ライフサイエンスコーパス: high myopia

1 10-11 for myopia; 8.5% vs 6.8%, P = .004 for high myopia).

2 ght-threatening complication associated with high myopia.

3 tant is likely to contribute to the onset of high myopia.

4 mmon fundus findings among Asian adults with high myopia.

5 mican gene polymorphisms could be related to high myopia.

6 ially associated with choroidal thickness in high myopia.

7 inically, was identified in 2 eyes (1%) with high myopia.

8 .32 x 10(-3)), a region previously linked to high myopia.

9 etinas of amblyopic children with unilateral high myopia.

10 en associated with patients with moderate to high myopia.

11 an important factor in preventing congenital high myopia.

12 The latter two were also predictors of high myopia.

13 ht vision, mild photophobia, and moderate to high myopia.

14 gene are causally related to MYP2-associated high myopia.

15 eneficial for subfoveal lesions secondary to high myopia.

16 ive residual astigmatism in individuals with high myopia.

17 ities of the ILM were exclusively present in high myopia.

18 e both potentially blinding complications of high myopia.

19 estimate the prevalence of adult myopia and high myopia.

20 ly onset, slow progression over decades, and high myopia.

21 SE of -6.0 D or less were considered to have high myopia.

22 the need for effective strategies to prevent high myopia.

23 ut retinal detachment in eyes with extremely high myopia.

24 y, contractures, mild skeletal dysplasia and high myopia.

25 ns (Visian ICL) implantation for moderate to high myopia.

26 ascular features of the choroid in eyes with high myopia.

27 ethnic origin, positive family history, and high myopia.

28 lose the macular hole in MH-associated RD in high myopia.

29 sion loss among almost 1 billion people with high myopia.

30 ht-threatening complications associated with high myopia.

31 iduals presented with excavated optic discs, high myopia (-1.00 to -16.00 diopters), and increased ax

32 D [SD 4.49]); rod dominated dystrophies (OR high myopia 10.1, P < .0001; OR high hyperopia 9.7, P =

33 se subjects also having the highest rates of high myopia (11.8%) and astigmatism (53.4%).

34 eral chromosomal regions have been linked to high myopia (12q, 17q, and 18q), to quantitative refract

35 , followed by cone-dominated dystrophies (OR high myopia 19.5, P < .0001; OR high hyperopia 10.7, P =

36 n [15.2%-31.5%]) and 163 million people with high myopia (2.7% of the world population; 95% CI, 86-38

37 were associated with the highest risk of SE high myopia 239.7; odds ratio (OR) mild hyperopia 263.2,

38 e prevalence of myopia (30.2% vs 23.4 %) and high myopia (4.8% vs 2.5%) were higher in second-generat

39 jected to be myopic and 48 million will have high myopia (- 5 D or worse).

40 rol group (< 6.00 diopters, n = 31) and four high myopia ( 6.00 diopters) groups: eyes without staphy

41 erical equivalence of -0.25 diopter [D]) and high myopia ( -6.0 D) was assessed.

42 A 20-year-old woman with bilateral high myopia (-6D) and a documented normal prior retinal

43 P = .02; OR: 0.18 [95% CI: 0.05, 0.68]) and high myopia (9% +/- 6% vs 42% +/- 10%; P = .01; OR: 0.13

44 I, 43.4%-55.7%]) and 938 million people with high myopia (9.8% of the world population; 479-2104 mill

45 In high myopia, a region resembling the myopic peripapillar

46 ease (most severe) were at greatest risk for high myopia, absence of binocular fusion, dyskinetic str

47 In eyes with high myopia, after adjusting for age, choroidal vascular

48 High myopia, age-related macular degeneration, or prosta

49 pia (24 mm < AL <= 26 mm; n = 114 eyes), and high myopia (AL > 26 mm; n = 46 eyes).

50 The prevalence of high myopia also increased from 1.39% (95% CI, 0.43%-2.3

51 e mechanism of the macular changes is due to high myopia, amblyopia, or a combination of the two.

52 long-term and projected trends of myopia and high myopia among young South Korean males and to evalua

53 vertical gaze shifts in patients with axial high myopia and a posterior shift from abduction to addu

54 The third eye had a history of high myopia and a scleral buckle procedure for retinal d

55 utcome was favorable, the left eye developed high myopia and amblyopia.

56 th ROP, the association of early, persistent high myopia and an elevated threshold at 10 degrees was

57 the cornea and sclera in chickens developing high myopia and astigmatism induced by form deprivation.

58 The overall rates of high myopia and astigmatism were 4.6% and 45.0%, respect

59 special needs children who have moderate to high myopia and difficulties wearing glasses or contact

60 Genomic DNA from five pedigrees (with high myopia and either protanopia or deuteranopia) that

61 eta-analysis of the prevalence of myopia and high myopia and estimated temporal trends from 2000 to 2

62 degrees of clarity in 25 eyes (18%): 17 had high myopia and extensive parapapillary atrophy.

63 a broad range (SD: 4.67 D) and included both high myopia and high hyperopia.

64 ropia; rates were 3.6% and 2.0% for moderate-high myopia and hyperopia, respectively.

65 excavated optic disc anomaly associated with high myopia and increased axial length.

66 edecessors for the correction of moderate to high myopia and maintenance of safe IOP levels without i

67 t role in the development and progression of high myopia and myopic retinopathy.

68 grees , 10.5 degrees ]/year) followed by the high myopia and no-myopia groups (8.1 degrees [5.3 degre

69 isease should be considered in children with high myopia and retinal dystrophy.

70 utosomal-recessive syndrome characterized by high myopia and sensorineural deafness.

71 Eyes with high myopia and staphyloma have less positive anterior c

72 Both cases exhibited high myopia and various degrees of occipital skull defec

73 StudyPopulation: Twenty-six patients with high myopia and/or myopic astigmatism received randomize

74 Contrast sensitivity declines with age, high myopia, and astigmatism.

75 Younger age, high myopia, and male sex continue to be associated with

76 ociated with younger age at time of surgery, high myopia, and male sex in several large retrospective

77 y (9 of 13, 70%) of patients had moderate-to-high myopia, and none were using protective eyewear when

78 dness or photophobia, reduced visual acuity, high myopia, and nystagmus.

79 usion, choroidal neovascularization (CNV) in high myopia, and other causes of CNV.

80 Most of these individuals also have high myopia, and some have retinal dystrophy and patchy

81 of retinal pigment epithelium (RPE) humps in high myopia, and to describe the distinctive features fr

82 ons in individuals of European ancestry with high myopia are scarce, hampering insights into the freq

83 our loci for nonsyndromic autosomal dominant high myopia at 18p11.31, 12q22-q23, 17q21-q23, and 7q36.

84 yperopia to 33.7% (standard error, 0.08) for high myopia at 85 years of age.

85 male [50.0%]) participants without myopia or high myopia at baseline, respectively, were included in

86 een noted to demonstrate increasing rates of high myopia at earlier ages, sometimes with associated v

87 Patients with high myopia (axial length > 26 mm) increased significant

88 POAG) and 44 healthy control eyes with axial high myopia (axial length >26 mm).

89 secondary MH, high myopia (axial length >26.5 mm), media opacity precl

90 rs and presented with ocular signs including high myopia, band keratopathy, t, nystagmus, retina, and

91 s a known candidate gene for MYP2-associated high myopia, based on its mapped location within the MYP

92 oroidal vascularity was greater in eyes with high myopia (beta = 0.032, P < .001).

93 on refractive lens exchange and cataract in high myopia between 1996 and 2004 included some 2036 eye

94 w variations in the prevalence of myopia and high myopia between regions and ethnic groups, and there

95 valence may reach 84% for myopia and 28% for high myopia by 2050.

96 Odds ratios (ORs) for myopia and high myopia by birth order, using logistic regression an

97 alting progression of myopia is critical, as high myopia can be complicated by a number of vision-com

98 of community-based WES studies compared with high myopia case-control WES studies.

99 individuals in each surgical group) and 171 high myopia cases (57 eyes of 57 individuals in each sur

100 impairment will occur if uncorrected, whilst high myopia causes sight-threatening complications.

101 Incidence of myopia and high myopia; change in spherical equivalent (SE) and axi

102 The high-myopia CNV group had significantly more CNV types,

103 Compared with the nAMD group, the high-myopia CNV group was significantly younger (P = 0.0

104 h myopia (HM) not meeting the PM definition (high-myopia CNV) are not classified as age-related macul

105 is retrospective study included 39 eyes with high-myopia CNV, 20 eyes with mCNV, and 20 eyes with AMD

106 me-wide DNA methylation analysis in a unique high-myopia cohort, showing extensive and discrete methy

107 and stability of refraction in patients with high myopia compared with similar short-term studies.

108 e MSE and were more likely to have myopia or high myopia compared with the control participants (40.2

109 Sixty-two eyes with high myopia complicated by mMNV were included.

110 In high myopia correction, femto-LASIK and PRK have better

111 etoid, hypotonic, and ataxic) more often had high myopia, CVI, dyskinetic strabismus, and gaze dysfun

112 ung men (mean age 21.59 +/- 1.15 years) with high myopia (defined as -6.0 diopter [D] or worse, mean

113 In eyes with extremely high myopia, despite comparable effects on MH closure fo

114 ncoded TGIF gene for MYP2 autosomal dominant high myopia did not identify sequence alterations associ

115 th order was associated with both myopia and high myopia (eg, comparing first- vs second-born individ

116 Myopia and high myopia estimates from 2000 to 2050 suggest signific

117 We suggest naming this entity high myopia-excavated optic disc anomaly.

118 underwent cataract surgery with a history of high myopia, eye trauma, or retinal detachment was 0.49%

119 sed from 50.6% in 2011 to 59.8% in 2023, and high myopia from 14.3% to 17.7%.

120 tch Myopia Study (MYST) and individuals with high myopia from the Rotterdam Study (RS) included 626 p

121 of postoperative residual astigmatism in the high myopia group (all P < 0.05).

122 opriately selected patients within this very high myopia group can be included as LASIK candidates.

123 The high myopia group mean age was 54.4 +/- 18.2 years (rang

124 gmatism development were more evident in the high myopia group than in the low myopia group (all P <

125 In the high myopia group, axial length had the best correlation

126 In the high myopia group, there was greater increase in photopi

127 Mild myopia and moderate to high myopia groups were negatively associated with devel

128 e residual astigmatism in the low myopia and high myopia groups, respectively, but these differences

129 ctively, were selected as the low myopia and high myopia groups.

130 Very high myopia (>/=-8.00 D) occurred in zone I in 2 of 52 (

131 Among risk factors evaluated, high myopia (>/=6 diopters; odds ratio [OR], 5.7; 95% CI

132 pared with those with emmetropia, those with high myopia had a significantly increased lifetime risk

133 High myopia had been present since age 18 months or youn

134 Although lens surgery for high myopia has a long History, it has been extremely co

135 A locus for autosomal dominant pathologic high myopia has been mapped to 18p11.31.

136 The genetic basis for congenital high myopia has frequently been connected to mutations i

137 Of all refractive errors, high myopia has the most severe visual consequences.

138 orrhage during pars plana vitrectomy include high myopia, history of previous retinal detachment surg

139 nvestigate the structural characteristics of high myopia (HM) in a Turkish cohort using spectral doma

140 However, CNV in elderly eyes with high myopia (HM) not meeting the PM definition (high-myo

141 Retinal detachment was associated with high myopia (HR, 6.12; 95% CI, 5.84-6.41), vitrectomy fo

142 rs (D)/> +0.5 D, and the cutoff for moderate-high myopia/hyperopia was 3.0 D.

143 ed from -25 to +14 diopters; 796 persons had high myopia (ie, a spherical equivalent of -6 diopters o

144 A total of 23 eyes with high myopia implanted with an angle-supported phakic IOL

145 has been identified in a number of cases of high myopia, implicating it in the aetiology of this dis

146 view, 16 years [range, 2-38 years]), all had high myopia in at least 1 eye and severely reduced visio

147 She had high myopia in both eyes (right eye - 20/60 with - 16D,

148 PD) to estimate the prevalence of myopia and high myopia in each country of the world.

149 d to be a candidate gene for MYP2-associated high myopia in single-nucleotide polymorphism studies.

150 ess the place of refractive lens exchange in high myopia in the light of more recent reports in the l

151 A sibling pair had unilateral high myopia in their right eyes and near emmetropia in t

152 High myopia incidence and prevalence is increasing world

153 The 8-year myopia and high myopia incidence were 14.0% (95% CI, 11.5%-17.4%) a

154 d Australia. The absolute risk of myopia and high myopia increased from 2007 to 2016.

155 (-/-)Fmod(-/-) mice show certain features of high myopia: increased axial length, thin sclera, and re

156 High myopia is a common complex-trait eye disorder, with

157 Although high myopia is a strong risk factor for glaucoma subtype

158 Congenital high myopia is an early-onset enlargement of the eye glo

159 High myopia is associated with an increased risk of sigh

160 uggests that choroidal thinning in eyes with high myopia is associated with the reduction in both its

161 Prevalence of high myopia is continuously increasing, thus, patients a

162 l history of choroidal neovascularization in high myopia is variable, and reports to date have some c

163 Very high myopia LASIK between - 10.00 to - 13.50 D is safe a

164 ci, including three previously identified AD high-myopia loci on 18p11.31, 12q22-q23, and 7q36.

165 identified risk factors include keratoconus, high myopia, low residual stromal bed thickness from exc

166 ce of myopia < or = -1.0 D was 16.8%, and of high myopia < or = -5.0 D, 2.4%.

167 myopia (-1.0 D to -2.99 D), and moderate to high myopia (</=-3.0 D).

168 D) and 11 (11.7%) were categorized as having high myopia (</=-5.00 D).

169 ical equivalence of <=-0.25 diopter [D]) and high myopia (<=-6.0 D) was assessed.

170 with RTs had a higher rate of pre-operative high myopia (<=-6.0D) (1.4%) in comparison with patients

171 hearing loss and both siblings had symmetric high myopia, normal stature, and ptosis.

172 Very high myopia occurred in zone II posterior in 1 of 58 (1.

173 vitrectomy, history of choroidal detachment, high myopia, ocular trauma, and open globe were associat

174 f myopia of -0.50 diopter (D) or less and of high myopia of -5.00 D or less, projected to the year 20

175 ad myopic fundi and features in keeping with high myopia on OCT, including choroidal thinning.

176 e a refractive surgery option for those with high myopia or astigmatism.

177 records, genetic correlations between RD and high myopia or cataract operation were, respectively, 0.

178 ascular Inner Retinal Defect Associated With High Myopia or Epiretinal Membrane," published online Ja

179 Patients with amblyopia, high myopia or hyperopia, coexisting retinal disease, or

180 years, to be male, and to have mild-moderate-high myopia or moderate-high hyperopia.

181 d large myopic shifts that often resulted in high myopia or severe anisometropia later in childhood.

182 ssociated significantly with both myopia and high myopia (OR, 2.43 and 2.31).

183 ading (OR: 1.69; 95% CI:1.12-2.55), parental high myopia (OR: 2.88; 95% CI:2.07-4.00), less outdoor t

184 "Pathologic" high myopia, or myopia of <=-6.00 diopters, predisposes

185 High myopia, or pathologic myopia, usually refers to a c

186 after 11 years of age, who also showed lower high-myopia ORs.

187 rend in increase of axial myopia, especially high myopias, over the 10-year period.

188 .004), and higher proportions of moderate to high myopia (P < 0.001) were found in patients with mirr

189 keratomileusis in patients with moderate and high myopia, particularly in the areas of visual quality

190 d to classify diagnoses such as degenerative high myopia, persistent fetal vasculature, retinopathy o

191 Recognizing the LRPAP1-related high myopia phenotype is important, and early childhood

192 ients 18 to 49 years of age with moderate to high myopia (preoperative corrected distance visual acui

193 The high myopia prevalence increased from 2.8% (95% CI, 1.95

194 .4%-9.1%, P < .001) subjects also had higher high myopia prevalence rates from the 1960s through the

195 Increasing myopia and high myopia prevalence was detected by decade in nearly

196 re was a 68% and 199% increase in myopia and high myopia prevalence, respectively.

197 Patients with diabetes mellitus, glaucoma, high myopia, pseudoexfoliation, traumatic cataract, subl

198 Local staphylomata in high myopia reflect ocular asphericity and correlate wit

199 is the first description of a nonsyndromic, high myopia-related, recessive RRD without any signs of

200 age showed markedly lower ORs for myopia and high myopia relative to Israeli-born controls or those a

201 % CI, 1.06-1.25; P = 4.60E-04 for myopia and high myopia, respectively) and the apparent dose respons

202 % CI, 1.11-1.30; P = 3.60E-06 for myopia and high myopia, respectively).

203 -0.5 diopter (D) for myopia, and < -5 D for high myopia, respectively.

204 erited disorder classically characterized by high myopia, retinal detachment, and occipital encephalo

205 The stratified analysis for high myopia revealed significant differences in UDVA (-0

206 , myopia (rg, 0.21; SE, 0.07; P = .004), and high myopia (rg, 0.23; SE, 0.09; P = .01).

207 A 36-year-old woman with high myopia (right eye: 6/15, -14.75D; left eye: 6/12, -

208 In this nationwide study, myopia and high myopia rose substantially over 13 years with narrow

209 [spherical equivalent (SE) 3.00 to 6.00D) to high myopia (SE > 6.00D)] were enrolled.

210 Eyes with high myopia (SE <-6.0 D) were more likely to have POAG (

211 A total of 120 eyes of 83 patients with high myopia (spherical equivalent >/=-6 diopters or axia

212 Patients with high myopia (spherical equivalent [SE] <= - 6 diopters [

213 terdam Study (RS) included 626 patients with high myopia (spherical equivalent of refractive error [S

214 population-based cohort study and mix-based high myopia study, a systematic literature review was al

215 Thirty high myopia subjects and fifty healthy subjects were enr

216 Healthy and high myopia subjects were imaged with the SS-OCTA system

217 all age groups (excluding 18- to 24-year-old high myopia subjects).

218 ic area under the curve (ROC-AUC) >= 0.75 in high-myopia subjects compared to controls.

219 Amblyopic children with unilateral high myopia tend to have a thicker fovea and thinner inn

220 In patients with moderate to high myopia, the AcrySof Cachet angle-supported pIOL pro

221 -cone dystrophy, a mild learning difficulty, high myopia, three limb post-axial polydactyly, horsesho

222 We now report significant linkage of high myopia to a second locus at the 12q21-23 region in

223 acquired conditions such as angioid streaks, high myopia, trauma, choroidal tumors, familial macular

224 ) and patient satisfaction in eyes with very high myopia (VHM) above - 10.00 diopters (D).

225 The findings provide an explanation for high myopia, vitreoretinal degeneration and retinal deta

226 en but should be suspected in the setting of high myopia, vitreoretinal degeneration, and encephaloce

227 udy population, the prevalence of myopia and high myopia was 42.0 and 2.0%, respectively, revealing a

228 Incidence of moderate-high myopia was also related to baseline age, nuclear op

229 High myopia was defined as myopic refractive error of </

230 defined as SE of -1.0 diopters (D) or less; high myopia was defined as SE of -5.0 D or less; any hyp

231 More very high myopia was found in eyes that received laser treatm

232 The most common disc finding associated with high myopia was peripapillary atrophy (81.2%), followed

233 High myopia was present in 9 of 115 eyes (7.8%) among 5

234 yopia-related macular finding in adults with high myopia was staphyloma (23%), followed by chorioreti

235 chanism(s) underlying the pathophysiology of high-myopia, we conducted methylation profiling in 18 ca

236 ited Kingdom and Israel suggested myopia and high myopia were approximately 10% more common in first-

237 type of housing, outdoor time, and parental high myopia were collected through a 23-question Google

238 Myopia and high myopia were defined as autorefraction of -0.75 diop

239 Myopia and high myopia were defined as spherical equivalents (SE) o

240 Myopia and high myopia were defined based on right eye refractive d

241 In 2011, odds of myopia and high myopia were over threefold higher in the most educa

242 Adults 40 years and older (n = 359) with high myopia were pooled from 3 population-based surveys

243 oving the detection of glaucoma in eyes with high myopia where traditional retinal layer segmentation

244 who require laser treatment may develop very high myopia, which has considerable clinical consequence

245 precious stroma in eyes with thin corneas or high myopia, which otherwise may not qualify for LASIK.

246 retrospective study involving eight cases of high myopia with foveoschisis and foveal detachment in w

247 X-linked high myopia with mild cone dysfunction and color vision

248 uscle weakness and bone dysplasia as well as high myopia, with evidence of clinical improvement of mo

249 tive surgeries in patients with moderate and high myopia, with or without astigmatism, especially in

250 Compared to patients with high myopia without staphyloma and normal controls, when

251 de a hierarchy of risk factors for RD onset: high myopia, young age, capsular rupture, history of eye