ライフサイエンスコーパス: high endothelial venule

1 ct sites in the paracortex, particularly the high endothelial venule.

2 Glycam1 facilitates leukocyte entry through high endothelial venules.

3 ent on O-glycans of various glycoproteins in high endothelial venules.

4 er/Thr, functions as an L-selectin ligand in high endothelial venules.

5 heir inability to access lymphoid tissue via high endothelial venules.

6 n vivo, and firm adhesion but not rolling on high endothelial venules.

7 ia L-selectin dependent extravasation across high endothelial venules.

8 t trafficking to lymphoid tissue by means of high endothelial venules.

9 oss a specialized microvasculature, known as high endothelial venules.

10 helial cell lines derived from rat aorta and high endothelial venules.

11 erations in perivascular FRCs and associated high endothelial venules.

12 and lymph, entering the lymphoid tissue via high endothelial venules.

13 and with peripheral node addressin (PNAd) on high endothelial venules.

14 d on Peyer's patch and mesenteric lymph node high endothelial venules.

15 essed in the adult lymphatic endothelium and high endothelial venules.

16 ester core polysaccharide) and to lymph node high endothelial venules.

17 ng of naive T cells into lymph nodes through high endothelial venules.

18 supporting the rolling of lymphocytes along high endothelial venules.

19 ular matrix protein, HP8/HEVIN, expressed in high endothelial venules.

20 ipheral lymph node addressins on specialized high endothelial venules.

21 ent interactions with the natural ligands on high endothelial venules.

22 tive attachment of leukocytes to specialized high endothelial venules.

23 e of B cells, T cells, germinal centers, and high endothelial venules.

24 e of B and T cell clusters, fibroblasts, and high endothelial venules.

25 ritical for the formation of lymph nodes and high endothelial venules.

26 ymphatic vessels but also from blood, across high endothelial venules.

27 ymphangiogenesis, and extensive induction of high endothelial venules.

28 g networks of follicular dendritic cells and high endothelial venules.

29 62P, in a transient or sustained fashion, on high endothelial venules.

30 ffects on dendritic cells, stromal cells and high endothelial venules.

31 6-sulfo sialyl Lewis X L-selectin ligand in high endothelial venules.

32 arbohydrate ligand 6-sulfo sialyl Lewis X on high endothelial venules.

33 es and reduced sticking of lymphocytes along high endothelial venules.

34 phocytes to salivary and lacrimal glands via high endothelial venules; 3) clonal expansion of autoimm

35 ance through specialized blood vessels named high endothelial venules, a process that increases marke

36 (BV) in LN are highly specialized, featuring high endothelial venules across which most of the reside

37 tal life, when only MAdCAM-1 is expressed on high endothelial venules, an unusual subset of CD4 + CD3

38 ked into LNs from both blood and tissues via high endothelial venules and afferent lymphatics, respec

39 21 and CCL19, but not CXCL12, are located in high endothelial venules and are, therefore, in an appro

40 Similarly, in certain lymphoid tissues, high endothelial venules and basal and subcapsular epith

41 ar tLTs, comprising B- and T-cell areas with high endothelial venules and dendritic cells.

42 the systemic circulation through MAdCAM-1(+) high endothelial venules and efferent lymphatics, and ha

43 peripheral nodal addressin (PNAd)-expressing high endothelial venules and enriched in B and Foxp3(+)

44 contact with PDGF-DD-expressing cells in the high endothelial venules and epithelium of tonsils, mela

45 The mutant CD4(+) T cells adhered poorly to high endothelial venules and exhibited defects in lymph

46 tis (RA) synovial tissue (ST), often contain high endothelial venules and follicular dendritic cells

47 ion and transgenic Lta expression, TOLS lack high endothelial venules and germinal centers.

48 a marked decrease in lymphocyte sticking to high endothelial venules and in recruitment of resident

49 mphoid organ chemokine (SLC) is expressed in high endothelial venules and in T cell zones of spleen a

50 on leukocytes mediating leukocyte rolling in high endothelial venules and inflamed microvessels.

51 the mucosal addressin MAdCAM-1 on lymph node high endothelial venules and its counterreceptor, the Pe

52 enter lymph nodes through and migrate along high endothelial venules and later disperse and integrat

53 High endothelial venules and lymphatic endothelium expre

54 hoid organs and 6Ckine has been localized to high endothelial venules and lymphatic endothelium, we p

55 egates of immune and stromal cells including high endothelial venules and lymphatic vessels that rese

56 impaired T-lymphocyte extravasation through high endothelial venules and reduced subsequent parenchy

57 where relatively high shear forces exist in high endothelial venules and sinusoids, respectively.

58 mphocytes and dendritic cells and containing high endothelial venules and stromal cells.

59 lidated into organized lymphoid tissue, with high endothelial venules and stromal reticulum.

60 Ac6ST-2 in L-selectin ligand biosynthesis in high endothelial venules and their importance in immune

61 ased rats was vascularized by aquaporin-1(+) high endothelial venules and vascular cell adhesion mole

62 travital imaging to show that, after exiting high-endothelial venules and before entry into lymph nod

63 pleen, the endothelial cells of capillaries, high endothelial venule, and sinusoids produced abundant

64 M-1, VCAM-1, MAdCAM-1, and PNAd) features of high endothelial venules, and ability to respond to anti

65 in their cellular content and organization, high endothelial venules, and lymphatic vessels (LVs).

66 ed exclusively on the lymphatic endothelium, high endothelial venules, and rarely on adult vascular e

67 ny cortical sinuses are situated adjacent to high endothelial venules, and some lymphocytes access th

68 e expression patterns of laminin proteins in high endothelial venule basement membranes and the corti

69 d immunity, OT-II cells arrested on DCs near high endothelial venules beginning shortly after extrava

70 VE-JAM is prominently expressed on high endothelial venules but is also present on the endo

71 ansiently up-regulated in the endothelium of high endothelial venules by the inflammatory cytokine tu

72 cells to their ligands CD34 and CD54 on the high endothelial venule can be enhanced during inflammat

73 tic cells can migrate to lymph nodes through high endothelial venule cells, and chemokines and nonche

74 ated follicular gastritis and MALT lymphomas high endothelial venules coexpressed mucosal addressin c

75 node addressin and sialyl 6-sulfo Lewis X in high endothelial venules, considerably reduced lymphocyt

76 i-CD40L mAb and a targeting antibody against high endothelial venules, delivered the treatment into L

77 l-dependent tumor suppression while inducing high endothelial venule development and germinal center-

78 presence of L-selectin ligands on lymph node high endothelial venules does not affect lymphocyte homi

79 -25-hydroxylase (Ch25h) is upregulated in LN high endothelial venules during viral infection.

80 Aortic and high endothelial venule EC treated identically resulted

81 e draining lymph node includes the growth of high endothelial venule endothelial cells and is functio

82 Although high endothelial venules expressing peripheral lymph nod

83 cell compartmentalization, the formation of high endothelial venules, follicular dendritic cell netw

84 Lymphatic vessels, as well as high endothelial venules, form within these lymphoid agg

85 ignificance: LTbetaR mediates tumor-specific high endothelial venule formation and immunomodulation o

86 t1 deficiency reduced angiogenesis, enhanced high endothelial venule formation, and promoted antitumo

87 excessive collagen deposition, and increased high endothelial venule formation.

88 eucine-rich alpha2 glycoprotein/leucine-rich high endothelial venule glycoprotein, suppressor of cyto

89 antigen), an L-selectin ligand expressed on high endothelial venules, has been shown to require a mi

90 Hec-6st is a highly specific high endothelial venule (HEV) gene that is crucial for r

91 Secondary lymphoid-tissue chemokine (SLC), a high endothelial venule (HEV)-associated chemokine, has

92 ing and rolling of lymphocytes by binding to high endothelial venule (HEV)-expressed ligands during r

93 icular dendritic cells (DC), associated with high endothelial venules (HEV) and clusters of T cells a

94 cyte binding to lymph node and Peyer's patch high endothelial venules (HEV) and inhibits T-cell extra

95 duces adenosine from AMP and is expressed on high endothelial venules (HEV) and subsets of lymphocyte

96 The presence of high endothelial venules (HEV) and tertiary lymphoid str

97 High endothelial venules (HEV) are specialized plump pos

98 High endothelial venules (HEV) are specialized veins whi

99 All NALT high endothelial venules (HEV) expressed PNAd, either as

100 tes the initial attachment of lymphocytes to high endothelial venules (HEV) in lymph nodes.

101 sed also on vascular endothelium, especially high endothelial venules (HEV) in lymphoid organs, such

102 ated sialyl Lewis(x), which are expressed on high endothelial venules (HEV) in secondary lymphoid org

103 eated cremaster muscles and in Peyer's patch high endothelial venules (HEV) of Core2GlcNAcT-I null (c

104 lomucin ligands such as CD34 and GlyCAM-1 on high endothelial venules (HEV) of lymph nodes results in

105 Lymphocyte trafficking across high endothelial venules (HEV) of peripheral lymph nodes

106 phocytes (>95% inhibition) from attaching to high endothelial venules (HEV) of Peyer's patches and ot

107 cyte adhesion to addressins expressed in the high endothelial venules (HEV) of secondary lymphoid org

108 dhesion to carbohydrate ligands expressed on high endothelial venules (HEV) of the secondary lymphoid

109 kocyte rolling and adhesion in Peyer's patch high endothelial venules (HEV) of wild-type, L-selectin-

110 merged functional blood vessels develop from high endothelial venules (HEV), in which the proliferati

111 othelial cells lining gut post-capillary and high endothelial venules (HEV), providing a prototypical

112 of lymphocyte binding in vitro to lymph node high endothelial venules (HEV), specialized vessels that

113 remain unknown, particularly with regard to high endothelial venules (HEV).

114 r in chronically inflamed lymph nodes around high endothelial venules (HEV).

115 using L-selectin to bind specific ligands on high endothelial venules (HEV).

116 of T cells to secondary lymphoid organs via high endothelial venules (HEV).

117 ween circulating lymphocytes and specialized high endothelial venules (HEV).

118 sialomucin-like receptors on the surface of high endothelial venules (HEV).

119 ohydrate ligands expressed on the surface of high endothelial venules (HEV).

120 L-selectin ligands on peripheral lymph node high endothelial venules (HEV).

121 eractions with specific ligands presented on high endothelial venules (HEV).

122 endent adhesion of these cells to lymph node high endothelial venules (HEV).

123 normally initiated by L-selectin (CD62L) in high endothelial venules (HEV).

124 eviously described ligands for L-selectin on high endothelial venules (HEV).

125 f L-selectin ligands expressed by lymph node high endothelial venules (HEV).

126 and donor-specific cell location relative to high endothelial venules (HEV).

127 igh T-cell infiltration, and the presence of high endothelial venules (HEV).

128 l lymph node addressing (PNAd) and MAdCAM on high endothelial venules (HEV).

129 ral lymph node addressin (PNAd) presented on high-endothelial venule (HEV)-like vessels.

130 e were characterized by greater expansion of high endothelial venules (HEVs) and lymphatic vessels in

131 (LNCs) tethered and rolled in postcapillary high endothelial venules (HEVs) and to a lesser extent i

132 High endothelial venules (HEVs) are specialised postcapi

133 High endothelial venules (HEVs) are specialized blood ve

134 g lymph nodes across vascular portals termed high endothelial venules (HEVs) because of lack of expre

135 High endothelial venules (HEVs) developed that expressed

136 mentalization, antigen presenting cells, and high endothelial venules (HEVs) expressing mucosal addre

137 We show that high endothelial venules (HEVs) in BALT express substant

138 e recirculation and endothelial phenotype at high endothelial venules (HEVs) in lymph node cortex.

139 s for lymphocyte L-selectin are expressed on high endothelial venules (HEVs) in peripheral lymph node

140 ipheral lymph node addressin (PNAd)-positive high endothelial venules (HEVs) in relationship to the s

141 the tethering and rolling of lymphocytes on high endothelial venules (HEVs) in secondary lymphoid or

142 receptor, mediates rolling of lymphocytes on high endothelial venules (HEVs) in secondary lymphoid or

143 es home to peripheral lymph nodes (PLNs) via high endothelial venules (HEVs) in the subcortex and inc

144 microscopy, we find that B cell adhesion to high endothelial venules (HEVs) is disrupted when CCR7 a

145 eased binding of monocytes to perifollicular high endothelial venules (HEVs) of lymph nodes draining

146 ctin on lymphocytes with sulfated ligands on high endothelial venules (HEVs) of lymph nodes results i

147 in (PNAd), a set of sialomucins displayed on high endothelial venules (HEVs) of lymph nodes.

148 ectin initiates lymphocyte interactions with high endothelial venules (HEVs) of lymphoid organs throu

149 -selectin mediates rolling of lymphocytes in high endothelial venules (HEVs) of peripheral lymph node

150 Here, we demonstrate that high endothelial venules (HEVs) of the greater omentum c

151 How high endothelial venules (HEVs) permit lymphocyte transm

152 (ICAM-1) and CCL21 chemokine, exclusively in high endothelial venules (HEVs) that are chief portals f

153 tensively studied, little is known about how high endothelial venules (HEVs) within Peyer's patches (

154 These vessels, designated tumor high endothelial venules (HEVs), appear to facilitate tu

155 ture phenotype of peripheral lymph node (LN) high endothelial venules (HEVs), defined as MAdCAM-1(low

156 ell migration to LNs, their interaction with high endothelial venules (HEVs), specialized blood vesse

157 (CM) rolled and firmly adhered (sticking) in high endothelial venules (HEVs), whereas naive T cells w

158 L-selectin binding to sialomucin ligands in high endothelial venules (HEVs).

159 not CD8(IL-2) cells, rolled and arrested in high endothelial venules (HEVs).

160 numbers of blood-borne monocytes to LNs via high endothelial venules (HEVs).

161 between lymphocytes and endothelial cells in high endothelial venules (HEVs).

162 bility to initiate rolling along specialized high endothelial venules (HEVs).

163 er, remnant LNs showed impaired formation of high endothelial venules (HEVs).

164 ein in the LN cortical ridge (CR) and around high endothelial venules (HEVs).

165 lymph nodes by interacting with and crossing high endothelial venules (HEVs).

166 edominately used CCR7 signaling to adhere to high endothelial venules (HEVs).

167 dent firm adhesion to the luminal surface of high endothelial venules (HEVs).

168 issues and rare cognate T cells entering via high endothelial venules (HEVs).

169 attenuated integrin-mediated firm arrest in high endothelial venules (HEVs).

170 3(-/-) mice has peripheral node addressin(+) high endothelial venules (HEVs).

171 ation of postcapillary venules into inflamed high-endothelial venules (HEVs) via lymphotoxin/lymphoto

172 Lymphocytes are recruited from blood by high-endothelial venules (HEVs).

173 Small venules (high endothelial venules [HEVs]) in inflammatory lesions

174 t Rgs1-/- B cells stick better to lymph node high endothelial venules, home better to lymph nodes, an

175 reduced Tregs and dendritic cells, decreased high endothelial venules, impaired the conduit system, a

176 tion is dependent on direct contact with the high endothelial venule in inflamed lymph node.

177 ng the simultaneous visualization of LVs and high endothelial venules in a lymph node of a living mou

178 nd B cell zones or in close association with high endothelial venules in adult lymph nodes.

179 ) is selectively expressed on endothelium of high endothelial venules in gut and gut-associated lymph

180 te, much like lymphocytes via L-selectin and high endothelial venules in lymph nodes and demonstrates

181 s expressed by only a few tissues, including high endothelial venules in lymph nodes, but inflammator

182 tes and sulfated carbohydrates restricted to high endothelial venules in lymph nodes.

183 79 as an inhibitor of lymphocyte adhesion to high endothelial venules in lymphoid organs.

184 eripheral node addressins are upregulated on high endothelial venules in peripheral and mesenteric ly

185 ential interaction with ligands expressed on high endothelial venules in secondary lymphoid organs su

186 ke conduits connect the external lamina with high endothelial venules in T-cell areas and also extend

187 duces reductions in the number of functional high endothelial venules in the nodes, and that relievin

188 ycans supported the binding of L-selectin to high endothelial venules in vitro and contributed in viv

189 ired for efficient attachment and rolling on high endothelial venules in vivo in both nonstimulated a

190 pendent lymphocyte adhesion to Peyer's patch high endothelial venules in vivo, but the factors respon

191 and mouse T cells, and prevented homing from high endothelial venules into murine LNs.

192 ation through the intercellular junctions of high endothelial venules is lacking.

193 rophils and L-selectin binding to lymph node high endothelial venules is reduced in the absence of ST

194 IL-33 (previously known as NF from high endothelial venules) is an IL-1 family cytokine tha

195 splenic red pulp and the luminal surface of high endothelial venules lacked HA.

196 ctin on lymphocytes with sulfated ligands on high endothelial venules leads to rolling and is critica

197 triad of defects, including overadherence to high-endothelial venules, less interstitial migration an

198 ted as potential recognition determinants on high endothelial venule ligands for L-selectin.

199 the accumulation of IL-12p40 protein around high endothelial venules located in close proximity to p

200 JAM/JAM 2 expression to be restricted to the high endothelial venule of tonsil and lymph nodes, and w

201 -tissue chemokine (SLC), is expressed in the high endothelial venules of lymph nodes and Peyer's patc

202 ocytes binds to peripheral node addressin on high endothelial venules of lymph nodes to mediate leuko

203 omucins that are constitutively displayed on high endothelial venules of lymph nodes.

204 we found that ATX had high expression in the high endothelial venules of lymphoid organs and was secr

205 e to the formation of the MECA-79 epitope in high endothelial venules of mouse lymph nodes.

206 esion molecule (MAdCAM), which is present on high endothelial venules of mucosal lymphoid organs.

207 Interestingly, high endothelial venules of peripheral and mesenteric ly

208 Trafficking across high endothelial venules of peripheral lymph nodes (PLN)

209 ration by mediating lymphocyte attachment to high endothelial venules of peripheral lymph nodes (PLN)

210 ency and velocity of transfectant rolling in high endothelial venules of peripheral lymph nodes using

211 re expressed in endothelial cells lining the high endothelial venules of peripheral lymph nodes, mese

212 ectin, was almost completely absent from the high endothelial venules of these mutant mice, whereas t

213 mor infiltration with a limited induction of high endothelial venules on tumor vasculature, provided

214 show that T cells roll on most Peyer's patch high endothelial venules (PP-HEVs), but preferentially a

215 PBMCs bind in vitro to MECA-79(+) high endothelial venules present in the PVS, suggesting

216 tin/IgM immunohistochemical probe and by the high endothelial venule-reactive monoclonal antibody MEC

217 hances BMAL1-controlled ICAM-1 expression in high endothelial venules, resulting in lymphocyte infilt

218 ysiological shear and is highly expressed by high endothelial venules, specialized vessels involved i

219 tructures that contained B and T cell zones, high endothelial venules, stromal cells, and the chemoki

220 dendritic cells, macrophages, plasma cells, high endothelial venules, supporting follicular dendriti

221 ice displayed enhanced intratumor content of high endothelial venules surrounded by high CD8(+) T-cel

222 as chemokines, regulate the phenotype of the high endothelial venule, the recruitment of lymphocytes,

223 e to enter Ag-stimulated lymph nodes through high endothelial venules, the cellularity of draining ly

224 ells (DCs), and residential macrophages near high endothelial venules, the results highlight critical

225 iates lymphocyte binding to, and rolling on, high endothelial venules; these are prerequisites for th

226 hesion to the luminal surface of specialized high endothelial venules, thus regulating lymphocyte rec

227 c insights into the functional adaptation of high endothelial venules to accelerate naive T cell recr

228 s form a network of fibers that radiate from high endothelial venules to all areas of the lymph node

229 Pase, R-Ras, in the functional adaptation of high endothelial venules to increase naive T cell traffi

230 ed endothelial cell proliferation, increased high endothelial venule trafficking efficiency and VCAM-

231 ed the B cell follicles while lymphatics and high endothelial venules were found at the B cell/T cell

232 discrete lymphoid aggregates associated with high endothelial venules) were detectable in 9 of 13 hea

233 -1 integrins, and CXCR4 to get access across high endothelial venules, whereas macrophage-1 Ag, LFA-1

234 We achieve in vivo molecular imaging of high endothelial venules with diameters as small as ~6.6

235 show that the development of PNAd-expressing high endothelial venules within intragraft lymphoid foll

236 extravasation of lymphocytes at specialized high endothelial venules within lymph nodes and other le