ライフサイエンスコーパス: heretofore

1 etry that has not been observed in chemistry heretofore.

2 such as cyclic voltammetry have been lacking heretofore.

3 f a climate-conflict link than has been seen heretofore.

4 than the recombinant alpha-synuclein studied heretofore.

5 be more important than has been appreciated heretofore.

6 nt approach has left the problem unresolved, heretofore.

7 evaluation of malaria control programs than heretofore.

8 id tumors and has been largely unappreciated heretofore.

9 e human infections caused by type emm59 GAS, heretofore an exceedingly rare cause of disease, spread

10 We found that many physiological roles heretofore ascribed to intracellular trehalose, includin

11 This spirochete, heretofore associated with LB only in Europe, is widely

12 ted by dietary proteins and not, as has been heretofore assumed, simply triggered by reduced caloric

13 riation associated with mental disorders has heretofore been based on the search for rare or common v

14 term pharmacosynthetics to describe what has heretofore been called pharmacogenetics or chemicogeneti

15 estigation of APOE and CVD pathology has not heretofore been conducted.

16 acids, and the primary lipid recipients have heretofore been defined as phosphatidylglycerol (PG) and

17 mising, human Treg cell infusion therapy has heretofore been difficult to implement in the clinic, an

18 sers" of the cytoskeleton and epigenome have heretofore been distinct.

19 antichondrogenic activity of Twist1 has not heretofore been established.

20 These types of reactions have not heretofore been examined in the gas phase.

21 y be used for glutathione synthesis, has not heretofore been identified as active in mammary cells.

22 No genes for Perrault syndrome have heretofore been identified.

23 s important features of the system that have heretofore been ignored (such as highly variable substra

24 s, an important class of substrates that has heretofore been incompatible with the harsh conditions r

25 en problems in biological research that have heretofore been insoluble.

26 nd spatial resolution are demanding and have heretofore been largely unavailable to researchers.

27 ntrinsic acidity of these imidazoles has not heretofore been measured; these experimental data provid

28 ledge could have great social value that has heretofore been overlooked.

29 with a greater degree of precision than has heretofore been possible.

30 s and the mechanisms that underlie them have heretofore been unclear.

31 The mechanism by which this occurs has heretofore been unknown.

32 To our knowledge, BiS has not heretofore been well studied as a functional measure of

33 wer >100 that permits separation of numerous heretofore "coeluting" isomers.

34 IgM, to that of IgM sufficient C57BL6x129Sv (heretofore, control) mice at different times after intra

35 buted to a reversed crystal growth mechanism heretofore described only in the synthesis of inorganic-

36 Our study brings together heretofore diverse observations on spontaneous cytoskele

37 We sought heretofore elusive evidence that human drug users could

38 mises to enable systematic dissection of the heretofore enigmatic structure/function relationships th

39 cuss new technologies that have allowed this heretofore enigmatic subset of B cells to be identified

40 triazolylidene carbenes) that have not been heretofore examined in vacuo.

41 6-chloropurine, xanthine) that have not been heretofore examined.

42 ve more profound effects on their hosts than heretofore expected.

43 Theories of breathing's neural origins have heretofore focused on intrinsically bursting "pacemaker"

44 T(DC) express genes heretofore found uniquely in T cells or dendritic cells,

45 ide a critical and comprehensive overview of heretofore generated data on renal denervation in experi

46 ith recent theoretical predictions that have heretofore gone unaddressed.

47 inolytic properties of this serpin that have heretofore gone unrecognized.

48 olyketide prymnesins from whole cells, which heretofore has not been reproduced since their original

49 n with other substances, including solvents, heretofore has stymied efforts to develop robust methods

50 tors in addition to mu-opioid receptors that heretofore have been associated with opiate respiratory

51 of modulating T cell-mediated immunity, that heretofore have been studied almost exclusively in the c

52 ancer progression, depending on factors that heretofore have been undefined.

53 To our knowledge, these five species heretofore have not been reported to cause mycotic infec

54 Heretofore, HumAb mice have been generated by disrupting

55 lants; however, no specific protein has been heretofore identified as activated by cAMP in a manner a

56 mote epigenetic changes, it has been unknown heretofore if 5ClC directly perpetrates a mutagenic outc

57 ncy to integrate niche complementarity and a heretofore-ignored mechanism of diminishing marginal pro

58 involved in interpreting space and time than heretofore imagined.

59 y motoneurons and not secondary motoneurons, heretofore impossible with conventional transgenic appro

60 ch has the highest coordination number known heretofore in chemistry.

61 IL24, which has not been recognized heretofore in MCs, was also tested for its effect on ker

62 beta-disubstituted enones, which have been a heretofore inaccessible substrate class.

63 light has enabled observation of PCET events heretofore inaccessible, revealing active site chemistry

64 of a heterochromatin function that have been heretofore inaccessible.

65 1p at its translation site could explain the heretofore-inexplicable phenomenon of cis preference-the

66 Heretofore, information on host factor requirements for

67 Heretofore, it remained unknown how predictive informati

68 dreds-of-picosecond Auger recombination, but heretofore lack FRET characterizations.

69 However, optical imaging technology has heretofore lacked the combination of spatial resolution

70 ligands that affect the activity of proteins heretofore lacking chemical probes.

71 introductions from a single source (MISS), a heretofore largely unexplored model.

72 ing the early blastula stages, a period when heretofore largely unknown events transmit LR patterning

73 nd harmonic generation spectroscopy has been heretofore limited to isotropic materials.

74 Weak complexing agents which have received heretofore little attention may play a key role in the b

75 ot pertain to superficial erosion, a process heretofore little understood mechanistically.

76 ied inherited variations in a plausible, yet heretofore low-priority candidate gene, SLCO1B1, as impo

77 were over-represented significantly in this heretofore LQTS cohort (13.2%) compared with exome aggre

78 Heretofore, models for actin assembly in cells generally

79 Heretofore, most genetic humanizations have involved dis

80 th biophysical and cell-based assays and are heretofore named ZMC2 (NSC319725) and ZMC3 (NSC328784).

81 ptive protein evolution, suggesting that the heretofore neglected dimensions of sequence space may ch

82 events have declined in recent decades, but heretofore no study has examined if there has been a tem

83 Heretofore, no evidence suggested that transfer RNAs (tR

84 into the cross-bridges by enzymes that have heretofore not been identified.

85 and organismal development in a way that has heretofore not been possible.

86 noninfectious stimuli in modulating GVHD has heretofore not been recognized.

87 ocytosis, the involvement of 26 of which has heretofore not been recognized.

88 lation status of an entire genome, which has heretofore not been reported.

89 he proteomes of human ASD vs. control brain, heretofore not done, would provide important data with w

90 enome-wide association study confirms a gene heretofore not implicated in cardiac pathophysiology as

91 eal, atomically thin quasi-2D materials were heretofore not well understood.

92 nds to the metal can help explain reactivity heretofore not yet understood in the halogenase SyrB2.

93 vina et al report the most extensive catalog heretofore of HLA-restricted immunogenic peptides derive

94 ocument that the periplasmic protein PA0808, heretofore of unknown function, affords self-protection

95 community-wide ivermectin distribution in a heretofore "off limits" health district in Cameroon and

96 exhibit long-wavelength absorption yet have heretofore only been available via semisynthesis from na

97 abilities than currently known, and settle a heretofore open question by showing that a universal clu

98 lack Sea suggests MTB play an important, but heretofore overlooked role in euxinic marine system iron

99 We propose that twitches represent a heretofore-overlooked form of motor exploration that hel

100 istic magnetizations was established for the heretofore poorly age-constrained Los Colorados Formatio

101 rst reverse genetic analysis of a "novel" or heretofore poorly understood gene implicated in an excee

102 Our study deciphers the fundamentals of the heretofore poorly understood molecular mechanism by whic

103 afficked across membrane barriers, a concept heretofore poorly understood.

104 -activity relationship studies that were not heretofore possible.

105 However, technical limitations have heretofore precluded examination of the relationship bet

106 cribed, presumed physiological barriers have heretofore precluded investigation of systemic gene deli

107 about variation in the TP of bats that have heretofore proven elusive.

108 nt amplitudes greatly exceeding those of all heretofore published ChR variants.

109 Heretofore, radionuclide myocardial perfusion imaging ha

110 s of the world has focused attention on this heretofore rare disease.

111 vity of neutrophils from healthy adults than heretofore recognized; their model predicts that this co

112 tions within the ATP-binding motifs of PTEN (heretofore referred to as PTEN ATP-binding mutations) ha

113 d that a group of sactipeptide-like peptides heretofore referred to as six cysteines in forty-five re

114 Precise lesion location is an important, but heretofore relatively neglected, prognostic factor in bo

115 ew member of this signaling cascade, an LTTR heretofore renamed QseD (quorum-sensing E. coli regulato

116 tructured material synthesis and a survey of heretofore reported materials systems.

117 is the most alpha3beta2-selective antagonist heretofore reported.

118 es able to deliver analytical precision that heretofore required reductionist biochemical approaches.

119 e measurements of cell-generated forces have heretofore required that cells be cultured on two-dimens

120 series of beta-lactamase inhibitors that had heretofore resisted optimization for in vivo activity.

121 ole of the microbiota in the pathogenesis of heretofore seemingly unrelated systemic auto-inflammator

122 een an OH donor and a covalent F acceptor, a heretofore somewhat ill-defined if not controversial int

123 Heretofore the evidence for this was limited to develope

124 everal LOX crystal structures are available, heretofore the rapid oxygenation of bound substrate has

125 Heretofore, the visualization of large biomolecular syst

126 Heretofore, these measurements have been interpreted in

127 Heretofore, thiol-specific fluorogenic reagents require

128 Heretofore this process was believed to serve only as a

129 Heretofore, this variance has been determined in a non-p

130 ty mass from undesirable to desirable states Heretofore, two external control approaches have been ta

131 cceptor poly-arylene chromophores which have heretofore unachieved pi-extension and substantial twist

132 show that ZEB1 promotes metastasis through a heretofore unappreciated cell non-autonomous mechanism,

133 ptor affinity profiling system also revealed heretofore unappreciated complexities underlying CD4/CCR

134 stone marks in meiotic prophase, revealing a heretofore unappreciated complexity of the epigenetic la

135 constant levels throughout life and define a heretofore unappreciated developmental heterogeneity wit

136 These results reveal a heretofore unappreciated dynamism of gene content.

137 We propose a heretofore unappreciated effect of chronic HFD on beta-c

138 n Markov model (HMM)-based filter to exploit heretofore unappreciated information inherent in all tra

139 LT of HIV-1-infected individuals may have a heretofore unappreciated role as a mediator of immune su

140 We found a heretofore unappreciated role for caspase-8 as a major p

141 These findings identify a heretofore unappreciated role for CXCR7 in vascular dysf

142 ial in higher plants and chlorophytes with a heretofore unappreciated role in diatoms.

143 sults further suggest that muscle may play a heretofore unappreciated role in regulating food intake.

144 n dehydrated mice, the latter highlighting a heretofore unappreciated role of GABAergic MnPO neurons

145 These findings suggest a heretofore unappreciated TAM receptor hierarchy in advan

146 Thus, substantial gastric toxicity is a heretofore unappreciated tamoxifen side effect.

147 -5-hmC pathway may be a relevant approach of heretofore unappreciated therapeutic utility.

148 Our data illustrate a heretofore unappreciated topological complexity in mTORC

149 present with glucose intolerance, which was heretofore unappreciated.

150 hic but potentially has a dynamic complexity heretofore unappreciated.

151 f neo-substrates for kinases could provide a heretofore-unappreciated modality for regulating kinase

152 these results demonstrate that ICP27 plays a heretofore-unappreciated role in modulating the efficien

153 t have both uncovered structural information heretofore unavailable by residue-level footprinting.

154 Findings offer heretofore unavailable comparison points for health syst

155 phogenesis of nodes of Ranvier all require a heretofore uncharacterized alternatively spliced giant e

156 dant isoform present before stimulation is a heretofore uncharacterized intracellular form of the IL-

157 Such changes could result in heretofore uncharacterized pathogenesis, potentially imp

158 horin3D (Sema3D), that genetically delineate heretofore uncharacterized proepicardial subcompartments

159 We show that Tempura forms a heretofore uncharacterized RabGGT complex that geranylge

160 These results indicate a heretofore unconsidered impact of CO2 anaesthesia on sub

161 ials by approximately 100 mV and, thus, is a heretofore unconsidered means of tuning the potential.

162 inciple yields a quantitative account of the heretofore undefined, but theoretically crucial, concept

163 que desosamine-anchoring functionality via a heretofore under-explored "substrate engineering" strate

164 eins using the same warhead and E3 ligase to heretofore underappreciated aspects of the ternary compl

165 ong evidence that choline kinase alpha has a heretofore underappreciated role in protein-protein inte

166 that modulate phagocytosis, which have been heretofore underappreciated.

167 Toxic waste sites are a major, and heretofore underrecognized, global health problem.

168 These data demonstrate heretofore undescribed adaptations underlying the revers

169 Surprisingly, using the same approach, a heretofore undescribed filamentous network within the lu

170 tosis [MH]), we identified an unexpected and heretofore undescribed frequent occurrence of myeloid ne

171 Taken together, these data identify a heretofore undescribed myocardin/BMP10 signaling pathway

172 These findings reveal a heretofore undescribed role for a Toll-like receptor in

173 tes of glucose-alanine cycling, and reveal a heretofore undescribed role for glucose-alanine in the r

174 on, and that bursicon plays an important and heretofore undescribed role in ecdysis behavior itself.

175 ze the potential for switching between these heretofore undetectable, differentiated pneumococcal sub

176 Li-(13) C and (6) Li-(15) N couplings reveal heretofore undetected transannular contacts (laddering)

177 The decrepit mouse model may represent a heretofore undiagnosed human disease and could serve as

178 pressure syntheses to allow for inroads into heretofore-undiscovered intermetallic systems for which

179 In addition, this heretofore undocumented POM-MOF interaction results in a

180 This heretofore unexplained phenomenon complicates interpreta

181 en de novo gene variants, we control for the heretofore unexplored confounding bias in coding-sequenc

182 In this study, we examine the heretofore unexplored role of Pin1 in CPCs.

183 We describe a heretofore-unexplored discovery pathway for novel antibi

184 agnetic resonance and mass spectroscopy as a heretofore unidentified alpha,beta-unsaturated lactone d

185 studies, however, suggest the existence of a heretofore-unidentified receptor for IL-1.

186 Surprisingly, a heretofore universal transition state interaction with t

187 The insight gained from the heretofore unknown ability of NAD(+) to function as a re

188 Implications of the heretofore unknown and anomalous self-limiting behavior

189 This model clarifies a heretofore unknown arrhythmia mechanism and extends our

190 Overall, our data identify heretofore unknown biological responses to VPA in buddin

191 Our results identify a heretofore unknown cellular enzyme activity associated w

192 mulated by IFNalpha; these genes represent a heretofore unknown class of non-IFN-stimulated gene IEGs

193 ether, these findings directly demonstrate a heretofore unknown contribution of the cranial neural cr

194 ther, these results suggest that pDCs play a heretofore unknown deleterious role during lethal dose I

195 ered MSN excitability in HD may be caused by heretofore unknown disturbances of astrocyte-mediated K(

196 Heretofore unknown effects of torcetrapib were revealed

197 r steps of the initiation process, revealing heretofore unknown features, including reversible format

198 ngs tie Hh signaling to rDNA repair and this heretofore unknown function may be critically important

199 d with cancer, suggesting the involvement of heretofore unknown genes in cancer.

200 e regarding gene functions of both known and heretofore unknown genes, as shown by the identification

201 In this paper, we demonstrate access to heretofore unknown heterotricyclic structures by leverag

202 cement in the hippocampus and demonstrates a heretofore unknown hypersensitivity of the CA3/CA4 to is

203 the efficacy of chemotherapy by blocking its heretofore unknown impact on PAF-R activation.

204 natural d-enantiomer, and the unnatural and heretofore unknown l-enantiomer, were converted to disac

205 the asymptomatic phase is exemplified by the heretofore unknown length of time from initial infection

206 hancement." Together, these results reveal a heretofore unknown macroscopic gradient of prior knowled

207 adhesin interacts with fibronectin (FN) in a heretofore unknown manner that prevents assembly of a FN

208 nto the bacterial cytoplasm, thus defining a heretofore unknown mechanism of intracytoplasmic membran

209 ults provide a rational basis to address the heretofore unknown mechanism of magnetogenetics.

210 of Ly6C(low) monocytes in tumors unveiled a heretofore unknown mechanism of resistance to anti-VEGF

211 g cancer cells is significant in revealing a heretofore unknown mechanism of tumorigenesis and metast

212 The data identify a heretofore unknown metabolic function of Notch and sugge

213 We also identify a heretofore unknown modification-an N-terminally bound gl

214 Thus, we demonstrate a heretofore unknown molecular mechanism for cough inducti

215 We report the identification of a heretofore unknown multispecies true-moss-cyanobacteria

216 occur by a radical chain mechanism involving heretofore unknown NHC-boryl radicals.

217 latory strategies and may help conceptualize heretofore unknown ones.

218 surement by fluorescence anisotropy reveal a heretofore unknown preference for binding single-strande

219 results were made possible by exploiting the heretofore unknown propensity of a hydrogen-bonding OH-a

220 Here we identify a heretofore unknown protein that we name GROWTH POLE RING

221 everal actinomycete genomes, we identified a heretofore unknown RIF resistance gene, RIF phosphotrans

222 acid ligand as the catalytic nucleophile, a heretofore unknown role for the alphaCys(113)-OH sulfeni

223 Our data suggest that SLC11A1 has a heretofore unknown role in activation of a large subset

224 In this study, we investigated the heretofore unknown role of Ogt in exocrine and endocrine

225 e results demonstrate an important role of a heretofore unknown signal in the cytoplasmic tail of CD1

226 Together these studies reveal a heretofore unknown step of intracellular cholesterol tra

227 nal anatomical data to identify coherent but heretofore unknown subgroups.

228 e describe protein S-nitrosylation in yeast (heretofore unknown) that is mediated by S-nitroso-CoA (S

229 The presence of a heretofore unknown, yet related, protein could explain t

230 The cellular receptor for these viruses was heretofore unknown.

231 l such large RNP granules first assemble was heretofore unknown.

232 r genes responsible for these syndromes were heretofore unknown.

233 o-fused sultams via complementary pairing of heretofore-unknown (o-fluoroaryl)sulfonyl aziridine buil

234 f insulin receptor signaling, highlighting a heretofore-unknown link between insulin sensitivity and

235 In summary, we report a heretofore-unknown role for trace amine systems in cloza

236 ndidates led to the discovery of three genes heretofore unlinked to malignant breast cancer that were

237 data for the phylum Cyanobacteria reveals a heretofore unobserved diversity in cyanobacterial CP12 p

238 ation of a NusB-NusE-dsRNA complex reveals a heretofore unobserved dsRNA binding site contiguous with

239 e very vibrations invoked in ZIF melting but heretofore unobserved for carboxylate MOFs, these metal-

240 )-Galbeta1-4GlcNAc also coordinate Ca(2+), a heretofore unobserved mode of galactose binding in a C-t

241 Crystalline collagen tubes represent a heretofore unobserved morphology of this common biomater

242 The meteorite also contains heretofore unobserved phases of iron-nickel and iron sul

243 lex in the presence of ADP and Mg(2+); and a heretofore unobserved RbsBC complex in the absence of co

244 The initial photochemical step is the heretofore unobserved reductive quenching of the low-ene

245 bocyclic substrate led to the discovery of a heretofore-unobserved mechanistic pathway, providing bic

246 Patients with NVAMD enjoy heretofore unprecedented vision gains when managed with

247 herwise photochromic benzo-/naphthopyrans is heretofore unprecedented.

248 nsity functional theory calculations favor a heretofore unpredicted pathway involving an iron(IV)-oxo

249 Our results indicate that one heretofore unquantified human health effect associated w

250 ted into a scientific database and provide a heretofore unrealized depth of sequence data based on mu

251 paring afforded by FLASH may someday provide heretofore unrealized opportunities for dose escalation

252 eful clinically and assist with discovery of heretofore unrecognized AMR pathways.

253 We found that ERK5, heretofore unrecognized as mediating TLR2 activation in

254 ally and antigenically similar organism as a heretofore unrecognized cause of acute febrile illness i

255 Finally, we identify a heretofore unrecognized class of piRNAs processed from c

256 putational methods, we show that a major and heretofore unrecognized cleavage in the phylogenetically

257 and activation of GSTP1 by EGFR as a novel, heretofore unrecognized component of the EGFR signaling

258 biased, forward genetic approach has found a heretofore unrecognized critical step in fasting energy

259 face patch system, moving faces recruited a heretofore unrecognized face patch.

260 Recent research suggests that other, heretofore unrecognized factors, such as the osteocyte-s

261 of the apoptotic phosphoproteome, revealing heretofore unrecognized forms of functional crosstalk be

262 This finding demonstrates a heretofore unrecognized function of the ventromedial pre

263 These data suggest that a heretofore unrecognized graft-infiltrating, short-lived

264 tes and link functional diversification to a heretofore unrecognized neuronal gradient of the CAZ ult

265 i (Cretaceous, North America), we detected a heretofore unrecognized ontogenetic series, sexual dimor

266 This constitutes a heretofore unrecognized process associated with loss of

267 of oxidized methionine in proteins may be a heretofore unrecognized regulatory event underlying immu

268 Elucidation of this heretofore unrecognized role for KLF15 now implicates th

269 Together, our data unveil a heretofore unrecognized role for PAFR in modulating acti

270 To our knowledge, our data unveil a heretofore unrecognized role for the GPCR BLT1 in contro

271 seascape configuration played a critical but heretofore unrecognized role in determining connectivity

272 These data demonstrate a heretofore unrecognized role of microbial metabolites an

273 These findings raise a heretofore unrecognized role of Sun1 in the selective ge

274 These experiments reveal a heretofore unrecognized role of the schistosome tegument

275 Heretofore unrecognized roles for which oxytocin may hav

276 for antiviral responses, plays a variety of heretofore unrecognized roles in antibacterial responses

277 Here we report that NETs provide a heretofore unrecognized scaffold and stimulus for thromb

278 profiling of 8 (SLM6031434) and discovered a heretofore unrecognized side cavity that increased inhib

279 Finally, a heretofore unrecognized solution-phase redistribution pr

280 Our data reveal a heretofore unrecognized strategy by which a pathogenic m

281 These findings reveal a heretofore unrecognized subterranean methane sink and co

282 m Rhodobacter sphaeroides has demonstrated a heretofore unrecognized ultrastructural complexity withi

283 Our results identify a heretofore unrecognized, homeostatic negative feedback m

284 These results describe a heretofore unrecognized, yet potentially general propert

285 These experiments identify a heretofore-unrecognized but functionally important subpo

286 total syntheses of (-)-herquline B (2) and a heretofore-unrecognized congener, (+)-herquline C (3), a

287 V) number in cerebral arterial myocytes as a heretofore-unrecognized downstream effector of TIMP3-ind

288 Thus, we elucidate a heretofore-unrecognized human amyloid-depolymerase syste

289 A heretofore-unrecognized multigene family encoding divers

290 ken together our findings identify Rab5 as a heretofore-unrecognized regulator of compound exocytosis

291 dramatic decrease in sepsis-induced PUMA, a heretofore unreported effect of IL-7.

292 Collectively, our findings suggest a heretofore-unreported function for mitoStat3 as a potent

293 form a highly extended stalk-like structure heretofore unseen in prokaryotic or eukaryotic protein s

294 It includes a heretofore unseen interaction motif between W77 of S3, t

295 Thus, these studies unveil heretofore unseen mechanisms by which inducible sensor d

296 Thus, these data reveal a heretofore unseen restructuring of an enzyme active site

297 to consider multiple DCs at each position, a heretofore unsolved problem, while adhering to a constra

298 N production in the liver, and they reveal a heretofore unsuspected aspect of the innate host respons

299 In this study, we provide evidence for a heretofore unsuspected role for Isc1p in mediating this

300 This pool of sphingolipids may play a heretofore unsuspected role in myocardial pathology or p