ライフサイエンスコーパス: heroin

1 opioid treatment (prescribing pharmaceutical heroin).

2 dendrocytes in regulating the motivation for heroin.

3 deaths is occurring, many of which are from heroin.

4 o a migration to other opioids, particularly heroin.

5 ersion of prescription opioid analgesics and heroin.

6 nor with methadone, naloxone, oxycodone, or heroin.

7 ther methamphetamine (0.1 mg/kg/infusion) or heroin (0.1 mg/kg/infusion) for 12 days (6 h/day).

8 mates (A/A) were allowed to self-administer heroin (0.25 mg/kg/unit dose, FR1 with a nose poke respo

9 on of fentanyl in a sample of fentanyl-laced heroin (1.3 wt % fentanyl, 2.6 wt % heroin, and 96.1 wt

10 When NOP (-/-) rats were tested for heroin (20 mug/infusion) and ethanol (10% v/v) self-admi

11 prior cocaine (35.5%), hallucinogen (49.4%), heroin (8.7%), and inhalant (30.4%) use.

12 (84%), and reported having recently injected heroin (81%) and/or crystal methamphetamine (71%).

13 heroin addiction and the damaging effects of heroin abuse on cognition and the salience network.

14 e allelic distribution of rs1137070 in 1,035 heroin abusers and 2,553 healthy controls and investigat

15 tion on gray matter volume (GMV) based on 78 heroin abusers and 79 healthy controls.

16 Heroin abusers with the C allele had lower measures of G

17 ncy of rs1137070 was significantly higher in heroin abusers.

18 Relative to placebo, heroin acutely reduced the fear-induced modulation of co

19 that had prior suggestive associations with heroin addiction (smallest p = 2.7 x 10(-8) for rs382301

20 iated with an increase in the sensitivity to heroin addiction and the damaging effects of heroin abus

21 Heroin addiction and the rs1137070 variant interactively

22 ral mechanisms that underlie greater risk of heroin addiction in carriers of the A118G SNP.

23 e results in substantially increased risk of heroin addiction in humans; however, the neurobiological

24 eQTL SNPs were significantly associated with heroin addiction in the Urban Health Study (smallest p =

25 it loci (cis-eQTL) SNPs for association with heroin addiction in the Urban Health Study and two repli

26 ted the interactive effects of rs1137070 and heroin addiction on gray matter volume (GMV) based on 78

27 l SNP allele rs1799971-A was associated with heroin addiction only in the presence of rs3778150-C (p

28 wever, the association between rs1137070 and heroin addiction remains unclear.

29 y = 16%-19%) being associated with increased heroin addiction risk.

30 The cost and pervasiveness of heroin addiction, including resistance to recovery from

31 ve strategy for the treatment of intractable heroin addiction, particularly in individuals who are re

32 ion of the subthalamic nucleus (STN HFS) for heroin addiction.

33 t STN HFS may have on relapse in humans with heroin addiction.

34 sisted therapies for the treatment of severe heroin addiction.

35 onsistent associations between rs1799971 and heroin addiction.

36 ron 1 SNPs have replicable associations with heroin addiction.

37 d that cue-elicited craving among detoxified heroin addicts was substantially attenuated following R-

38 r abstinence in rats with extended access to heroin, an animal model of compulsive heroin taking.

39 vaccine granted greater efficacy in blunting heroin analgesia in murine behavioral models compared to

40 ivalent or higher affinity antibodies toward heroin and 6-AM.

41 ved by other drugs of abuse and metabolites (heroin and cannabis abuse).

42 r clonidine blocks stress-induced seeking of heroin and cocaine.

43 kers, excreted following human metabolism of heroin and codeine.

44 hemically and behaviorally more sensitive to heroin and exhibit reduced Crem expression in the nucleu

45 perversely accelerated narco-trafficking of heroin and fentanyl with consequent increases in opioid

46 ioids along with increased use of drugs like heroin and fentanyl, has led to an epidemic in addiction

47 nly a potent immune response but one against heroin and its multiple psychoactive molecules.

48 its impact upon the immune response against heroin and its psychoactive metabolites.

49 te the unique electrochemical fingerprint of heroin and mixing agents as well as possible interferenc

50 The 1 vaccine-induced antibodies bound to heroin and other abused opioids, including hydrocodone,

51 anyl and fentanyl analogues in mixtures with heroin and other adulterants, excipients, and bulking ag

52 l suppression in dilute binary mixtures with heroin and other common adulterants and excipients at 30

53 y analysis showed significantly lower use of heroin and other illicit opioids in the extended-release

54 ine drug tests, and number of days of use of heroin and other illicit opioids.

55 ne in maintaining short-term abstinence from heroin and other illicit substances and should be consid

56 hydrochloride in maintaining abstinence from heroin and other illicit substances in newly detoxified

57 u-opioid receptors (MOPRs) are the target of heroin and other prescription opioids, which are current

58 dified, but remarkably, motivation to obtain heroin and palatable food was enhanced in operant self-a

59 s to opiates, including motivation to obtain heroin and palatable food.

60 al of Psychiatry in Basel were studied after heroin and placebo administration, while 17 healthy cont

61 s well as in rats trained to self-administer heroin and primary striatal neurons treated with chronic

62 t prevailing illicit drugs (such as cocaine, heroin, and (meth)amphetamine), their precursors and der

63 yl-laced heroin (1.3 wt % fentanyl, 2.6 wt % heroin, and 96.1 wt % lactose).

64 lying conditioned reinforcement and cocaine, heroin, and alcohol seeking.

65 -) rats to study the motivation for cocaine, heroin, and alcohol self-administration in the absence o

66 recreational drug, often in combination with heroin, and can result in lethality during overdose.

67 e initial classification of being related to heroin, and lack of information on local policy changes

68 o compare UDT results for cocaine, fentanyl, heroin, and methamphetamine before vs after US declarati

69 ts, probably reflecting the effectiveness of heroin-assisted therapies for the treatment of severe he

70 rain oxygen responses induced by intravenous heroin at low, human-relevant doses.

71 This pattern is potentiated by heroin, attenuated by medication-assisted treatments for

72 has shown that a single maintenance dose of heroin attenuates psychophysiological stress responses i

73 Here we show that cocaine and heroin can induce long-lasting deficits in the ability t

74 induced hyperlocomotion following a 50 mg/kg heroin challenge.

75 lowing repeated subcutaneous and intravenous heroin challenges in mice and rats.

76 Following a series of heroin challenges over six months in vaccinated monkeys,

77 ntribute to context-induced reinstatement of heroin, cocaine, and alcohol seeking, but not yet for me

78 d, including mephedrone, methadone, cocaine, heroin, codeine, and tetrahydrocannabinol (THC) and thei

79 tabolites of mephedrone, methadone, cocaine, heroin, codeine, and tetrahydrocannabinol (THC).

80 s of drug withdrawal, and then reinstated to heroin-conditioned cues.

81 ter heroin or sucrose and were reinstated by heroin-conditioned or sucrose-conditioned cues.

82 otherapy options for opioid use disorders, a heroin conjugate vaccine was developed through comprehen

83 oin self-administration showed incubation of heroin craving after forced but not voluntary abstinence

84 heroin self-administration and incubation of heroin craving and introduces a fully automatic social s

85 nce prevented the emergence of incubation of heroin craving in both sexes.

86 nt of cocaine and heroin seeking in rats and heroin craving in humans.

87 Heroin craving was significantly reduced under active ib

88 , including the phenomenon of "incubation of heroin craving" (the time-dependent increases in heroin

89 raction) on momentary ratings of cocaine and heroin craving.

90 ntary abstinence would prevent incubation of heroin craving.

91 w astroglial processes themselves respond to heroin cues or if changes in astroglial morphology are n

92 y widespread heightened neural activation to heroin cues.

93 hine hydrochloride (the active ingredient in heroin), delivered under supervision, is effective for t

94 ol in which a light/tone cue was paired with heroin delivery, followed by 2 weeks of drug withdrawal,

95 International Consortium on the Genetics of Heroin Dependence [ICGHD]).

96 alamic circuits was related to the degree of heroin dependence, supporting the significance of condit

97 terventions is the best treatment option for heroin dependence, there is limited research focusing sp

98 6Met gene variants, but by the length of the heroin dependency.

99 ere negatively correlated with the length of heroin dependency.

100 actors influence recovery consequences among heroin dependent patients have shown mixed results.

101 gative recovery consequences by gender among heroin dependent patients in Shanghai, China.

102 Our findings indicate that female heroin dependent patients tend to have less negative rec

103 double-blind, vehicle-controlled design, 22 heroin-dependent and heroin-maintained outpatients from

104 plasma BDNF and the BDNF Val66Met SNP in 172 heroin-dependent patients and 102 healthy controls were

105 ce processing after the placebo treatment in heroin-dependent patients transiently normalizes after a

106 In heroin-dependent patients, plasma BDNF levels were negat

107 ates psychophysiological stress responses in heroin-dependent patients, probably reflecting the effec

108 NF Val66Met nucleotide polymorphism (SNP) in heroin-dependent patients.

109 he acute dopaminergic effects of cocaine and heroin determined by in vivo microdialysis, on the reinf

110 increased for high, but attenuated for low, heroin doses with concomitant alterations in mesolimbic

111 trong preference for the palatable food over heroin during the choice-based voluntary abstinence.

112 synthesizing measures of marijuana, cocaine, heroin, ecstasy, methamphetamines, synthetic marijuana,

113 After heroin extinction, there was an enduring reduction in sy

114 of illicit drugs (cocaine, methamphetamine, heroin, fentanyl, and its analogues), adulterants, and d

115 g-Evans rats were trained to self-administer heroin for 10 d.

116 stressor in rats trained to self-administer heroin, generalizes to other abused drugs, including coc

117 Deuterium (H(dAc)) and cognate protium heroin (H(Ac)) haptens were compared head to head in an

118 nsequence of regioselective deuteration of a heroin hapten and its impact upon the immune response ag

119 enethylpiperidine (4-ANPP), norfentanyl, and heroin has been achieved, and the ability to distinguish

120 ever, producing an efficient vaccine against heroin has been particularly challenging because of the

121 ription and illegal opioids (e.g., morphine, heroin) has led to major problems with addiction and ove

122 Opioid addiction, including addiction to heroin, has markedly increased in the past decade.

123 and CpG oligodeoxynucleotide (ODN) generated heroin "immunoantagonism", reducing heroin potency by >1

124 trochemical strategies to selectively detect heroin in street samples without the use of complicated

125 on of dopamine levels produced by cocaine or heroin in the nucleus accumbens shell.

126 pH 12.0 allowed a more accurate detection of heroin in the presence of most common mixing agents.

127 verdose deaths from prescription opioids and heroin in the United States over the past 20 years is be

128 In this age group, poisonings from heroin increased from 0.96 (95% CI, 0.75-1.18) to 2.51 (

129 Importantly, we demonstrate that heroin-induced adaptations occur only in the D1(+) subse

130 induced high anti-1 IgG levels that reduced heroin-induced antinociception and locomotive behavioral

131 st the functional role of Sox10 in mediating heroin-induced behavioral plasticity, we selectively ove

132 d that this drug still powerfully attenuates heroin-induced brain oxygen responses.

133 omotor effects of heroin were abolished, and heroin-induced catalepsy was increased.

134 as an important mediator and contributor in heroin-induced cell-specific synaptic plasticity.

135 relatively low dose (2 mg/kg) fully blocked heroin-induced decreases in brain oxygen levels.

136 Vaccinated mice had reduced heroin-induced hyperlocomotion following a 50 mg/kg hero

137 vivo microdialysis was used to measure acute heroin-induced increases of striatal dopamine in the GG

138 Heroin-induced neuronal activation was modified at both

139 ate the role of peripheral ORs in triggering heroin-induced respiratory depression and subsequent bra

140 possibly because of the greater increases of heroin-induced striatal dopamine in the GG mice.

141 0 or BRG1 decreased the motivation to obtain heroin infusions in a progressive ratio test without alt

142 ends in heroin use, heroin use disorder, and heroin injection overall and by age, race, and geographi

143 STN HFS prevented the re-escalation of heroin intake after abstinence in rats with extended acc

144 ghts that show that inflammatory pain alters heroin intake through a desensitization of MORs located

145 In the presence of inflammatory pain, heroin intake under an FR schedule was increased for hig

146 Heroin is a highly abused opioid and incurs a significan

147 As heroin is converted to morphine in man, selective revers

148 ory studies to date, craving for cocaine and heroin is greater with the combination of drug cues and

149 uced drug craving and stress-induced initial heroin lapse.

150 e-controlled design, 22 heroin-dependent and heroin-maintained outpatients from the Centre of Substan

151 patients transiently normalizes after acute heroin maintenance treatment.

152 proportion of urinalyses positive for street heroin markers (margin, 10% of the observed rate in the

153 h 95% CI, -0.04 to 0.2; P < .001) and use of heroin (mean difference, -3.2 with 95% CI, -4.9 to -1.5;

154 low nanomolar antiserum affinity for the key heroin metabolite, 6-acetylmorphine (6AM), with minimal

155 For this purpose, heroin, mixing agents (adulterants, cutting agent, and i

156 abuse consisting of a prescription opioid or heroin (N = 10,784) at entry to 1 of 150 drug treatment

157 ine, amphetamine, methamphetamine, morphine, heroin, nicotine, or alcohol seeking, as assessed in rod

158 cannabis, club drug, cocaine, hallucinogen, heroin, nonheroin opioid, sedative/tranquilizer, and/or

159 Participants who had injected heroin or been in prison were more likely to choose to t

160 Participants who reported injecting heroin or being in prison during the 3 months before ope

161 and methamphetamine addictions, but not for heroin or cocaine addiction.

162 r and then choose between an addictive drug (heroin or methamphetamine) and social interaction.

163 ats (n = 62) were trained to self-administer heroin or sucrose and were reinstated by heroin-conditio

164 riment 2, we trained rats to self-administer heroin or sucrose for 12 hours per day (extended access)

165 OR] 1.8, 95% CI 1.4-2.2; p<0.0001), injected heroin (OR 1.5, 1.1-2.1; p=0.007), or had been in prison

166 isit than those who did not report injecting heroin (OR 3.0, 95 % CI 1.3-7.3; p=0.01) or being in pri

167 9971, have been conclusively associated with heroin/other opioid addiction, despite their biological

168 e by ethanol may be a contributory factor in heroin overdose deaths.

169 Moreover, heroin-paired cues increased tissue inhibitor of metallo

170 Presenting heroin-paired cues transiently increased MMP-9 activity

171 x or fewer bags versus more than six bags of heroin per day) and randomly assigned (1:1) to continue

172 ring antibodies caused marked attenuation of heroin potency (>4-fold) in a schedule-controlled respon

173 enerated heroin "immunoantagonism", reducing heroin potency by >15-fold.

174 and were grouped by use of opioid agonists (heroin, prescription opioids), antagonists (naltrexone),

175 n, activation of SNr GABA neurons attenuated heroin-primed, but not cue-induced, reinstatement of dru

176 by overuse of acidifier for dissolving brown heroin prior to injection (aOR 2.10 [95% CI 1.04-4.22]).

177 Reporting significant increases in heroin-related deaths since 2014, the New England region

178 gues), leading to an increase in adulterated heroin-related deaths.

179 d a publicly available data set of suspected heroin-related emergency calls (n = 6,246) to map overdo

180 The number of suspected heroin-related emergency calls was also positively assoc

181 Overall, our data suggest that heroin-related histone H3 hyperacetylation contributes t

182 entified areas with high numbers of reported heroin-related incidents and features of the built envir

183 Higher numbers of heroin-related incidents were found to be associated wit

184 that striatal FYN is an important driver of heroin-related neurodegenerative-like pathology and drug

185 eas activation of SNr GABA neurons inhibited heroin reward and relapse.

186 ORs in the SNr is more effective in reducing heroin reward than blockade of MORs in the VTA.

187 atory response in drug intake due to reduced heroin reward.

188 s more effective than in the VTA in reducing heroin reward.

189 first studies to examine the acquisition of heroin SA in this mouse model.

190 Next, we assessed relapse to heroin seeking after 1 and 15 abstinence days.

191 The time-dependent increase in heroin seeking after cessation of drug self-administrati

192 The differential regulation of heroin seeking and extinguished seeking by different MMP

193 egative affect in sustaining compulsive-like heroin seeking and taking and providing neurobiological

194 imity was restored during 15 minutes of cued heroin seeking but returned to extinction levels by 120

195 in craving" (the time-dependent increases in heroin seeking during abstinence).

196 ght a previously unknown role for the PVT in heroin seeking following a period of abstinence.

197 ular nucleus of the thalamus (PVT) abolished heroin seeking in chronically food-restricted rats.

198 s shell, but not core, projectors attenuated heroin seeking in FDR rats.

199 eward and motivation) in the augmentation of heroin seeking in food-restricted rats.

200 edure decreases reinstatement of cocaine and heroin seeking in rats and heroin craving in humans.

201 accumbens projections in the augmentation of heroin seeking induced by chronic food restriction.

202 ens shell projections in the augmentation of heroin seeking induced by chronic food restriction.SIGNI

203 djacent to accumbens synapses contributes to heroin seeking induced by cues.

204 Cue-induced heroin seeking transiently increased synaptic proximity

205 astroglial morphological plasticity on cued heroin seeking, a morpholino antisense strategy was used

206 logical plasticity in astrocytes potentiated heroin seeking.

207 2 activity around D2-MSNs during cue-induced heroin seeking.

208 s the reinstatement of cocaine, alcohol, and heroin seeking.

209 sociation with synapses and potentiated cued heroin seeking.

210 s in astroglial morphology are necessary for heroin seeking.

211 n encoding vulnerability to reinstatement of heroin-seeking and provide insight into the specific neu

212 of corticothalamic projections did not alter heroin-seeking behavior.

213 tural neural plasticity, reduce alcohol- and heroin-seeking behaviour, and produce antidepressant-lik

214 SNs exacerbates cue-induced reinstatement of heroin-seeking in high- but not low-risk rats, again wit

215 of suppressing cue-induced reinstatement of heroin-seeking in high- but not low-risk rats.

216 ergence in the encoding of heroin-taking and heroin-seeking in rats.

217 to the self-administration context for a 3 h heroin-seeking test under extinction conditions during w

218 impairments were detected in the striatum of heroin self-administering rats.

219 al self-administration (6 days) and then for heroin self-administration (12 days).

220 rmore, G/G male mice escalated the amount of heroin self-administration across 10 extended-access ses

221 ional readout of acetylated lysines, reduced heroin self-administration and cue-induced drug-seeking

222 ve effect of rewarding social interaction on heroin self-administration and incubation of heroin crav

223 ion of FYN activity significantly attenuates heroin self-administration and responding for drug-paire

224 fects of a HCRT-R2 antagonist, NBI-80713, on heroin self-administration in rats allowed short- (1 h;

225 t with a long duration of action, attenuates heroin self-administration in rhesus monkeys, suggesting

226 A rat heroin self-administration model was used to obtain tran

227 We show that heroin self-administration negatively regulates the acti

228 e compared effects of cocaine, morphine, and heroin self-administration on two forms of extinction le

229 We also found no sex differences in heroin self-administration or the strong preference for

230 Transgenic rats were trained on a heroin self-administration protocol in which a light/ton

231 ever, male and female rats with a history of heroin self-administration showed incubation of heroin c

232 n outbred rats following intermittent-access heroin self-administration that identifies subgroups as

233 imbic DA transmission and on rat intravenous heroin self-administration under fixed ratio (FR) and pr

234 SNr GABA neurons caused a robust increase in heroin self-administration with an extinction pattern, s

235 bition of VTA DA neurons reduced intravenous heroin self-administration, whereas activation of these

236 t altering the acquisition or maintenance of heroin self-administration.

237 d (2) male and female rats with a history of heroin self-administration.

238 yte differentiation and maturation following heroin self-administration.

239 oned cues in rats (n = 21) with a history of heroin self-administration.

240 ) or long- (12 h; LgA) access to intravenous heroin self-administration.

241 es that occur in vulnerable groups following heroin self-administration.

242 VTA GABA neurons inhibited cocaine, but not heroin, self-administration, whereas activation of SNr G

243 lace aversion and inhibited cocaine, but not heroin, self-administration, whereas optogenetic activat

244 ochemical strategies was tested on realistic heroin street samples from forensic cases, showing promi

245 An improved synthesis of a haptenic heroin surrogate 1 (6-AmHap) is reported.

246 ess to heroin, an animal model of compulsive heroin taking.

247 e into the RMTg but not into the VTA reduced heroin taking.

248 , indicating a divergence in the encoding of heroin-taking and heroin-seeking in rats.

249 Immunization of mice with an optimized heroin-tetanus toxoid (TT) conjugate formulated with adj

250 e and female G/G mice self-administered more heroin than did A/A mice over a 10-day period, possibly

251 For heroin, the mean was not significantly greater than 0, b

252 cal therapies and devices, and growth in the heroin trade, as well as population mixing during armed

253 nced rats or rats trained to self-administer heroin under extended access conditions exhibited normal

254 y outcomes were self-reported days of street heroin use (primary), days of any street-acquired opioid

255 Lifetime heroin use and DSM-IV heroin use disorder.

256 The prevalence of heroin use and heroin use disorder increased significant

257 eatment in populations at increased risk for heroin use and heroin use disorder.

258 ational campaigns regarding harms related to heroin use and the need to expand access to treatment in

259 ce, patterns, and associated demographics of heroin use and use disorder from 2001-2002 to 2012-2013

260 the proportion of respondents meeting DSM-IV heroin use disorder criteria (63.35% [SE, 4.79%] in 2001

261 The prevalence of heroin use and heroin use disorder increased significantly, with greate

262 ttle is know about the course of heroin use, heroin use disorder, and associated factors.

263 h data to characterize trends in heroin use, heroin use disorder, and heroin injection overall and by

264 d anxiety in drug-abstinent individuals with heroin use disorder.

265 lations at increased risk for heroin use and heroin use disorder.

266 idate for targeted clinical interventions in heroin use disorder.

267 Lifetime heroin use and DSM-IV heroin use disorder.

268 aking FYN a promising therapeutic target for heroin use disorder.

269 drug use, in drug-abstinent individuals with heroin use disorder.

270 istone H3, showing dynamic correlations with heroin use history and acute opiate toxicology.

271 orylation of its target Tau are increased by heroin use in the post-mortem human striatum, as well as

272 between the prescription opioid epidemic and heroin use in this population.

273 se of prescription opioids before initiating heroin use increased across time among white individuals

274 edical use of prescription opioids preceding heroin use increased among white individuals, supporting

275 Heroin use is an urgent concern in the United States.

276 estriction.SIGNIFICANCE STATEMENT Relapse to heroin use is one of the major obstacles in the treatmen

277 4, 17.0); that associated with recent opioid/heroin use was 13.2% (95% CrI: 6.6, 20.7); and that asso

278 is (-1.44; 90% CI, -3.22 to 0.27) for street heroin use, although the margin of 4 days was not exclud

279 e associations of recent cocaine use, opioid/heroin use, and hazardous alcohol use with unsuppressed

280 attributed to wound contamination related to heroin use, and the source of 5 cases was unknown.

281 Little is know about the course of heroin use, heroin use disorder, and associated factors.

282 se and Health data to characterize trends in heroin use, heroin use disorder, and heroin injection ov

283 enorphine access to callers reporting active heroin use, particularly those with Medicaid coverage.

284 y target in the physiopathology of long-term heroin use.

285 matin accessibility of the human striatum in heroin users and matched controls.

286 e that plasma BDNF concentration in habitual heroin users are not affected by BDNF Val66Met gene vari

287 homogeneous European Caucasian population of heroin users for transcriptional and epigenetic profilin

288 train in the anthrax outbreak among European heroin users.

289 Development of a heroin vaccine has become a major research focal point;

290 d potential clinical utility of an effective heroin vaccine in treating opioid use disorders.

291 Place preference to heroin was not modified, but remarkably, motivation to o

292 , however, the motivation to self-administer heroin was unchanged, indicating a divergence in the enc

293 In contrast, locomotor effects of heroin were abolished, and heroin-induced catalepsy was

294 ged 15 to 19 years, poisonings attributed to heroin were also identified.

295 SI-MS, as the signals of methamphetamine and heroin were completely suppressed by matrix and substrat

296 nistration of these prescription opioids and heroin, which has been previously established to induce

297 nted arrays of cocaine, methamphetamine, and heroin with a deposited-mass ranging nominally from 10 p

298 Mixtures of heroin with other drugs (cocaine, 3,4-methylenedioxymeth

299 by stimuli that were previously paired with heroin withdrawal.

300 the default mode network during conditioned heroin withdrawal.