ライフサイエンスコーパス: hepatocyte nuclear factor

1 ding a chloroplast dimerization co-factor of hepatocyte nuclear factor 1 (DCoH)/pterin-4alpha-carbino

2 GFBP-1 promoter activation was via an intact hepatocyte nuclear factor 1 (HNF-1) site and was depende

3 cells, we have identified a highly conserved hepatocyte nuclear factor 1 (HNF1) binding site residing

4 experimental process was defined by studying hepatocyte nuclear factor 1 (HNF1), which binds DNA as a

5 ing and for the transcription factor variant hepatocyte nuclear factor 1 (vhnf1) in specification of

6 th factor (Fgf) signals from r4; and variant hepatocyte nuclear factor 1 (vhnf1, also known as tcf2),

7 olamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha), a gene that was rece

8 odenal homeobox-1, BETA2/NeuroD, Nkx6.1, and hepatocyte nuclear factor 1 alpha), beta-cell metabolic

9 ntly down-regulated pathways associated with hepatocyte nuclear factor 1 homeobox A (Hnf1a) and hepat

10 Hepatocyte nuclear factor 1 homeobox alpha (HNF1alpha) i

11 Common variants in the hepatocyte nuclear factor 1 homeobox B (HNF1B) gene are

12 tion cells in human cirrhotic livers express hepatocyte nuclear factor 1 homeobox B (HNF1beta).

13 cinomas, which expressed Napsin A and HNF1B (hepatocyte nuclear factor 1 homeobox B), markers of clea

14 Heterozygous deletion or mutation in hepatocyte nuclear factor 1 homeobox B/transcription fac

15 lpha1-antitrypsin messenger RNA, albumin and hepatocyte nuclear factor 1 protein were detected in the

16 es for known trans-acting factors, including hepatocyte nuclear factor 1, Forkhead box A1 and CCCTC-b

17 osa lipase/histamine N-methyltransferase and hepatocyte nuclear factor 1, respectively.

18 ent genome-wide association study identified hepatocyte nuclear factor 1-alpha (HNF1A) as a key regul

19 48; 95% CI, 2.83-10.61; P = 4.4 x 10(-7)) in hepatocyte nuclear factor 1-alpha (HNF1A), the gene resp

20 the binding site of the transcription factor hepatocyte nuclear factor-1 (HNF-1) and specifically sup

21 , in LLC-PK cells, but not in HepG2 cells, a hepatocyte nuclear factor-1 (HNF-1) binding site was cri

22 Herein, we investigated the role of a hepatocyte nuclear factor-1 (HNF-1) cis-acting element t

23 arkedly decreases mRNA and protein levels of hepatocyte nuclear factor-1 (HNF-1), a transcription fac

24 Herein, we show that hepatocyte nuclear factor-1 alpha (HNF-1 alpha), GATA-4,

25 zygous mutations in the transcription factor hepatocyte nuclear factor-1 alpha (HNF1A or TCF1 gene) r

26 mon polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha and plasma C-reactive

27 tissue-specific transcription factor HNF-1 (hepatocyte nuclear factor-1) through binding the coactiv

28 Region A binds hepatocyte nuclear factor-1, which acts as an accessory

29 subtypes based on inactivating mutations in hepatocyte nuclear factor 1A, activating mutations in be

30 subtypes based on inactivating mutations in hepatocyte nuclear factor 1A, activating mutations in be

31 Hepatocyte nuclear factor-1a (HNF-1alpha) is a transcrip

32 DCoHm (dimerization cofactor of hepatocyte nuclear factor 1alpha ( HNF1alpha) from muscl

33 Variants in HNF1A encoding hepatocyte nuclear factor 1alpha (HNF-1A) are associated

34 nal farnesoid X receptor (FXR) signaling via hepatocyte nuclear factor 1alpha (HNF-1alpha) compared w

35 nts with diabetes caused by mutations in the hepatocyte nuclear factor 1alpha (HNF-1alpha) gene have

36 Mutations in hepatocyte nuclear factor 1alpha (HNF-1alpha) lead to ma

37 tus, results most commonly from mutations in hepatocyte nuclear factor 1alpha (HNF-1alpha).

38 The role of hepatocyte nuclear factor 1alpha (HNF1 alpha) in the reg

39 acious first-line treatment in patients with hepatocyte nuclear factor 1alpha (HNF1A) diabetes, but S

40 with glucokinase (GCK)-diabetes (MODY2) and hepatocyte nuclear factor 1alpha (HNF1A)-diabetes (MODY3

41 rotumoral interaction of Akt2 signaling with hepatocyte nuclear factor 1alpha (HNF1alpha) and PPARgam

42 ur previous in vitro studies have identified hepatocyte nuclear factor 1alpha (HNF1alpha) as an oblig

43 llular carcinoma development, directly binds hepatocyte nuclear factor 1alpha (HNF1alpha) mRNA, a neg

44 IRT1 regulates the expression of FXR through hepatocyte nuclear factor 1alpha (HNF1alpha).

45 Transcription factor 1 (Tcf1; hepatocyte nuclear factor 1alpha [HNF1alpha]) is critica

46 f hepatocyte-enriched transcription factors (hepatocyte nuclear factor 1alpha [HNF1alpha], -1beta, -3

47 adenomas combined with genetic analysis for hepatocyte nuclear factor 1alpha and beta-catenin mutati

48 Hepatocyte nuclear factor 1alpha, a transcription factor

49 ritical regulator of pregnane X receptor and hepatocyte nuclear factor 1alpha, and inactivation of th

50 rs, CCAAT/enhancer-binding protein alpha and Hepatocyte nuclear factor 1alpha, which are known to be

51 In patients with multiple HCAs, hepatocyte nuclear factor 1alpha-inactivated HCAs showed

52 3 (MODY3) is caused by haploinsufficiency of hepatocyte nuclear factor-1alpha (encoded by TCF1).

53 GATA-4, -5, and -6 zinc finger and hepatocyte nuclear factor-1alpha (HNF-1alpha) homeodomai

54 Hepatocyte nuclear factor-1alpha (HNF-1alpha) mutations

55 the cells with expression cassettes encoding hepatocyte nuclear factor-1alpha (HNF-1alpha) or HNF-4.

56 c syndrome most commonly due to mutations in hepatocyte nuclear factor-1alpha (HNF-1alpha).

57 ic heterozygous variant in the gene encoding hepatocyte nuclear factor-1alpha (HNF1A).

58 Hepatocyte nuclear factor-1alpha (HNF1alpha) is a transc

59 mutations in the transcriptional activator, hepatocyte nuclear factor-1alpha (HNF1alpha).

60 total HNF1A transcript levels, but residual hepatocyte nuclear factor-1alpha protein activity in G31

61 Mutations in hepatocyte nuclear factor 1B (HNF1B), which is a transcr

62 The transcription factor hepatocyte nuclear factor 1beta (HNF1beta) is ubiquitous

63 Hepatocyte nuclear factor 1beta (HNF1beta)-associated di

64 er biliary cytokeratins or nuclear levels of hepatocyte nuclear factor 1beta.

65 Here, we evaluated the potential role of hepatocyte nuclear factor-1beta (HNF-1beta) in regulatin

66 Hepatocyte nuclear factor-1beta (HNF-1beta) is a homeodo

67 Hepatocyte nuclear factor-1beta (HNF-1beta) is a Pit-1,

68 Hepatocyte nuclear factor-1beta (HNF-1beta) is a Pit-1,

69 Hepatocyte nuclear factor-1beta (HNF-1beta) is a tissue-

70 Hepatocyte nuclear factor-1beta (HNF-1beta) is a tissue-

71 Hepatocyte nuclear factor-1beta (HNF-1beta) is a transcr

72 The transcription factor hepatocyte nuclear factor-1beta (HNF-1beta) is essential

73 The transcription factor hepatocyte nuclear factor-1beta (HNF-1beta) regulates ti

74 E4C is regulated by the transcription factor hepatocyte nuclear factor-1beta (HNF-1beta), mutations o

75 ation of epithelial markers, E-cadherin, and hepatocyte nuclear factor-1beta.

76 onal repression of PKD genes Pkd1, Pkd2, and hepatocyte nuclear factor-1beta.

77 The hepatocyte nuclear factor 3 (HNF-3) proteins are members

78 main that includes binding sites for NKX2.1, hepatocyte nuclear factor 3 (HNF-3), or cAMP response el

79 The hepatocyte nuclear factor 3 (HNF-3)/fork head (fkh) fami

80 elements that included GATA (-110/-105) and hepatocyte nuclear factor 3 (HNF3) (-96/-88) motifs.

81 Mutation of the area II hepatocyte nuclear factor 3 (HNF3) binding element in th

82 Hepatocyte nuclear factor 3 (HNF3) inhibits nuclear horm

83 64A variant has a stronger homology with the hepatocyte nuclear factor 3 (HNF3)-binding site than +11

84 or-dependent HBV replication is inhibited by hepatocyte nuclear factor 3 (HNF3).

85 ng Sp1, Sp3, thyroid transcription factor 1, hepatocyte nuclear factor 3 and activating transcription

86 In contrast, hepatocyte nuclear factor 3 antagonizes nuclear hormone

87 ated that PHx could induce the expression of hepatocyte nuclear factor 3 gamma (HNF3gamma) when viral

88 The data suggest that hepatocyte nuclear factor 3 may be important for basal I

89 (CCAAT/enhancer binding protein)/HNF-3beta (hepatocyte nuclear factor 3) and AP-1(activator protein

90 overexpression of the transcription factors hepatocyte nuclear factor 3, octamer-binding protein 1,

91 a (FKHR), a recently described member of the hepatocyte nuclear factor 3/forkhead homeotic gene famil

92 Hepatocyte nuclear factors 3 alpha, beta, and gamma (Fox

93 e method to identify a previously unreported hepatocyte nuclear factor-3 site created in intron 8 of

94 istone H2A co-occupies, along with the FoxA (hepatocyte nuclear factor-3) transcription factor, DNA f

95 oic acid receptor, retinoic acid X receptor, hepatocyte nuclear factor-3, glucocorticoid receptor, nu

96 Hepatocyte nuclear factors-3 (Foxa-1-3) are winged forkh

97 The winged helix transcription factors, hepatocyte nuclear factors 3alpha, -beta, and -gamma (HN

98 er-specific transcription factors, including hepatocyte nuclear factor 3beta (HNF-3beta), HNF-6alpha,

99 This study led to the identification of hepatocyte nuclear factor 3beta (HNF3 beta), a transcrip

100 The forkhead transcription factor hepatocyte nuclear factor 3beta (HNF3beta) is essential

101 B virus (HBV) transgenic mice expressing rat hepatocyte nuclear factor 3beta (HNF3beta) were generate

102 of forkhead box A2 (FoxA2, previously called hepatocyte nuclear factor 3beta [HNF-3beta]), which caus

103 tion factor Foxa2 (Forkhead box a2, formerly Hepatocyte nuclear factor 3beta) in pancreatic beta cell

104 in which increased hepatic expression of the hepatocyte nuclear factor-3beta (HNF-3beta) protein was

105 tiated into epithelioid cells that expressed hepatocyte nuclear factor-3beta (HNF-3beta), GATA4, cyto

106 The winged helix transcription factor, hepatocyte nuclear factor-3beta (HNF-3beta), mediates th

107 ker histone H5 and the DNA-binding domain of hepatocyte nuclear factor 3gamma (HNF-3gamma), making it

108 In this study, we cloned the cowpea bruchid hepatocyte nuclear factor 4 (CmHNF-4) and demonstrated i

109 The orphan nuclear receptor hepatocyte nuclear factor 4 (HNF-4) regulates the expres

110 l HBV promoters by decreasing the binding of hepatocyte nuclear factor 4 (HNF-4), HNF-3, and fetoprot

111 enes repressed by beta-catenin bind Tcf-4 on hepatocyte nuclear factor 4 (Hnf-4)-responsive elements.

112 The nuclear hormone receptors hepatocyte nuclear factor 4 (HNF4) and retinoid X recept

113 The nuclear hormone receptors hepatocyte nuclear factor 4 (HNF4) and the retinoid X al

114 expression of the nuclear hormone receptors hepatocyte nuclear factor 4 (HNF4) and the retinoid X re

115 Hepatocyte nuclear factor 4 (HNF4) family are transcript

116 Hepatocyte nuclear factor 4 (HNF4) is the most ancient f

117 reatly altering the efficiency of binding of hepatocyte nuclear factor 4 (HNF4) to this recognition s

118 Hepatocyte nuclear factor 4 (HNF4) transcription factor

119 We present a model of hepatocyte nuclear factor 4 (Hnf4)-induced lipotoxicity

120 enhances CYP2D6 promoter transactivation by hepatocyte nuclear factor 4 (HNF4alpha), a known transcr

121 ut model of the tumor-suppressive isoform of hepatocyte nuclear factor 4 alpha ("P1-HNF4alpha") in th

122 major isoforms of the transcription factor, hepatocyte nuclear factor 4 alpha (HNF-4 alpha), in live

123 lls give rise to both hepatocytes [marked by hepatocyte nuclear factor 4 alpha (HNF-4alpha) expressio

124 Finally, we show that hepatocyte nuclear factor 4 alpha (HNF-4alpha) plays a k

125 Hes6 subsequently represses hepatocyte nuclear factor 4 alpha (HNF-4alpha)-activated

126 rol of some genes is critically dependent on hepatocyte nuclear factor 4 alpha (HNF-4alpha; NR2A1), w

127 Among 14 alleles, hepatocyte nuclear factor 4 alpha (HNF4A) AA (rs2144908,

128 , extracellular signal-related kinase (ERK), hepatocyte nuclear factor 4 alpha (HNF4A) and tumor necr

129 sion is enhanced by the transcription factor hepatocyte nuclear factor 4 alpha (HNF4A) through increa

130 Hepatocyte nuclear factor 4 alpha (HNF4A), a liver-enric

131 ndependent microarray studies identified the hepatocyte nuclear factor 4 alpha (HNF4A), a transcripti

132 Elevated HGF induced hepatocyte nuclear factor 4 alpha (Hnf4a), which compete

133 enriched OATP2B1 variant promoter identified hepatocyte nuclear factor 4 alpha (HNF4alpha) as a novel

134 ts the up-regulation and activation of human hepatocyte nuclear factor 4 alpha (HNF4alpha) in a p53-d

135 Hepatocyte nuclear factor 4 alpha (HNF4alpha) is a trans

136 Hepatocyte nuclear factor 4 alpha (HNF4alpha) is critica

137 owed that over 83% of cells were albumin and hepatocyte nuclear factor 4 alpha (HNF4alpha) positive,

138 s constitutive androstane receptor (CAR) and hepatocyte nuclear factor 4 alpha (HNF4alpha) to induce

139 Hepatocyte nuclear factor 4 alpha (HNF4alpha), a member

140 Hepatocyte nuclear factor 4 alpha (HNF4alpha), the maste

141 ess maintained functional gene regulation by hepatocyte nuclear factor 4 alpha (HNF4alpha), whereas f

142 a constitutive androstane receptor (CAR) and hepatocyte nuclear factor 4 alpha (HNF4alpha).

143 scan the human genome for sites that bind to hepatocyte nuclear factor 4 alpha (HNF4alpha).

144 s, including six previously unknown loci (in hepatocyte nuclear factor 4 alpha [HNF4A], fucosyltransf

145 CPOBOP treatment caused transient decline in hepatocyte nuclear factor 4 alpha expression concomitant

146 Fs, CCAAT/enhancer-binding protein alpha and hepatocyte nuclear factor 4 alpha, in the livers of five

147 rate-responsive element-binding protein, and hepatocyte nuclear factor 4 alpha, were also found to be

148 en receptor, both of which were dependent on hepatocyte nuclear factor 4 alpha.

149 we show that the nuclear hormone receptors, hepatocyte nuclear factor 4 and retinoid X receptor alph

150 ucture of the ligand binding domain of human hepatocyte nuclear factor 4 gamma (HNF4gamma).

151 d potential 20q candidates, including HNF4A (hepatocyte nuclear factor 4, alpha), TOMM34 (translocase

152 and mature hepatocytes were characterized by hepatocyte nuclear factor 4-alpha (HNF-4alpha) and album

153 Hepatocyte nuclear factor 4-alpha (HNF4A) is a transcrip

154 otassium channel subunit Kir6.2 (KCNJ11) and hepatocyte nuclear factor 4-alpha (HNF4A) SNPs (0.01 < P

155 (n = 188), glucokinase (GCK)-MODY (n = 118), hepatocyte nuclear factor 4-alpha (HNF4A)-MODY (n = 40),

156 Hepatocyte nuclear factor 4-alpha (HNF4alpha) is a well

157 (A6 and EpCam) and hepatocyte-specific (i.e. hepatocyte nuclear factor 4-alpha) antibodies.

158 physically and functionally interacted with hepatocyte nuclear factor-4 alpha (HNF-4 alpha), a nucle

159 e response element-binding protein (ChREBP), hepatocyte nuclear factor-4 alpha (HNF-4alpha) and perox

160 Variants in hepatocyte nuclear factor-4 alpha (HNF4 alpha), a transc

161 ream of the primary beta-cell promoter P2 of hepatocyte nuclear factor-4 alpha (HNF4A).

162 cyte nuclear factor 1 homeobox A (Hnf1a) and hepatocyte nuclear factor 4A (Hnf4a), known modifiers of

163 e network, which was down-regulated in mouse hepatocyte nuclear factor 4A knockout mice; were early-s

164 ass represented 29% of all HCCs; expressed a hepatocyte nuclear factor 4A-driven gene network, which

165 They also expressed alpha-fetoprotein, hepatocyte nuclear factor-4a, and a metabolic marker, cy

166 Two nuclear receptors, hepatocyte nuclear factor 4alpha (HNF-4alpha) and alpha(

167 Hepatocyte nuclear factor 4alpha (HNF-4alpha) is a liver

168 ired for binding of the transcription factor hepatocyte nuclear factor 4alpha (HNF-4alpha) to the pro

169 The hepatocyte nuclear factor 4alpha (HNF-4alpha; also known

170 of upstream transcription factors, including hepatocyte nuclear factor 4alpha (Hnf4a) and Hnf1a, as w

171 Common and rare variants of the hepatocyte nuclear factor 4alpha (HNF4A) gene have been

172 ry regions bound by the transcription factor hepatocyte nuclear factor 4alpha (HNF4A) was reduced dur

173 Hepatocyte nuclear factor 4alpha (HNF4alpha) activated t

174 Both hepatocyte nuclear factor 4alpha (HNF4alpha) and CES1 we

175 er, PGC-1alpha is induced and interacts with hepatocyte nuclear factor 4alpha (HNF4alpha) and other t

176 on was found to be under the control of both hepatocyte nuclear factor 4alpha (HNF4alpha) and peroxis

177 Hepatocyte nuclear factor 4alpha (HNF4alpha) and retinoi

178 nal link between the orphan nuclear receptor hepatocyte nuclear factor 4alpha (HNF4alpha) and transcr

179 tional knockout mice have shown that loss of hepatocyte nuclear factor 4alpha (HNF4alpha) blocks the

180 ure assays were employed to demonstrate that hepatocyte nuclear factor 4alpha (HNF4alpha) bound to th

181 Hepatocyte nuclear factor 4alpha (HNF4alpha) controls th

182 Here we report that hepatocyte nuclear factor 4alpha (HNF4alpha) dictates th

183 We show here that Hepatocyte Nuclear Factor 4alpha (HNF4alpha) directly in

184 o decreased by 45% in the setting of reduced hepatocyte nuclear factor 4alpha (HNF4alpha) expression.

185 Hepatocyte nuclear factor 4alpha (HNF4alpha) has an impo

186 The nuclear receptor hepatocyte nuclear factor 4alpha (HNF4alpha) has just re

187 enesis by targeting the gluconeogenic factor hepatocyte nuclear factor 4alpha (HNF4alpha) in both cel

188 Loss of the nuclear hormone receptor hepatocyte nuclear factor 4alpha (HNF4alpha) in hepatocy

189 Hepatocyte nuclear factor 4alpha (HNF4alpha) is a master

190 Hepatocyte nuclear factor 4alpha (HNF4alpha) is a novel

191 We show that the transcription factor hepatocyte nuclear factor 4alpha (HNF4alpha) is a target

192 Hepatocyte nuclear factor 4alpha (HNF4alpha) is essentia

193 Here we report that hepatocyte nuclear factor 4alpha (Hnf4alpha) is essentia

194 The nuclear receptor hepatocyte nuclear factor 4alpha (HNF4alpha) is tumor su

195 We previously reported that hepatocyte nuclear factor 4alpha (HNF4alpha) participate

196 Hepatocyte nuclear factor 4alpha (HNF4alpha) regulates g

197 Hepatocyte nuclear factor 4alpha (HNF4alpha) regulates t

198 Hepatocyte nuclear factor 4alpha (HNF4alpha) strongly ac

199 Here we show that hepatocyte nuclear factor 4alpha (HNF4alpha), a liver-en

200 zation of tumor suppressor proteins Rb, p53, hepatocyte nuclear factor 4alpha (HNF4alpha), and CCAAT/

201 ), LXRalpha, liver receptor homolog (LRH-1), hepatocyte nuclear factor 4alpha (HNF4alpha), and short

202 oters including the glucocorticoid receptor, hepatocyte nuclear factor 4alpha (HNF4alpha), and the pe

203 /arginine-rich splicing factor 3 (Srsf3) and hepatocyte nuclear factor 4alpha (Hnf4alpha), and was cr

204 ion of a known positive regulator of CYP2D6, hepatocyte nuclear factor 4alpha (HNF4alpha), did not ch

205 Multiple nuclear receptors, including hepatocyte nuclear factor 4alpha (HNF4alpha), retinoid X

206 ession by inhibiting DNA-binding activity of hepatocyte nuclear factor 4alpha (HNF4alpha).

207 mouse liver genome, and are co-recruited by hepatocyte nuclear factor 4alpha (HNF4alpha).

208 ing the activity of the transcription factor hepatocyte nuclear factor 4alpha (HNF4alpha).

209 r data show that PGC-1alpha interaction with hepatocyte nuclear factor 4alpha (HNF4alpha, NR2A1) dire

210 ing protein-1c (SREBP-1c) strongly inhibited hepatocyte nuclear factor 4alpha and peroxisome prolifer

211 We identified hepatocyte nuclear factor 4alpha as a regulatory factor

212 ntrol on the hepatocyte transcription factor hepatocyte nuclear factor 4alpha by modulating its activ

213 matrigel, suggesting that down-regulation of hepatocyte nuclear factor 4alpha expression is involved

214 These findings support a role of hepatocyte nuclear factor 4alpha in controlling claudin-

215 TNFalpha inhibited the induction of hepatocyte nuclear factor 4alpha induced by OSM and matr

216 R-specific agonist and adenovirus expressing hepatocyte nuclear factor 4alpha or constitutively activ

217 X-Gal staining showed Adamts7 expression in hepatocyte nuclear factor 4alpha(+) hepatocytes and desm

218 ICD) mice is accompanied by re-expression of hepatocyte nuclear factor 4alpha(HNF4alpha), possibly in

219 HNF4alpha (hepatocyte nuclear factor 4alpha) plays an essential rol

220 damage, increase in expression of HNF4alpha (hepatocyte nuclear factor 4alpha), a key driver associat

221 The tumor cells coexpressed hepatocyte (hepatocyte nuclear factor 4alpha), progenitor/biliary (k

222 were found in the perigenic regions: HNF4A (hepatocyte nuclear factor 4alpha), SLC12A5 (potassium-ch

223 the presence of the liver-specific markers, hepatocyte nuclear factor 4alpha, albumin, cytokeratin 1

224 way linking FXR to changes in hepatic p-JNK, hepatocyte nuclear factor 4alpha, and finally SR-BI.

225 indicated that viral replication mediated by hepatocyte nuclear factor 4alpha, retinoid X receptor al

226 acid receptor, the retinoid X receptor, the hepatocyte nuclear factor 4alpha, the chicken ovalbumin

227 l cell adhesion molecule-negative (EpCAM(-)) hepatocyte nuclear factor 4alpha-positive (HNF4alpha(+))

228 y genes, including nuclear factor kappaB and hepatocyte nuclear factor 4alpha.

229 rent feedforward loop between miR-337-3p and hepatocyte nuclear factor 4alpha.

230 It has been shown previously that hepatocyte nuclear factor-4alpha (HNF-4) and the alpha(1

231 ich was accompanied by restoring activity of hepatocyte nuclear factor-4alpha (HNF-4alpha) and peroxi

232 Mutations in the gene encoding hepatocyte nuclear factor-4alpha (HNF-4alpha) result in

233 Hepatocyte nuclear factor-4alpha (HNF-4alpha), a liver-e

234 eneration was associated with an increase in hepatocyte nuclear factor-4alpha (HNF-4alpha), a liver-e

235 s-regulatory element transcription factor as hepatocyte nuclear factor-4alpha (HNF-4alpha), and confi

236 is dependent on the orphan nuclear receptor hepatocyte nuclear factor-4alpha (HNF-4alpha), the gene

237 d the CAR-dependent inhibition was linked to hepatocyte nuclear factor-4alpha (HNF4alpha)-mediated tr

238 ere we show that the orphan nuclear receptor hepatocyte nuclear factor-4alpha (HNF4alpha; HNF4A) is c

239 Down-regulation of hepatocyte nuclear factor-4alpha expression and defectiv

240 Reduced hepatocyte nuclear factor-4alpha was associated with act

241 ivated receptor gamma coactivator 1alpha and hepatocyte nuclear factor-4alpha were increased in IUGR

242 rs showed membranous EpCAM(+)/HNF-4alpha(+) (hepatocyte nuclear factor-4alpha) staining and were cont

243 or PGC-1alpha partners, including PPARalpha, hepatocyte nuclear factor-4alpha, and estrogen receptor

244 ryl hydrocarbon receptor, but not of CYP3A4, hepatocyte nuclear factor-4alpha, or pregnane X receptor

245 epatocyte transcriptional factors, including hepatocyte nuclear factor-4alpha, that is early down-reg

246 nctions in synergy with the nuclear receptor hepatocyte nuclear factor-4alpha.

247 rs: CCAAT-enhancer binding protein-alpha and hepatocyte nuclear factor-4alpha.

248 tein but no change in expression of GAPDH or hepatocyte nuclear factor-4alpha.

249 Our previous work demonstrated that hepatocyte nuclear factor 4alpha1 (HNF4alpha1, NR2A1) in

250 Hepatocyte nuclear factor 6 (HNF-6) belongs to the famil

251 Hepatocyte nuclear factor 6 (HNF-6) is a member of the o

252 The hepatocyte nuclear factor 6 (HNF6 or ONECUT-1) protein i

253 complexes between the DNA-binding domains of hepatocyte nuclear factor 6 (HNF6) and forkhead box a2 (

254 lexes between the DNA binding domains of the hepatocyte nuclear factor 6 (HNF6) and Forkhead Box a2 (

255 xplore the requirement for downregulation of hepatocyte nuclear factor 6 (HNF6) expression in the ass

256 Hepatocyte nuclear factor 6 (HNF6) is required for liver

257 Here, we report that hepatocyte nuclear factor 6 (HNF6), a liver-enriched tra

258 regulated transcriptional activators (STAT5, hepatocyte nuclear factor 6 [HNF6], FOXA1, and FOXA2) an

259 ts was positively correlated (p < 0.05) with hepatocyte nuclear factor 6 and estrogen receptor-alpha

260 ntin, and the transcription factors SOX9 and hepatocyte nuclear factor 6.

261 Notch signaling and hepatocyte nuclear factor-6 (HNF-6) are two genetic fact

262 Mutations in Pdx1 or upstream hepatocyte nuclear factors cause autosomal forms of earl

263 Our results indicate that binding sites for hepatocyte nuclear factors (especially HNF-1 and HNF-4)

264 e mouse Oatp4 putative response elements for hepatocyte nuclear factor (HNF) 1, CAAT/enhancer binding

265 homeodomain-containing transcription factor, hepatocyte nuclear factor (HNF) 1, plays a central role

266 n activity was obtained by cotransfection of hepatocyte nuclear factor (HNF) 3gamma or HNF4alpha.

267 In addition, a hepatocyte nuclear factor (HNF) 3gamma-containing comple

268 Our recent DNA microarrays have identified hepatocyte nuclear factor (HNF) 4alpha and insulin-like

269 Hepatocyte nuclear factor (HNF) 4alpha regulates the exp

270 le canaliculi, probably through an effect on hepatocyte nuclear factor (HNF) 4alpha.

271 of cytochrome P450 2D6 (CYP2D6) promoter by hepatocyte nuclear factor (HNF) 4alpha.

272 Hepatocyte nuclear factor (HNF) 6 (also known as OC-1) i

273 ice), combined (or not) with inactivation of hepatocyte nuclear factor (HNF) 6 (Foxa3-Cre/Dicer(loxP/

274 ified miR-122 as a direct target of the LETF hepatocyte nuclear factor (HNF) 6.

275 The hepatocyte nuclear factor (HNF) family regulates complex

276 pancreatic transcription factors, including hepatocyte nuclear factor (HNF)-1 and HNF-3, form a tigh

277 estine-specific Cdx homeodomain proteins and hepatocyte nuclear factor (HNF)-1, which are conserved i

278 Mutations in hepatocyte nuclear factor (HNF)-1alpha (MODY3) account f

279 ygous mutations in the transcription factors hepatocyte nuclear factor (HNF)-1alpha and -1beta result

280 ansporters; and 4) nuclear protein levels of hepatocyte nuclear factor (HNF)-1alpha and retinoid X re

281 ucokinase (GCK) and the transcription factor hepatocyte nuclear factor (HNF)-1alpha are the most comm

282 Diabetes in subjects with hepatocyte nuclear factor (HNF)-1alpha gene mutations (m

283 ysiology of the beta-cell, with mutations in hepatocyte nuclear factor (HNF)-1alpha, HNF-4alpha, insu

284 were subclassified into 14 inflammatory, 20 hepatocyte nuclear factor (HNF)-1alpha-mutated, one beta

285 The hepatocyte nuclear factor (HNF)-3 homologous DNA binding

286 ion of the apo A-I promoter, which binds the hepatocyte nuclear factor (HNF)-3beta.

287 e of suppression of its key transactivators, hepatocyte nuclear factor (HNF)-4alpha and HNF6.

288 tations in the human HNF4A gene encoding the hepatocyte nuclear factor (HNF)-4alpha are known to caus

289 Hepatocyte nuclear factor (HNF)-4alpha is part of a tran

290 some proliferator-activated receptor (PPAR), hepatocyte nuclear factor (HNF)-4alpha, and liver X rece

291 Overexpression of hepatocyte nuclear factor (HNF)-4alpha, which binds to t

292 and -99, and this sequence was shown to bind hepatocyte nuclear factor (HNF)-6.

293 x1 strongly and specifically interacted with hepatocyte nuclear factor (HNF)4alpha, an important tran

294 enes such as glucagon, forkhead homeobox A2, hepatocyte nuclear factor (HNF)4alpha, and HNF1alpha.

295 It also involves dynamic expression of hepatocyte nuclear factor (Hnf)4alpha, Yes-associated pr

296 Foxa3 (HNF-3gamma) act in concert with other hepatocyte nuclear factors (HNF) to coordinately regulat

297 Hepatocyte nuclear factors (HNFs) -1alpha, -3beta, -4alp

298 Analysis of hepatocyte nuclear factors (HNFs) showed that transcript

299 The hepatic promoter depends on a cluster of hepatocyte nuclear factor sites 123-155 bp upstream of t

300 including C/EBP, nuclear factor-kappaB, and hepatocyte nuclear factor were found in the region upstr