ライフサイエンスコーパス: high specificity

1 -prostate-cancer cells in the sample (giving high specificity).

2 operation are risk-adverse (low sensitivity, high specificity).

3 The method has also high specificity.

4 statin-expressing cortical interneurons with high specificity.

5 reduced serum cholesterol with exceptionally high specificity.

6 aring uninvolved large airway brushings with high specificity.

7 lecular resolution with low invasiveness and high specificity.

8 ics methods are well suited because of their high specificity.

9 K) and 0.1% for PIK3CA exon 20 (H1047R) with high specificity.

10 tion reaction was carried out by m-CPBA with high specificity.

11 rotease activities with high sensitivity and high specificity.

12 that rely on three separate tests to achieve high specificity.

13 residue interactions are responsible for the high specificity.

14 contacts close to ligand binding sites with high specificity.

15 ther validated by detecting genomic DNA with high specificity.

16 oth the abdomen and pelvis while maintaining high specificity.

17 uires that they "recognize" one another with high specificity.

18 ismissing benign variants with exceptionally high specificity.

19 ng pocket and that FES binds to ERalpha with high specificity.

20 agnosis, and so the algorithms were tuned at high specificity.

21 otein complexes whose subunits interact with high specificity.

22 te seems a limiting factor, results indicate high specificity.

23 49 dB/m rules in liver steatosis with a very high specificity.

24 beta-glycoside ligands while still achieving high specificity.

25 mysial antibodies tests were associated with high specificity.

26 information about unlabeled live cells with high specificity.

27 affinities (Kd approximately 10(-12) m) and high specificity.

28 novel substrates of kinases while retaining high specificity.

29 ty tissue can show perivesical invasion with high specificity.

30 P688, which binds to an allosteric site with high specificity.

31 nstrate subpicomolar limit of detection with high specificity.

32 mentary nucleic acids with high affinity and high specificity.

33 potentially be used for genome editing with high specificity.

34 tallation in endogenous RNA transcripts with high specificity.

35 ridging assays combine good sensitivity with high specificity.

36 on of an aptamer with both high affinity and high specificity.

37 ct 8-OHdG in an artificial urine sample with high specificity.

38 in is compatible to bind the human ACE2 with high specificity.

39 r APEX2 to the human telomerase RNA hTR with high specificity.

40 nsitivity (the detection limit of 22 nM) and high specificity.

41 monitor T-cell activation and expansion with high specificity.

42 ification appear to have low sensitivity and high specificity.

43 assive hepatocellular carcinoma subtype with high specificity.

44 immune cells, particularly macrophages, with high specificity.

45 ploid cotton genome with high-efficiency and high-specificity.

46 lts than did traditional RIDTs, with equally high specificities.

47 that could predict cluster assignment with a high specificity (0.88), sensitivity (0.89) and accuracy

48 sitivity (98.5% vs. 53.7%) while maintaining high specificity (86.7% vs. 93.3%) in the detection of o

49 n Assessment Method for the ICU maintained a high specificity (87%) and sensitivity (78%) in post hoc

50 NanoDisk-MS also exhibited high specificity (87.1-100%) in both healthy and high-ri

51 ion with low sensitivity (45%, 27 of 60) but high specificity (89%).

52 tive biomarker of in vivo drug response with high specificity (92%) and strong positive predictive va

53 s (52% of MS vs 7% of non-MS cases), yielded high specificity (93%) in differentiating MS from non-MS

54 83%) and positive predictive value (40%) but high specificity (94%) and negative predictive value (99

55 n with WBC levels of >=10 cells/mm(3) showed high specificity (94.5%) and was a better predictor of F

56 Seq was negative in all samples suggesting a high specificity (95% CI, 82%-100%) and up to 100% posit

57 T-PCR had low clinical sensitivity (75%) but high specificity (96%).

58 ocedure codes for mechanical ventilation had high specificity (96.0%; 95% CI, 95.8-96.2), but only mo

59 The assays exhibited high specificities (98.6%) when tested against an animal

60 96.5%) and Wiener (94.0% to 97.1%); both had high specificity (98.8% to 100.0% and 96.7% to 99.3%, re

61 the lowest sensitivity (88.0% to 92.0%) but high specificity (99.0% to 100.0%).

62 This process modifies with high specificity a conserved Pro, shares with the deacet

63 ct quantification of ribosomal proteins with high specificity, accuracy, and throughput.

64 One of the antibodies, M25, showed high specificity against an antigen we identify here as

65 y to a given target family while maintaining high specificity against interferents, due to the lack o

66 detect the cDNA from SARS-CoV-2 (1 pg) with high specificity against SARS-CoV (2003).

67 indices showed overall low sensitivities and high specificities (among them myocardial contraction fr

68 ogical molecules in the molecular crowd with high specificity and accuracy, uncovering unique propert

69 Each emm real-time PCR assay showed high specificity and accurately identified the respectiv

70 subunits: an aptamer domain that binds with high specificity and affinity to a target ligand and an

71 with unique recognition properties including high specificity and affinity, rapid response and simple

72 Given its high specificity and affinity, we anticipate that these

73 SA) binds to the placental receptor CSA with high specificity and affinity.

74 talloinsertors that bind DNA mismatches with high specificity and are preferentially cytotoxic to MMR

75 f DSB hotspots - they bind DSB hotspots with high specificity and are required for DSB formation ther

76 , only this newly developed CLIA test showed high specificity and correlated with the "gold standard"

77 The high specificity and correlation with the virus neutrali

78 ive and quantitative with 93.3% sensitivity, high specificity and detection limit of 4.57IU/microl.

79 e apoferritin molecules in vitreous ice with high specificity and determines their orientation and lo

80 Novel protein-based antifibrotic drugs show high specificity and efficacy, but their use in the trea

81 ne editing in multiple human cell lines with high specificity and efficiencies of up to ~50%.

82 l region than to PAM-proximal region and the high specificity and efficiency for shorter protospacers

83 their substrate-binding cavities, exhibiting high specificity and efficiency.

84 ed the biotransformation kinetics in vivo at high specificity and examined this process at the chemic

85 this platform exhibits pM-range sensitivity, high specificity and good reproducibility, making it wel

86 cilitated antigen clasping and achieved both high specificity and high potency.

87 ified severe reactors and low threshold with high specificity and high sensitivity.

88 omplementary interaction with high affinity, high specificity and high stability.

89 The BAT diagnosed PA with high specificity and identified severe reactors and low

90 However, development of small molecules with high specificity and in vivo efficacy for mutagenic TLS

91 nt drug that blocks phosphodiesterase 5 with high specificity and is used to treat erectile dysfuncti

92 for on-chip nucleic acid testing due to its high specificity and isothermal reaction conditions.

93 is a robust method to quantify analytes with high specificity and multiplexing ability, hence we aime

94 tical density threshold to 1.0 resulted in a high specificity and negative predictive value.

95 All PFPs exhibited high specificity and negative predictive values for iden

96 an elevated measurement, characterized by a high specificity and positive likelihood ratio, may indi

97 Plasma miR371 expression predicts aGCM with high specificity and positive predictive value.

98 re histologically validated and demonstrated high specificity and positive predictive value.

99 Responders could be identified with high specificity and positive-predictive value.

100 hosphinic pseudopeptide inhibitors that show high specificity and potency toward these proteases.

101 have been identified that target ASICs with high specificity and potency.

102 oupled autoinhibition allows RfaH to achieve high specificity and potent activation of gene expressio

103 Conclusion FDG PET/CT demonstrates high specificity and PPV for detecting distant metastasi

104 opulation cases at a threshold that also has high specificity and PPV, and could be used as a screeni

105 n of these goals will require reactions with high specificity and precise control.

106 trial-adjudicated CVEs during follow-up with high specificity and predictive value, but imperfect sen

107 Biological filters demonstrate both high specificity and rapid motion or high flux of protei

108 the ex-vivo kinetics of sCD73 activity with high specificity and reproducibility and is suitable for

109 sensitive enrichment of cTnI (<1 ng/mL) with high specificity and reproducibility, while simultaneous

110 ors that offer the advantages of robustness, high specificity and selectivity for histamine as a targ

111 ng 11C-BU99008 PET, a novel radioligand with high specificity and selectivity for imidazoline 2 bindi

112 n methods that predicted liver necrosis with high specificity and selectivity in an independent valid

113 A fragments mixed with samples, revealed the high specificity and selectivity in methylation analysis

114 ring NQO1 activity in vitro and in vivo with high specificity and selectivity.

115 form was able to detect each HBV marker with high specificity and sensitivity (with three orders of m

116 ssay that is capable of resolving 5 hmC with high specificity and sensitivity and demonstrate its uti

117 ay can be used to immunophenotype NLHPL with high specificity and sensitivity and rapidly purify LP c

118 s (BV); this subtype could be predicted with high specificity and sensitivity based on the Nugent sco

119 ucleocapsid (N)-based ELISAs not only showed high specificity and sensitivity but also did not show a

120 nant nuts which could then be monitored with high specificity and sensitivity by selective reaction m

121 ectrochemical biosensor and demonstrated its high specificity and sensitivity capabilities in detecti

122 come (P= .009); a ratio of >/=0.55 pg/mL had high specificity and sensitivity for a poor outcome (100

123 ive showed predominantly renal clearance and high specificity and sensitivity for detecting low level

124 Detecting target analytes with high specificity and sensitivity in any fluid is of fund

125 resulting catalog of TCRbeta sequences with high specificity and sensitivity in both the original co

126 Due to the high specificity and sensitivity of MS and no need to us

127 We developed an inhibition ELISA with high specificity and sensitivity that is applicable in r

128 recently derived genome-wide PRS have shown high specificity and sensitivity to identify CAD cases i

129 wo types of aptamer linkers were studied and high specificity and sensitivity to MPT64 was observed f

130 diagnose acute cellular rejection (ACR) with high specificity and sensitivity would significantly adv

131 With simultaneously high specificity and sensitivity, and convenient use for

132 Due to its high specificity and sensitivity, SPARK has the potentia

133 n tenfold diluted plasmid standard exhibited high specificity and sensitivity, stable repeatability a

134 silico, bound the minimal FLAG sequence with high specificity and sensitivity.

135 ic PWV, and aortic bifurcation diameter with high specificity and sensitivity.

136 l processes from normal liver processes with high specificity and sensitivity.

137 the detection of low abundance binders with high specificity and sensitivity.

138 gs in the form of peptide-MHC complexes with high specificity and sensitivity; however, how subtle di

139 tegy relying on "immutable ligands" with the high specificity and speed of Raman microspectroscopy.

140 Given its high specificity and superior sensitivity, TPPA is prefe

141 ng immunotherapeutic agents because of their high specificity and the ability to target immune cells

142 bit cytosolic sulfotransferases (SULTs) with high specificity and therapeutically relevant affinities

143 s) that bind ion channels and receptors with high specificity and therefore are important pharmacolog

144 ction in which a large binding site provides high specificity and, in combination with conformational

145 ate gene editing tool also indicate that the high-specificity and programmability of CRISPR system ca

146 imit of detection as low as 0.056 ng/mL with high specificity, and also showed excellent applicabilit

147 UAAs are incorporated with high specificity, and functionally active transporters h

148 signal amplification have high sensitivity, high specificity, and good correlation with HCV RNA leve

149 his platform exhibits muM range sensitivity, high specificity, and good reproducibility, and the assa

150 that this apoptosis probe has low toxicity, high specificity, and high affinity to apoptotic cells.

151 The high sensitivity, high specificity, and rapid detection capacity of the SE

152 egulatory phenotypes: low TF residence time, high specificity, and tunable cooperativity.

153 otein array (RPPA) technology uses panels of high-specificity antibodies to measure proteins and prot

154 Here, we developed high-specificity approaches to genetically track and man

155 nships in the biological network and exhibit high specificity associated with the related diseases.

156 e the number of suitable targeting sites for high-specificity base editing.

157 high sensitivity based on stiffness and with high specificity based on fluidity.

158 gned to target the abnormal fibroblasts with high specificity because many classes of chemotherapeuti

159 ding proteins such as fimbrin and espin show high specificity between these two bundle types within t

160 tematically evolved to create high-affinity, high-specificity binding peptides to a protein target in

161 ocess involving numerous factors acting with high specificity, both temporally and by location.

162 f cytokine-induced B cells in vitro with the high specificity BTK inhibitor Tirabrutinib inhibited CD

163 could predict severity of appendicitis with high specificities, but low sensitivities.

164 HPV16/18 and HPV E6/E7 mRNA had high specificity, but lower sensitivity.

165 inding affinity by 2 (41-nt, KD = 45 pM) and high specificity by 10, was used successfully to constru

166 sphorylated at the plasma membrane, and with high specificity by the apically localized kinase LOK.

167 ut appendicitis and are distinguishable with high specificity by using a PSV greater than 10 cm/sec a

168 dRNAs can be combined with high-specificity Cas9 variants, which often do not elimi

169 nment and identification of myocarditis with high specificity challenging in clinical trials and othe

170 igh-sensitivity screening test followed by a high-specificity confirmatory test.

171 However, this reported high specificity contradicts Cas12a's natural role as an

172 At 20% and 50% prevalence, only FibroTest high specificity cutoff plus VCTE was equivalent to or b

173 etection [LODs] ranging from 1 to 30 fM) and high specificity (distinguishing miRNAs with a single nu

174 Cardiolipin (CL) analysis demands high specificity, due to the extensive diversity of CL s

175 cated that the proposed biosensor provides a high specificity, easy, good sensitivity and fast approa

176 mechanical cantilever sensor system that has high specificity, fast response time and is easily appli

177 ere we show that an artificial aldolase with high specificity for acetone as the aldol donor can be r

178 Conclusions (18)F-FDG PET/CT had high specificity for all IE subtypes; however, sensitivi

179 t receptor association constants, and showed high specificity for alpha V beta 3 in HUVECs (K d 35 nM

180 ve disclosed the structural basis for PllA's high specificity for alpha-galactoside-containing ligand

181 apidity (30 seconds) at ambient temperature, high specificity for BPs amidst other alcohol-containing

182 indicate that the small molecule GAT1508 has high specificity for brain GIRK1/2 channel subunits, dir

183 e WISH algorithms had a good sensitivity and high specificity for C trachomatis (sensitivity 71.7%, s

184 P-C(CD) is part of the CCNC by virtue of its high specificity for CENP-A nucleosomes and ability to s

185 ow the central domain of CENP-C achieves its high specificity for CENP-A nucleosomes and how CENP-C a

186 It has high specificity for cisplatin and potentially other Pt(

187 ually well on different platforms, exhibited high specificity for crab over other types of crustacean

188 s2 proteins catalyze spacer integration with high specificity for CRISPR repeat junctions.

189 Conclusion: The high specificity for detecting residual tumor suggests t

190 Although LS-IVCM has a high specificity for diagnosing filamentous fungal kerat

191 y and PF LAM assays have low sensitivity but high specificity for diagnosis of TBP.

192 Such FET sensor shows high specificity for different matching degrees of compl

193 The immunosensor showed high specificity for discriminating DENV IgG against ant

194 LLL12 exhibits high specificity for inhibiting STAT3 phosphorylation an

195 YAMAT-seq has high specificity for mature tRNAs and high sensitivity t

196 ng it challenging to produce antibodies with high specificity for NAT1 or NAT2.

197 These modifications all revealed high specificity for Psi.

198 DJ001 displays high specificity for PTPsigma and antagonizes PTPsigma v

199 ption of REEs compared to cells lacking LBT, high specificity for REEs, and an adsorption preference

200 rapid oxime reaction (>150 M(-1) s(-1)) with high specificity for the abasic (AP) site of DNA.

201 h sensitivity in convalescent-phase sera and high specificity for the Abbott, Euroimmun, and Ortho-Cl

202 r findings suggest that thioredoxins evolved high specificity for their sole electron donor TrxR whil

203 MRR detection provides the added high specificity for these selective gas-phase separatio

204 sed as EphA2-targeting agents owing to their high specificity for this receptor.

205 a new aptasensor with high-sensitivity, and high-specificity for detection of diazinon, was discover

206 ing, in simulated wound fluid which exhibits high specificity, good linearly from 0 to 800microM, and

207 lizable strategies that accomplish this with high specificity have been slow to emerge.

208 -resolution localization microscopy, such as high specificity, high resolution, and the ability to im

209 t amongst the algorithm variants that have a high specificity (i.e. >90%), Farrington Flexible has th

210 istinguish non-COVID related pneumonias with high specificity in diverse patient populations.

211 ug displayed long blood-circulation time and high specificity in inducing cancer-cell apoptosis, thus

212 ng MMP-targeting antibodies that can achieve high specificity in interactions with their targets.

213 tubulin with both high affinity in vitro and high specificity in living cells, exhibited substantial

214 We further find that high specificity in nonequilibrium models is in a trade-

215 nsors offer large signal-to-noise ratios and high specificity in single molecule binding measurements

216 uorine MRI demonstrated high sensitivity and high specificity in the imaging of mononuclear cells bot

217 L5(+)T-bet(+) B-cells is observed, revealing high specificity in this response.

218 GagDeltap6 binds to Psi RNA with high specificity in vitro and also selectively packages

219 Cas12a can bind and cut dsDNA targets with high specificity in vivo, making it an ideal candidate f

220 al TetR fold to bind aromatic isoprenes with high specificity, including CoQ intermediates that likel

221 High specificity is achieved by employing nanobodies (Nb

222 ombined observations lead us to propose that high-specificity, low-affinity attachment of MERS-CoV to

223 On clinical samples, it showed high specificities, moderately high sensitivities for Gr

224 ty (down to 100 genomic copies/reaction) and high specificity (no cross-reactivity with other mcr var

225 sive mcfDNA-Seq had moderate sensitivity and high specificity, NPV, and PPV for pulmonary IMI after H

226 To understand the molecular basis for the high specificity of AceCas9 for its PAM, we determined t

227 Antibody-drug conjugates (ADCs) combine the high specificity of antibodies with cytotoxic payloads.

228 nbiased whole genome sequencing demonstrates high specificity of base editing in monkey embryos.

229 ncisella novicida Cas9 (FnCas9) shows a very high specificity of binding to its intended targets and

230 The high specificity of CHMFL-BTK-11 makes it a useful pharm

231 However, the high specificity of Cry toxins can also prove to be a li

232 We conclude that high specificity of immune priming can evolve rapidly fo

233 udy, an assay is developed that exploits the high specificity of molecular beacon (MB) probes with th

234 e tools for live-cell imaging because of the high specificity of peptide sequences for their biomolec

235 The high specificity of PFI-3 for family VIII was achieved t

236 appearance of proteolysis products indicates high specificity of PqqF/PqqG for serine side chains.

237 tor (TF) residence times on the DNA with the high specificity of regulation.

238 y studies with non-specific molecules proved high specificity of the artificial receptors for the tar

239 malian species tested in the study confirmed high specificity of the determination.

240 specific antibody surface that confirmed the high specificity of the developed immunoassays.

241 acteria show negative results, verifying the high specificity of the present strategy.

242 ful detection of PSA in plasma, indicate the high specificity of the sensing system.

243 A high specificity of the sensor chip to detect cortisol w

244 The high sensitivity and very high specificity of the Xpert MTB/RIF assay supports its

245 ivation pathway for transcription-reconciles high specificity of transcriptional regulation with fast

246 The high specificity of ubiquitination is regulated by the i

247 perfect or near-perfect sensitivity and very high specificity, often small subtle abnormalities on a

248 GSH) and hydrogen peroxide (H(2) O(2) ) with high specificity on a basis of domino reactions on the b

249 ecificity of 89% (95% CI: 88, 90) by using a high-specificity operating threshold.

250 nd a quick response within 5 s, as well as a high specificity over other antibiotics such as kanamyci

251 individual eyes at the high sensitivity and high specificity points, respectively.

252 This equation has a high specificity, PPV with a moderate NPV and sensitivit

253 o acid side chains by targeted reagents with high specificity, probing structural changes at selected

254 Due to the high specificity, quantitation in various biological mat

255 a high sensitivity (range, 87.6%-100%) and a high specificity (range, 97.2%-100%).

256 sensor displayed desired properties such as high specificity, relatively low detection limit (30 nM

257 e assemblies, of which ~40% are invisible to high specificity short-read genotyping approaches.

258 from Mk exosomes (MkExos), target HSPCs with high specificity since they have no effect on other onto

259 a graphene field effect transistor (FET) for high-specificity, single-nucleotide mismatch detection.

260 al structures while simultaneously achieving high specificity so that diverse bitter toxins can be de

261 traditional trial outcomes to identify CVEs, high specificity suggests claims could be used to trigge

262 0, 12 mum), followed by an endoprotease with high specificity (Tail21, 8 mum), and HP at 600 MPa (HP6

263 heir ability to bind long DNA sequences with high specificity, TALEs have been used in many applicati

264 we demonstrate labeling of fixed cells with high specificity that correlates well with fluorescent l

265 orithm can predict, with low sensitivity but high specificity, the impending occurrence of severe sep

266 cal diagnosis had high sensitivity to AD and high specificity to dementia with Lewy body/Parkinson de

267 high sensitivity to detect small tumors and high specificity to distinguish malignant from benign ti

268 assembly of nucleosomes, and DNA motifs with high specificity to nucleosomes have been identified.

269 a murine precursor antibody that binds with high specificity to pGlu3-Abeta monomers, oligomers and

270 is thaliana) chloroplast psbA mRNA bind with high specificity to psbA mRNA in vivo.

271 The peptide substrates show high specificity to the cognate proteases, with negligib

272 445.2, bound with low nanomolar affinity and high specificity to the receptor-binding domain (RBD) of

273 C. guilliermondii) simultaneously with very high specificity to the species level in less than 80 mi

274 with the participation of the N-lobe, endows high specificity to this protein.

275 The developed FNanoBiT assay revealed high specificity toward FB1 with no cross-reactivity wit

276 gmL(-1), wide linearity (50-500ngmL(-1)) and high specificity toward NGAL detection from small sample

277 ovide enhanced sensitivity, while PCR offers high specificity toward target DNA.

278 re recent studies have generally indicated a high specificity toward the ubiquitous plant cell wall m

279 erization of the recombinant GH8ErCel showed high specificity towards barley beta-glucan and lichenan

280 recombinant metagenome-derived enzyme showed high specificity towards beechwood xylan (288.1 IU/mg),

281 d in glucose monitoring systems owing to its high specificity towards glucose.

282 has a high binding affinity and a relatively high specificity towards SARS-CoV-2 S1 protein, which ca

283 targets, 'alternative TSAs', defined here as high-specificity tumour antigens arising from non-SNV ge

284 ptures blood circulating monocytes (MC) with high specificity under a range of shear stresses.

285 arious substrates into desired products with high specificity under mild conditions, their effectiven

286 ates the detection of peritoneal tumors with high specificity upon intraperitoneal tumor targeting an

287 nsferase activity in Enterobacteriaceae with high specificity using the standard disk susceptibility

288 vely with enhanced detection sensitivity and high specificity, using the magnetic coupling between gl

289 ficity and activity, identifying LZ3 Cas9, a high specificity variant with a unique +1 insertion prof

290 e further engineered this system to create a high-specificity variant and minimized the system to fac

291 E does not deaminate adenosine, enabling the high-specificity versions of CURE to create fewer missen

292 olar sensitivities, sub-second kinetics, and high specificity. Viral- or transgenic-mediated expressi

293 Moreover, high specificity was demonstrated, together with success

294 To develop a sequential, two-step assay with high specificity, we used PBMCs from kidney recipients (

295 tural protein 3 (NS3):1406-1415 epitope with high specificity when presented by HLA-A2.

296 This sensor also exhibits high specificity where no significant response is observ

297 The biosensor showed a high specificity which could discriminate between comple

298 n CEA protein and anti-CEA in real-time with high specificity, which revealed selective electrical de

299 itivity (0.5 ng/mL using 100 muL of plasma), high specificity, wide linear range, complete automation

300 -associated optical and electron signal at a high specificity, with an interspace of ~41 angstrom of