ライフサイエンスコーパス: hepatotropic

1 when mice were challenged with an unrelated hepatotropic adenovirus as a nonspecific stimulus.

2 In a murine model of intravenous hepatotropic adenovirus infection, liver-primed antivira

3 ntiviral immunity in humanized mice during a hepatotropic adenovirus infection.

4 Hepatotropic adenovirus was introduced intravenously int

5 e evaluated by challenging these mice with a hepatotropic adenovirus.

6 hepatitis C virus (HCV) are considered to be hepatotropic and are a major cause of hepatocellular car

7 hepatitis in humans, is unique in that it is hepatotropic and is released from hepatocytes without ly

8 mically modified siRNA-GalNAc conjugates are hepatotropic and long-acting and have the potential to t

9 ed an infectious clone and chimeric virus of hepatotropic and lymphotropic HCV strains derived from a

10 highly neurovirulent MHV-JHM strain and the hepatotropic and mildly neurovirulent A59 strain in acut

11 uses of ALF in adults include drug toxicity, hepatotropic and non-hepatotropic viruses, herbal and di

12 chemical, serologic, and molecular tests for hepatotropic and other viruses, as well as radiologic an

13 We sought to determine whether HGV was hepatotropic and to determine whether coinfection with H

14 ne and containing the strain A59 (moderately hepatotropic) and JHM (neurotropic) spike genes in the b

15 tion, as expression of immunity against this hepatotropic bacterial pathogen is dependent on antigen-

16 se (HE), which is not produced by MHV-A59, a hepatotropic but only mildly neurovirulent strain.

17 infected with murine hepatitis virus A59, a hepatotropic coronavirus, resulted in significant reduct

18 Hepatitis B virus (HBV) is a hepatotropic DNA virus that replicates by reverse transc

19 s B virus as prototype, are small, enveloped hepatotropic DNA viruses which replicate by reverse tran

20 ly being investigated particularly for their hepatotropic effects.

21 Hepadnaviruses are hepatotropic enveloped DNA viruses with an icosahedral c

22 es infected with hepatitis C virus (HCV), an hepatotropic flavivirus that frequently causes persisten

23 GB virus B (GBV-B) is a recently discovered hepatotropic flavivirus that is distantly related to hep

24 Utilization of a strictly hepatotropic, HCV-related rodent hepacivirus (RHV) model

25 ma cells generated in SLOs, whereas strictly hepatotropic hepaciviral infection elicits locally prime

26 impanzees, while GB virus B (GBV-B), another hepatotropic hepacivirus, infects small New World primat

27 fide liver cells and support replication of hepatotropic hepatitis B virus (HBV).

28 rdiotropic coxsackievirus B3 (CVB3), and the hepatotropic hepatitis C virus (HCV) mediate translation

29 Hepatitis A virus (HAV) is an hepatotropic human picornavirus that is associated only

30 tory rats recapitulates the lifelong chronic hepatotropic infection and immune evasion of HCV.

31 protective or pathological responses during hepatotropic infections and autoimmune liver disease.

32 ered in Norway rats can establish high-titer hepatotropic infections in laboratory mice with immunolo

33 nized mouse model for studying HCV and other hepatotropic infections, human immune response and hepat

34 injury, gene regulation, drug toxicity, and hepatotropic infections.

35 scopy demonstrating the potential use of our hepatotropic, ligand-modified nanoparticles.

36 Although remaining hepatotropic like AAV2, the AAV2G9 chimera mediates rapi

37 ved from GB virus B (GBV-B), an unclassified hepatotropic member of the family Flaviviridae that is c

38 acivirus (EHCV; nonprimate hepacivirus) is a hepatotropic member of the Flaviviridae family that infe

39 that HBeAg-negative shrew HBVs cause intense hepatotropic monoinfections and low within-host genomic

40 is its localization within the virion of the hepatotropic/neurotropic A59 strain of MHV.

41 (-/-)mice and tested the ability of MHV A59 (hepatotropic/neurotropic) and JHM (neurotropic) Mac1 mut

42 ctional antiviral immune responses against a hepatotropic pathogen in humanized HLA-transgenic mice.

43 the dynamic behavior whereby CD8 TE control hepatotropic pathogens and suggest how liver fibrosis mi

44 Hepatotropic pathogens can take advantage of this niche

45 ll subversion, leading to the persistence of hepatotropic pathogens such as HCV.IMPORTANCE Developmen

46 n perceived as passive bystanders that allow hepatotropic pathogens such as Plasmodium to develop rel

47 and HCV infection, and possibly other human hepatotropic pathogens, and prove useful for antiviral d

48 l animal model that accurately recapitulates hepatotropic pathogens, including hepatitis C virus (HCV

49 pathogenesis and vaccine development against hepatotropic pathogens.

50 altered the systemic tropism of AAV9 into a hepatotropic phenotype, characterized by markedly increa

51 tropic JHM strain does not reproduce the A59 hepatotropic phenotype.

52 Hepatitis A virus (HAV) is a hepatotropic picornavirus that causes acute liver diseas

53 ere, we show that hepatitis A virus (HAV), a hepatotropic picornavirus, ablates type 1 IFN responses

54 studies, we show that hepatitis A virus, an hepatotropic picornavirus, broadly manipulates the host

55 Hepatoviruses are atypical hepatotropic picornaviruses that are released from infec

56 Taking advantage of the hepatotropic properties of adenovirus vectors, gene tran

57 d have reduced liver disease associated with hepatotropic PTV infection.

58 Here, we show that hepatotropic revertant variants may be selected from the

59 Hepatitis C virus (HCV) is a hepatotropic RNA virus frequently associated with chroni

60 Hepatitis C virus (HCV) is a hepatotropic RNA virus that can cause acute and chronic

61 bstitution in nsp1 of JHM.WU or A59, another hepatotropic strain, significantly attenuates replicatio

62 NASH complicates hepatotropic viral disease.

63 r Mvarphi uniquely up-regulated SR-AI during hepatotropic viral infection and displayed increased exp

64 +) DCs are highly immunogenic in response to hepatotropic viral infection and serve as a major APC to

65 However, in response to hepatotropic viral infection, the liver's ability to swi

66 insight into the response of the liver to a hepatotropic viral infection.

67 tigate it could enhance our understanding of hepatotropic viral infections and lead to improved vacci

68 Persistent hepatotropic viral infections are a common etiologic age

69 Antiviral T cell responses in hepatotropic viral infections such as hepatitis B virus

70 Although both are hepatotropic viral infections, there are important diffe

71 8(+) T cells (CD8 TE) play a key role during hepatotropic viral infections.

72 GB virus B (GBV-B) is a hepatotropic virus and close relative of HCV.

73 A previously unrecognized hepatotropic virus has been suspected as a potential eti

74 in the liver during acute infection with the hepatotropic virus murine cytomegalovirus (MCMV) involve

75 Hepatitis B virus (HBV) is a hepatotropic virus that can cause severe liver diseases.

76 HBV is a hepatotropic virus that infects human hepatocytes expres

77 Although HCV is primarily a hepatotropic virus, an increasing body of evidence sugge

78 Historically, HEV was described as a hepatotropic virus, but has recently been associated wit

79 iHALT successfully compensates for strictly hepatotropic virus-induced SLO-evasion strategies to pre

80 HCV) is a single-stranded positive-sense RNA hepatotropic virus.

81 This study does not support HGV as a primary hepatotropic virus.

82 esponse against viruses may be important for hepatotropic viruses (e.g., hepatitis B and C) to develo

83 ar renal transplant recipients infected with hepatotropic viruses (HBV and HCV) have a high rate of a

84 The impact of infection with hepatotropic viruses (hepatitis B virus [HBV] and hepati

85 a high frequency of coinfections with other hepatotropic viruses and ongoing fibrosis, leading to ci

86 Hepatotropic viruses are important causes of human disea

87 ghts highlight the complex crosstalk between hepatotropic viruses during coinfection and suggest that

88 nce, CD8 T-cell antiviral efficiency against hepatotropic viruses has been linked to their capacity t

89 regulated via distinct pathways that involve hepatotropic viruses or cytokines.

90 clinical models of persistent infection with hepatotropic viruses such as HBV, dysfunctional virus-sp

91 s (FVH) is a devastating condition caused by hepatotropic viruses such as hepatitis A virus (HAV), he

92 The responses of CD8(+) T cells to hepatotropic viruses such as hepatitis B range from dysf

93 No known hepatotropic viruses were detected in the tested normal

94 tious complications (including recurrence of hepatotropic viruses), and deliver immunosuppression wit

95 flares may be caused by infection with other hepatotropic viruses, and this situation may inhibit HBV

96 include drug toxicity, hepatotropic and non-hepatotropic viruses, herbal and dietary supplements, an

97 mphocytes (CTLs) or infection with unrelated hepatotropic viruses, including lymphocytic choriomening

98 ed as a model of choice for studies of other hepatotropic viruses.

99 ral infection, with a particular emphasis on hepatotropic viruses.

100 t initial infection with either of these two hepatotropic viruses.

101 linically relevant in chronic persistence of hepatotropic viruses.

102 and may also be useful for studies of other hepatotropic viruses.

103 and screen for combination therapies against hepatotropic viruses.

104 hways cause recurrent ALF in response to non-hepatotropic viruses.

105 d patients who become superinfected by other hepatotropic viruses; they suggest that pharmacological