ライフサイエンスコーパス: hepatic cell

1 istinct signaling pathways in intestinal and hepatic cells.

2 a large increase in the number of apoptotic hepatic cells.

3 amino acid dampening of insulin signaling in hepatic cells.

4 in 1) coregulator via NF-kappaB signaling in hepatic cells.

5 fibroblasts, but not in lymphoid, myeloid or hepatic cells.

6 bled the linkage of CTGF to FN and activated hepatic cells.

7 r enzymes, and the presence of few apoptotic hepatic cells.

8 ity to HCV when ectopically expressed in non-hepatic cells.

9 (APAP) induced toxicity in hepatic and extra-hepatic cells.

10 can be utilized to regulate adhesion between hepatic cells.

11 many of which are expressed specifically in hepatic cells.

12 ndrial complex I activity in both muscle and hepatic cells.

13 he question of how HCV is able to persist in hepatic cells.

14 hepatitis C virus (HCV) replication in human hepatic cells.

15 .1 or I.4 in breast, ovarian, placental, and hepatic cells.

16 ls, which may account for HCV persistence in hepatic cells.

17 ent inhibitor of IFN-alpha expression by the hepatic cells.

18 dogenous interferon-alpha (IFN-alpha) in the hepatic cells.

19 -HCV ability of recombinant IFN-alpha in the hepatic cells.

20 play a major role in targeting Ad vectors to hepatic cells.

21 tates the interaction between sporozoite and hepatic cells.

22 d abuse, on HCV replicon expression in human hepatic cells.

23 iapoptotic and mitogenic actions of IL-22 in hepatic cells.

24 ng to negatively regulate GATA-4 function in hepatic cells.

25 3beta DNA binding complexes were enriched in hepatic cells.

26 trated that AMPK was inhibited by ethanol in hepatic cells.

27 neural tubules, gut, pulmonary bronchi, and hepatic cells.

28 serpin allele that fails to be activated in hepatic cells.

29 CV RNA expression in the replicon containing hepatic cells.

30 of genes that are specifically expressed in hepatic cells.

31 sions of transplanted, lentivirus-transduced hepatic cells.

32 ting apical protein trafficking in polarized hepatic cells.

33 n liver cells, but had minimal effect in non-hepatic cells.

34 rol-sensitive signal transduction pathway in hepatic cells.

35 the uptake and ultimate expression of DNA in hepatic cells.

36 greatly reducing reporter gene expression in hepatic cells.

37 nd Co-induced signaling and EPO induction in hepatic cells.

38 -induced gamma-fibrinogen gene expression in hepatic cells.

39 of acute-phase plasma protein (APP) genes in hepatic cells.

40 een described in neutrophils, monocytes, and hepatic cells.

41 or major PC biosynthetic pathway in all non-hepatic cells.

42 tercellular adhesion molecule-1 (ICAM-1), on hepatic cells.

43 r set of acute phase plasma protein genes in hepatic cells.

44 by interleukin (IL)-6 and glucocorticoids in hepatic cells.

45 sferase reporter gene in both nonhepatic and hepatic cells.

46 ich pRb modulates the apoptotic threshold in hepatic cells.

47 induce rapid growth arrest and apoptosis in hepatic cells.

48 ellular interaction and architecture between hepatic cells.

49 e tested against Caco-2 intestinal and HepG2 hepatic cells.

50 tagonist SPA70, which degrades PXR in HepaRG hepatic cells.

51 by intracellular cholesterol levels in human hepatic cells.

52 c transgenes without transducing tolerogenic hepatic cells.

53 ntly suppressed in NASH models and steatotic hepatic cells.

54 stry, and that tag strong eQTLs of CHST15 in hepatic cells.

55 upregulated by type I and II interferons in hepatic cells.

56 e of the LDLR and attenuated LDL uptake into hepatic cells.

57 degradation pathways upon MEHP treatment on hepatic cells.

58 miRNAs) that regulate LDLR activity in human hepatic cells.

59 icking but did block hyperphosphorylation in hepatic cells.

60 ities displayed negligible toxicity on human hepatic cells.

61 to differentiate to phenotypically distinct hepatic cells.

62 rotein and consequent copper accumulation in hepatic cells.

63 uciferase reporter assays in mouse and human hepatic cells.

64 le saturated fatty acid exhibits toxicity in hepatic cells.

65 expression of primary and mature miR-122 in hepatic cells.

66 the functional maturation of cocultured KDR- hepatic cells.

67 onal activation of PCK1 and G6PC in cultured hepatic cells.

68 assay for HBV-receptor expression screens in hepatic cells.

69 even in the absence of insulin in muscle and hepatic cells.

70 iR-33* reduces fatty acid oxidation in human hepatic cells.

71 , generate KDR+ hepatic progenitors and KDR- hepatic cells.

72 es on ApoB degradation were then observed in hepatic cells.

73 atient-derived induced pluripotent stem cell-hepatic cells.

74 examined in HIV-1- and HCV-coinfected human hepatic cells.

75 ive of enhancing tolerance of transduced non-hepatic cells, AAV vectors were engineered to co-express

76 FGF21 was upregulated and released from the hepatic cells and adipocytes into the circulation and in

77 immunopathogenesis of HCV in both immune and hepatic cells and are relevant to the development of hos

78 ility of gene transfer to diseased liver and hepatic cells and demonstrate the potential of a novel t

79 Interestingly, although normal hepatic cells and hepatoma cancer cells expressed a comp

80 tivation of gluconeogenic gene expression in hepatic cells and in mouse liver by PGC-1alpha.

81 excess lipid accumulation, both in cultured hepatic cells and in mouse livers.

82 stress increased cholesterol accumulation in hepatic cells and in the livers of apolipoprotein E knoc

83 nol on lipin-1 were investigated in cultured hepatic cells and in the livers of chronic ethanol-fed m

84 lase (ACC), and SREBP-1 were assessed in rat hepatic cells and in the livers of ethanol-fed mice.

85 The FHIT gene is expressed in normal hepatic cells and is not expressed or is abnormally expr

86 pid content and stimulates beta-oxidation in hepatic cells and liver by an autophagy-lysosomal pathwa

87 -mediated knockdown of PPARdelta in cultured hepatic cells and liver tissue reduced LPCAT3 mRNA level

88 3 methylation levels in CARM1-overexpressing hepatic cells and liver tissues from metformin-fed mice.

89 sitive regulator of HCV replication in human hepatic cells and may compromise IFN-alpha therapy.

90 ptional activation of PCK1 and G6PC in human hepatic cells and mouse liver was FoxO1-dependent and fu

91 lesteryl ester hydrolysis in transformed rat hepatic cells and primary rat hepatocytes.

92 ed specific HBV receptor/ligand complexes on hepatic cells and quantified the turnover kinetics.

93 tetracycline, and cyclosporin A) in cultured hepatic cells and the livers of different animal models

94 h to instruct their own differentiation into hepatic cells and to non-cell-autonomously support the f

95 e whether HA or HA fragments induced iNOS in hepatic cells, and to characterize the signaling pathway

96 further expand as protocols used to generate hepatic cells are improved.

97 ubsequently mechanistically characterized in hepatic cells as well as by dietary interventions and he

98 igh-fat diet and carbon tetrachloride, where hepatic cells become senescent.

99 We measured nucleosome occupancy in human hepatic cells before and after treatment with transformi

100 the SCF/c-kit signal transduction systems in hepatic cell biology.

101 and SMADs in mediating TGF-beta functions in hepatic cells, but it is not clear how STATs are activat

102 rgeted AAV vectors allow transduction of non-hepatic cells, but this necessitates development of stra

103 that PE inhibits IL-6 activation of STAT3 in hepatic cells by a p42/44 mitogen-activated protein kina

104 at fluoxazolevir inhibits fusion of HCV with hepatic cells by binding HCV envelope protein 1 to preve

105 Here we report that infection of hepatic cells by HCV stimulates nuclear factor kappa B (

106 se latter findings suggest that infection of hepatic cells by L. monocytogenes in vivo does not requi

107 that opioid abuse favors HCV persistence in hepatic cells by suppressing IFN-alpha-mediated intracel

108 e functions, the malignant transformation of hepatic cells can have a severe impact on the liver's me

109 We suggest virally infected hepatic cells can process potent CD1d-presented liver Ag

110 f compound 4b, and in vitro studies in AML12 hepatic cells confirmed the absence of toxicological eff

111 in expression of a murine CYP2D5 homolog in hepatic cells, confirming the selective ability of C/EBP

112 irectional, condition-dependent regulator of hepatic cell Cp expression.

113 Several hepatic cell culture and mouse models were used to study

114 il (CRF-V, normal-V) using liver homogenate, hepatic cell culture for 8 h, and in vitro liver perfusi

115 mation and a potential for three-dimensional hepatic cell cultures as in vitro models of cholangiopat

116 hough preparations of PHH contain up to 100% hepatic cells, cultures of differentiated HepaRG cells a

117 ded in TPEF images, such as inflammatory and hepatic cell damage, equally important as collagen depos

118 Despite evidence for apoptotic signaling, hepatic cell death after APAP is generally considered ne

119 Its role in hepatic cell death and hepatic diseases is not clear.

120 Thus, TRAIL plays a crucial role in hepatic cell death and hepatic inflammation.

121 and adaptive immune systems, the role of the hepatic cell death and the gut-liver axis, and recommend

122 eta1 signaling that was associated with less hepatic cell death as assessed by terminal deoxynucleoti

123 d accumulation, necroinflammation, and focal hepatic cell death in mice than rats.

124 erimental models of hepatitis, we found that hepatic cell death in vivo was dramatically reduced in T

125 tosis, indicating that TRAIL may not mediate hepatic cell death.

126 ed by eosinophils in response to large-scale hepatic cell death.

127 he functional maturation and preservation of hepatic cells derived from human induced pluripotent ste

128 und that pigtail macaque (Macaca nemestrina) hepatic cells derived from induced pluripotent stem cell

129 highlight how tight quantitative control of hepatic cell differentiation is exerted through specific

130 at gp130 signaling for APP gene induction in hepatic cells differs qualitatively from that controllin

131 n of the acute-phase plasma protein genes in hepatic cells during infection and injury.

132 Additionally, hepatic cells expressing full-length PHD2(D315E) were le

133 Hepatic cells expressing the non-phosphorylatable C/EBPb

134 genetic inactivation of Fgf10 also result in hepatic cell fate conversion.

135 whether Notch signaling also underlies adult hepatic cell fate decisions is largely unknown.

136 ide a functional link between IDH mutations, hepatic cell fate, and IHCC pathogenesis, and present a

137 d growth and commitment of the endoderm to a hepatic cell fate.

138 Culture of hepatic cells for 8 h was associated with an increase in

139 e specifically modified human chromosomes to hepatic cells for functional tests.

140 eration of functional hepatocyte-like cells (hepatic cells) from human embryonic stem cells (hESCs).

141 the mechanisms by which TGF-beta influences hepatic cell functions remain incompletely defined.

142 to induction of p450 expression and that in hepatic cells genes are also induced to block apoptosis,

143 resent an important mechanism for control of hepatic cell growth and hepatocarcinogenesis.

144 tional cytokine pivotal in the regulation of hepatic cell growth, differentiation, migration, extrace

145 smembrane domain (TMD) proteins in polarized hepatic cells has been inferred but never directly demon

146 availability of the HCV replicon containing hepatic cells has provided a unique opportunity to inves

147 ing that holoHC is transported into cultured hepatic cells (HepG2) via the asialoglycoprotein recepto

148 TCDCA produces toxicity in mouse primary hepatic cells (HSCs) and induces mitochondrial permeabil

149 Hepatic cells, identified based on the cell-specific exp

150 of the RSK1-DN mutant in L6 myocytes and FAO hepatic cells improved insulin action on glucose uptake

151 onsequences of N-myc up-regulation in rodent hepatic cells in culture.

152 fferential in-gel electrophoresis to analyze hepatic cells in early response to virosome-induced memb

153 Promoter 2, 5' to exon II, is active only in hepatic cells in promoter assays in vitro.

154 Excessive nitric oxide (NO) generated by hepatic cells in response to lipopolysaccharide (LPS) an

155 y generate significant numbers of functional hepatic cells in this noninjury large animal model and t

156 in determining adenovirus infectivity toward hepatic cells in vivo.

157 uciferase reporter genes in transduced mouse hepatic cells in vivo.

158 (iii) internalization of L. monocytogenes by hepatic cells in vivo.

159 Not only cholangiocytes but also other hepatic cells including hepatic stellate cells and macro

160 and physiological/pathological functions in hepatic cells including hepatocytes, cholangiocytes, Kup

161 We demonstrated that silencing of SAMHD1 in hepatic cells increased HBV replication, while overexpre

162 , we found that HFE increases TfR2 levels in hepatic cells independent of holo-Tf.

163 r-derived cells and minimal or modest in non-hepatic cells, indicating that a liver-specific factor i

164 Overexpression of miR-33b in human hepatic cells inhibits PCK1 and G6PC expression, leading

165 These cytokines regulate hepatic cell interaction and crosstalk of the various in

166 d modulating the cellular phenotype to alter hepatic cell interactions.

167 hat Pdx1-VP16 is able to selectively convert hepatic cells into pancreatic endocrine precursor cells.

168 strated that oncogenic regulation by Gab2 in hepatic cells involved multiple signaling molecules, inc

169 The data suggest that OB-RL action in hepatic cells is equivalent to that of IL-6 receptor.

170 Our results imply that hepatic cells lack trans-Golgi network (TGN)-based machi

171 (+) and ATP are not efficiently sustained in hepatic cells, largely because of transcriptional repres

172 ic clinical syndrome due to a sudden loss of hepatic cells leading to multiorgan failure.

173 Tolerogenic hepatic cells limit clinical disease through PD-L1 or ad

174 fferentiation and cell metabolism in a human hepatic cell line (HepG2).

175 in RA-induced signaling in a non-transformed hepatic cell line AML 12.

176 morphology on the culture of an immortalised hepatic cell line and mouse primary hepatocytes.

177 chromatin, and depletion of C/EBPalpha in a hepatic cell line decreased hDBP expression.

178 atterns in zebrafish models and in the human hepatic cell line HepaRG shared many similarities, while

179 INDO activity is not induced in the hepatic cell line HepG2.

180 in the HEK293-RXFP1 cAMP assay and the human hepatic cell line LX-2.

181 cytes and in the bile transporter-expressing hepatic cell line McNtcp.24, leading to a significant in

182 study, we generated a stably transfected rat hepatic cell line named WB-1 that expresses an active fo

183 Studies in a human hepatic cell line revealed that BCO2 is expressed as an

184 ing glucose homeostasis was deciphered using hepatic cell line system, which found up-regulation of g

185 a simple system, by using a non-transformed hepatic cell line that is able to express sufficient amo

186 a simple system, by using a non-transformed hepatic cell line that is able to express sufficient amo

187 ammatory hormones and iron was examined in a hepatic cell line that secretes plasma proteins.

188 In the human hepatic cell line, HepG2, apolipoprotein B100 (apoB100)

189 E exists as endoproteolyzed fragments in the hepatic cell line, HepG2.

190 mplex with Cdk2 in the NS5A-expressing human hepatic cell line.

191 how that human primary hepatocytes and human hepatic cell lines (Huh7 and HepG2) spontaneously produc

192 HCV-pp efficiently infected tamarin hepatic cell lines and primary marmoset hepatocyte cultu

193 demonstrate that TMPRSS6 is up-regulated in hepatic cell lines by hypoxia and by other activators of

194 n liver during the APR and can be induced in hepatic cell lines by interleukin-6 (IL-6), an acute-pha

195 and cancer-derived epithelial intestinal and hepatic cell lines following intoxication with CDT/CdtB

196 s animal models, or in transformed malignant hepatic cell lines in which thyroid hormone receptor (TR

197 pic expression of CLDN1 rendered several non-hepatic cell lines permissive to HCV infection.

198 Hepatic cell lines serve as economical and reproducible

199 ilin, in cardiovascular disease, and because hepatic cell lines that stably express wild-type or muta

200 However, the utility of hepatic cell lines to examine bile acid homeostasis and

201 ffects of ethanol on primary hepatocytes and hepatic cell lines were also studied in vitro.

202 Primary hepatocytes and hepatic cell lines were used for in vitro analyses.

203 Transient transfection of hepatic cell lines with NHERF1 or NHERF2 caused a signif

204 these two tight junction proteins in various hepatic cell lines, indicating that E-cadherin plays an

205 In hepatic cell lines, SIRT1 can directly activate HIF-2alp

206 Hepatic cell lines, such as Huh7, could provide a cost-e

207 eases paracellular permeability in polarized hepatic cell lines, supporting the hypothesis that parac

208 In hepatic cell lines, the downregulation of FSP27beta resu

209 Using human hepatic cell lines, we determined that TRAP80 selectivel

210 d CRISPR-Cas9-mediated inactivation in human hepatic cell lines, we found that FOCAD deficiency compr

211 atty acid oxidation and insulin signaling in hepatic cell lines, whereas inhibition of endogenous miR

212 ts increased LPCAT3 mRNA levels in all three hepatic cell lines.

213 tion using a panel of well characterized rat hepatic cell lines.

214 at reduced secreted ApoC-III levels in human hepatic cell lines.

215 nd LDL-cholesterol uptake in human and mouse hepatic cell lines.

216 In cultured hepatic cells, lipid availability dictates the rate of a

217 Here, by analyzing ICAM-1_KO human hepatic cells, liver organoids from ICAM-1_KO mice and r

218 AM and AFP to reveal HCC subtypes similar to hepatic cell maturation lineages, which may enable progn

219 g field in which the epigenomic microRNAs of hepatic cells may be manipulated with potential therapeu

220 low-density lipoprotein (LDL) receptors from hepatic cell membranes.

221 issue-specific function was demonstrated for hepatic cells micropatterned alone and in coculture with

222 y, establishing concurrent gain- and loss-of-hepatic cell mobilization conditions.

223 rvations suggest that MI-R injury can induce hepatic cell mobilization to support myocardial survival

224 distant cardioprotective mechanism involving hepatic cell mobilization to the ischemic myocardium in

225 expression of paracellular junction genes in hepatic cells of rat and human origin.

226 down-regulation of ApoH expression in either hepatic cells or mouse livers by RNA interference result

227 itors carry a high risk for toxic effects to hepatic cells or show moderate improvement.

228 thophysiology of cholangiopathies, and these hepatic cells orchestrate the coordinated response again

229 miRNA in the liver, appears to maintain the hepatic cell phenotype, and its inhibition decreases tot

230 a membrane (PM) proteins in three classes of hepatic cells: polarized and differentiated WIF-B cells,

231 ith enhanced IFNgamma production within some hepatic cell populations but also with decreased numbers

232 Analysis of hepatic cell populations revealed preferred GFAP promote

233 an and mouse liver samples and primary mouse hepatic cell populations were used for Western blot anal

234 he liver, the role of TLRs in the individual hepatic cell populations, and the implication of TLR sig

235 In normal hepatic cells, preproET-1 messenger RNA (mRNA) was detec

236 nificantly different in phenotype from other hepatic cells previously reported as candidates for live

237 Although FGFR1 is expressed by hepatic cell progenitors and adult nonparenchymal cells,

238 This triggered hepatic cell proliferation as well as activation of proc

239 apy slightly impaired liver regeneration and hepatic cell proliferation compared with control.

240 suppression of SDF-1 resulted in decrease of hepatic cell proliferation, implying the repair process

241 atocytes are proposed to be the most plastic hepatic cell, providing a reservoir for hepatocyte proli

242 with multiplicity of infection (MOI, vector:hepatic cell ratio).

243 7.5 times more nanomaterial interaction with hepatic cells relative to peripheral cells.

244 that Plasmodium berghei parasites infecting hepatic cells rely on the PVM transmembrane protein UIS3

245 ors effecting entry of L. monocytogenes into hepatic cells remain to be determined.

246 (MAPK) signaling pathways in intestinal and hepatic cells, respectively, and thereby regulates diver

247 licular and basolateral domains of polarized hepatic cells, respectively.

248 iated gene transfer of murine TGF-beta1 into hepatic cells results in the expression of biologically

249 These results show for the first time that hepatic cells secrete ferritin, that this ferritin secre

250 In hepatic cells, Smad and SnoN proteins converge with p53

251 in pericentral hepatocytes, a population of hepatic cells specialized in xenobiotic detoxification.

252 Hepatic cell-specific expression of the human apolipopro

253 cific gene expression signatures, pathogenic hepatic cell subpopulations and master regulator network

254 he HB channels were subsequently seeded with hepatic cells suspended in a collagen hydrogel.

255 been observed in specific subpopulations of hepatic cells that express some of the known cholangiocy

256 riptional features in myeloid, lymphoid, and hepatic cells that indicate the presence of multiple pro

257 ssion of acute phase plasma protein genes in hepatic cells through the action of gp130, the signal-tr

258 apolipoprotein B (apoB) mRNA is regulated in hepatic cells to achieve a steady state proportion of ed

259 stigated the ability of distinct lineages of hepatic cells to become liver CSCs and the phenotypic an

260 alpha1-ACT localizes to the nuclei of hepatic cells to control chromatin condensation and prol

261 s the signal that enables target cardiac and hepatic cells to learn to desensitize their responses.

262 potent negative regulator of the response of hepatic cells to pro-inflammatory cytokines, particularl

263 e proliferation of terminally differentiated hepatic cells to regenerate the original size of the adu

264 ature miR-181b were augmented on exposure of hepatic cells to TGFbeta and were significantly reduced

265 mia type I and a stringent in vivo model for hepatic cell transplantation.

266 th non-alcoholic steatohepatitis (NASH), and hepatic cells treated with fatty acids.

267 ession datasets provided further support for hepatic cell-type and AHR-regulated disruption of the af

268 ovides a comprehensive atlas that covers all hepatic cell types and is instrumental for further disse

269 sis likely involves actions of the different hepatic cell types and multiple extrahepatic signals.

270 n, proliferation, and morphogenesis of other hepatic cell types during liver development and regenera

271 Death of hepatocytes and other hepatic cell types is a characteristic feature of liver

272 ol (Chol)-conjugated siRNAs, which enter all hepatic cell types, and hepatocyte-selective tri-N-acety

273 tudy of the biology of ductal and periductal hepatic cell types, including progenitors.

274 on of nitric oxide (NO) by several different hepatic cell types.

275 and Wnts are not uniformly expressed by all hepatic cell types.

276 lncRNA expression patterns across different hepatic cell types.

277 mmation, and fibrosis by targeting different hepatic cell types.

278 inding of this preparation to cultured human hepatic cells was both dose dependent and saturable.

279 on polymorphonuclear neutrophils (PMNs) and hepatic cells was increased more than twofold.

280 The gene expression pattern of rat hepatic cells was studied during their differentiation i

281 To get more insight into COP1 in hepatic cells, we examined the impact of COP1 on insulin

282 pical plasma membrane protein trafficking in hepatic cells, we found that specific inhibition of Vps3

283 The mobilized hepatic cells were able to express and release trefoil f

284 Twenty-two hours after the injection of LPS, hepatic cells were isolated by collagenase and pronase d

285 these cells, a proportion of the regenerated hepatic cells were shown to be donor-derived.

286 use liver metabolism and on normal and tumor hepatic cells were studied.

287 atient-derived induced pluripotent stem cell-hepatic cells with a JNK inhibitor reduced accumulation

288 Although stimulation of hepatic cells with interleukin-6 induces the expression

289 IL-1Ra is produced by hepatic cells with the characteristics of an acute phase

290 s induce hepatic genes and stabilize nascent hepatic cells within the endodermal epithelium.