ライフサイエンスコーパス: hetero-oligomer

1 ers did not form (except for s-erbB2-s-erbB4 hetero-oligomers).

2 esting that Byr2-SAM and Ste4-SAM may form a hetero-oligomer.

3 , while gH323-gL168 is the smallest secreted hetero-oligomer.

4 for the transition from a homo-oligomer to a hetero-oligomer.

5 s motif determines the size of the resultant hetero-oligomers.

6 ceptors that allow formation of Frizzled-LRP hetero-oligomers.

7 -2 homodimers, homo-oligomers, and Bcl-2/Bax hetero-oligomers.

8 in oligomeric complexes, as either homo- or hetero-oligomers.

9 they can assemble with P2X(2) subunits into hetero-oligomers.

10 interactions associating homo-oligomers and hetero-oligomers.

11 c constraints that favor homo-oligomers over hetero-oligomers.

12 preferentially to Kv1.2-possessing homo- or hetero-oligomers.

13 in cultured mammalian cells formed homo- and hetero-oligomers.

14 SAM domains are known to form homo- and hetero-oligomers.

15 e mechanism by which caveolins-1 and -2 form hetero-oligomers.

16 is provided by the ability to form distinct hetero-oligomers.

17 nd homo-tetramers as well as contributing to hetero-oligomers.

18 Other beta-crystallins were present only as hetero-oligomers.

19 1, beta1 and beta2 connexin to assemble into hetero-oligomers.

20 identified, and if they existed as homo- or hetero-oligomers.

21 by Western blotting, to assay for homo- and hetero-oligomers.

22 alidated homo-oligomers into pseudosymmetric hetero-oligomers.

23 bind guanine nucleotides and form rod-shaped hetero-oligomers.

24 omers, as well as the formation of MDL1-MDL2 hetero-oligomers.

25 her homo-oligomers or with other proteins as hetero-oligomers.

26 interacts with Abeta and tau, forming toxic hetero-oligomers.

27 mble intracellularly into tightly associated hetero-oligomers.

28 ormational equilibria from homo-oligomers to hetero-oligomers.

29 wt alphaA- or wt alphaB- crystallin to form hetero-oligomers.

30 lecules only occur in flotillin-2-containing hetero-oligomers.

31 complex between MREG and peripherin-2-ROM-1 hetero-oligomers.

32 resence of high molecular weight Stoml2-Mfn2 hetero-oligomers.

33 strategy to explore new regulatory roles in hetero-oligomers.

34 21 activated kinase 2 (PAK2) recruits septin hetero-oligomers, a molecular interaction that forms a r

35 c processes specifically require Red1p-Hop1p hetero-oligomers, a novel genetic screen was used to ide

36 dition, the presence of alphaA(1-162) in the hetero-oligomers also affects the degradation of wt alph

37 th and disease, including homo-oligomers and hetero-oligomers, also termed epichaperomes, and examine

38 these immunosubunits and the PA28 alpha/beta hetero-oligomer alters proteasome catalytic functions an

39 36-88 fragment does not form MinE+/MinE36-88 hetero-oligomers, although MinE36-88 affects the topolog

40 The two human proteins form hetero-oligomers, an association that does not require i

41 is specified, in part, by the UNC-86::MEC-3 hetero-oligomer and not by MEC-3 alone.

42 the in vivo translation of sequence-defined hetero-oligomers and biomaterials.

43 from ancestral GTPases and co-assemble into hetero-oligomers and cytoskeletal filaments.

44 analysis showed that all LL-37 peptides form hetero-oligomers and nanoclusters with Abeta40, but LL-3

45 cytoskeletal proteins that dynamically form hetero-oligomers and organize membrane microdomains for

46 This suggests that hetero-oligomers and small nanoclusters may represent an

47 inhibition of Abeta fibrillation, form more hetero-oligomers and smaller nanoclusters.

48 least 12 GTP-binding proteins that can form hetero-oligomers and that are sometimes found in associa

49 The chaperonin TRiC is an obligate hetero-oligomer, and we identify variants in seven of it

50 rization; another suggests that higher order hetero-oligomers are 'nucleated' by ligand-induced homod

51 KCTD12/KCTD16 hetero-oligomers are abundant in the hippocampus, where

52 We noted that the larger HspB1-HspB5 hetero-oligomers are less active and that HspB6 activate

53 No hetero-oligomers are observed between the mismatch repai

54 structural and functional properties of such hetero-oligomers are poorly understood.

55 These caveolin hetero-oligomers are thought to represent the assembly u

56 These caveolin hetero-oligomers are thought to represent the functional

57 Different hetero-oligomer arrangements, generated by constructing

58 closed C4-symmetric two-component rings, and hetero-oligomers assembled on a cyclic homo-oligomeric c

59 ce") cause thermoinstability of yeast septin hetero-oligomer assembly, and human disease.

60 face mutants, operates during de novo septin hetero-oligomer assembly, and requires specific cytosoli

61 ents in live cells reveal that KCTD12/KCTD16 hetero-oligomers associate with both the receptor and th

62 By contrast, hetero-oligomers bearing mutations in the activation loo

63 consistent with the REG alpha(N50Y)/REG beta hetero-oligomer being a heptamer composed of three alpha

64 Here we show that UNC-86::MEC-3 hetero-oligomer-binding sites are also found in the prom

65 tivity or prevented the formation of MIF-MDL hetero-oligomers blocked the observed synergism.

66 The exact stoichiometry of Smad homo- and hetero-oligomers both before and after ligand stimulatio

67 ty of available septins to assemble distinct hetero-oligomers, but the underlying mechanism was unkno

68 ns, including A3G homo-oligomers and A3G-A3F hetero-oligomers, but the viral infectivity factor remai

69 as a model for exploring the formation of a hetero-oligomer by brightness analysis directly in livin

70 species, which can be sequestered in vivo in hetero-oligomers by pathological amyloids.

71 These hetero-oligomers can also be formed in vitro by mixing t

72 The hetero-oligomer chaperone function was found to be equiv

73 ith up to six different components, branched hetero-oligomers, closed C4-symmetric two-component ring

74 sma membrane; it is likely that A2BR forms a hetero-oligomer complex for better function.

75 They signal through a hetero-oligomer complex of BMP receptors.

76 cteriophage lambda terminase holoenzyme is a hetero-oligomer composed of the A and Nu1 lambda gene pr

77 ic asialoglycoprotein receptor (ASGP-R) is a hetero-oligomer composed of two subunits, designated H1

78 In hippocampus, most AMPA-Rs are hetero-oligomers composed of GluR1/GluR2 or GluR2/GluR3

79 hange activity is provided by Na,K-ATPase, a hetero-oligomer consisting of a catalytic alpha-subunit

80 amma-aminobutyric acid (GABA)A receptor is a hetero-oligomer consisting of five subunits, the combina

81 t that the Cct ring is comprised of a single hetero-oligomer containing eight subunits of differentia

82 ntracellularly active receptor complexes are hetero-oligomers containing ErbB2.

83 odimers of gB, gC, and gD were detected, and hetero-oligomers containing gB cross-linked to gC, gC to

84 The mass of the REG alpha(N50Y)/REG beta hetero-oligomer determined by electrospray ionization ti

85 d-induced erbB receptor extracellular domain hetero-oligomers did not form (except for s-erbB2-s-erbB

86 est that RetS and GacS form a domain-swapped hetero-oligomer during the planktonic growth phase of P.

87 olish the formation of matrilin 1/matrilin 3 hetero-oligomers, eliminate the secretion of mutant matr

88 While GPCR assembly into hetero-oligomers facilitates signal integration of diffe

89 eriments in live cells demonstrate that KCTD hetero-oligomers form at least tetramers and that these

90 Hetero-oligomer formation also occurs with rIAPP but lea

91 We observed that hetero-oligomer formation between HspB1 and HspB5 leads

92 We became interested in hetero-oligomer formation between human heat-shock prote

93 The pattern of hetero-oligomer formation between this construct and an

94 Here, we analyzed hetero-oligomer formation in human cells and in vitro us

95 ytical ultracentrifugation and by studies of hetero-oligomer formation in non-denaturing polyacrylami

96 Therefore, hetero-oligomer formation is not necessary for the induc

97 It appears that hetero-oligomer formation occurs more generally for chlo

98 Our results show that the effect of hetero-oligomer formation on the composition of the sHsp

99 ion of D/A in the SPD(-/-) mouse resulted in hetero-oligomer formation with mouse SP-A and did not co

100 protein transport in vivo minimally requires hetero-oligomer formation.

101 that NTP binding plays a role downstream of hetero-oligomer formation.

102 However, hetero-oligomers formed from REG subunits lacking the la

103 We now show that hetero-oligomers formed from REGalpha activation loop mu

104 However, the proportion of hetero-oligomers formed were less than predicted by a bi

105 the two isoforms influences the fraction of hetero-oligomers formed.

106 symmetric homo-oligomers and pseudosymmetric hetero-oligomers generated for each system have identica

107 monomeric Gc or Gn alone but recognized the hetero-oligomer glycoprotein complex (Gc+Gn) when Gc and

108 The chaperone activity of HspB1-HspB6 hetero-oligomers, however, was modulated in a substrate-

109 l experiments demonstrate that KCTD12/KCTD16 hetero-oligomers impart unique kinetic properties on G-p

110 KCTD12/KCTD16 hetero-oligomers impart unique kinetic properties to GAB

111 PopB and PopD guide the assembly of a unique hetero-oligomer in membranes.

112 ides, demonstrating that PA28 functions as a hetero-oligomer in vivo.

113 Its most prominent form is a hetero-oligomer in which small subunits (SSU) stabilize

114 eric REG alpha mutant (N50Y) forms an active hetero-oligomer in which the molar ratio of REG beta to

115 veal that NHERF-1 and NHERF-2 form homo- and hetero-oligomers in a cellular context.

116 we show that the KCTD proteins also assemble hetero-oligomers in all possible dual combinations.

117 velopment of an ELISA to detect amylin-Abeta hetero-oligomers in brain tissue and blood.

118 cells allowed the quantitation of homo- and hetero-oligomers in cells transfected with different rat

119 PB4 and HSPB5 homo-oligomers and HSPB4/HSPB5 hetero-oligomers in delaying the aggregation of the lens

120 s a model in which membrane targeted CaMK-II hetero-oligomers in nodal cells transduce the left-sided

121 ies suggest formation of flotillin homo- and hetero-oligomers in other cell types, but so far knowled

122 predominant formation of flotillin-1 and -2 hetero-oligomers in resting and chemokine-stimulated hum

123 n showed that the two isoforms can also form hetero-oligomers in Sf9 cells.

124 TACI-l and TACI-s formed homo- and hetero-oligomers in soluble and membrane-bound forms.

125 ew assay can detect circulating amylin-Abeta hetero-oligomers in the blood and is sensitive to their

126 , thereby implicating a role for Red1p-Hop1p hetero-oligomers in these processes.

127 termine how these two sHSPs interact to form hetero-oligomers in vitro and whether, by doing so, ther

128 xtures of rice and agave Rca form functional hetero-oligomers in vitro, but only the rice isoforms de

129 te that HSP27 and alphaB formed polydisperse hetero-oligomers in vitro, which had an average molecula

130 All AtHIR proteins could form homo- and hetero-oligomers in vivo and were enriched in membrane m

131 phaB-crystallin), and HspB6 (Hsp20) can form hetero-oligomers in vivo However, the impact of hetero-o

132 ia1 and mDia2 FH2 domains form homo- but not hetero-oligomers in vivo, and that oligomerization is ab

133 re found in 10% of homo-oligomers and 30% of hetero-oligomers including Bax, Troponin C, and Early En

134 structurally recombined them to make 24 new hetero-oligomers, including ABC heterotrimers, A2B2 hete

135 ese findings and indicate that KCTD12/KCTD16 hetero-oligomers increase the duration of slow IPSCs.

136 T protein did not result in the formation of hetero-oligomers, indicating that cSHMT subunits do not

137 nt of 103Q to the aggresome via formation of hetero-oligomers, indicating the aggresome targeting in

138 TRAF3-TRAF5 hetero-oligomers interacted with CD40, indicating that T

139 virus fusion (F) and attachment glycoprotein hetero-oligomers is largely unknown.

140 uitment of complement component C1q to these hetero-oligomers leads to clustering-dependent activatio

141 assemble into large, polydisperse homo- and hetero-oligomers, making them challenging structural and

142 ave activation domains, the formation of the hetero-oligomer may create a strong activator.

143 ith previous suggestions that both homo- and hetero-oligomers may possess biological activity.

144 Our data therefore support that KCTD hetero-oligomers modulate physiologically induced K(+) c

145 HEXIM1 and HEXIM2 can form stable homo- and hetero-oligomers (most likely dimers), which may nucleat

146 ar ratio of approximately 1.2, the resulting hetero-oligomers observed by ESI-TOF MS were again predo

147 ild-type enzyme subunits was not detected in hetero-oligomers obtained from a coexpression experiment

148 The TRiC/CCT chaperonin is a 1-MDa hetero-oligomer of 16 subunits that assists the folding

149 Na,K-ATPase is a hetero-oligomer of alpha and beta-subunits.

150 We propose that a single, higher-order hetero-oligomer of gpA and gpNu1 functions throughout la

151 e antimicrobial protein calprotectin (CP), a hetero-oligomer of the S100 family members S100A8 and S1

152 ble agent showed that monomers and homo- and hetero-oligomers of all three subtypes are expressed on

153 isms that control the formation of homo- and hetero-oligomers of caveolins that are essential for cav

154 nding site was required for the formation of hetero-oligomers of Cx26 and Cx32 but not for Cx32 homom

155 stability and FRET efficiency for homo- and hetero-oligomers of fluorescent protein-labeled forms of

156 Hetero-oligomers of G-protein-coupled receptors have bec

157 nto homodimeric and hetero-oligomeric forms; hetero-oligomers of gB-gC, gC-gD, gD-gB, gH-gL, gC-gL an

158 nce that GABAB receptors also associate with hetero-oligomers of KCTD subunits.

159 noprecipitates with p53-281G suggesting that hetero-oligomers of p53-281G and p53 del 1-293 are defec

160 r-order homo-oligomers of RHL1, higher-order hetero-oligomers of RHL1 and RHL2 with two-to-one stoich

161 rotein-protein interactions within homo- and hetero-oligomers of RXR, cognate ligands control the rel

162 whereas the GP complex (GPc), consisting of hetero-oligomers of SSP, GP1, and GP2, forms the viral e

163 Hetero-oligomers of TatB and TatC form circular substrat

164 3)Rs did not bind directly to CaM-Sepharose, hetero-oligomers of type-I/III IP(3)Rs retained the abil

165 ments suggest that the Rep proteins can form hetero-oligomers on the AAV hairpin DNA.

166 Septin hetero-oligomers polymerize into cytoskeletal filaments

167 Full-length TRAF3 and TRAF5 formed hetero-oligomers, presumably through their predicted iso

168 receptor activation (one min) KCTD12/KCTD16 hetero-oligomers produce moderately desensitizing fast d

169 During short activation (2 s) KCTD12/KCTD16 hetero-oligomers produce nondesensitizing slowly deactiv

170 ombinant BRIZ1 and BRIZ2 preferentially form hetero-oligomers rather than homo-oligomers, and the coi

171 homo-oligomers and the VPAC1-VPAC2 receptor hetero-oligomers reached the cell surface, where recepto

172 nomers but form various noncovalent homo- or hetero-oligomers related to specific activities in human

173 X-ray crystallographic structures of peptoid hetero-oligomers, revealing that peptoid macrocycles can

174 omers arranged into random sequences [random hetero oligomers (RHOs)] can selectively bind to a model

175 entrations, the REGalphaDeltai/REGbetaDeltai hetero-oligomers stimulated the proteasome less than REG

176 Septin proteins form hetero-oligomers that associate with membranes of specif

177 and D2 receptors have been proposed to form hetero-oligomers that couple to Galphaq proteins, and SK

178 zzled receptors, forming membrane-associated hetero-oligomers that interact with both Disheveled (via

179 yosin II filaments, and septins, GTP-binding hetero-oligomers that polymerize to form a membrane-asso

180 o be defined by the combination of homo- and hetero-oligomers that they stabilize upon binding.

181 1 or 1:4 (alphaA(1-162) : wt) ratios to form hetero-oligomers, the degradation of alphaA(1-162) was s

182 d1p facilitates the formation of Hop1p/Red1p hetero-oligomers, thereby enabling the formation of func

183 oth alpha and beta subunits are required for hetero-oligomers to bind the proteasome.

184 that IFITM family members work as homo- and hetero-oligomers to modulate virus entry.

185 cer-related genes, including homo-oligomers, hetero-oligomers, transmembrane proteins and complexes w

186 ility that some chemokines could form unique hetero-oligomers using the same oligomerization motifs.

187 we show that HDAC4 and HDAC5 form homo- and hetero-oligomers via a conserved coiled-coil domain near

188 nclude that GRF1 and GRF2 can form homo- and hetero-oligomers via their DH domains, that mutational i

189 Formation of heptamer Cpn10/Cpn20 hetero-oligomers was also observed with the Arabidopsis

190 However, substantial formation of hetero-oligomers was observed between recombinant recept

191 The VPAC1-VPAC2 hetero-oligomers were modulated by vasoactive intestinal

192 However, hetero-oligomers were synthesized with a longer lag peri

193 e secretin-VPAC1 and secretin-VPAC2 receptor hetero-oligomers were unaffected by ligand treatment.

194 that PDZ-RhoGEF and LARG can form homo- and hetero-oligomers, whereas p115RhoGEF can only homo-oligo

195 ted serine protease (MASP)-3/collectin-L1/K1 hetero-oligomer, which impacts cardiac neural crest cell

196 reover, we found that ClpB95 and ClpB80 form hetero-oligomers, which are similar in size to the homo-

197 f both isoforms resulted in the formation of hetero-oligomers, which distributed between the cytosol

198 s in favour of the presence of a left-handed hetero-oligomer with an orientation compatible with the

199 e, but no longer forms a high molecular mass hetero-oligomer with caveolin-1.

200 e ryanodine receptor (RyR1) is isolated as a hetero-oligomer with FKBP12, whereas the cardiac ryanodi

201 amino acids of gL can form a stable secreted hetero-oligomer with gL and gH792, respectively, while g

202 pase recruitment domain (CARD) forms a large hetero-oligomer with the active caspase-9.

203 receptor (D(1)R) has been proposed to form a hetero-oligomer with the D(2) dopamine receptor (D(2)R),

204 50) acts as a dominant negative by forming a hetero-oligomer with the full-length APC and preventing

205 REGbetaDeltai was able to form hetero-oligomers with a single site, monomeric REGalpha

206 onfiguration and that these mutants produced hetero-oligomers with a truncated form of gB consisting

207 Conversely, formation of hetero-oligomers with alphaA(1-162) enhanced the degrada

208 dition, each of these three receptors formed hetero-oligomers with each other.

209 The chaperonin complexes are made up of hetero-oligomers with eightfold symmetry, and the proper

210 period showed a negligible capacity to form hetero-oligomers with endogenous type III IP(3)Rs, based

211 APIP6 forms homo-oligomers or hetero-oligomers with IPI1.

212 rilin 3 may be dependent on the formation of hetero-oligomers with matrilin 1.

213 ion, the C-terminal MinE22-88 fragment forms hetero-oligomers with MinE+ when the proteins are co-exp

214 that RapA2 formed neither homo-oligomers nor hetero-oligomers with RapB (a distinct CHDL protein), in

215 itional C-terminal amino acids formed active hetero-oligomers with REGbeta.

216 Fbeta receptor complex, Smad2 and Smad3 form hetero-oligomers with Smad4 and translocate into the nuc

217 t AtDHDPS and MtDHDPS3 interact and may form hetero-oligomers with strongly reduced enzymatic activit

218 Synaptotagmin IV forms hetero-oligomers with synaptotagmin I, resulting in syna

219 ach of these mutants formed partially active hetero-oligomers with the monomer REGalpha(N50Y).

220 However, the de novo design of protein hetero-oligomers with three or more distinct chains with

221 Pseudosymmetric hetero-oligomers with three or more unique subunits with

222 We construct linearly arranged hetero-oligomers with up to six different components, br

223 were not transported to the cell surface as hetero-oligomers with wild-type gB, suggesting that the

224 alphaA(1-162) forms hetero-oligomers with wt alphaA- and alphaB-crystallins.

225 are capable of producing stable, functional hetero-oligomers with WT LukS.

226 equently assemble into higher order homo- or hetero-oligomers within their natural lipid environment.