ライフサイエンスコーパス: hereditary cancer syndrome

1 s were compared by sex, race, histology, and hereditary cancer syndrome.

2 half of the alleles associated with a common hereditary cancer syndrome.

3 von Hippel-Lindau disease is a hereditary cancer syndrome.

4 olorectal, gastric, or pancreatic cancer for hereditary cancer syndromes.

5 unusual in an individual patient, except in hereditary cancer syndromes.

6 advised for patients and family members with hereditary cancer syndromes.

7 roduction by members of families affected by hereditary cancer syndromes.

8 ain hereditary gastrointestinal polyposis or hereditary cancer syndromes.

9 r, (2) review biomarker data suggestive of a hereditary cancer syndrome, (3) facilitate ordering tumo

10 ts with germline mutations associated with a hereditary cancer syndrome (51%) reported a CRC diagnosi

11 ch repair genes cause Lynch syndrome (LS), a hereditary cancer syndrome affecting approximately 20-25

12 mmended, genetic testing of minors for adult hereditary cancer syndromes, along with risks and benefi

13 quencing, 79 had mutations associated with a hereditary cancer syndrome and 21 had variants of uncert

14 tumor suppressor gene (VHL) underlie the VHL hereditary cancer syndrome and also occur in most sporad

15 checkpoint control have been seen in certain hereditary cancer syndromes and at early stages of cell

16 he clinical profile, including the extent of hereditary cancer syndromes and family history of cancer

17 ious CRC, previous multiple large polyps, or hereditary cancer syndromes) and 66% were located distal

18 suppressor gene causes the von Hippel-Lindau hereditary cancer syndrome, and somatic mutations of thi

19 s determined to be at high risk for having a hereditary cancer syndrome, and tumor-only sequencing fo

20 Many hereditary cancer syndromes are associated with an incre

21 Though hereditary cancer syndromes are rare, their study has pr

22 Hereditary cancer syndromes are typically caused by muta

23 way deregulation in human cancer and certain hereditary cancer syndromes, as well as in murine models

24 Lynch syndrome is a hereditary cancer syndrome associated with high risks of

25 onal symposium on the surgical management of hereditary cancer syndromes at the annual ASCO and SSO m

26 Six patients had variants associated with hereditary cancer syndromes (ATM = 2, BRCA1 = 2, BRCA2 =

27 ed with increased susceptibility not only to hereditary cancer syndromes but also to other diseases;

28 von Hippel-Lindau (VHL) disease is a hereditary cancer syndrome caused by germ line mutation

29 von Hippel-Lindau (VHL) disease is a hereditary cancer syndrome caused by germline mutations

30 ngs thus link cytokinetic abnormalities to a hereditary cancer syndrome characterized by chromosomal

31 Given the implications of a hereditary cancer syndrome diagnosis for preventive care

32 crine neoplasia (MEN) types 1 and 2 are rare hereditary cancer syndromes expressing a variety of main

33 There are also hereditary cancer syndromes for which testing is not yet

34 These results indicate that, as with certain hereditary cancer syndromes, genomic destabilization is

35 Great interest in predictive testing for hereditary cancer syndromes has been reported.

36 More than 20 different hereditary cancer syndromes have now been defined and at

37 g cancer diagnosis, and can be attributed to hereditary cancer syndromes, immune or hormonal factors,

38 Screening for hereditary cancer syndromes in patients with CRC should

39 ablished guidelines recommend evaluation for hereditary cancer syndromes in patients younger than 50

40 with evaluable data, 35% had an identifiable hereditary cancer syndrome, including 23 with Lynch synd

41 ion genetic testing is now possible for many hereditary cancer syndromes, including hereditary nonpol

42 Hereditary cancer syndromes infer high cancer risks and

43 This rare hereditary cancer syndrome is characterized by bone infa

44 In 20% of patients with YO-CRC, a hereditary cancer syndrome is found as the underlying ca

45 It has been suggested that MEN1, like many hereditary cancer syndromes, is caused by mutation in a

46 cycle enzyme fumarate hydratase (FH) cause a hereditary cancer syndrome known as hereditary leiomyoma

47 cal, pathologic, and genetic features of the hereditary cancer syndromes known to be associated with

48 le genes have been implicated in single-gene hereditary cancer syndromes, many of which are associate

49 out the spectrum of diseases associated with hereditary cancer syndromes may improve disease diagnosi

50 However, the term 'hereditary cancer syndrome' may be misleading, as a larg

51 In this review, we highlight the most common hereditary cancer syndromes, most attributable to genes

52 all percent of colorectal cancers are due to hereditary cancer syndromes, of which hereditary nonpoly

53 inflammatory bowel disease, history of CRC, hereditary cancer syndromes), previous colonoscopy at th

54 Hereditary cancer syndromes provide powerful insights in

55 d cascade genetic counseling and testing for hereditary cancer syndromes, providing relatives the opp

56 Hereditary cancer syndromes represent ~10% of all incide

57 DNA testing is no small matter, given that a hereditary cancer syndrome's sequelae may be far reachin

58 The possibility of a hereditary cancer syndrome should be assessed for every

59 MMRd is associated with hereditary cancer syndromes such as Lynch syndrome and c

60 von Hippel-Lindau (VHL) disease is a rare hereditary cancer syndrome that causes a predisposition

61 multiple mole melanoma (FAMMM) syndrome is a hereditary cancer syndrome that results from mutations i

62 Recent studies of a relatively rare hereditary cancer syndrome, von Hippel-Lindau (VHL) dise

63 Patients with an identified hereditary cancer syndrome were compared with those with

64 age 40 years or younger and lacking a known hereditary cancer syndrome were identified from the CCFR

65 deubiquitinating enzyme BAP1 is mutated in a hereditary cancer syndrome with a high risk for mesothel

66 e-ubiquitinating enzyme BAP1 is mutated in a hereditary cancer syndrome with increased risk of mesoth

67 now have a good opportunity to better define hereditary cancer syndromes with associated hematologic

68 e introduction of genomic technologies, more hereditary cancer syndromes with hematologic malignancie