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1 e origin of stereoselectivity in this ketene heterodimerization.
2 d, due to analytical challenges in measuring heterodimerization.
3 Toll-like receptor-1/2 (TLR-1/2) and TLR-2/6 heterodimerization.
4 c was weakened, attenuating IL-2Rbeta-gammac heterodimerization.
5 tant domain Calpha is dependent on alphabeta heterodimerization.
6 deficiency, has on ZnT1, ZnT3, and ZnT4 upon heterodimerization.
7 an interfacial cavity formed through subunit heterodimerization.
8 GIT1 to activate Ras and promote B-Raf/c-Raf heterodimerization.
9 responding to a segment that is required for heterodimerization.
10 eve high transporter stability and efficient heterodimerization.
11 ithin the TM domain is necessary for p45-p75 heterodimerization.
12 the N terminus of MGAT2, is required for the heterodimerization.
13 e acetylation state of PAF49 does not affect heterodimerization.
14 R) domains of the receptors undergo homo- or heterodimerization.
15 retained in the cytosol upon wild-type DJ-1 heterodimerization.
16 ate cell survival and death through homo- or heterodimerization.
17 In Caco-2 cells, CCK enhanced CCK1R/CCK2R heterodimerization.
18 oGEFs as well as their co-recruitment due to heterodimerization.
19 binding domains (LBDs) and constitutive homo/heterodimerization.
20 the amount of ghrelin and state of receptor heterodimerization.
21 ing a Rac-1 construct via rapamycin-mediated heterodimerization.
22 ains that mediate either homodimerization or heterodimerization.
23 arrangements associated with the c-Fos/c-Jun heterodimerization.
24 s that are likely involved in their homo- or heterodimerization.
25 AK3 and PAK1 signaling may be coordinated by heterodimerization.
26 F49 were sufficient to provide the basis for heterodimerization.
27 lex and that they may serve to stabilize I-D heterodimerization.
28 and that blade I is required for CD44 MMP-14 heterodimerization.
29 cross-activation of GRPR signaling by MOR1D heterodimerization.
30 inactivating proteins with rapamycin-induced heterodimerization.
31 and PEG coimmobilized through leucine zipper heterodimerization.
32 asic helix-loop-helix domain, which mediates heterodimerization.
33 emble into complexes, through both homo- and heterodimerization.
34 of unc-10/RIM mutants deficient for C2A/RIM heterodimerization.
35 oes not identify interactions that may favor heterodimerization.
36 s of the interactions inducing CH3 interface heterodimerization.
37 mical properties, many times related to poor heterodimerization.
38 D is a dimerization domain for PHYB homo and heterodimerization.
39 by bi-specific ligands that induce receptor heterodimerization.
40 oint mutations in FGFR3 (A391E and G380R) on heterodimerization.
41 elective small molecule inhibitor of MYC-MAX heterodimerization, 10058-F4, on myeloma cell lines as w
43 ted by these findings, we here uncovered the heterodimerization, altered subcellular localization, an
44 These results led us to hypothesize that heterodimerization alters the intrinsic catalytic proper
46 is of (-)-communesin F based on a late-stage heterodimerization and aminal exchange is described.
48 ary zone electrophoresis to measure rates of heterodimerization and DeltaGHet for seven ALS-variant a
50 scular plant emergence, conditioned obligate heterodimerization and generated the critical function i
52 f to CBFbeta is mutually exclusive with RUNX heterodimerization and impacts the expression of genes w
53 usion, sumoylation of Nrf2 and MafG enhances heterodimerization and increases GCLC expression, which
54 /L as was nearly complete inhibition of HER3 heterodimerization and phosphorylation, thereby preventi
55 e-linked construct to induce IL-36R.IL-1RAcP heterodimerization and predicted the binding affinity du
57 heteroallelic combinations, as well as SHELL heterodimerization and subcellular localization by yeast
59 hen a PKA-activated Ras promotes Raf-1/B-Raf heterodimerization, and are inhibited by interfering wit
60 data imply that RAR agonist enhances RAR-RXR heterodimerization, and chromatin binding/dimerization a
61 embrane skeleton, suppression of C-RAF/B-RAF heterodimerization, and inhibition of C-RAF kinase activ
62 NA-binding domain (tandem-winged helix), the heterodimerization, and the linker domain were essential
63 PtrSND1s, making them nonproductive through heterodimerization, and thereby modulating the SND1 tran
65 uR1 and mGluR5 in a manner inconsistent with heterodimerization, and thus suggest an interaction betw
67 o-hole interface, the molecular mechanism of heterodimerization, and to engineer Fc domains that coul
70 al knockout mice of all neuroligins to avoid heterodimerization artifacts, we show, in hippocampal CA
71 cally required for growth factor-induced RAF heterodimerization as well as for MEK dissociation from
72 ependent MAPK signalling by antagonizing RAF heterodimerization as well as the conformational changes
76 reactivation of JAK-STAT signalling and with heterodimerization between activated JAK2 and JAK1 or TY
77 te from a dominant-negative effect caused by heterodimerization between AQP4 and AQP4-Delta4, which w
80 Protein-protein interaction assays reveal heterodimerization between PpSMF1 and PpSCRM1, which, to
81 imaging model system by detecting changes in heterodimerization between RXRalpha and one of its partn
83 -terminal domain (NTD) of the GluN1 promotes heterodimerization between the NTDs of GluN1 and GluN2,
84 n of PDGFRA by EGFR and EGF-induced receptor heterodimerization, both of which are abolished by EGFR
85 uggests a possible structural basis for Her2 heterodimerization, but all available structures for dim
86 olecules designed to inhibit HIF-2alpha-ARNT heterodimerization by binding an internal cavity of the
87 s that allows the quantification of receptor heterodimerization by dual-color fluorescence cross-corr
88 main with an alpha-helical cap that mediates heterodimerization by forming an intermolecular helix bu
89 that the temporal regulation of Neurog2-E47 heterodimerization by GSK3 is a central component of the
93 ion, pertuzumab-mediated inhibition of ErbB2 heterodimerization decreased AKT phosphorylation, cell g
94 a Nab3 self-association defect, a Nab3-Nrd1 heterodimerization defect, a Nrd1-polymerase II binding
98 long intra-molecular coiled-coil arms with a heterodimerization domain at one end and an ABC-like nuc
100 fibroblasts with mutations in the alpha/beta heterodimerization domain seems to be associated with a
101 ng mutations outside the alpha/beta spectrin heterodimerization domain, four had normal brain imaging
103 constituent LNR (Lin12-Notch repeat) and HD (heterodimerization) domains, at forces similar to those
104 nts can be physiologically important through heterodimerization, even when inactive alone, and can co
116 While methods exist for studying receptor heterodimerization in cell membranes, they are limited t
120 Y1009, rationalizing LsdA and LsdB homo- and heterodimerization in vivo A structure of an LsdA.phenyl
121 he physiological relevance of 5-HT2 receptor heterodimerization in vivo Accordingly, exogenous expres
122 t 2.47 A resolution, revealed a mechanism of heterodimerization in which UL50 clamps onto helices of
123 sion, yet increased glomerular VEGF receptor heterodimerization, indicating differential signaling by
124 age RNA homodimerization or to encourage RNA heterodimerization, indicating that HIV-1 and HIV-2 RNA
126 biology assays revealed that PD-L1:CD80 cis-heterodimerization inhibited both PD-L1:PD-1 and CD80:CT
127 HER2 antibody pertuzumab, which blocks HER2 heterodimerization, inhibited growth induced by hereguli
128 trengths and weaknesses of all of the PA-PB1 heterodimerization inhibitors, we analyze their hypothes
129 cellular sites within CaV1.2-alpha1C permits heterodimerization-initiated channel inhibition with rap
130 have high binding affinity for the ERCC1-XPF heterodimerization interface by interacting with the XPF
131 to surface residues in the characterized M50 heterodimerization interface substantially decreased UL5
132 ined asymmetric architecture, with extensive heterodimerization interfaces and AHR interdomain intera
134 cificity in receptor homodimerization versus heterodimerization is essential in determining the role
139 biology, and receptor dimerization (homo- or heterodimerization) is central to signal transduction.
140 dividual K8, K18, or K19 but is limited upon heterodimerization (K8/K18 or K8/K19) in the absence of
141 ired in unc-10 mutants deficient for C2A/RIM heterodimerization, leading to decreased release probabi
142 ucines abolished protein disulfide isomerase heterodimerization, lipid transfer, and apoB secretion,
143 of common target promoters, suggesting that heterodimerization may be required for the full regulati
144 dorsal root ganglion neurons indicating that heterodimerization may provide greater diversity of leak
145 family III(a + c)1 members, which suggests a heterodimerization mechanism conserved in angiosperms.
146 regulation of MST1/2 includes both homo- and heterodimerization, mediated by helical SARAH domains, t
147 ults demonstrate that Pi-regulated PiT1-PiT2 heterodimerization mediates Pi sensing independently of
149 at substrate dimerization (homo- or possibly heterodimerization) might represent a general principle
150 amic range, we employed improved optogenetic heterodimerization modules and engineered a photosensiti
152 ether, our results provide evidence that the heterodimerization of 6TM-MOR with beta2-AR underlies a
153 AM1 and AM2 receptors formed by the obligate heterodimerization of a G protein-coupled receptor, the
156 reveal the molecular basis for the homo- and heterodimerization of AFF proteins and implicate the AFF
157 Recent development suggests that homo- and heterodimerization of APP and APP-like proteins (APLPs),
160 eir spatial colocalization via light-induced heterodimerization of cryptochrome 2 and a dCas9-CIBN fu
164 al and can be applied to study the homo- and heterodimerization of GPCRs and other transmembrane prot
166 close a computational study on the homo- and heterodimerization of isocyanides, in particular on the
167 hat mutations within either interface weaken heterodimerization of isolated half hinges in vitro but
169 scribe an unprecedented catalytic asymmetric heterodimerization of ketenes of wide substrate scope.
170 xtensive studies of the catalytic asymmetric heterodimerization of ketenes to give ketene heterodimer
174 of unsymmetrical cyclobutanes by controlled heterodimerization of olefins remains a substantial chal
177 pendent TGF-beta signaling by disrupting the heterodimerization of TbetaRI and TbetaRII receptors.
178 cubane 4Fe-4S cluster, which is crucial for heterodimerization of TFEalpha/beta and its engagement w
181 restricted to the receptor itself, allowing heterodimerization of the four EGFR family members witho
182 ligand-mediated co-internalization following heterodimerization of the GHS-R1a receptor with the dopa
184 tes lymphocyte function by signaling through heterodimerization of the IL-2Rbeta and gammac receptor
188 sAbs) having two unique Fab domains requires heterodimerization of the two heavy chains and pairing o
189 of the NC, ND and NE sequences and directed heterodimerization of these photosensory regions with th
190 ltaneous measurement of homodimerization and heterodimerization of type I receptor domains in their n
194 gth among all possible homodimerizations and heterodimerizations of these three NHERF proteins by pul
195 ults demonstrate that the impact of receptor heterodimerization on endocytic recruitment is controlle
196 here, we investigate the impact of receptor heterodimerization on endocytic recruitment using a fami
201 tional regulator and serves as an obligatory heterodimerization partner for at least 20 other nuclear
202 Among the top hits was MAX, the obligate heterodimerization partner for MYC family proteins that
203 ncur with RXRalpha functioning as obligatory heterodimerization partner for several nuclear receptors
205 on of Notch-1, ErbB4, pErbB4, and pEGFR, the heterodimerization partner of ErbB4, suggesting increase
206 targeted via bexarotene, a ligand of Nurr1's heterodimerization partner retinoid X receptor (RXR).
207 sponse element (XRE) in association with the heterodimerization partner, the AhR nuclear translocator
208 taining loosely organized domains, while its heterodimerization partners use a surface patch on their
211 and tetrasubstituted cyclobutanes through a heterodimerization process involving two different alken
213 We found that ATP-binding and Smc1-Smc3 heterodimerization promote conformational changes within
216 significantly and consistently improved the heterodimerization rate of this format (>=95%) by induci
218 ivity studies show that the competitive HER4 heterodimerization reactions have a profound impact on t
220 ither AR-V7 homodimerization nor AR-V7/AR-FL heterodimerization requires cofactors or DNA binding.
221 tatic interactions that facilitate efficient heterodimerization, resulting in bispecific antibodies w
222 Broadly, these observations indicate that heterodimerization results from the divergence of homodi
224 r receptor Nurr1 can be activated by RXR via heterodimerization (RXR-Nurr1) and is a promising target
225 engineered is by creating "knob" and "hole" heterodimerization sites in the CH3 domains of two antib
226 Structural determinants responsible for heterodimerization specificity of bZIP53 are poorly unde
227 tions that modulate the homodimerization and heterodimerization states to define additional roles of
228 d DAF-38 form heterodimers, and we show that heterodimerization strongly increases cAMP inhibition in
229 Moreover, we used constant heavy domain 3 heterodimerization substitutions to create TTR-mediated
231 hydrolysis, and the CRY2-CIBN light-mediated heterodimerization system to create an optogenetic PLD (
233 Here, we explore the possibility to develop heterodimerization system with a range of mechanical sta
236 of-of-principle by generating nanobody-based heterodimerization systems induced by cannabidiol with h
237 or a variety of regulatory possibilities via heterodimerization that could impact song behavior in ze
238 of Mycobacterium tuberculosis induces TLR1/2 heterodimerization to elicit proinflammatory-type respon
239 successfully drive human IgG1 CH3 or IgM CH4 heterodimerization to levels similar to or above those o
240 the molecular basis of TLR1 and TLR6-driven heterodimerization upon LPA binding underlines the highl
242 incipally reliant on ligand-induced Fzd/LRP6 heterodimerization, versus the allosteric mechanisms see
243 ated with an increased receptor binding, and heterodimerization was associated with a decreased recep
245 ligation assays demonstrated that BRAF-CRAF heterodimerization was increased in fixed tumor samples
246 were substituted with alanine, the PiT1-PiT2 heterodimerization was no longer regulated by extracellu
247 pendent Pi transport activity, the PiT1-PiT2 heterodimerization was still regulated by extracellular
248 ent subunits were linked together to enforce heterodimerization), we characterized the biophysical an
249 NMT3A(R882mut) relied on a motif involved in heterodimerization, whereas its various chromatin-bindin
250 pical DR1 sequence favors PPARalpha/RXRalpha heterodimerization, whereas the switch from RXRalpha to
251 y interacts with VDR and RXR promoting their heterodimerization, which is critical for VDR:RXR target
252 the cytostatic activity of C/EBPbeta through heterodimerization, which prevents senescence and suppre
254 and receptor tyrosine kinases, suggests that heterodimerization with a strongly recruited receptor ca
255 1 cytoplasmic tail and does not entail beta1 heterodimerization with an alpha-subunit or its localiza
256 tidylinositol 3-kinase/Akt signaling through heterodimerization with and activation by other ErbB rec
257 A dimerization leads us to propose a mode of heterodimerization with ARNT that is supported by both b
258 f Bcl-xL in mitochondria, increase in Bcl-xL heterodimerization with Bax in mitochondria, and reduced
259 lation of the alpha3 precursor prevented its heterodimerization with beta1, whereas CD151 association
261 to wild-type B-Raf kinase domain leading to heterodimerization with C-Raf causing a paradoxical hype
262 eased C/EBPbeta homodimer formation, whereas heterodimerization with C/EBPgamma was relatively unaffe
265 the widest repertoire of PAMPs owing to its heterodimerization with either TLR1 or TLR6, broadening
266 or via a ligand-independent process through heterodimerization with ErbB2 overexpressed in breast tu
271 lls with NO increased the level of ITGalpha6 heterodimerization with ITGbeta1 but not with ITGbeta4.
272 tivates the receptor kinase BRI1 by inducing heterodimerization with its co-receptor kinase BAK1; how
273 inal domain of PRG, which is responsible for heterodimerization with LARG, strongly inhibited Ca(2+)-
277 to produce bispecific antibodies by driving heterodimerization with mutations in the CH3 domain of e
281 "knob-into-hole" technology for heavy chain heterodimerization with one heavy chain consisting of a
282 y identified regions in Ostbeta required for heterodimerization with Ostalpha, trafficking of the Ost
283 ot bind EGF-like ligands, relying instead on heterodimerization with other (ligand-bound) EGFR-family
285 Transcriptional activation by CHOP involves heterodimerization with other members of the basic leuci
286 These modifications include competitive HER4 heterodimerization with other members of the ErbB family
288 at mediate their homodimerization as well as heterodimerization with other SARAH domain-containing pr
289 competent itself as it requires aPC-induced heterodimerization with PAR-2 (human podocytes) or PAR-1
295 hrough homodimerization of MMP-14 as well as heterodimerization with the cell surface adhesion molecu
296 PIF1 is also degraded in the dark by direct heterodimerization with the positively acting factor HFR
297 lation of MMP7 transcription did not require heterodimerization with the retinoid X receptor (RXR), i
298 LR expressed on human monocytes, by inducing heterodimerization with TLR1 in an NADPH oxidase-depende