1 cDNA encoding a self-cleaving ribozyme from
hepatitis delta virus.
2 cyte-specific entry of hepatitis B virus and
hepatitis delta virus.
3 ized novel viruses related to coronaviruses,
hepatitis delta virus and huge phages, respectively, and
4 titis C virus, human immunodeficiency virus,
hepatitis delta virus,
and alanine aminotransferase leve
5 Self-cleaving hammerhead, hairpin,
hepatitis delta virus,
and glmS ribozymes comprise a fam
6 self-cleaving RNAs: the hammerhead, hairpin,
hepatitis delta virus,
and in vitro-selected lead-depend
7 adult HBsAg carriers, 42% had antibodies to
hepatitis delta virus (
anti-HDV).
8 auliflower mosaic virus 35S promoter and the
hepatitis delta virus antigenomic ribozyme with a downst
9 In the
hepatitis delta virus antigenomic ribozyme, imidazole bu
10 In the ribozyme of
hepatitis delta virus antigenomic RNA, two short duplexe
11 Hepatitis D virus (also known as
hepatitis delta virus)
can establish a persistent infect
12 The RNA enzyme (ribozyme) from
hepatitis delta virus catalyzes self-cleavage of a phosp
13 ulture model enabling functional genomics of
hepatitis delta virus entry and infection.
14 Hepatitis delta virus expresses two essential proteins,
15 ive secondary structure, based on a modified
hepatitis delta virus genome.
16 ween a variety of catalysts that include the
hepatitis delta virus,
hammerhead, X motif and Tetrahyme
17 Hepatitis delta virus has no FDA approved therapy and it
18 Ribozymes of
hepatitis delta virus have been proposed to use an activ
19 012 (amber/W site) in the antigenomic RNA of
hepatitis delta virus (
HDV) allows two essential forms o
20 Hepatitis delta virus (
HDV) and cytoplasmic polyadenylat
21 little information on the early kinetics of
hepatitis delta virus (
HDV) and hepatitis B surface anti
22 The small, 195-amino-acid form of the
hepatitis delta virus (
HDV) antigen (deltaAg-S) is essen
23 RNA editing of the
hepatitis delta virus (
HDV) antigenome at the amber/W si
24 Hepatitis delta virus (
HDV) assembly also uses the envel
25 ge hepatitis delta antigen (HDAg-L) mediates
hepatitis delta virus (
HDV) assembly and inhibits HDV RN
26 The paucity of data regarding the extent of
hepatitis delta virus (
HDV) associated health care burde
27 Hepatitis delta virus (
HDV) can dramatically worsen live
28 679-nt genomic and antigenomic RNAs of human
hepatitis delta virus (
HDV) can fold into a rod-like str
29 The circular RNA genome of
hepatitis delta virus (
HDV) can fold into an unbranched
30 The antigenomic RNA of
hepatitis delta virus (
HDV) can form a short duplex, P2a
31 Hepatitis delta virus (
HDV) causes both acute and chroni
32 Hepatitis delta virus (
HDV) causes the most severe form
33 Infection with
hepatitis delta virus (
HDV) causes the most severe form
34 The two ribozymes of
hepatitis delta virus (
HDV) cleave faster in divalent me
35 Hepatitis delta virus (
HDV) contains a circular RNA whic
36 Hepatitis delta virus (
HDV) contains a viroid-like circu
37 Hepatitis delta virus (
HDV) contains a viroid-like circu
38 Hepatitis delta virus (
HDV) contains two RNA species (HD
39 Hepatitis delta virus (
HDV) contains two types of hepati
40 n (deltaAg-S and deltaAg-L, respectively) of
hepatitis delta virus (
HDV) differ only in the 19-aa C-t
41 The human pathogenic
hepatitis delta virus (
HDV) employs a unique self-cleavi
42 Hepatitis delta virus (
HDV) encodes one protein, hepatit
43 Hepatitis delta virus (
HDV) encodes two isoforms of its
44 Hepatitis delta virus (
HDV) expresses two essential prot
45 dates utilize self-cleaving ribozymes of the
hepatitis delta virus (
HDV) family for processing their
46 The circular genome and antigenome RNAs of
hepatitis delta virus (
HDV) form characteristic unbranch
47 As early as 5 days after DNA copies of the
hepatitis delta virus (
HDV) genome or even in vitro-tran
48 Hepatitis delta virus (
HDV) genome replication requires
49 transfected with a cDNA expressing a mutated
hepatitis delta virus (
HDV) genome that could only repli
50 elf-cleaving sequences or ribozymes from the
hepatitis delta virus (
HDV) genomic RNA and its compleme
51 The genome of the human
hepatitis delta virus (
HDV) harbors a self-cleaving cata
52 Hepatitis delta virus (
HDV) has a circular RNA genome th
53 Hepatitis delta virus (
HDV) has been detected in the min
54 The ribozymes of
hepatitis delta virus (
HDV) have so far been studied pri
55 Assembly of
hepatitis delta virus (
HDV) in infected human hepatocyte
56 Hepatitis delta virus (
HDV) infection and spread in vivo
57 Therapies for chronic
hepatitis delta virus (
HDV) infection are unsatisfactory
58 Chronic
hepatitis delta virus (
HDV) infection causes severe live
59 Hepatitis delta virus (
HDV) infection is associated with
60 Hepatitis delta virus (
HDV) infection of humans was firs
61 vere form of chronic liver disease caused by
hepatitis delta virus (
HDV) infection superimposed on ch
62 The sera of 46 Italian patients with chronic
hepatitis delta virus (
HDV) infection were analyzed for
63 titis B virus (HBV) genotypes A to I support
hepatitis delta virus (
HDV) infectivity.
64 A woodchuck-derived
hepatitis delta virus (
HDV) inoculum was created by tran
65 ed that the replication of the RNA genome of
hepatitis delta virus (
HDV) involves redirection of RNA
66 The genome of
hepatitis delta virus (
HDV) is a 1,679-nucleotide (nt) s
67 Hepatitis delta virus (
HDV) is a cause of acute and chro
68 Hepatitis delta virus (
HDV) is a circular pathogenic RNA
69 Hepatitis delta virus (
HDV) is a defective satellite vir
70 Hepatitis delta virus (
HDV) is a highly pathogenic human
71 Hepatitis delta virus (
HDV) is a human hepatitis-causing
72 The
hepatitis delta virus (
HDV) is a human pathogen and sate
73 Human
hepatitis delta virus (
HDV) is a natural subviral agent
74 Hepatitis delta virus (
HDV) is a natural subviral agent
75 Hepatitis delta virus (
HDV) is a pathogenic human virus
76 Hepatitis delta virus (
HDV) is a satellite of hepatitis
77 o genetic similarity between them.IMPORTANCE
Hepatitis delta virus (
HDV) is a satellite of hepatitis
78 Hepatitis delta virus (
HDV) is a satellite virus of hepa
79 Hepatitis delta virus (
HDV) is a significant human patho
80 Hepatitis delta virus (
HDV) is a small single-stranded R
81 Hepatitis delta virus (
HDV) is a small, defective RNA vi
82 Hepatitis delta virus (
HDV) is a subviral human pathogen
83 Hepatitis delta virus (
HDV) is a subviral human pathogen
84 Hepatitis delta virus (
HDV) is a subviral pathogen that
85 IMPORTANCE
Hepatitis delta virus (
HDV) is a unique virus that cause
86 Hepatitis delta virus (
HDV) is an unusual RNA agent that
87 Hepatitis delta virus (
HDV) is geographically classified
88 Hepatitis delta virus (
HDV) is known to express a protei
89 In a natural setting,
hepatitis delta virus (
HDV) is only found in patients th
90 Hepatitis delta virus (
HDV) is responsible for the most
91 Intrinsic to the life cycle of
hepatitis delta virus (
HDV) is the fact that its RNAs un
92 Hepatitis delta virus (
HDV) is the most severe form of v
93 The self-cleaving ribozyme of the
hepatitis delta virus (
HDV) is the only catalytic RNA kn
94 Hepatitis delta virus (
HDV) is unique relative to all kn
95 haracterizations of genetic variations among
hepatitis delta virus (
HDV) isolates have focused princi
96 Most
hepatitis delta virus (
HDV) prevalence estimates from th
97 Hepatitis delta virus (
HDV) produces two essential forms
98 The large form of the
hepatitis delta virus (
HDV) protein (L) can be isoprenyl
99 Hepatitis delta virus (
HDV) replicates by a double rolli
100 Hepatitis delta virus (
HDV) replicates by RNA-dependent
101 Hepatitis delta virus (
HDV) replicates its circular RNA
102 Hepatitis delta virus (
HDV) replication and packaging re
103 Hepatitis delta virus (
HDV) replication involves process
104 Moderation of
hepatitis delta virus (
HDV) replication is a likely prer
105 f the genomic and antigenomic ribozymes from
hepatitis delta virus (
HDV) requires divalent cation for
106 Hepatitis delta virus (
HDV) requires host RNA editing at
107 Replication of the genome of
hepatitis delta virus (
HDV) requires RNA-directed RNA sy
108 The
hepatitis delta virus (
HDV) ribozyme and HDV-like ribozy
109 nto an oligoribonucleotide substrate for the
hepatitis delta virus (
HDV) ribozyme and investigated th
110 mogeneous RNA transcripts: one encodes a 3'-
hepatitis delta virus (
HDV) ribozyme and the other, used
111 f RNA-bound magnesium hydrate in crystals of
hepatitis delta virus (
HDV) ribozyme and to follow the e
112 While the
hepatitis delta virus (
HDV) ribozyme can undergo self-cl
113 The
hepatitis delta virus (
HDV) ribozyme catalyzes a self-cl
114 The
hepatitis delta virus (
HDV) ribozyme is a self-cleaving
115 The
hepatitis delta virus (
HDV) ribozyme is a self-cleaving
116 A small ribozyme related in structure to the
hepatitis delta virus (
HDV) ribozyme occurs in a number
117 erous group II intron domain 5-domain 6, and
hepatitis delta virus (
HDV) ribozyme RNA constructs.
118 The
Hepatitis Delta Virus (
HDV) ribozyme self-cleaving activ
119 nd product forms of the cis-cleaving genomic
hepatitis delta virus (
HDV) ribozyme show a divalent met
120 The
hepatitis delta virus (
HDV) ribozyme uses a cytosine to
121 The
hepatitis delta virus (
HDV) ribozyme uses the nucleobase
122 The
Hepatitis Delta Virus (
HDV) ribozyme was the first RNA e
123 Well-ordered crystals of a genomic
hepatitis delta virus (
HDV) ribozyme, a large, globular
124 In the
hepatitis delta virus (
HDV) ribozyme, site-specific self
125 In the case of the
hepatitis delta virus (
HDV) ribozyme, there are three hi
126 pseudoknot structure similar to that of the
hepatitis delta virus (
HDV) ribozyme.
127 The
hepatitis delta virus (
HDV) ribozymes are self-cleaving
128 ndary structures proposed for the cis-acting
hepatitis delta virus (
HDV) ribozymes contain four duple
129 Hepatitis delta virus (
HDV) ribozymes employ multiple ca
130 rally and biochemically related to the human
hepatitis delta virus (
HDV) ribozymes.
131 Hepatitis delta virus (
HDV) RNA forms an unbranched rod
132 m of regulation for the ribozyme activity of
hepatitis delta virus (
HDV) RNA in infected cells is unk
133 cleavage site in the antigenomic sequence of
hepatitis delta virus (
HDV) RNA is 33-nt downstream of t
134 Hepatitis delta virus (
HDV) RNA replicates in the nuclei
135 When the
hepatitis delta virus (
HDV) RNA was released by treatmen
136 pendent RNA replication and transcription of
hepatitis delta virus (
HDV) RNA, generating a full-lengt
137 In models of the replication of human
hepatitis delta virus (
HDV) RNA, it is generally assumed
138 ion of the 1,679-nucleotide (nt) unit-length
hepatitis delta virus (
HDV) RNAs in the livers of two HD
139 The
hepatitis delta virus (
HDV) S-HDAg and L-HDAg antigens a
140 Hepatitis B virus (HBV) and
hepatitis delta virus (
HDV) share the HBV envelope prote
141 with DNA-directed mRNA constructs containing
hepatitis delta virus (
HDV) target sequences.
142 erase inhibitor, and phase III candidate for
hepatitis delta virus (
HDV) therapy, for further follow-
143 A host-mediated RNA-editing event allows
hepatitis delta virus (
HDV) to express two essential pro
144 Hepatitis delta virus (
HDV) uses a host-encoded RNA-edit
145 Hepatitis delta virus (
HDV) uses genomic and antigenomic
146 We analyzed changes in hepatitis B virus and
hepatitis delta virus (
HDV) viral loads (VL) during teno
147 Efficient assembly of
hepatitis delta virus (
HDV) was achieved by cotransfecti
148 This study assessed the epidemiology of
hepatitis delta virus (
HDV) within the University of Uta
149 ecific drugs are currently available against
hepatitis delta virus (
HDV), a defective virus leading t
150 Infection by the
hepatitis delta virus (
HDV), a satellite of the hepatiti
151 on of replication of the RNA genome of human
hepatitis delta virus (
HDV), a series of linear RNAs con
152 Hepatitis delta virus (
HDV), a single-stranded RNA virus
153 ction of primary human hepatocytes either by
hepatitis delta virus (
HDV), a subviral agent that uses
154 a central role in the replication scheme of
hepatitis delta virus (
HDV), allowing the virus to produ
155 Interestingly, a human pathogen,
hepatitis delta virus (
HDV), also replicates via a rolli
156 The
hepatitis delta virus (
HDV), an infectious human pathoge
157 The
hepatitis delta virus (
HDV), an infectious human pathoge
158 As for
hepatitis delta virus (
HDV), another cause of liver dise
159 iral agent of human hepatitis B virus (HBV),
hepatitis delta virus (
HDV), requires only the envelope
160 mic and antigenomic RNA strands of the human
hepatitis delta virus (
HDV), where they serve a crucial
161 No specific therapy exists for
hepatitis delta virus (
HDV), which can cause severe live
162 Lacking an RNA-dependent RNA polymerase,
hepatitis delta virus (
HDV), which contains a circular R
163 Such difficulties can be circumvented with
hepatitis delta virus (
HDV), which needs the HBV large e
164 s were similar to those observed for HBV and
hepatitis delta virus (
HDV), which shares the same L, M,
165 We show that large
hepatitis delta virus (
HDV)-like ribozymes are activated
166 Patients transplanted for
hepatitis delta virus (
HDV)-related cirrhosis are report
167 ly define the breadth and specificity of the
hepatitis delta virus (
HDV)-specific T-cell response in
168 pproximately 20 million are co-infected with
hepatitis delta virus (
HDV).
169 feron alpha is the only treatment option for
hepatitis delta virus (
HDV).
170 Two classes of pathogenic RNAs (
hepatitis delta virus in animals and viroids in plants)
171 Activity of the two ribozymes from
hepatitis delta virus in monovalent salts was examined a
172 improve clinical management of patients with
hepatitis delta virus infection.
173 The
hepatitis delta virus large antigen (lHDAg) is a virally
174 The two forms of the
hepatitis delta virus ribozyme are derived from the geno
175 ons (minus sense) of the NS gene joined to a
hepatitis delta virus ribozyme at its 3' end.
176 l II polymerase promoter at the 5' end and a
hepatitis delta virus ribozyme at the 3' end.
177 secondary (18)O kinetic isotope effects for
hepatitis delta virus ribozyme catalysis that reveal a d
178 The
hepatitis delta virus ribozyme catalyzes an RNA cleavage
179 of the T7 promoter and upstream of the human
hepatitis delta virus ribozyme domain, we inserted a com
180 formed molecular dynamics simulations on the
hepatitis delta virus ribozyme in the product form and a
181 The
hepatitis delta virus ribozyme is a small, self-cleaving
182 NA polymerase promoter and the autocatalytic
hepatitis delta virus ribozyme of a transcription plasmi
183 gth HCV cDNA plasmid containing a cis-acting
hepatitis delta virus ribozyme to control 3' cleavage.
184 ectivity of the plasmid, a cDNA encoding the
hepatitis delta virus ribozyme was added to the 3' end o
185 btilis RNaseP and an artificial trans-acting
hepatitis delta virus ribozyme were expressed as the exo
186 solated from the antigenomic sequence of the
hepatitis delta virus ribozyme with the P2 and P3 stems
187 catalytic RNAs, the hairpin ribozyme and the
hepatitis delta virus ribozyme, and that the shifts are
188 eet western yellows virus pseudoknot and the
hepatitis delta virus ribozyme, despite distinct structu
189 For the
hepatitis delta virus ribozyme, we predict several nonna
190 ription by T7 RNA polymerase and cleavage by
hepatitis delta virus ribozyme.
191 Hepatitis delta virus ribozymes have been proposed to pe
192 rsistently normal; after several years, both
hepatitis delta virus RNA and serum HBsAg became undetec
193 The two ribozymes found in
hepatitis delta virus RNA form related but non-identical
194 The unusual structure of
hepatitis delta virus RNA has previously been shown to e
195 s of hepatitis B surface antigen (HBsAg) and
hepatitis delta virus RNA.
196 RNA-protein complexes (RNPs) formed by the
hepatitis delta virus RNAs and protein, HDAg, perform cr
197 delta antigen, it was partially defective in
hepatitis delta virus RNP incorporation.
198 ame envelope proteins, hepatitis B virus and
hepatitis delta virus use the sodium/taurocholate cotran