ライフサイエンスコーパス: hepatitis delta

1 gulated in CD8(+) T cells from patients with hepatitis delta.

2 valid surrogate endpoint in the treatment of hepatitis delta.

3 died of fulminant recurrent hepatitis B and hepatitis delta.

4 tion for fulminant recurrent hepatitis B and hepatitis delta.

5 of chronic delta hepatitis, disappearance of hepatitis delta and B virus markers, and improvement in

6 The self-cleaving hairpin, hammerhead, hepatitis delta and Neurospora VS RNAs each adopt unique

7 relapses may occur after PEG-IFNa therapy of hepatitis delta and thus the term sustained virological

8 ve for HBV serologic markers were tested for hepatitis delta antibody (HDAb) at 2 time periods: 1988-

9 titis delta virus (HDV) encodes one protein, hepatitis delta antigen (deltaAg), a 195-amino-acid RNA

10 anched rod structure that is associated with hepatitis delta antigen (HDAg) in cells replicating HDV.

11 e used this method to examine the effects of hepatitis delta antigen (HDAg) on the ribozyme activitie

12 by these RNAs with the virus-encoded protein hepatitis delta antigen (HDAg) perform essential roles i

13 unbranched rodlike structure of HDV RNA and hepatitis delta antigen (HDAg), a basic, disordered, oli

14 of an elongation factor, in the presence of hepatitis delta antigen (HDAg), and in the presence of t

15 ly distinct forms of the sole viral protein, hepatitis delta antigen (HDAg), from the same open readi

16 roles of the two forms of the viral protein, hepatitis delta antigen (HDAg), in HDV RNA replication a

17 iated with the sole virally encoded protein, hepatitis delta antigen (HDAg), in infected cells; howev

18 rs a single coding region whose product, the hepatitis delta antigen (HDAg), is expressed in two isof

19 HDV genome encodes two forms of hepatitis delta antigen (HDAg), small HDAg (HDAg-S), whi

20 me, antigenome, and mRNA; the latter encodes hepatitis delta antigen (HDAg), the viral protein.

21 ws two essential forms of the viral protein, hepatitis delta antigen (HDAg), to be synthesized from a

22 s, whereas HDV RNA encodes a single protein, hepatitis delta antigen (HDAg), which is required for vi

23 However, in the presence of hepatitis delta antigen (HDAg), which is the only protei

24 mRNA, which encodes the sole viral protein, hepatitis delta antigen (HDAg).

25 circular RNA which encodes a single protein, hepatitis delta antigen (HDAg).

26 o essential forms of the sole viral protein, hepatitis delta antigen (HDAg).

27 s a 0.8-kb, polyadenylated mRNA encoding the hepatitis delta antigen (HDAg).

28 two isoforms of its principal gene product, hepatitis delta antigen (HDAg).

29 iral genome that altered the sequence of the hepatitis delta antigen (HDAg).

30 The large hepatitis delta antigen (HDAg-L) mediates hepatitis delt

31 The small hepatitis delta antigen (HDAg-S) is expressed throughout

32 d when expressed in the absence of the small hepatitis delta antigen (HDAg-S).

33 The large form of hepatitis delta antigen (L-HDAg), which is responsible f

34 d by the intracellular accumulation of large hepatitis delta antigen (L-HDAg).

35 wn antiparallel coiled-coils (those from the hepatitis delta antigen (PDB ID code 1A92) and the bovin

36 ring requirement for the de novo-synthesized hepatitis delta antigen and temperature dependence, we f

37 required for production of the viral protein hepatitis delta antigen long form (HDAg-L), which is nec

38 ion, combined with our previous finding that hepatitis delta antigen mRNA synthesis is likely perform

39 Two forms of the sole HDV protein, hepatitis delta antigen, are derived from a single open

40 raction with and incorporation of free large hepatitis delta antigen, it was partially defective in h

41 ctor SL1 could be precipitated together with hepatitis delta antigen, suggesting the association of H

42 ch as glutamate receptor (GluR) subunits and hepatitis delta antigen.

43 itis delta virus (HDV) contains two types of hepatitis delta antigens (HDAg) in the virion.

44 ), which encode the small and large forms of hepatitis delta antigens (S- and L-HDAg), respectively.

45 s (simian virus 40), as well as those of the hepatitis delta enveloped virus large form antigen, with

46 to analyze the clinical long-term outcome of hepatitis delta in relation to different antiviral treat

47 Hepatitis delta is associated with a high rate of death

48 ual posttreatment rate of clinical events in hepatitis delta patients eligible for PEG-IFNa therapy i

49 gth HCV cDNA plasmid containing a cis-acting hepatitis Delta ribozyme to control 3' cleavage, and inf

50 of lHDAg is required for the assembly of the hepatitis delta viral particle, these results suggest th

51 adult HBsAg carriers, 42% had antibodies to hepatitis delta virus (anti-HDV).

52 012 (amber/W site) in the antigenomic RNA of hepatitis delta virus (HDV) allows two essential forms o

53 Hepatitis delta virus (HDV) and cytoplasmic polyadenylat

54 little information on the early kinetics of hepatitis delta virus (HDV) and hepatitis B surface anti

55 The small, 195-amino-acid form of the hepatitis delta virus (HDV) antigen (deltaAg-S) is essen

56 RNA editing of the hepatitis delta virus (HDV) antigenome at the amber/W si

57 Hepatitis delta virus (HDV) assembly also uses the envel

58 ge hepatitis delta antigen (HDAg-L) mediates hepatitis delta virus (HDV) assembly and inhibits HDV RN

59 The paucity of data regarding the extent of hepatitis delta virus (HDV) associated health care burde

60 Hepatitis delta virus (HDV) can dramatically worsen live

61 679-nt genomic and antigenomic RNAs of human hepatitis delta virus (HDV) can fold into a rod-like str

62 The circular RNA genome of hepatitis delta virus (HDV) can fold into an unbranched

63 The antigenomic RNA of hepatitis delta virus (HDV) can form a short duplex, P2a

64 Hepatitis delta virus (HDV) causes both acute and chroni

65 Hepatitis delta virus (HDV) causes the most severe form

66 Infection with hepatitis delta virus (HDV) causes the most severe form

67 The two ribozymes of hepatitis delta virus (HDV) cleave faster in divalent me

68 Hepatitis delta virus (HDV) contains a circular RNA whic

69 Hepatitis delta virus (HDV) contains a viroid-like circu

70 Hepatitis delta virus (HDV) contains a viroid-like circu

71 Hepatitis delta virus (HDV) contains two RNA species (HD

72 Hepatitis delta virus (HDV) contains two types of hepati

73 n (deltaAg-S and deltaAg-L, respectively) of hepatitis delta virus (HDV) differ only in the 19-aa C-t

74 The human pathogenic hepatitis delta virus (HDV) employs a unique self-cleavi

75 Hepatitis delta virus (HDV) encodes one protein, hepatit

76 Hepatitis delta virus (HDV) encodes two isoforms of its

77 Hepatitis delta virus (HDV) expresses two essential prot

78 dates utilize self-cleaving ribozymes of the hepatitis delta virus (HDV) family for processing their

79 The circular genome and antigenome RNAs of hepatitis delta virus (HDV) form characteristic unbranch

80 As early as 5 days after DNA copies of the hepatitis delta virus (HDV) genome or even in vitro-tran

81 Hepatitis delta virus (HDV) genome replication requires

82 transfected with a cDNA expressing a mutated hepatitis delta virus (HDV) genome that could only repli

83 elf-cleaving sequences or ribozymes from the hepatitis delta virus (HDV) genomic RNA and its compleme

84 The genome of the human hepatitis delta virus (HDV) harbors a self-cleaving cata

85 Hepatitis delta virus (HDV) has a circular RNA genome th

86 Hepatitis delta virus (HDV) has been detected in the min

87 The ribozymes of hepatitis delta virus (HDV) have so far been studied pri

88 Assembly of hepatitis delta virus (HDV) in infected human hepatocyte

89 Hepatitis delta virus (HDV) infection and spread in vivo

90 Therapies for chronic hepatitis delta virus (HDV) infection are unsatisfactory

91 Chronic hepatitis delta virus (HDV) infection causes severe live

92 Hepatitis delta virus (HDV) infection is associated with

93 Hepatitis delta virus (HDV) infection of humans was firs

94 vere form of chronic liver disease caused by hepatitis delta virus (HDV) infection superimposed on ch

95 The sera of 46 Italian patients with chronic hepatitis delta virus (HDV) infection were analyzed for

96 titis B virus (HBV) genotypes A to I support hepatitis delta virus (HDV) infectivity.

97 A woodchuck-derived hepatitis delta virus (HDV) inoculum was created by tran

98 ed that the replication of the RNA genome of hepatitis delta virus (HDV) involves redirection of RNA

99 The genome of hepatitis delta virus (HDV) is a 1,679-nucleotide (nt) s

100 Hepatitis delta virus (HDV) is a cause of acute and chro

101 Hepatitis delta virus (HDV) is a circular pathogenic RNA

102 Hepatitis delta virus (HDV) is a defective satellite vir

103 Hepatitis delta virus (HDV) is a highly pathogenic human

104 Hepatitis delta virus (HDV) is a human hepatitis-causing

105 The hepatitis delta virus (HDV) is a human pathogen and sate

106 Human hepatitis delta virus (HDV) is a natural subviral agent

107 Hepatitis delta virus (HDV) is a natural subviral agent

108 Hepatitis delta virus (HDV) is a pathogenic human virus

109 Hepatitis delta virus (HDV) is a satellite of hepatitis

110 o genetic similarity between them.IMPORTANCE Hepatitis delta virus (HDV) is a satellite of hepatitis

111 Hepatitis delta virus (HDV) is a satellite virus of hepa

112 Hepatitis delta virus (HDV) is a significant human patho

113 Hepatitis delta virus (HDV) is a small single-stranded R

114 Hepatitis delta virus (HDV) is a small, defective RNA vi

115 Hepatitis delta virus (HDV) is a subviral human pathogen

116 Hepatitis delta virus (HDV) is a subviral human pathogen

117 Hepatitis delta virus (HDV) is a subviral pathogen that

118 IMPORTANCE Hepatitis delta virus (HDV) is a unique virus that cause

119 Hepatitis delta virus (HDV) is an unusual RNA agent that

120 Hepatitis delta virus (HDV) is geographically classified

121 Hepatitis delta virus (HDV) is known to express a protei

122 In a natural setting, hepatitis delta virus (HDV) is only found in patients th

123 Hepatitis delta virus (HDV) is responsible for the most

124 Intrinsic to the life cycle of hepatitis delta virus (HDV) is the fact that its RNAs un

125 Hepatitis delta virus (HDV) is the most severe form of v

126 The self-cleaving ribozyme of the hepatitis delta virus (HDV) is the only catalytic RNA kn

127 Hepatitis delta virus (HDV) is unique relative to all kn

128 haracterizations of genetic variations among hepatitis delta virus (HDV) isolates have focused princi

129 Most hepatitis delta virus (HDV) prevalence estimates from th

130 Hepatitis delta virus (HDV) produces two essential forms

131 The large form of the hepatitis delta virus (HDV) protein (L) can be isoprenyl

132 Hepatitis delta virus (HDV) replicates by a double rolli

133 Hepatitis delta virus (HDV) replicates by RNA-dependent

134 Hepatitis delta virus (HDV) replicates its circular RNA

135 Hepatitis delta virus (HDV) replication and packaging re

136 Hepatitis delta virus (HDV) replication involves process

137 Moderation of hepatitis delta virus (HDV) replication is a likely prer

138 f the genomic and antigenomic ribozymes from hepatitis delta virus (HDV) requires divalent cation for

139 Hepatitis delta virus (HDV) requires host RNA editing at

140 Replication of the genome of hepatitis delta virus (HDV) requires RNA-directed RNA sy

141 The hepatitis delta virus (HDV) ribozyme and HDV-like ribozy

142 nto an oligoribonucleotide substrate for the hepatitis delta virus (HDV) ribozyme and investigated th

143 mogeneous RNA transcripts: one encodes a 3'- hepatitis delta virus (HDV) ribozyme and the other, used

144 f RNA-bound magnesium hydrate in crystals of hepatitis delta virus (HDV) ribozyme and to follow the e

145 While the hepatitis delta virus (HDV) ribozyme can undergo self-cl

146 The hepatitis delta virus (HDV) ribozyme catalyzes a self-cl

147 The hepatitis delta virus (HDV) ribozyme is a self-cleaving

148 The hepatitis delta virus (HDV) ribozyme is a self-cleaving

149 A small ribozyme related in structure to the hepatitis delta virus (HDV) ribozyme occurs in a number

150 erous group II intron domain 5-domain 6, and hepatitis delta virus (HDV) ribozyme RNA constructs.

151 The Hepatitis Delta Virus (HDV) ribozyme self-cleaving activ

152 nd product forms of the cis-cleaving genomic hepatitis delta virus (HDV) ribozyme show a divalent met

153 The hepatitis delta virus (HDV) ribozyme uses a cytosine to

154 The hepatitis delta virus (HDV) ribozyme uses the nucleobase

155 The Hepatitis Delta Virus (HDV) ribozyme was the first RNA e

156 Well-ordered crystals of a genomic hepatitis delta virus (HDV) ribozyme, a large, globular

157 In the hepatitis delta virus (HDV) ribozyme, site-specific self

158 In the case of the hepatitis delta virus (HDV) ribozyme, there are three hi

159 pseudoknot structure similar to that of the hepatitis delta virus (HDV) ribozyme.

160 The hepatitis delta virus (HDV) ribozymes are self-cleaving

161 ndary structures proposed for the cis-acting hepatitis delta virus (HDV) ribozymes contain four duple

162 Hepatitis delta virus (HDV) ribozymes employ multiple ca

163 rally and biochemically related to the human hepatitis delta virus (HDV) ribozymes.

164 Hepatitis delta virus (HDV) RNA forms an unbranched rod

165 m of regulation for the ribozyme activity of hepatitis delta virus (HDV) RNA in infected cells is unk

166 cleavage site in the antigenomic sequence of hepatitis delta virus (HDV) RNA is 33-nt downstream of t

167 Hepatitis delta virus (HDV) RNA replicates in the nuclei

168 When the hepatitis delta virus (HDV) RNA was released by treatmen

169 pendent RNA replication and transcription of hepatitis delta virus (HDV) RNA, generating a full-lengt

170 In models of the replication of human hepatitis delta virus (HDV) RNA, it is generally assumed

171 ion of the 1,679-nucleotide (nt) unit-length hepatitis delta virus (HDV) RNAs in the livers of two HD

172 The hepatitis delta virus (HDV) S-HDAg and L-HDAg antigens a

173 Hepatitis B virus (HBV) and hepatitis delta virus (HDV) share the HBV envelope prote

174 with DNA-directed mRNA constructs containing hepatitis delta virus (HDV) target sequences.

175 erase inhibitor, and phase III candidate for hepatitis delta virus (HDV) therapy, for further follow-

176 A host-mediated RNA-editing event allows hepatitis delta virus (HDV) to express two essential pro

177 Hepatitis delta virus (HDV) uses a host-encoded RNA-edit

178 Hepatitis delta virus (HDV) uses genomic and antigenomic

179 We analyzed changes in hepatitis B virus and hepatitis delta virus (HDV) viral loads (VL) during teno

180 Efficient assembly of hepatitis delta virus (HDV) was achieved by cotransfecti

181 This study assessed the epidemiology of hepatitis delta virus (HDV) within the University of Uta

182 ecific drugs are currently available against hepatitis delta virus (HDV), a defective virus leading t

183 Infection by the hepatitis delta virus (HDV), a satellite of the hepatiti

184 on of replication of the RNA genome of human hepatitis delta virus (HDV), a series of linear RNAs con

185 Hepatitis delta virus (HDV), a single-stranded RNA virus

186 ction of primary human hepatocytes either by hepatitis delta virus (HDV), a subviral agent that uses

187 a central role in the replication scheme of hepatitis delta virus (HDV), allowing the virus to produ

188 Interestingly, a human pathogen, hepatitis delta virus (HDV), also replicates via a rolli

189 The hepatitis delta virus (HDV), an infectious human pathoge

190 The hepatitis delta virus (HDV), an infectious human pathoge

191 As for hepatitis delta virus (HDV), another cause of liver dise

192 iral agent of human hepatitis B virus (HBV), hepatitis delta virus (HDV), requires only the envelope

193 mic and antigenomic RNA strands of the human hepatitis delta virus (HDV), where they serve a crucial

194 No specific therapy exists for hepatitis delta virus (HDV), which can cause severe live

195 Lacking an RNA-dependent RNA polymerase, hepatitis delta virus (HDV), which contains a circular R

196 Such difficulties can be circumvented with hepatitis delta virus (HDV), which needs the HBV large e

197 s were similar to those observed for HBV and hepatitis delta virus (HDV), which shares the same L, M,

198 We show that large hepatitis delta virus (HDV)-like ribozymes are activated

199 Patients transplanted for hepatitis delta virus (HDV)-related cirrhosis are report

200 ly define the breadth and specificity of the hepatitis delta virus (HDV)-specific T-cell response in

201 pproximately 20 million are co-infected with hepatitis delta virus (HDV).

202 feron alpha is the only treatment option for hepatitis delta virus (HDV).

203 ized novel viruses related to coronaviruses, hepatitis delta virus and huge phages, respectively, and

204 auliflower mosaic virus 35S promoter and the hepatitis delta virus antigenomic ribozyme with a downst

205 In the hepatitis delta virus antigenomic ribozyme, imidazole bu

206 In the ribozyme of hepatitis delta virus antigenomic RNA, two short duplexe

207 The RNA enzyme (ribozyme) from hepatitis delta virus catalyzes self-cleavage of a phosp

208 ulture model enabling functional genomics of hepatitis delta virus entry and infection.

209 Hepatitis delta virus expresses two essential proteins,

210 ive secondary structure, based on a modified hepatitis delta virus genome.

211 Hepatitis delta virus has no FDA approved therapy and it

212 Ribozymes of hepatitis delta virus have been proposed to use an activ

213 Two classes of pathogenic RNAs (hepatitis delta virus in animals and viroids in plants)

214 Activity of the two ribozymes from hepatitis delta virus in monovalent salts was examined a

215 improve clinical management of patients with hepatitis delta virus infection.

216 The hepatitis delta virus large antigen (lHDAg) is a virally

217 The two forms of the hepatitis delta virus ribozyme are derived from the geno

218 ons (minus sense) of the NS gene joined to a hepatitis delta virus ribozyme at its 3' end.

219 l II polymerase promoter at the 5' end and a hepatitis delta virus ribozyme at the 3' end.

220 secondary (18)O kinetic isotope effects for hepatitis delta virus ribozyme catalysis that reveal a d

221 The hepatitis delta virus ribozyme catalyzes an RNA cleavage

222 of the T7 promoter and upstream of the human hepatitis delta virus ribozyme domain, we inserted a com

223 formed molecular dynamics simulations on the hepatitis delta virus ribozyme in the product form and a

224 The hepatitis delta virus ribozyme is a small, self-cleaving

225 NA polymerase promoter and the autocatalytic hepatitis delta virus ribozyme of a transcription plasmi

226 gth HCV cDNA plasmid containing a cis-acting hepatitis delta virus ribozyme to control 3' cleavage.

227 ectivity of the plasmid, a cDNA encoding the hepatitis delta virus ribozyme was added to the 3' end o

228 btilis RNaseP and an artificial trans-acting hepatitis delta virus ribozyme were expressed as the exo

229 solated from the antigenomic sequence of the hepatitis delta virus ribozyme with the P2 and P3 stems

230 catalytic RNAs, the hairpin ribozyme and the hepatitis delta virus ribozyme, and that the shifts are

231 eet western yellows virus pseudoknot and the hepatitis delta virus ribozyme, despite distinct structu

232 For the hepatitis delta virus ribozyme, we predict several nonna

233 ription by T7 RNA polymerase and cleavage by hepatitis delta virus ribozyme.

234 Hepatitis delta virus ribozymes have been proposed to pe

235 rsistently normal; after several years, both hepatitis delta virus RNA and serum HBsAg became undetec

236 The two ribozymes found in hepatitis delta virus RNA form related but non-identical

237 The unusual structure of hepatitis delta virus RNA has previously been shown to e

238 s of hepatitis B surface antigen (HBsAg) and hepatitis delta virus RNA.

239 RNA-protein complexes (RNPs) formed by the hepatitis delta virus RNAs and protein, HDAg, perform cr

240 delta antigen, it was partially defective in hepatitis delta virus RNP incorporation.

241 ame envelope proteins, hepatitis B virus and hepatitis delta virus use the sodium/taurocholate cotran

242 Hepatitis D virus (also known as hepatitis delta virus) can establish a persistent infect

243 titis C virus, human immunodeficiency virus, hepatitis delta virus, and alanine aminotransferase leve

244 Self-cleaving hammerhead, hairpin, hepatitis delta virus, and glmS ribozymes comprise a fam

245 self-cleaving RNAs: the hammerhead, hairpin, hepatitis delta virus, and in vitro-selected lead-depend

246 ween a variety of catalysts that include the hepatitis delta virus, hammerhead, X motif and Tetrahyme

247 cDNA encoding a self-cleaving ribozyme from hepatitis delta virus.

248 cyte-specific entry of hepatitis B virus and hepatitis delta virus.

249 IFNalpha-based antiviral therapy of hepatitis delta was independently associated with a lowe