ライフサイエンスコーパス: hibernating

1 laviventer), which spend 7-8 months per year hibernating.

2 The bacterial hibernating 100S ribosome is a poorly understood form of

3 Bacterial hibernating 100S ribosomes (the 70S dimers) are excluded

4 584 segments, 24% (n = 140) were labeled as hibernating; 23% (n = 136) as stunned; 30% (n = 177) as

5 mine, was observed in 83% of stunned, 59% of hibernating, 35% of remodeled and 13% of scarred myocard

6 l because only 55% of segments classified as hibernating actually improved resting function after rev

7 Ascorbate levels in the CSF doubled in hibernating AGS (not determined in TLS), while brain asc

8 me, and hematological features of blood from hibernating and active free-ranging subadult brown bears

9 The brain tissue from hibernating and euthermic animals was examined 3 days af

10 utyric acid ([GABA](ecf)) in striatum of non-hibernating and hibernating arctic ground squirrels to t

11 e trabecular bone and bone marrow, comparing hibernating and summer active bears through sequencing o

12 se-3-like activity was not different between hibernating and summer kidneys.

13 nconsistent bloodstream amino acid supply by hibernating and waiting for more nutrient to be provided

14 d by fibrosis from that arising from viable (hibernating and/or stunned) myocardium has important imp

15 ptable mammals, spending up to half the year hibernating, and the remainder of the year attempting to

16 It may also be induced in nonhibernators via hibernating animal serum factors or delta-opiate peptide

17 emical findings were compared with untreated hibernating animals (n = 7), sham-normal animals (n = 5)

18 amatically attenuated around probe tracks in hibernating animals compared to euthermic controls.

19 respect from nature: Diving, burrowing, and hibernating animals living in diverse environments are m

20 While many animals, such as hibernating animals or migrating birds, evolved strategi

21 similarities between calorie-restricted and hibernating animals suggest the effects of CR may be par

22 shutdown of cellular functions that permits hibernating animals to tolerate severe reductions in cer

23 Kidneys from both summer and hibernating animals tolerated ex vivo CI, confirming tha

24 SCs were observed postsynaptic to cones from hibernating animals, although depolarized cones were abl

25 ernation confers radio-protective effects in hibernating animals, and this has led to the investigati

26 mans are lacking, several reports, mainly on hibernating animals, demonstrated that melatonin supplem

27 An uncharacterized factor derived from hibernating animals, hibernation induction trigger (HIT)

28 34 interactions were disrupted in brain from hibernating animals, in which eIF-2alpha was highly phos

29 imer-like phosphorylation is also present in hibernating animals, mitosis, or during embryonic develo

30 In hibernating animals, reduction of immunoreactive phospho

31 tolerance to cerebral ischemia exhibited by hibernating animals.

32 earch and conservation strategies to benefit hibernating animals.

33 BA](ecf)) in striatum of non-hibernating and hibernating arctic ground squirrels to test the hypothes

34 neural microstructure from groups of animals hibernating at different ambient temperatures revealed t

35 Millions of hibernating bats across North America have died from whi

36 he overwintering behaviors of North American hibernating bats are limited to a handful of species.

37 Population estimates of hibernating bats are often calculated by researchers ent

38 ose syndrome (WNS) is an emerging disease of hibernating bats associated with cutaneous infection by

39 drome (WNS) is an emerging disease affecting hibernating bats in eastern North America that causes ma

40 cause severe declines in several species of hibernating bats in North America.

41 We show, in hibernating bats infected with Geomyces destructans, tha

42 xiting activity after arousal from torpor of hibernating bats is important for bat ecology and conser

43 nt wildlife fungal disease of cave-dwelling, hibernating bats that has led to unprecedented mortaliti

44 ts a pronounced northward range expansion of hibernating bats within the next 80 years.

45 activity increased with increasing number of hibernating bats, but more so for western small-footed m

46 ctivity differed by species, cave, number of hibernating bats, moon phase, and weather variables.

47 proliferates at low temperatures and targets hibernating bats, resulting in their premature arousal f

48 s (Pd) has killed millions of North American hibernating bats.

49 uctans on the skin (including the muzzle) of hibernating bats.

50 cal response to disuse and malnutrition, but hibernating bears are largely resistant to this phenomen

51 In contrast, hibernating bears show no bone loss over the prolonged p

52 on and delayed recovery of metabolic rate in hibernating bears suggest that the majority of metabolic

53 hat fast during lactation, such as seals and hibernating bears.

54 f bone formation and osteoblast signaling in hibernating bears.

55 murs of Madagascar are obligate hibernators, hibernating between 3 and 7 months a year.

56 sured metabolic rate and body temperature in hibernating black bears and found that they suppress met

57 Administration of serum derived from hibernating black bears to rabbits affords protection ag

58 ranscription-PCR products from euthermic and hibernating brain and compared them using differential d

59 as reduced 3-fold in cell-free extracts from hibernating brain at 37 degreesC, eliminating hypothermi

60 rpose of this study was to determine whether hibernating brain tissue is tolerant to penetrating brai

61 of the catalytic subunit of PP2A (PP2A/C) in hibernating brains and livers.

62 oxically, long-term immobilized free-ranging hibernating brown bears and paralyzed spinal cord injury

63 an antithrombotic signature in platelets of hibernating brown bears with heat shock protein 47 (HSP4

64 Among patients with ischemic cardiomyopathy, hibernating, but not ischemic, myocardium identifies whi

65 Hibernating cardiomyocytes are reversibly hypocontractil

66 illustrate a predominant use of the site by hibernating cave bears and denning hyaenas, coupled with

67 eds of thousands of individual RBCs from the hibernating common noctule bat (Nyctalus noctula), the n

68 approximately 124% and 99%, respectively, in hibernating compared with cold control preparations with

69 RNAP-delta-HelD)(2) structure that resembles hibernating eukaryotic RNAP I suggest that HelD might al

70 Thus, the torpid/awakening cycle of the hibernating European hamster causes a rapid and reversib

71 rrels that did not hibernate or had not been hibernating for several weeks.

72 one of euthermic (control), cold control and hibernating golden hamsters.

73 ignaling are regulated in skeletal muscle of hibernating grizzly bear.

74 mpared with hepatic transcriptomic data from hibernating grizzly bears (Ursus arctos horribilis) and

75 Isolated hibernating ground squirrel and mouse RTECs were subject

76 d for weeks in brain and other organs of the hibernating ground squirrel, Spermophilus tridecemlineat

77 uirrels (T(b) range 34.7-38.9 degrees C) and hibernating ground squirrels (T(b) range 2.9-3.9 degrees

78 BA](ecf) was determined in unrestrained, non-hibernating ground squirrels (T(b) range 34.7-38.9 degre

79 , suggest that light can reach the retina of hibernating ground squirrels maintained in the laborator

80 rites, and spines from several cell types in hibernating ground squirrels retract on entry into torpo

81 ng hibernation and arousal in two species of hibernating ground squirrels suggest that it could play

82 d shutdown of cellular function that permits hibernating ground squirrels to tolerate "trickle" blood

83 bular epithelial cells (RTECs) isolated from hibernating ground squirrels would be protected against

84 eriments, we looked at mlEPSCs from cones of hibernating ground squirrels, which exhibit dramatically

85 -2) was observed in the brains and livers of hibernating ground squirrels.

86 everal types of neurons in fixed slices from hibernating ground squirrels.

87 n cold controls and markedly enhanced in the hibernating group at all frequencies tested.

88 In the hibernating group, NTG alone improved wall thickening in

89 ificantly enhanced in both cold controls and hibernating groups, while vasoconstriction in response t

90 ificantly increased in the renal arteries of hibernating hamsters compared with controls, but not com

91 The ultrastructure of MFT in hibernating hamsters showed a significant reduction in s

92 y in the pancreas, but when expressed in the hibernating heart it liberates fatty acids from triglyce

93 val underlies the sustained viability of the hibernating heart.

94 on after revascularization in these areas of hibernating heart.

95 In hibernating hearts, icMSCs increased Ki67+ cardiomyocyte

96 y be related to the temperature range of its hibernating host.

97 teristics of the cardiac interstitium in the hibernating human myocardium and evaluate whether active

98 ular necrosis and apoptosis did not occur in hibernating kidneys.

99 g perfusion was significantly reduced in the hibernating LAD region in comparison with the normal rem

100 increased from 2.4+/-0.04 to 4.7+/-0.7 mm in hibernating LAD regions (P<0.05) whereas remote wall-thi

101 muscle of arctic ground squirrels, comparing hibernating (late in a torpor and during torpor re-entry

102 , we used convergent evolutionary changes in hibernating lineages to define conserved cis-regulatory

103 and a long-term (1976-2008) data set from a hibernating mammal (the yellow-bellied marmot) inhabitin

104 of the dynamics of the body temperature of a hibernating mammal is presented.

105 c comparative method applied to more than 20 hibernating mammalian species, we found support for both

106 Hibernating mammals are remarkable for surviving near-fr

107 shortage and/or reduced ambient temperatures hibernating mammals become heterothermic, allowing their

108 Torpor in hibernating mammals defines the nadir in mammalian metab

109 In contrast, hibernating mammals demonstrate limited muscle loss over

110 Neurons in hibernating mammals exhibit a dramatic form of plasticit

111 Hibernating mammals possess a unique ability to reduce t

112 Hibernating mammals survive for periods up to 6 mo in th

113 emonstrate that resting myosin is altered in hibernating mammals, contributing to significant changes

114 In hibernating mammals, cooling induces loss of synaptic co

115 ypothermic and hypometabolic torpid state in hibernating mammals, we investigated the potential for t

116 uction and energy expenditure in infants and hibernating mammals-also exists in adult humans.

117 has been shown to be cerebral protective in hibernating mammals.

118 Apoptotic myocytes were observed in the hibernating myocardial region in all pigs (4.8 +/- 2.3%)

119 vidence for a local inflammatory reaction in hibernating myocardial segments from patients undergoing

120 sion imaging detects impaired resting MBF in hibernating myocardial segments.

121 ly perfused remote regions from animals with hibernating myocardium (32+/-7%).

122 20+/-77 myocytes per 10(6) myocyte nuclei in hibernating myocardium (P<0.05).

123 nt in LVEF was associated with the volume of hibernating myocardium (viable myocardium with contracti

124 coronary artery (LAD) stenosis that produced hibernating myocardium after 3 months.

125 licits a gene program of survival protecting hibernating myocardium against cell death.

126 ibitory cytokines are elevated in regions of hibernating myocardium and account in part for the depre

127 GF-5 may afford a way to restore function in hibernating myocardium and ameliorate heart failure in c

128 renergic receptor densities occur in viable, hibernating myocardium and may account in part for the o

129 period (P<0.05 versus untreated animals with hibernating myocardium and normal shams).

130 Swine with hibernating myocardium arising from a chronic left anter

131 that can accurately determine the amount of hibernating myocardium as well as the presence and degre

132 re is evidence to suggest that patients with hibernating myocardium benefit most from revascularizati

133 coplasmic reticulum proteins were present in hibernating myocardium but absent in stunned myocardium

134 thickening at low-dose DSE may be limited in hibernating myocardium by severe hypoperfusion.

135 umented with a proximal LAD stenosis develop hibernating myocardium characterized by relative reducti

136 ysiological and molecular characteristics of hibernating myocardium develop rapidly after a critical

137 Hibernating myocardium developed a significant downregul

138 Previous studies have suggested that hibernating myocardium eventually results in progressive

139 proved clinically useful for distinguishing hibernating myocardium from irreversibly injured myocard

140 nuclear density to 995+/-100 nuclei/mm(2) in hibernating myocardium from the instrumented group versu

141 fter 2 weeks, when physiological features of hibernating myocardium had developed.

142 acked necrosis, might have been mistaken for hibernating myocardium had only histology been evaluated

143 rsibility of protein changes that develop in hibernating myocardium have an impact on functional reco

144 Although humans and swine with hibernating myocardium have an increased risk of sudden

145 al function and heart failure, dysfunctional hibernating myocardium improves after pravastatin.

146 Hibernating myocardium in patients with collateral-depen

147 ced flow and increased FDG characteristic of hibernating myocardium in similarly instrumented pigs af

148 Delayed recovery of hibernating myocardium in the absence of scar may reflec

149 Previous studies of hibernating myocardium in the fasting state have shown r

150 cyte >10%) and increased glycogen typical of hibernating myocardium in the LAD region (33+/-3% of myo

151 New modalities to detect hibernating myocardium include 99mTc-sestamibi, contrast

152 lts indicate that icMSCs improve function in hibernating myocardium independent of coronary flow or r

153 Several models purported to represent hibernating myocardium involve a coronary stenosis (CS)

154 The diagnosis of hibernating myocardium involves (a) documenting left ven

155 These data support the notion that hibernating myocardium is a pathophysiological substrate

156 Hibernating myocardium is a state of persistently impair

157 Hibernating myocardium is accompanied by a downregulatio

158 his study was performed to determine whether hibernating myocardium is adaptive or is destined to und

159 lation of oxygen consumption and function in hibernating myocardium is an adaptive response that prev

160 Hibernating myocardium is associated with persistent red

161 Hibernating myocardium is characterized by reduced regio

162 ata indicate that the proteomic phenotype of hibernating myocardium is dynamic and has similarities t

163 0.65+/-0.08 (mean+/-SEM) mL.min(-1).g(-1) in hibernating myocardium of instrumented pigs compared wit

164 F-A improves contractile function of chronic hibernating myocardium of pigs to a level comparable to

165 on tomography identified ischemia, scar, and hibernating myocardium on the survival benefit associate

166 Swine with chronic hibernating myocardium received autologous intracoronary

167 Hibernating myocardium refers to chronically dysfunction

168 Thus, physiologic and structural features of hibernating myocardium remain constant for at least two

169 ster and more precise method for determining hibernating myocardium remains the holy grail of noninva

170 , can be initiated by regional dysfunctional hibernating myocardium resulting from a severe coronary

171 in function and oxygen consumption at rest, hibernating myocardium retains the ability to increase m

172 and the presence of ischemia and/or stunned/hibernating myocardium should be assessed for optimal ma

173 designed to study apoptosis in hypoperfused hibernating myocardium subtending severe coronary stenos

174 tricular dysfunction (LVD) may have areas of hibernating myocardium that improve functionally after r

175 gene expression is regionally upregulated in hibernating myocardium to a level intermediate between t

176 te the serial changes in the response of the hibernating myocardium to dobutamine stimulation after r

177 is heterogeneous, varying from predominantly hibernating myocardium to irreversible scarring.

178 f contractile reserve and thallium uptake in hibernating myocardium to myocardial structure in humans

179 descending artery (LAD) stenosis to produce hibernating myocardium underwent percutaneous revascular

180 egion (33+/-3% of myocytes from animals with hibernating myocardium versus 15+/-4% of myocytes from s

181 ascularization in the setting of significant hibernating myocardium was associated with improved surv

182 Human hibernating myocardium was characterized by an upregulat

183 Hibernating myocardium was characterized by severe regio

184 n the fasting state, FDG uptake in pigs with hibernating myocardium was heterogeneous and was increas

185 Although, originally, hibernating myocardium was identified by a mismatch betw

186 After 3 months (n=8), hibernating myocardium was present as reflected by reduc

187 The physiological substrate of hibernating myocardium was present before SCD, with redu

188 An interaction between treatment and hibernating myocardium was present such that early revas

189 At 3 months, physiological features of hibernating myocardium were confirmed, with depressed LA

190 MCE parameters of perfusion in hibernating myocardium were similar to segments with nor

191 The improvement of wall thickening of hibernating myocardium with NTG and dobutamine, from 23.

192 We previously produced hibernating myocardium with reduced resting flow in pigs

193 ing artery (LAD) stenosis to produce chronic hibernating myocardium with regional contractile dysfunc

194 f ischemic and dysfunctional myocardium (ie, hibernating myocardium) and infarct size were each indep

195 n reversible loss of cardiomyocyte function (hibernating myocardium), which is amenable to therapeuti

196 t persistent myocardial stunning can lead to hibernating myocardium, 13 pigs were chronically instrum

197 nal myocardium with reduced resting flow, or hibernating myocardium, after 3 mo.

198 emodeling in the cardiac interstitium of the hibernating myocardium, an important predictor of recove

199 There was no lactate production in hibernating myocardium, and lactate uptake increased dur

200 identification of candidates with regions of hibernating myocardium, because these patients stand to

201 measured the expression of survival genes in hibernating myocardium, both in patients surgically trea

202 hat dobutamine echocardiography can identify hibernating myocardium, but laboratory studies suggest t

203 Hibernating myocardium, characterized by reductions in f

204 In hibernating myocardium, icMSCs increased function (perce

205 ion in coronary BF in conscious pigs induced hibernating myocardium, ie, perfusion-contraction matchi

206 Hibernating myocardium, ischemic myocardium, and scarred

207 In hibernating myocardium, MIBG deposition was decreased in

208 Using an established model of chronic hibernating myocardium, mini-swine underwent 90% proxima

209 this preclinical swine model of ischemic and hibernating myocardium, the combined delivery of circula

210 t in perfusion reserve is well recognized in hibernating myocardium, there is substantial controversy

211 tensive defects in HED uptake were found for hibernating myocardium, with regional retention approxim

212 ion is attenuated in patients and swine with hibernating myocardium.

213 mpathetic norepinephrine uptake in pigs with hibernating myocardium.

214 survival of medically treated patients with hibernating myocardium.

215 entricular dysfunction are features of human hibernating myocardium.

216 ative to revascularisation for patients with hibernating myocardium.

217 lic adjustments could facilitate survival of hibernating myocardium.

218 r non-hibernators according to the volume of hibernating myocardium.

219 the excess mortality seen in the setting of hibernating myocardium.

220 the observed depression of function seen in hibernating myocardium.

221 l, molecular, and morphological phenotype of hibernating myocardium.

222 pinephrine uptake-1 mechanism is impaired in hibernating myocardium.

223 ta4 in a translational large animal model of hibernating myocardium.

224 he result of a mixture of scarred as well as hibernating myocardium.

225 tural adaptations was evaluated in pigs with hibernating myocardium.

226 ntadecanoic acid (IPPA), to identify viable, hibernating myocardium.

227 EGF(165) GTx may successfully rescue foci of hibernating myocardium.

228 n PET has been used successfully to diagnose hibernating myocardium.

229 cardium having the physiological features of hibernating myocardium.

230 nctional recovery after revascularization in hibernating myocardium.

231 nse to dobutamine have been used to identify hibernating myocardium.

232 ventricular arrhythmias, and reperfusion of hibernating myocardium.

233 ustained, the result is necrosis rather than hibernating myocardium.

234 gh-dose dobutamine from inducing ischemia in hibernating myocardium.

235 has been increasingly used for detection of hibernating myocardium.

236 rapeutic efficacy in a large animal model of hibernating myocardium.

237 stenosis and to 78+/-17 mL 7 days later with hibernating myocardium.

238 th through myocyte apoptosis in hypoperfused hibernating myocardium.

239 inducing deterioration of wall thickening in hibernating myocardium.

240 by inducing angiogenesis and regeneration in hibernating myocardium.

241 injected transendocardially in the areas of hibernating myocardium.

242 s using a clinically relevant swine model of hibernating myocardium.

243 ncreasing myocardial perfusion in swine with hibernating myocardium.

244 resting myocardial blood flow is reduced in hibernating myocardium.

245 d stability of sympathetic dysinnervation in hibernating myocardium.

246 d for at least 2 mo after the development of hibernating myocardium.

247 ) to improve flow and function in swine with hibernating myocardium.

248 titative CMR perfusion imaging is reduced in hibernating myocardium.

249 beta-receptor adenylyl cyclase signaling in hibernating myocardium.

250 Many of these patients have "hibernating" myocardium secondary to chronic ischemia wi

251 reas of nonfunctional but viable (stunned or hibernating) myocardium can also contribute to the devel

252 he reversibility of molecular adaptations of hibernating myocytes.

253 EF might be mediated by improved function of hibernating or ischaemic myocardium, or both.

254 ntractile myocardium, which is distinct from hibernating or stunned myocardium.

255 ersibly hypocontractile myocardium as simply hibernating or stunned.

256 ars and garden dormice during the vulnerable hibernating period.

257 murs (genus Cheirogaleus), the only obligate hibernating primate.

258 factors ribosome modulation factor (RMF) and hibernating promoting factor (HPF) were shown to directl

259 ed transmural variation in FDG uptake in the hibernating region (LAD/normal), which averaged 2.5 +/-

260 p, NTG alone improved wall thickening in the hibernating region modestly from 11.4+/-7.2% at baseline

261 in(-1)) dobutamine on wall thickening in the hibernating region.

262 zation may be an adaptive mechanism in such "hibernating" regions.

263 cterize dysfunctional myocardium as stunned, hibernating, remodeled and nonviable.

264 This study is the first of its kind in a hibernating reptile and provides key insight into this e

265 Hibernating ribosomes are formed by the activity of one

266 Notably, we show that hibernating ribosomes exclusively bind to the outer mito

267 Here we investigated eukaryotic hibernating ribosomes from the microsporidian parasite S

268 Replenishment of zinc to cells harboring hibernating ribosomes restores Mrf instability and disso

269 in situ structural analyses reveal that the hibernating ribosomes tether to fragmented mitochondria

270 We show that microsporidian spores contain hibernating ribosomes that are locked in a dimeric (100S

271 proteins, we determined that BPOET activates hibernating ribosomes via 23S rRNA pseudouridine synthas

272 peratures for brief intervals throughout the hibernating season.

273 a marker of active remodeling, was higher in hibernating segments than in segments with persistent dy

274 trophic effects extend to myoblasts from non-hibernating species (including C. elegans), as documente

275 duced a torpor-like state similar to that in hibernating species and characterized by a marked fall i

276 y plays a primary adaptive role which allows hibernating species to tolerate such phenomena.

277 ate to elicit therapeutic hypothermia in non-hibernating species, including humans.

278 iod of snow cover also have implications for hibernating species.

279 Hibernating squirrels alternate between periods of torpo

280 The results show that [GABA](ecf) in non-hibernating squirrels was 73 nM and this level was decre

281 In vivo fiber photometry of SON neurons from hibernating squirrels, together with RNA sequencing and

282 the changes from a state of activity to the hibernating state are poorly understood; however, the se

283 itiation, regulation, and maintenance of the hibernating state.

284 Myocardial segments were defined as hibernating, stunned, remodeled or scarred.

285 crobiome-mediated urea nitrogen recycling in hibernating thirteen-lined ground squirrels (Ictidomys t

286 hermoregulatory differences between mice and hibernating thirteen-lined ground squirrels (Ictidomys t

287 yzes the regulation of ischemic tolerance in hibernating thirteen-lined ground squirrels (Spermophilu

288 cantly reduced as was its kinase activity in hibernating thirteen-lined ground squirrels.

289 states and then used comparative genomics of hibernating versus nonhibernating lineages to identify c