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1 stabsorptive rates and that avoid first-pass hepatic clearance.
2  of drugs, especially with low or negligible hepatic clearance.
3 cilitating glucocorticoid production and LPS hepatic clearance.
4 gent from the blood was used as a measure of hepatic clearance.
5 rt by their short half-life due to excessive hepatic clearance.
6 oprotein composition indicative of increased hepatic clearance.
7 tive ester 3(R) at a rate beyond the maximal hepatic clearance.
8 related protein 1 (LRP1), which drives FVIII hepatic clearance and antigen presentation in dendritic
9 eas in MODY3 patients may be due to impaired hepatic clearance and elevated plasma concentrations of
10 ing first-pass elimination in the liver, and hepatic clearance) and systemic exposure (i.e., CFA) of
11 h this estimation, effects from differential hepatic clearance are normalized, allowing for a better
12 s common in vitro techniques used to predict hepatic clearance as well as current challenges and rece
13 action unbound in plasma (fup) and intrinsic hepatic clearance (CLint) parameters were estimated in s
14 ming at high plasma protein binding and high hepatic clearance, concurrently with an early stage asse
15   For hepatic uptake transporter substrates, hepatic clearance depends not only on the rates of elimi
16 ach will be especially advantageous for high hepatic clearance drugs.
17             Prospective predictions of human hepatic clearance for anionic/zwitterionic compounds, wh
18                                  The average hepatic clearance fraction in the two-compartment model
19 ted perfused trout liver model that measures hepatic clearance has been proposed for validating IVIVE
20 ion of CEA (PELPK motif) responsible for its hepatic clearance in three of eight patients with high C
21                                              Hepatic clearance involves the LDL receptor (LDLR) and p
22 ost commonly employed methodology to predict hepatic clearance is termed in vitro to in vivo extrapol
23  of TG-rich lipoproteins primarily through a hepatic clearance mechanism mediated by the LDLR/LRP1 ax
24 r-bearing mice despite lack of saturation of hepatic clearance mechanisms.
25  suggesting the possibility of rapid in vivo hepatic clearance mediated by oxidative metabolism.
26 ial 90 min of the PET scan, the steady-state hepatic clearance of (64) Cu was estimated to be slightl
27                                              Hepatic clearance of (99m)Tc-mebrofenin was studied with
28      Type 2 diabetes mellitus (T2DM) impairs hepatic clearance of atherogenic postprandial remnant li
29      Type 2 diabetes mellitus (T2DM) impairs hepatic clearance of atherogenic postprandial triglyceri
30                                          The hepatic clearance of atRA is mediated primarily by CYP26
31 ct in a gene other than NTCP that influences hepatic clearance of bile salts.
32 Accumulating evidence suggests that impaired hepatic clearance of cholesterol-rich TRL remnants leads
33 x from peripheral cells as well as the rapid hepatic clearance of FC from plasma HDL.
34                                    Intrinsic hepatic clearance of fluorescent bile acids (2-7 mL/g li
35                                              Hepatic clearance of fVIII is mediated by the LDL recept
36 s is powerful for the prediction of rates of hepatic clearance of ionizable chemicals.
37  severe hypercholesterolemia due to impaired hepatic clearance of LDL.
38  used to qualitatively predict the potential hepatic clearance of nine psychotropic drugs with variou
39 hrough an APOE-dependent pathway to increase hepatic clearance of remnant lipoproteins.
40                                              Hepatic clearance of remnants occurs via low density lip
41 eins into BAT, subsequently accelerating the hepatic clearance of the cholesterol-enriched remnants.
42 tivate blood-borne thrombin leading to rapid hepatic clearance of the thrombin-inhibitor complex.
43                       Similarly, the in vivo hepatic clearance of these drugs, a measure of liver dru
44   Our findings indicate that ethanol impairs hepatic clearance of translocated pathobionts, via decre
45                                              Hepatic clearance of triglyceride-rich lipoproteins depe
46 ran sulfate proteoglycan syndecan-1 mediates hepatic clearance of triglyceride-rich lipoproteins in m
47                    Here, we investigated the hepatic clearances of five chemicals (pyrene, phenanthre
48 y targeting either production, lipolysis, or hepatic clearance, or a combination of these mechanisms.
49                        There was progressive hepatic clearance over time, providing the highest lesio
50                               Both renal and hepatic clearance pathways were observed.
51  correction for potential binding effects on hepatic clearance provided the most accurate predictions
52  A model-based assessment indicated that the hepatic clearance rate of freely dissolved chemicals was
53          In this study, we measured in vitro hepatic clearance rates for 50 IOCs using a pooled batch
54                               Thus, multiple hepatic clearance receptors cooperate to eliminate secre
55       Inhibition of known glycan-recognizing hepatic clearance receptors showed involvement of multip
56 human primates (NHPs)], to predict the human hepatic clearance using a diverse set of acidic/zwitteri
57         We found that measured and predicted hepatic clearances were in very good agreement (root mea
58 f particular importance is the prediction of hepatic clearance, which determines drug exposure and co
59 metastases and elevated liver enzymes (rapid hepatic clearance with liberation of free I-).