uptake.
32                                              Hepatic bile acid synthesis is controlled, in part, by a
33 rm complex in the SHP-mediated inhibition of hepatic bile acid synthesis via coordinated chromatin mo
34                         On ursodiol therapy, hepatic bile acid synthesis was enhanced 2-fold compared
35 uced FGF19/15-mediated hepatic repression of hepatic bile acid synthesis, resulting in hypercholanemi
36  Here we report a role of TFEB in regulating hepatic bile acid synthesis.
37 dy is to investigate the role of TGFbeta1 in hepatic bile acid synthesis.
38 ntracellular metabolite of glucose, controls hepatic bile acid synthesis.
39  with lower FGF19/15 and resultant increased hepatic bile acid synthesis.
40 rthermore, FXR, PXR, and CAR protect against hepatic bile acid toxicity in a complementary manner, su
41                   The mechanism for abnormal hepatic bile acid transport was investigated in an 18-mo
42 n hepatocytes, plays a physiological role in hepatic bile acid transport.
43 for pathologic alterations in intestinal and hepatic bile acid transporter expression.
44 on, correlating with suppression of critical hepatic bile acid transporter gene expression, including
45 ion of bile salt export pump (BSEP), a major hepatic bile acid transporter.
46 ice had altered expression of genes encoding hepatic bile acid transporters and cholesterol and fatty
47                  The molecular regulation of hepatic bile acid transporters during cholestasis is lar
48 hydroxylase, sterol-12alpha-hydroxylase, and hepatic bile acid transporters on both sinusoidal and ca
49 ic adenosine monophosphate (cAMP) stimulates hepatic bile acid uptake by translocating sodium-tauroch
50                                              Hepatic bile acid uptake kinetics were determined in wil
51               Interestingly, the major human hepatic bile acid uptake transporter NTCP, but not rat N
52 OB2) regulates metabolic pathways, including hepatic bile acid, lipid, and glucose homeostasis.
53 ted in aberrant gene expression profiles for hepatic bile acid-responsive genes consistent with chole
54 chromatography/mass spectroscopy analysis of hepatic bile acids indicated no difference in levels of
55                     In response to increased hepatic bile acids, SHP gene expression is induced and t
56 -derived-fat-promoted taurine conjugation of hepatic bile acids, which increases the availability of
57 etion of bile acids, leading to elevation of hepatic bile acids.
58 gulating the expression of genes involved in hepatic bile and fatty acid synthesis, glucose metabolis
59                             The radiolabeled hepatic bile area within the gallbladder lumen was trace
60 subcutaneous implants alters partitioning of hepatic bile between gallbladder and small intestine and
61           We showed in this study that intra-hepatic bile duct cells could be grown using a human liv
62 at many dividing pre-cystic renal tubule and hepatic bile duct cells from Tsc1, Tsc2 and Pkd1 heteroz
63  Following common bile duct ligation or left hepatic bile duct ligation, the expression of p53, c-Myc
64 nd osteopontin ( Spp1 ), markers assigned to hepatic bile duct-associated macrophages, and were enric
65                       We characterized extra hepatic bile ducts (EHBD)s at various ages from 2 to 40
66 o biliary epithelial cells (BECs) lining the hepatic bile ducts leads to cholestatic liver diseases.
67  the liver, pancreas, gall bladder and extra-hepatic bile ducts(6,7).
68 ng and dilatation of the intra- and/or extra-hepatic bile ducts.
69 lized polycystin to renal tubular epithelia, hepatic bile ductules, and pancreatic ducts, all sites o
70              In the basal state, more of the hepatic bile entered the gallbladder (67%) than the smal
71                                              Hepatic bile entered the gallbladder continuously during
72                                 Radiolabeled hepatic bile entered the gallbladder first along its cen
73                                              Hepatic bile enters the gallbladder continuously during
74          The aim of the project was to study hepatic bile entry into and the transit pattern within t
75 technique of bile collection gives access to hepatic bile from donors and recipients for bile analysi
76 netic resonance analysis has been applied to hepatic bile from selected liver grafts to evaluate its
77                  The results showed that the hepatic bile from steatotic grafts collected before tran
78 s received 111-185 MBq 99mTc-mebrofenin as a hepatic bile marker.
79      Radiolabeled CE was increased 3-fold in hepatic bile of Cel(-/-) mice, and the mass of CE in gal
80                           Significantly less hepatic bile partitioned into the gallbladder in progest
81                                              Hepatic bile partitioning and gallbladder emptying were
82     FGF19/FGF15 is an endocrine regulator of hepatic bile salt and lipid metabolism, which has shown
83 lt lampreys tolerate cholestasis by altering hepatic bile salt composition, while maintaining normal
84 Sister of P-glycoprotein (SPGP) is the major hepatic bile salt export pump (BSEP).
85 cytes and may act as a gatekeeper to prevent hepatic bile salt overload.
86                                              Hepatic bile salt secretion and bile formation are essen
87               We show that key components of hepatic bile salt synthesis and ileal transport pathways
88              Instead, NTCP inhibition shifts hepatic bile salt uptake from mainly periportal hepatocy
89                                   Disrupting hepatic bile salt uptake, by inhibition of sodium-tauroc
90 acid, which results in toxic accumulation of hepatic bile salts, ER stress and liver injury.
91 sis occurred in the absence of any defect in hepatic bile secretion.
92                                          The hepatic bile transit rate was calculated (as mm2/min) an
93 ides is transported in a rat model measuring hepatic bile transport.
94                                              Hepatic bile was collected from eight liver donors (four
95  Total radiolabeled transport from plasma to hepatic bile was more rapid in Cel(-/-) mice.
96 he 6-hour recovery of [(14) C]cholesterol in hepatic bile was significantly lower in both groups of k