ライフサイエンスコーパス: hereditary prostate cancer

1 iated with a significantly increased risk of hereditary prostate cancer.

2 A total of 74 North American families with hereditary prostate cancer.

3 The hereditary prostate cancer 1 (HPC1) allele maps to the R

4 a strong candidate for the long sought after hereditary prostate cancer 1 (HPC1) allele.

5 chromosome 1q24-q31 interval, including the hereditary prostate cancer 1 (HPC1) locus.

6 The RNASEL gene, a strong candidate for the hereditary prostate cancer 1 allele (HPC1), encodes a si

7 ncer families that show linkage to the HPC1 (hereditary prostate cancer 1) region at 1q24-25.

8 ified as a candidate susceptibility gene for hereditary prostate cancer and as a risk factor for spor

9 e 1q24-25 region in 772 families affected by hereditary prostate cancer and ascertained by the member

10 NKX3.1 may play a role in susceptibility to hereditary prostate cancer and underscore a role for NKX

11 r accentuated among men meeting criteria for hereditary prostate cancer, and further still for those

12 r study shows that a significant fraction of hereditary prostate cancers are diagnosed in advanced st

13 Among hereditary prostate cancer cases diagnosed under age 60

14 ine mapping linkage analysis at 8p among 206 hereditary prostate cancer families also provided eviden

15 sequenced the NKX3.1 gene in 159 probands of hereditary prostate cancer families recruited at Johns H

16 amilies, which represent a stratification of hereditary prostate cancer families with potentially inc

17 ases and 222 controls) and family-based (159 hereditary prostate cancer families) association study w

18 y genome-wide scans, encompassing some 1,500 hereditary prostate cancer families, indicate that prost

19 A recent study of hereditary prostate cancer has provided evidence for a p

20 d with prostate cancer risk in families with hereditary prostate cancer (HPC) and in patients with no

21 reviously performed a genome-wide search for hereditary prostate cancer (HPC) genes, finding evidence

22 The search for susceptibility loci in hereditary prostate cancer (HPC) has proven challenging

23 Multiple genome-wide scans for hereditary prostate cancer (HPC) have identified suscept

24 nd linkage studies in families affected with hereditary prostate cancer (HPC) have implicated this re

25 We investigate its contribution to hereditary prostate cancer (HPC) in independent study po

26 nd prostate cancer susceptibility in several hereditary prostate cancer (HPC) populations, we hypothe

27 nkage analyses, in 159 pedigrees affected by hereditary prostate cancer (HPC), using 24 markers on th

28 recently identified as a candidate gene for hereditary prostate cancer (HPC).

29 C2/ELAC2 gene at 17p11 in 159 pedigrees with hereditary prostate cancer (HPC); (2) a mutation-screeni

30 ecently been proposed as a candidate for the hereditary prostate cancer (HPC1) gene.

31 A 10-cM genomewide scan of 94 families with hereditary prostate cancer, including 432 affected men,

32 Recent studies suggest that hereditary prostate cancer is a complex disease involvin

33 small proportion of all families affected by hereditary prostate cancer, it appears to play a more pr

34 ided by the identification of other putative hereditary prostate cancer loci on Xq27-28, 1q42-43, and

35 on human chromosome 1q24, near the putative hereditary prostate cancer locus (HPC1).

36 dentify the susceptibility genes involved in hereditary prostate cancer (OMIM 176807) and hyperparath

37 recently identified as a candidate gene for hereditary prostate cancer (PC).

38 Recent studies suggest that hereditary prostate cancer (PRCA) is a complex disease,

39 NPs were further genotyped in a total of 159 hereditary prostate cancer probands, 245 sporadic prosta

40 Most importantly, the subset of hereditary prostate cancer probands, whose families prov

41 We have recently mapped a locus for hereditary prostate cancer (termed HPCX) to the long arm

42 mine if these loci were also associated with hereditary prostate cancer, we genotyped them in a famil