ライフサイエンスコーパス: heterologous

1 In agreement, heterologous activation of PKC by stimulating the chemok

2 Heterologous (Ad26,MVA or MVA,Ad26) and homologous Ad26,

3 nt with morphine results in a surprising and heterologous adaptation in kinase-dependent desensitizat

4 that chronic treatment with morphine induced heterologous adaptations in kinase regulation of G prote

5 thoroughly examined.METHODSThe novel 2-dose heterologous Adenovirus type 26.ZEBOV (Ad26.ZEBOV) and m

6 Both heterologous and homologous Ad26,MVA Ebola vaccine regim

7 A(H3N2)v vaccine did not provide sufficient heterologous antibody responses against the new 2010.1 c

8 Memory B cells (MBCs) can respond to heterologous antigens either by molding new specificitie

9 arantee the OMV compartmentalization of most heterologous antigens in quantities high enough to elici

10 associated with impaired immune response to heterologous antigens, and that antiviral therapy may am

11 osorbent assay formats, using homologous and heterologous assay conjugates, with limits of detection

12 4 activity by persulfidation was tested in a heterologous assay using the Chlamydomonas reinhardtii C

13 oops and leads to the accumulation of stable heterologous associations, suggesting that the Rad54 ATP

14 of S. maltophilia and reduced the numbers of heterologous bacteria, signaling that another effector(s

15 AwM, conferring enhanced protection against heterologous bacterial challenge.

16 Heterologous BCG prime-boost regimens represent a promis

17 ading to triptolide are the prerequisite for heterologous bioproduction.

18 de biosynthetic pathway and consequently the heterologous bioproduction.

19 Finally, an infection and heterologous booster vaccination model revealed no role

20 CD80(+) subset, and few GCs arose following heterologous boosters, demonstrating that recall respons

21 livery; in both conventional vaccination and heterologous boosting of parenteral BCG immunisation.

22 Using genes from a heterologous but related ICE, we found that the exclusio

23 subnanomolar affinity and protected against heterologous CCHFV challenge in a STAT1-knockout mouse m

24 dy 13G8 protects STAT1-knockout mice against heterologous CCHFV challenge using a clinical isolate fr

25 d by voltage-clamp experiments using various heterologous cell expression systems (Xenopus oocytes, C

26 utant Kir3.4 (+/-native Kir3.1) in different heterologous cell expression systems resulted in increas

27 ell line and then grown in the presence of a heterologous cell line changed their growth rate to that

28 to that seen in conditioned Giardia from the heterologous cell line.

29 Electrophysiological studies in a heterologous cell system confirmed that this channel is

30 DAT with PP1 and PP2A in the mouse brain and heterologous cell systems.

31 2-hydroxyglutarate, both in tumors and in a heterologous cell-based assay designed to functionally e

32 evidence of stable homodimers of SERCA2a in heterologous cells and cardiomyocytes.

33 ansport of GluK2 in the secretory pathway in heterologous cells and primary neurons.

34 With functional characterizations in both heterologous cells and rodent cortical neurons by patch-

35 FAT coimmunoprecipitated when coexpressed in heterologous cells, and the LZ mutation disrupted this a

36 In heterologous cells, mutant receptors had enhanced NMDA r

37 the proper trafficking of TMC1 to the PM in heterologous cells.

38 e trafficking to the plasma membrane (PM) in heterologous cells.

39 vitro and CaMKII association with Shank3 in heterologous cells.

40 rth mutants on TRPM7 ion channel function in heterologous cells.

41 nto a heterologous receptor and expressed in heterologous cells.

42 unique pseudo-heterodimer PfCCT protein in a heterologous cellular context using the thermosensitive

43 ght (VHMW)] by expressing in F. tularensis a heterologous chain-length regulator gene (wzz) from the

44 T cells, H5N1 (2:6) was protected against a heterologous challenge from H3N2 virus (X31).

45 ion-induced cytidine deaminase (AID) between heterologous challenges of West Nile, Japanese encephali

46 n to being protective against homologous and heterologous challenges, the rabbit antibodies significa

47 VE was assessed by heterologous CHMI after 12 or 24 weeks.

48 s (multi-dose priming) showed 40% VE against heterologous CHMI, while dose escalation of PfSPZ using

49 ver vascular niche comprise the formation of heterologous communication hubs in which tumor cell-deri

50 ver vascular niche comprise the formation of heterologous communication hubs in which tumor cell-deri

51 Heterologous competition-binding experiments indicated t

52 ing filoviruses (Ebola, Sudan, Marburg) or a heterologous contemporary lineage II strain of LASV.

53 ork found that ScThi5 functioned poorly in a heterologous context.

54 is sufficient to drive readthrough even in a heterologous context.

55 blic health risk, we evaluated the levels of heterologous cross-reactive antibodies to A(H3N2)v clust

56 % of the subjects demonstrated reactivity to heterologous CSP and MSP-1(42), and a similar proportion

57 inomatous and sarcomatous elements including heterologous differentiation, yielding a faithful geneti

58 are vital weapons for prokaryotes to resist heterologous DNA and survive from the constant invasion

59 was observed that the proteins possessing a heterologous donor strand, derived from the CS6 subunit

60 In particular, the heterologous EBNA1-expressing adenovirus, boosted by EBN

61 pe glycoprotein (GP), do not protect against heterologous ebolaviruses.

62 Heterologous, ectopic expression of a plant bipartite si

63 BCG vaccination has beneficial nonspecific (heterologous) effects that protect against nonmycobacter

64 symptoms among children acquiring partially heterologous emm types belonging to a previously detecte

65 desorption/ionization (MALDI) analyses, and heterologous enzyme production identified the lactonase

66 The heterologous enzymes are generally less active than thei

67 BIA pathways in microorganisms by combining heterologous enzymes can also give access to BIAs throug

68 nd Mycobacterium tuberculosis gyrases and of heterologous enzymes reconstituted from subunits of two

69 ect this posttranslational modification in a heterologous experimental system and also in planta.

70 Through genetic, metabolomic, and heterologous expression analyses, we established their c

71 Here, we used bioinformatics, genetics, heterologous expression and biochemical experiments to i

72 lyses of Grin1 variants have been done using heterologous expression and the in vivo function of Grin

73 ene expression patterns, in combination with heterologous expression assays and analyses of CRISPR/Ca

74 Heterologous expression experiments in the defective yea

75 antiapoptotic role of these five IAPs using heterologous expression in a tractable in vivo model, th

76 We demonstrate through heterologous expression in Arabidopsis thaliana that LuT

77 Here, we report the cloning and heterologous expression in camelina (Camelina sativa) of

78 from purified protein components followed by heterologous expression in E. coli and spectroscopic ana

79 ate extraordinary substrate tolerance during heterologous expression in E. coli and upon purification

80 n on the activity of the A(1)-receptor after heterologous expression in HEK293 cells.

81 redominantly studied in planta because their heterologous expression in microbial systems is problema

82 suberin-related genes was induced by ShMYB78 heterologous expression in Nicotiana benthamiana leaves.

83 Heterologous expression in Saccharomyces cerevisiae reve

84 Direct cloning allowed for rapid heterologous expression in Streptomyces coelicolor, lead

85 ing horizontal gene transfer in the wild and heterologous expression in the lab.

86 1), was characterized functionally following heterologous expression in Xenopus oocytes, and mediates

87 nsor IRE1alpha, that are required for robust heterologous expression of alpha6beta4, an nAChR subtype

88 Heterologous expression of an ATPase inhibitor completel

89 isms, potentially providing clues to improve heterologous expression of antibiotics.

90 Heterologous expression of AoCYP94B1 in the atcyp94b1 Ar

91 ticipate this host system will be useful for heterologous expression of BGCs from anaerobic bacteria.

92 Here, heterologous expression of both SOR and membrane-bound t

93 Our results demonstrate that heterologous expression of DvABCB1 in Sf9 and HEK293 cel

94 lbox and providing the possibility for rapid heterologous expression of gene clusters from Streptomyc

95 Heterologous expression of homologous lbtA from Legionel

96 e utilization, which can be corrected by the heterologous expression of human MCUR1.

97 Heterologous expression of human membrane proteins is a

98 nerated a similar Rad3 signaling defect, and heterologous expression of human RECQ1, BLM, and RECQ4 r

99 Heterologous expression of MtTPS10 in yeast led to produ

100 in a truncated protein as shown in vitro by heterologous expression of mutant M1AP.

101 he activation kinetics of Na(V) channels and heterologous expression of Na(V)1.2 in HEK-293 cells rev

102 rd piecing together a viable pathway for the heterologous expression of nitrogenase and identifying v

103 logy with NifDK, is a major challenge in the heterologous expression of nitrogenase.

104 Further experiments suggested that heterologous expression of OsPIP1;3 in cyanobacterium al

105 Heterologous expression of OsWAKL21.2 in Arabidopsis (Ar

106 Heterologous expression of the CMT-associated PMP22_L16P

107 channel remain poorly characterized because heterologous expression of this ion channel yields only

108 Heterologous expression of this protein in PIEZO1-defici

109 Heterologous expression of TspA from S. aureus strain RN

110 Conversely, heterologous expression of TSPAN-7 with Ca(V) 1.2 and Ca

111 Heterologous expression of unc-7 in touch-insensitive ch

112 l pathway requiring amidohydrolase CbiZ, and heterologous expression of V. cholerae CobS was sufficie

113 Heterologous expression of wild-type, but not phosphatas

114 Moreover, the heterologous expression of zebrafish alpha9 subunits ind

115 Heterologous expression of ZmMYB167 in the C(3) model sy

116 In a heterologous expression system, Mel activates the human

117 1.3 from primary human beta-cells and from a heterologous expression system.

118 orm heteromeric channels when expressed in a heterologous expression system.

119 n Slo2.2/Slack P(o) is doubled by SCYL1 in a heterologous expression system.

120 to epilepsy are poorly understood, although heterologous expression systems and mouse models have de

121 asis for the low level of Nav1.9 currents in heterologous expression systems is not understood.

122 miscuous inhibition by Gbetagamma protein in heterologous expression systems, primary neurons and in

123 When tethered to RNAs in heterologous expression systems, RDE-3 can add long stre

124 ffects of drugs on human cardiac currents in heterologous expression systems.

125 liary subunit for the trafficking of Cx43 in heterologous expression systems.

126 ariety of preparations, including native and heterologous expression systems.

127 r alpha6beta4 nAChR-selective agonists using heterologous expression systems.

128 and functional consequences were explored in heterologous expression systems.

129 tulate native hippocampal A-type currents in heterologous expression systems.

130 eteromeric K(+) channel-mediated currents in heterologous expression systems; (ii) molecular dynamics

131 We use heterologous expression to functionally reconstitute hum

132 oot hair phenotype of other Atget lines, its heterologous expression together with the coreceptor AtG

133 Here we describe the construction, heterologous expression, and actions of a synthetic huma

134 lcemia-associated missense variants impaired heterologous expression, plasma membrane targeting, and/

135 Using heterologous expression, we show that the T415N substitu

136 includes a novel lncRNA predictor using the heterologous features we designed.

137 d with components of the T2SS that allow for heterologous fibre assembly.

138 vity between the virus-specific antisera and heterologous filovirus antigens.

139 format, utilizing a backbone derived from a heterologous flavivirus (such as YF) as a delivery vecto

140 duce antibody-dependent enhancement (ADE) of heterologous flavivirus infection.

141 Thus, the use of heterologous flavivirus species as a live attenuated vac

142 c autologous fusion/fission, did not undergo heterologous fusions in gsm1 or gsp1 zygotes.

143 cers have revealed their potential to direct heterologous gene expression in a highly cell-type-speci

144 nd that this activity can be imported into a heterologous gene locus.

145 pothesized cell cycle-dependent functions of heterologous genes by reporting the dynamics of encoded

146 of a lethal gene, and analyze corresponding heterologous genes.

147 Heterologous gO recombinants were constructed in which 6

148 In a yeast-based assay, where heterologous GPCRs are coupled to chimeric G proteins, E

149 A85A vaccinations 1 month apart using either heterologous (Group 1, aerosol-intradermal; Group 2, int

150 The activity pattern of heterologous gyrases is in agreement with structural fea

151 As was not excluded fully, and variants with heterologous HA packaging signals were detected at low l

152 However, incorporation of the heterologous HAs was not excluded fully, and variants wi

153 d antibodies that neutralized homologous and heterologous HCV genotypes, blocked the interaction betw

154 ation yielded a hypofusogenic phenotype, the heterologous HeV F/NiV G (HF/NG) combination yielded a h

155 nst the SHIV1157ipd3N4 challenge virus and a heterologous HIV-1 CRF01 Env, CNE8.

156 constituting initial biosynthetic steps in a heterologous host and generating transgenic pathway muta

157 site Cu(A) Depending on source organism, the heterologous host E. coli can, in some cases, compensate

158 We employed Caenorhabditis elegans as a heterologous host to understand the temporal dynamics of

159 M and THM when individually expressed in the heterologous host, Mycobacterium smegmatis mc(2)-155.

160 c library using Lactococcus lactis MG1363 as heterologous host.

161 (BCM), facilitating improved production in a heterologous host.

162 , and expression of reconstructed operons in heterologous hosts has confirmed that most pathways are

163 though EcLamB-dependent in their recombinant heterologous hosts, these newly isolated ZZ phages also

164 oduction of diosgenin and derived analogs in heterologous hosts.

165 ical and other applications by expression in heterologous hosts.

166 aimed primarily at evaluating the safety of Heterologous Human Adult Liver-derived Progenitor Cells

167 s achieved by double-stranded breaks made by heterologous I-CeuI endonuclease and the degradation act

168 packaging signals limit reassortment between heterologous IAV strains in a segment-dependent manner.

169 These data indicate that the modulation of heterologous immune responses is induced by vaccination

170 Virus-induced heterologous immunity is considered a barrier to transpl

171 Our findings challenge the notion that heterologous immunity is necessarily detrimental in LT a

172 e is epidemiological proof that these impair heterologous immunity.

173 The use of heterologous immunization regimens and improved vector s

174 Using heterologous in vivo assays and mutagenesis, we demonstr

175 (inactivated Pitman Moore rabies virus) and heterologous (inactivated vesicular stomatitis virus) an

176 infection alters the response to subsequent heterologous infection, inducing an exaggerated asthma-l

177 infection alters the response to subsequent heterologous infection, inducing an intensified asthma-l

178 ctivation by proinflammatory cytokines after heterologous infection.

179 uld be safe, and effectively protect against heterologous infection.

180 ential for BCG to provide protection against heterologous infections, by induction of innate immune m

181 oral immunity can impact immune responses to heterologous infections.

182 unity, contributes toward protection against heterologous infections.

183 erin (BCG) contributes to protection against heterologous infections.

184 M. tuberculosis is associated with enhanced heterologous innate immune responses similar to those ac

185 We employ a heterologous media-independent induction system to expre

186 aluable tool for fast and flexible design of heterologous metabolic pathways for plastid metabolic en

187 translation and controlling polyA lengths of heterologous mRNAs.

188 Using a heterologous NHE6-deficient cell expression system, we s

189 Surprisingly, however, while the heterologous NiV F/HeV G (NF/HG) combination yielded a h

190 We show that NPA inhibits PIN activity in a heterologous oocyte system and that expression of NPA-se

191 Abs did not recapitulate the full breadth of heterologous or autologous virus neutralization by conte

192 The heterologous overexpression of this esterase proved a re

193 mimicking hypoxia, ruling out an artifact of heterologous overexpression.

194 Specifically, the heterologous overproduction of six Apd6 enzymes demonstr

195 fusogenic capacities between homologous and heterologous pairs of NiV and HeV glycoproteins.

196 Using a more stringent CHMI, with heterologous parasites (different Pf strain), we assesse

197 n and BCG vaccination on B cell responses to heterologous pathogen recall antigens.

198 ociated with increased antibody responses to heterologous pathogens in human subjects.

199 n did not alter levels of antibodies against heterologous pathogens.

200 biosynthetic pathway to 1 was established by heterologous pathway reconstitution in A. nidulans, whic

201 KS modules bearing exchanged TE domains from heterologous pathways and challenged them with both nati

202 or automating the identification of possible heterologous pathways; however, these searches may retur

203 lays a fully reversed selectivity toward the heterologous pheromone with only five point mutations, a

204 C can also contribute to agonist-induced and heterologous phosphorylation.

205 The analysis of a wide representation of heterologous plant species corroborated that two of the

206 le-cell electrophysiology, we show here that heterologous PMP22 expression increases the amplitude of

207 ast, cell-based signaling assays showed that heterologous polymerizing domains functionally substitut

208 poxvirus NYVAC-HIV vectors in homologous or heterologous prime-boost combinations in mice.

209 on a new duck cell line either alone or in a heterologous prime-boost regimen with recombinant chimpa

210 Heterologous prime-boost regimens have been shown to eli

211 Heterologous prime-boost regimens induce potent cellular

212 The standard and accelerated heterologous prime-boost regimens were well-tolerated an

213 t human randomised clinical trial to explore heterologous prime-boost regimes using aerosol and syste

214 findings support further development of this heterologous prime-boost strategy.IMPORTANCE Immune resp

215 tance of selecting optimal priming agents in heterologous prime-boost vaccination settings.

216 Our study shows that such heterologous prime-boost vaccinations against EBV-associ

217 Heterologous prime/boost viral vectored vaccination has

218 rodent models expressing small ruminants or heterologous prion proteins.

219 biosynthetic pathway has facilitated stable heterologous production of betalains in several plant an

220 ield, exploring new host organisms for their heterologous production, and engineering their secretion

221 ntly of orientation and whether located in a heterologous promoter or intron.

222 infections, indicating that T. ovis confers heterologous protection against lethal T. lestoquardi in

223 shown to reduce disease severity and provide heterologous protection.

224 that have the potential to confer antiviral heterologous protection: innate-induced trained immunity

225 hat NHR2 and NHR4 domains can be replaced by heterologous protein domains conferring tetramerization

226 s one of the most widely used host cells for heterologous protein expression in structural biological

227 recombinant viruses that express a separate heterologous protein in addition to the 12 viral protein

228 rus gains the capacity to express a separate heterologous protein in addition to the full complement

229 o-chloroplasts accumulate the same amount of heterologous protein than wild-type organelles, confirmi

230 g a reverse-engineered influenza virus and a heterologous protein vaccination and infection challenge

231 e to generate recombinant viruses encoding 2 heterologous proteins (mRuby and UnaG) in addition to NS

232 t this peptidic degron can be used to target heterologous proteins for destruction with IMiDs in a ti

233 insights into the structure and function of heterologous proteins in the physiological intracellular

234 bind single-stranded DNA and help to recruit heterologous proteins to their sites of action.

235 ll complement of viral proteins and multiple heterologous proteins.

236 ble but retains the ability to interact with heterologous proteins.

237 rus infections and vectors for expression of heterologous proteins.IMPORTANCE Chikungunya virus is an

238 In addition, in trans complementation using heterologous RanBP genes from Aspergillus nidulans was s

239 The presence of long-lived and heterologous reactivity and its functional significance,

240 e phagosomal damage even when spliced into a heterologous receptor and expressed in heterologous cell

241 nexplored by biophysical techniques as their heterologous recombinant expression poses significant di

242 f collaborating IPKSs was investigated using heterologous reconstitution and biochemical studies.

243 of compounds in the citridone family through heterologous reconstitution of the pfp pathway.

244 By systematic defense gene prediction and heterologous reconstitution, here we discover 29 widespr

245 post-dose 2; responses were higher following heterologous regimens.

246 tect against disease following homologous or heterologous reinfection.

247 8) of the recurrent parasites resulted from heterologous relapses whose 50% are from by sibling/reco

248 This study investigated heterologous responses in 167 infants in the same trial

249 gous challenges as well as a multi-factorial heterologous risk enhancement.

250 d able to accommodate significant amounts of heterologous RNA sequence, raising the possibility of us

251 ologous RV, infection with a STAT1-sensitive heterologous RV strain induced IFN-stimulated transcript

252 ay effectively suppresses the replication of heterologous RV strains.

253 against sepsis caused by both homologous and heterologous S. pneumoniae strains.

254 Heterologous self-association domain cryptochrome 2 prom

255 Insertion of heterologous sequences into rDNA leads to repression ass

256 cGMP-based luciferase assay that reports on heterologous sGC activity in Escherichia coli and identi

257 onses and fail to enhance protection against heterologous SHIV challenge.IMPORTANCE HIV, the virus th

258 ation of human CD4(+) Th17 cells that harbor heterologous specificity for other fungi, which may expl

259 o interrogate in vitro cytokine responses to heterologous stimulants (killed pathogens) and Toll-like

260 birth alters in vitro cytokine responses to heterologous stimulants in the neonatal period.

261 eased production of IFN-gamma in response to heterologous stimulation and TLR ligands.

262 duced changes in other cytokine responses to heterologous stimulation vary by pathogen.

263 ced more proinflammatory cytokines following heterologous stimulation with Escherichia coli and Strep

264 ds to changes in IFN-gamma responsiveness to heterologous stimulation.

265 IIV), but neutralizing antibody responses to heterologous strains have not been extensively character

266 es from volunteers and NHPs that neutralized heterologous strains of HCV primarily interacted with ep

267 Seroresponse rates to homologous and heterologous strains were lower in subjects vaccinated w

268 higher seroresponse rates to homologous and heterologous strains, and their sera generated larger an

269 Crystal structures, in vitro, and heterologous studies have fueled a model in which ARF di

270 Three booster immunizations with a heterologous subtype C trimeric gp140 protein vaccine we

271 event efficient functional interactions with heterologous subunits.

272 ed a combination of comparative genomics and heterologous synthetic misexpression to isolate function

273 ctivity of chlamydial DapF in vitro and in a heterologous system (Escherichia coli).

274 In both Arabidopsis and a heterologous system, ELF3 fused with green fluorescent p

275 its phosphorylation by CotH in vivo and in a heterologous system.

276 s the dynamics of Z rings reconstituted in a heterologous system.

277 ever, low functional expression of Nav1.9 in heterologous systems (e.g. in human embryonic kidney 293

278 tatin-specific Rab-GTPase inhibition both in heterologous systems and cardiomyocytes.

279 0 kDa fragment that is also observed in some heterologous systems and may have a significant role in

280 of promising anti-microbial therapeutics in heterologous systems.

281 human can all function as a cold receptor in heterologous systems.

282 h autologous and select high mannose-bearing heterologous tier 2 pseudoviruses than those immunized w

283 tibodies that occasionally cross-neutralized heterologous tier 2 viruses, sometimes at high titer.

284 associated with increased neutralization of heterologous tier 2 viruses.IMPORTANCE Engineered SOSIP

285 mutant with various forms of TPS1 and with a heterologous TPS (OtsA) from Escherichia coli, under the

286 ltransferase via trafficking to the vacuole, heterologous transporters to facilitate intracellular ro

287 ralizing breadth elicited by boosting with a heterologous trimer containing the second most prevalent

288 s could bind to sites on both autologous and heterologous trimers.

289 Heterologous two-dose Ad26,MVA regimens containing an EB

290 urally acquired protection against partially heterologous types suggests that emm type-based vaccines

291 By analyzing interstrain heterologous UL74(gO) recombinants, we showed that gO di

292 A/MVA vaccination do not significantly boost heterologous V1V2 and V2 HS responses and fail to enhanc

293 icient strain of Escherichia coli expressing heterologous VcChiP could grow on M9 minimal medium supp

294 to worsened pathologic findings on secondary heterologous viral challenge, whereas the reversed infec

295 responses, which protect against subsequent heterologous viral challenge.

296 erally associated with protection but in the heterologous viral vector + nAb group, titers <300 were

297 her alone to induce nAbs, or together with a heterologous viral vector regimen to elicit nAbs and cel

298 l combinations utilizing N and L proteins of heterologous viruses resulted in M segment minigenome ac

299 ed to improvement of cross-neutralization of heterologous viruses.

300 eered to utilize xylose through expressing a heterologous xylose catabolizing pathway.