ライフサイエンスコーパス: heritable

1 ity with obesity measures and are moderately heritable.

2 ary within and across species and are partly heritable.

3 , relates to memory training benefit, and is heritable.

4 otal choroid plexus volume was significantly heritable.

5 Coronary artery disease is partly heritable.

6 ymbiosis, and that the shuffled community is heritable.

7 regulation, suggesting that the phenotype is heritable.

8 ls, and so may offer selective advantages if heritable.

9 Tourette's syndrome is polygenic and highly heritable.

10 ardiovascular and metabolic risk, are highly heritable.

11 ion-deficit/hyperactivity disorder (ADHD) is heritable.

12 ssociated with breast cancer risk and highly heritable.

13 inment and intelligence test performance are heritable.

14 Both trauma exposure and depression are heritable.

15 known, including metabolites that are highly heritable(2,3), or those that are influenced by the gut

16 hereas CMR-derived LV mass was only modestly heritable (20%).

17 IPTs and drug experimentation were modestly heritable (5-11%).

18 Plant height was highly heritable (91.9%), followed by the peduncle length (90.2

19 Human personality is 30-60% heritable according to twin and adoption studies.

20 iverse lines of Z. mays, which we show to be heritable across several environments.

21 The relatively small number of heritable, ADHD-associated developmental neural phenotyp

22 Major depressive disorder is heritable and a leading cause of disability.

23 Given that CVD is highly heritable and abnormal blood flow may increase risk, we

24 Complex brain disorders are highly heritable and arise from a complex polygenic risk archit

25 e find that adipose cell-type composition is heritable and confirm the positive association between a

26 ver, only part of this increased variance is heritable and contributes to selection responses.

27 n, we determined that plasmid restriction is heritable and dominant.

28 uters able to reproduce themselves and use a heritable and evolvable code to optimize survival.

29 eful marker beyond performance per se, being heritable and having unique predictive value for long-te

30 Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of neurodevelopmental

31 nvironmental factors, obesity is known to be heritable and highly polygenic; the majority of inherite

32 tion in gene expression has been shown to be heritable and is often associated with differences in di

33 Maternal weight was heritable and itself subject to maternal effects.

34 cquisition, whereby susceptibility is partly heritable and moderated by specific behavioral, cellular

35 High blood pressure (BP) remains the major heritable and modifiable risk factor for cardiovascular

36 Smoking is a major heritable and modifiable risk factor for many diseases,

37 e typical onset of AD; additionally, several heritable and non-heritable modifiers of this effect wer

38 ults, we then estimated the contributions of heritable and nonheritable factors to this variation in

39 Consequently, imprinting can impact heritable and nonheritable variation, resemblance of rel

40 Heritable and novel nonparental differentially methylate

41 Glutamate levels in the left thalamus were heritable and positively correlated with liability for s

42 Alzheimer's disease (AD) is highly heritable and recent studies have identified over 20 dis

43 Tooth form is considered to be highly heritable and selectively neutral and, therefore, to be

44 schizophrenia are both moderately to highly heritable and share significant genetic risk despite dis

45 yses revealed mutual eye gaze to be modestly heritable and significant genetic correlations between b

46 acogenomics provides the potential to unveil heritable and somatic genetic variations for guiding pre

47 We confirm that resistance is heritable and that the enhancement requires RecA, SOS in

48 ed that heterogeneity in circadian period is heritable and used a multi-omics approach to investigate

49 d samples from 359 patients with idiopathic, heritable, and drug-induced PAH and 72 age- and sex-matc

50 However, mental health is substantially heritable, and genetic influences may contribute to the

51 havioral genetics stating that everything is heritable, and I describe results from large-scale meta-

52 These states are heritable, and on high glucose, arresters grow and divid

53 these groups is moderately phylogenetically heritable, and that its distribution is shaped by repeat

54 Formula: see text]), were also substantially heritable, as described previously.

55 Heritable associations between viruses and parasitoid wa

56 Hereditary pancreatitis (HP) is a heritable, autosomal-dominant disorder with recurrent ac

57 Advancing the genomics of this highly heritable biomarker of CYP2A6, the main metabolic enzyme

58 Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging.

59 n's disease (PD) and schizophrenia (SCZ) are heritable brain disorders that involve dysregulation of

60 ion analysis were conducted on the subset of heritable brain traits that showed significant evidence

61 Heritable BTs can enable informed mate choice via indire

62 ency to become sensitized to an allergen, is heritable but seldom ascribed to mutations within specif

63 The disease has long been considered heritable but still little is known about the host genet

64 riation in most male morphometric traits was heritable, but found no evidence of trait trade-offs nor

65 Susceptibility to cancer is heritable, but much of this heritability remains unexpla

66 DGRP) that resistance to infection is highly heritable, but our understanding of how the effects of g

67 udies report that dental caries is partially heritable, but there is uncertainty in the magnitude of

68 ly in tumour types associated with increased heritable cancer risk in BRCA1/2 carriers (BRCA-associat

69 The study of dominantly heritable cancers has provided insights about tumor deve

70 Patients were diagnosed with heritable cardiac disease in 39 cases (9.3%).

71 Among patients diagnosed with a heritable cardiac disease, the nearest affected relative

72 Heritable cardiomyopathies are a class of heart diseases

73 As both EO and NPD are heritable central nervous system disorders, we assessed

74 yperactivity-impulsivity was associated with heritable change in white matter tracts metrics and chan

75 The method also allowed heritable changes in dauer larvae of Auanema, despite th

76 Heritable changes in DNA 5mC methylation have been assoc

77 Since prostate cancer is highly heritable, common variants associated with prostate canc

78 Alcohol consumption is a heritable complex trait.

79 Neurodevelopmental disorders have a heritable component and are associated with region speci

80 Psychiatric diseases have a strong heritable component known to not be restricted to DNA se

81 idemiological studies indicate a substantial heritable component of MPNs that is among the highest kn

82 mber variants (CNVs) could contribute to the heritable component of risk, but the two previous genome

83 Depression has a heritable component that has remained difficult to eluci

84 Family studies have identified a heritable component to self-harm that is partially indep

85 ic health burden, and evidence that it has a heritable component, ME/CFS has not yet benefited from t

86 ommon chronic respiratory disease that has a heritable component.

87 g-term disability and death worldwide, has a heritable component.

88 tability, exploring the presence of multiple heritable components and its genetic overlap with common

89 le overlap between genetic contributions and heritable components of host environment.

90 Eating disorders are complex heritable conditions influenced by both genetic and envi

91 These strains acquired heritable conserved transcriptomes, yet one strain conta

92 Cattle breeds present heritable, contrasting phenotypes of tick loads, taurine

93 The highly heritable DA excretion trait is substantially influenced

94 ants in key cardiomyocyte genes as causes of heritable DCM, including mutations in LMNA, which encode

95 ic sequences result in dominant or recessive heritable deafness forms in humans and mice.

96 he degree to which microbiome composition is heritable decays with time, and selection can only act a

97 Finally, heritable deletion mutations of at least 50 kbp can be r

98 TTN gene (TTNtv) are the commonest cause of heritable dilated cardiomyopathy.

99 cancer requires the integration of multiple heritable dimensions at the resolution of the single cel

100 Pseudoxanthoma elasticum is a heritable disease caused by ABCC6 deficiency.

101 Many heritable diseases of dogs are found among breeds of sim

102 Mitochondrial dysfunction underlies many heritable diseases, acquired pathologies, and aging-rela

103 such as regulation of gene expression, human heritable diseases, and response to environmental stress

104 with environmental factors to impact risk of heritable diseases.

105 f etiological inquiry and as a biomarker for heritable diseases.

106 Schizophrenia is a highly heritable disorder for which anatomical brain alteration

107 Marfan syndrome (MFS) is a heritable disorder of connective tissue, caused by mutat

108 icit hyperactivity disorder (ADHD), a highly heritable disorder with an array of candidate genes and

109 Schizophrenia is a complex highly heritable disorder.

110 finding resilience variants for any complex, heritable disorder.

111 ent treatments may soon become available for heritable ectopic mineralization disorders with applicat

112 Recent studies on heritable ectopic mineralization disorders with defined

113 neralized arterial calcification of infancy, heritable ectopic mineralization disorders without effec

114 eudoxanthoma elasticum (PXE), a prototype of heritable ectopic mineralization disorders, is caused by

115 Safe and effective heritable editing of the human genome is years away from

116 pothesis that intergenerational, non-genetic heritable effects influence refractive development, usin

117 ch uses predefined genetic barcodes that are heritable, enabling cell populations to be tagged, poole

118 Genome-wide examination of heritable endogenous small interfering RNAs (endo-siRNAs

119 n the present study, we investigated whether heritable endosymbionts that cause different reproductiv

120 This heritable enhancement-through-grafting phenotype is RdDM

121 We report here that heritable epigenetic factors that are stimulated by tran

122 These results show that heritable epigenetic heterogeneity is fundamental in inf

123 DNA methylation is an important heritable epigenetic mark that plays a crucial role in t

124 nce in S. solfataricus The identification of heritable epigenetic marks in this work further supports

125 DNA methylation is a heritable epigenetic modification that plays an essentia

126 direct histone H3K9 trimethylation and drive heritable epigenetic modification.

127 Heritable epimutation information allowed us to reconstr

128 can be employed to study transgenerationally heritable epimutations in clonal or sexually derived mut

129 spectrum indicates that transgenerationally heritable epimutations originate mainly from DNA methyla

130 aged available knowledge on nonheritable and heritable factors affecting midazolam pharmacokinetic in

131 Our results suggest that shared heritable factors are common and may lead to many false

132 relative heterogeneity of the population, no heritable factors associated with uridine diphosphate gl

133 ntal conditions, suggesting that non-genetic heritable factors contribute to their etiology.

134 To investigate the influence of heritable factors on CH, we performed deep targeted sequ

135 orate the presence of indirect assortment on heritable factors.

136 dditional studies to investigate the role of heritable factors.

137 by a complex interplay of environmental and heritable factors.

138 These temporal covariances reflect how heritable fitness variation in the population leads chan

139 contributing to the long-term maintenance of heritable fitness variation.

140 Finally, the heritable form of PVOD is due to biallelic mutations of

141 in myocilin were confirmed to be linked to a heritable form of the prevalent eye disease, glaucoma, a

142 The heritable forms of epidermolysis bullosa (EB), a phenoty

143 izophrenia) have, in contrast, lagged behind heritable frameworks of explanation.

144 knowledgements 1258 References 1258 SUMMARY: Heritable gains or losses of cytosine methylation can ar

145 nstruct designs is to achieve rapid, robust, heritable gene editing, the formation of unintended muta

146 ic events, as some have been shown to induce heritable gene expression changes, shape patterns of met

147 es over subtelomeric domains that produces a heritable gene expression state that enables resistance

148 ns, revealing an unanticipated mechanism for heritable gene silencing.

149 he addiction liability of amphetamines has a heritable genetic component.

150 urce of all genetic novelty and the cause of heritable genetic disorders.

151 ndividuals, our method provides non-chimeric heritable GT in one generation.

152 ration under limited P conditions was highly heritable (H(2) = 0.85), as was mid-pod lower leaf P con

153 Premature responding was found to be heritable (h(2) = 13-16%), with significant linkage (LOD

154 we observed sun seeking to be significantly heritable (h2 >= 58%).

155 We identified 4 moderately heritable (h2 = 36-48%) eating behavior patterns labeled

156 es of all the subfields were estimated to be heritable (h2 from 0.14 to 0.27, all p < 1 x 10(-16)) an

157 phic cardiomyopathy (HCM) is the most common heritable heart disease.

158 ic mechanism of disease pathogenesis in this heritable HF syndrome.

159 porosis and osteoporotic fracture are highly heritable; however, determining the genetic architecture

160 TS is highly heritable; however, the underlying genetic basis and mol

161 vo in both atherosclerotic rabbits (Watanabe Heritable Hyper Lipidemic [WHHL], 13-mo-old male, n = 5)

162 ith tumor latitude, and describe tumors with heritable hyperactivity of an endogenous mutational proc

163 efficacy in LDL receptor deficient Watanabe Heritable Hyperlipidemic rabbits.

164 tal germ-cell fate is based on discrete cell-heritable identities.

165 Bipolar disorder is a highly heritable illness, associated with alterations of brain

166 CRISPR-Cas systems provide heritable immunity against viruses by capturing short in

167 as defining other immune traits likely to be heritable in humans.

168 Our findings suggest that VS traits are heritable in Landrace and Yorkshire gilts.

169 This pattern was heritable in the absence of selection and independent of

170 ECG measures of LV mass are estimated as heritable in twin and family-based analyses and heritabi

171 (VW) measurements, were moderately to highly heritable in Yorkshire, with 0.46 +/- 0.10, 0.55 +/- 0.1

172 sociation analysis at DDC locus to elucidate heritable influences on renal DA production.

173 und that these traits were highly subject to heritable influences.

174 mental conditions, their role as carriers of heritable information is often considered anecdotal.

175 The propagation of heritable information requires both efficient and accura

176 3.3 assembly complexes provide non-DNA-based heritable information that can markedly influence adult

177 e further demonstrate that stable, partially-heritable insulator disruption can be achieved through c

178 ments of an analogous segment containing the heritable Iowa mutation, Asp23Asn.

179 ch and preimplantation genetic diagnosis for heritable kidney diseases.

180 Here, we use a naturally variable and heritable learning behavior called latent inhibition (LI

181 levels accounted for variability in some non-heritable lipids.

182 ermline variants emphasize the importance of heritable low-penetrance markers in PTC.

183 urements, would advance our understanding of heritable LV traits.

184 epression and maintains heterochromatin in a heritable manner.

185 Telomere length is a heritable marker of cellular age that is associated with

186 al dynamics during exercise and recovery are heritable markers but do not carry independent prognosti

187 mutations during development, to be used as heritable markers for lineage reconstruction, has been p

188 ), and since morphological traits are highly heritable, mate choice is expressed as a positive correl

189 Mendel proposed that the heritable material is particulate and that transmission

190 fast has been determined to exhibit the most heritable meal timing.

191 Schizophrenia is a highly heritable mental disorder characterized by functional dy

192 Bipolar disorder (BD) is one of the most heritable mental illnesses, but the elucidation of its g

193 ritance studies, identifies gene-associated, heritable methylation repatterning.

194 ost development, which is rarely achieved in heritable microbe/insect interactions.

195 ability estimates greater than 10% with most heritable microbes having potential clinical relevance,

196 urinary microbiome for older women with many heritable microbial taxa.

197 AD; additionally, several heritable and non-heritable modifiers of this effect were identified.

198 in glpK produce small colonies that exhibit heritable multidrug increases in minimal inhibitory conc

199 Autism spectrum disorder (ASD) is a largely heritable, multistage prenatal disorder that impacts a c

200 details in pseudoxanthoma elasticum (PXE), a heritable multisystem ectopic mineralization disorder.

201 Xia and colleagues show that heritable mutations are kept in check in the male germli

202 ontribution of active TEs to the creation of heritable mutations remains unknown.

203 g treatment without selection of genetically heritable mutations.

204 Heritable natural variation in telomere length exists in

205 Huntington's disease is a heritable neurodegenerative disease that is caused by a

206 ivity disorder (ADHD) is a common and highly heritable neurodevelopmental disorder with a complex pat

207 ASD is considered to be a heritable neurodevelopmental disorder, but there is limi

208 eimer's disease is a debilitating and highly heritable neurological condition.

209 activity disorder (ADHD) is a common, highly heritable neuropsychiatric disorder.

210 e clinically widely heterogeneous and highly heritable, often being caused by single gene defects.

211 rafting effects on tomato plant performance, heritable over five generations, demonstrating the agric

212 g adaptive gene expression programs that are heritable over long biological timescales.

213 ated in pre-clinical PAH, idiopathic PAH and heritable PAH with missense p.H288Y KLF2 mutation.

214 d downstream effectors have been reported in heritable PAH.

215 a possible mechanistic link between PoPH and heritable PAH.

216 me genetic background, but show variation in heritable patterns of DNA methylation.

217 ents were also highly repeatable, suggesting heritable patterns of splicing in platelets.

218 yperactivity disorder (ADHD) is a common and heritable phenotype frequently accompanied by insomnia,

219 loops that can spontaneously switch between heritable phenotypes in the absence of DNA mutation.

220 e 1980s, the scope of their contributions to heritable phenotypes is now starting to be uncovered.

221 lligence as one of the likely causal, partly-heritable phenotypes that might bridge the gap between m

222 anscriptional changes also contribute to the heritable phenotypic variation required for evolution.

223 at control the relative levels of successful heritable plant genome editing were addressed using simp

224 A heritable polymorphism within regulatory sequences of th

225 er, for many rare entities, our knowledge of heritable predisposition is incomplete.

226 The mechanisms by which this heritable priming occurs are largely unknown.

227 Bipolar disorder (BD) is a highly heritable psychiatric disorder characterized by episodes

228 Bipolar disorder is a highly heritable psychiatric disorder.

229 it hyperactivity disorder (ADHD) is a highly heritable psychiatric disorder.

230 BD), and major depressive disorder (MDD) are heritable psychiatric disorders with partially overlappi

231 Rationale: Idiopathic and heritable pulmonary arterial hypertension (PAH) are rare

232 Bmpr2) are the main genetic risk factor for heritable pulmonary arterial hypertension (PAH) with inc

233 pproximately 40% of retinoblastoma cases are heritable, resulting from a germline mutation in RB1.

234 g scan every 6 months after the diagnosis of heritable retinoblastoma (median age, 6 months) until 36

235 However, survivors of heritable retinoblastoma have a significantly increased

236 We then used these data to estimate heritable risk and develop predictive models of this her

237 Hyperlipidemia is a highly heritable risk factor for coronary artery disease (CAD).

238 antitative ultrasound speed of sound (SOS)-a heritable risk factor for osteoporotic fracture-can iden

239 e for an intervention, genomic prediction of heritable risk factors could decrease the number needing

240 -density lipoprotein cholesterol (LDL-C) are heritable risk factors for cardiovascular disease, yet t

241 pes have long been known to be influenced by heritable risk factors, directly confirmed by the past d

242 ts demonstrate that essentially all vitiligo heritable risk is captured by array-based genotyping and

243 These 90 variants explained 16-36% of the heritable risk of Parkinson's disease depending on preva

244 This study provides evidence that heritable risks of PBTs are in-part attributable to some

245 As a heritable sequence-specific adaptive immune system, CRIS

246 s when variants affect both traits through a heritable shared factor, remains a particularly challeng

247 C3 correlates with MRE-assessed fibrosis, is heritable, shares genetic correlation with liver steatos

248 Heritable silencing does not impact mutation rate but dr

249 We tune low, intermediate and high levels of heritable silencing of a URA3 reporter under selection b

250 in marks could be important specifically for heritable silencing of genes which are flagged as 'forei

251 Thus, we propose that the heritable silencing of the Cd4 gene in CD8(+) T cells ex

252 Moreover, at intermediate or low levels of heritable silencing we find that populations evolve more

253 o extend mutation databases in patients with heritable skin diseases.

254 bes frequency-dependent selection for fixed, heritable strategies in a population of competing indivi

255 enance represents common significant learned/heritable survival strategies evolved for phylum-diverse

256 ons and second-site suppressors resulting in heritable survivors from 1.2 million zygotes.

257 g the pea aphid Acyrthosiphon pisum, and its heritable symbiont, Hamiltonella defensa, which protects

258 cs between parasitoids and aphids containing heritable symbionts that confer resistance against paras

259 Relative to non-significantly heritable TGs, heritable TGs had a greater number of associations with

260 Relative to non-significantly heritable TGs, heritable TGs had a greater number of ass

261 The synthetic asexual-propagation trait is heritable through multiple generations of clones.

262 t the capability to produce such dimers is a heritable trait and how variation in structures of natur

263 These findings confirm that weight loss is a heritable trait and provide evidence by which a novel va

264 oduce three strains, called SARC, with a new heritable trait of super acid resistance.

265 Whole body lean mass (WBLM) is a heritable trait predicting sarcopenia.

266 that could indicate limits to plasticity or heritable trait variation.

267 ts suggest that while obesity is a partially heritable trait, it is still modifiable by environmental

268 Although macular thickness is a highly heritable trait, there are no prior reported genome-wide

269 that cortical cell diameter is a pivotal and heritable trait, which is strongly related to the energy

270 analysis, we show that that weight loss is a heritable trait, with estimated heritability (h (2) = 0.

271 The extraction of desirable heritable traits for crop improvement from high-throughp

272 PRS (p<5x10(-05)) derived from GWAS and 551 heritable traits from the UK Biobank study (N = 334,398)

273 MENT Impulsive personality traits (IPTs) are heritable traits that are governed by frontal-subcortica

274 Impulsive personality traits are complex heritable traits that are governed by frontal-subcortica

275 among repeatable genes for associations with heritable traits, including known and novel platelet exp

276 n carriers and the ways in which they encode heritable traits.

277 ADHD is an extreme expression of continuous heritable traits.

278 The identification of a heritable tumor predisposition often leads to changes in

279 elevated fitness, but despite twinning being heritable, twin births occur only at low frequencies in

280 mass spectrometry (LC-MS) were significantly heritable under the classical ACE twin model (h(2) = 0.2

281 there is only moderate improvement in total heritable variance explained for biomass (7.6%) and plan

282 There is no advantage in total heritable variance for SLA and TSC.

283 genes account for an enriched proportion of heritable variance in in-vivo functional MRI signal ampl

284 for trees under extreme conditions, have the heritable variation and genetic diversity necessary to e

285 Heritable variation in gene expression is common within

286 de empirical evidence of naturally occurring heritable variation in loner behavior in the model socia

287 of local adaptation and extensive range-wide heritable variation in storage, we demonstrate that adap

288 Heritable variation in, and genetic correlations among,

289 y relates to the Resilience Project, namely: heritable variation that promotes resistance to disease

290 on theory and propose that selection acts on heritable variation to optimize longevity in light of co

291 climate change will be limited by a lack of heritable variation within northern populations and by a

292 ions (epimutations) could thus contribute to heritable variation within populations and be subject to

293 tify regions and genes that account for this heritable variation.

294 and the influence of "conditions of life" on heritable variation.

295 ondrial dysfunction is an important cause of heritable vision loss.

296 Traits ranged from lowly to moderately heritable, which indicated the potential for selection o

297 FTD is highly heritable with mutations in progranulin accounting for 5

298 ajor depressive disorder (MDD) is moderately heritable, with a high prevalence and a presumed high he

299 as, in adults, all traits were significantly heritable, with little support for V(M).

300 ound that HIV-1 acquisition is polygenic and heritable, with SNP heritability estimates explaining 28