ライフサイエンスコーパス: high-affinity antibody

1 (Tfh) cell is required for the production of high affinity antibody.

2 lasticity of the antigen-combining site of a high-affinity antibody.

3 to produce plasma cells capable of secreting high-affinity antibody.

4 necessary, indirectly, for the production of high affinity antibodies.

5 fh) cell responses is pivotal for generating high affinity antibodies.

6 called RESP for efficient identification of high affinity antibodies.

7 wth of B cells and plasma cells that produce high affinity antibodies.

8 T follicular cells help B cells generate high-affinity antibodies.

9 ity of the natural immune system to generate high-affinity antibodies.

10 on of germinal centres and the production of high-affinity antibodies.

11 incorporated into hapten design to generate high-affinity antibodies.

12 es the generation of a diverse repertoire of high-affinity antibodies.

13 rm germinal centers (GC) but fail to produce high-affinity antibodies.

14 (SHM) critically underlies the generation of high-affinity antibodies.

15 (SHM)--two processes essential for producing high-affinity antibodies.

16 er 12 months, suggesting poor maintenance of high-affinity antibodies.

17 of germinal center (GC) B-cell responses and high-affinity antibodies.

18 late GC entry is lowered in the presence of high-affinity antibodies.

19 on the GC reaction and in the generation of high-affinity antibodies.

20 nity maturation, directing the production of high-affinity antibodies.

21 germline lineage-diverse, broadly reactive, high-affinity antibodies.

22 ) B cells is essential for the production of high-affinity antibodies.

23 red for GC development and the production of high-affinity antibodies.

24 xpression, and capacities to yield IgG2c and high-affinity antibodies.

25 tion that is required for the development of high-affinity antibodies.

26 ction by cytotoxic mechanisms, cytokines and high-affinity antibodies.

27 rs of germinal center B cells and absence of high-affinity antibodies.

28 s to form germinal centers (GCs) and produce high-affinity antibodies.

29 clonal selection lead to B cells expressing high-affinity antibodies.

30 n (SHM) in V(D)J exons for the generation of high-affinity antibodies.

31 plasma cells that secrete antigen-specific, high-affinity antibodies.

32 nation of which results in the production of high-affinity antibodies.

33 pecific CD4 T cell responses, in addition to high-affinity antibodies.

34 munoglobulin variable (IgV) genes to produce high-affinity antibodies.

35 been employed to facilitate the selection of high-affinity antibodies.

36 ation, and rapid clonal expansion to produce high-affinity antibodies.

37 from their CICs with fixed platelets reveals high-affinity antibody (Ab) against platelet glycoprotei

38 The generation of high-affinity antibodies (Abs) plays a critical role in

39 ed this design with nanoparticles containing high-affinity antibodies (Abs) to TfR.

40 fh) cells are essential for the formation of high affinity antibodies after vaccination or infection.

41 Maintaining high-affinity antibodies after vaccination may be import

42 B cells do not generate germinal centers and high-affinity antibody after protein immunization.

43 ant source of humoral immunity by generating high affinity antibodies against a pathogen.

44 High-affinity antibodies against a conserved epitope cou

45 The generation of high-affinity antibodies against pathogens and vaccines

46 interactions with CD4(+) T cells to develop high-affinity antibodies against proteins.

47 We generated a fully human high-affinity antibody against FasL that binds to and ne

48 entre (GC) is required for the generation of high affinity antibodies and immunological memory.

49 l for the generation of genetically diverse, high affinity antibody and robust humoral immunity, but

50 GC functions are not sufficient to generate high-affinity antibodies and B cell memory.

51 nomenon where specific epitopes are bound by high-affinity antibodies and blocked from B cell recogni

52 ermutation is critical for the generation of high-affinity antibodies and effective immune responses,

53 5 for normal production of isotype-switched, high-affinity antibodies and for a memory response.

54 nity maturation, and the development of most high-affinity antibodies and memory B cells.

55 e counterproductive, in B cells that express high-affinity antibodies and undergo the greatest number

56 arp boundary between an outer shell of bound high-affinity antibody and an inner antibody-free core h

57 AID plays a central role in the synthesis of high affinity antibodies, and APOBEC3G inactivates human

58 e deaminase (AID) is critical for generating high-affinity antibodies, and deamination by APOBEC-3 pr

59 complexes (ICs), facilitate the selection of high-affinity antibodies, and protect B cells in germina

60 TFH) cells are essential in the induction of high-affinity antibodies, and their precursor memory com

61 SHM) in immunoglobulin genes is required for high affinity antibody-antigen binding.

62 Detailed analysis of factors governing high affinity antibody-antigen interactions yields impor

63 non-affinity interactions while maintaining high-affinity antibody-antigen interactions.

64 High affinity antibodies are generated in mice and human

65 High-affinity antibodies are critical for host protectio

66 B cells producing high-affinity antibodies are destined to differentiate i

67 High-affinity antibodies are generated by somatic hyperm

68 re memory B cells and plasma cells producing high-affinity antibodies are generated during T cell-dep

69 High-affinity antibodies are often identified through di

70 Three high-affinity antibodies are presented in this study as

71 Our findings provide insight into how high-affinity antibodies are selected within GCs and are

72 e-molecule sensitivity, and they require two high-affinity antibodies as well as stringent washing to

73 s, particularly in subjects who did not have high affinity antibodies at baseline.

74 To produce high-affinity antibodies, B cells must undergo iterative

75 To create high-affinity antibodies, B cells target a high rate of

76 Our results indicate that pre-existing high-affinity antibodies bias germinal centre and memory

77 High-affinity antibodies bind effectively even with a si

78 The production of high-affinity antibodies by B cells is essential for pat

79 deadly pathogens requires the production of high-affinity antibodies by B cells, which are generated

80 This presents an opportunity for designing high-affinity antibodies by connecting via a flexible pe

81 The germinal center (GC) reaction produces high-affinity antibodies by random mutation and selectiv

82 Vaccines generate high-affinity antibodies by recruiting antigen-specific

83 the Pfs47 vaccine to elicit higher titers of high-affinity antibodies, capable of inducing strong TRA

84 Here, we show that surface capture with a high-affinity antibody combined with kinetic fingerprint

85 The generation of high-affinity antibodies depends on the ability of B cel

86 IgM, secreted rapidly by plasmablasts, from high-affinity antibodies derived from later-arising memo

87 The GAD autoantibodies were high affinity (antibody dissociation constant, 0.06-0.78

88 rtant anatomical site for the development of high affinity antibodies during T-cell dependent B cell

89 , coupled to selection by antigen, generates high-affinity antibodies during germinal center (GC) B c

90 licular helper cells (Tfh) and production of high-affinity antibody during a primary response are inc

91 lection of immunoglobulins that produces the high-affinity antibodies essential for effective humoral

92 sis of any biomolecular target for which two high-affinity antibodies exist by detecting the approxim

93 que HCDR3 clusters, broadening the number of high affinity antibodies, expanding the total number of

94 This has spurred efforts to generate high affinity antibodies for use in cancer therapy.

95 this problem, we have generated recombinant high-affinity antibodies for a collection of thirteen cy

96 in driving the germinal centre reaction and high affinity antibody formation.

97 ers (GCs) in the generation and selection of high affinity antibody-forming cells (AFCs), we have ana

98 res central to the generation of long-lived, high-affinity, antibody-forming B cells.

99 e backbone NMR assignments for two distinct, high affinity antibody fragments (single chain variable

100 as highlighted by the development of robust high affinity antibody fragments derived from the breast

101 face plasmon resonance method that relied on high-affinity antibody fragments to obtain RAS-binding c

102 cognizing components of TCRs are replaced by high-affinity antibody fragments, and costimulation is p

103 le the rapid isolation and identification of high affinity antibodies from immunised rats.

104 lone may be sufficient for the generation of high-affinity antibodies from phage-displayed libraries;

105 CVpp, and affinity studies found moderate-to-high-affinity antibodies in all domains.

106 The development of high-affinity antibodies in response to infection is an

107 The maturation process of high-affinity antibodies is a result of intricate intera

108 ivo findings demonstrate that the need for a high-affinity antibody is dependent on the density of th

109 s absence, the GC reaction and production of high-affinity antibody is severely impaired.

110 ulation is contained to ensure generation of high-affinity antibody is unknown.

111 vent these challenges, we have made use of a high affinity antibody labeled with orthogonal fluoropho

112 s significantly accelerates the discovery of high-affinity antibody leads.

113 large enough variable surface area to select high-affinity antibody mimics is significant because a s

114 immunoglobulin genes is required to produce high affinity antibody molecules.

115 R), two processes that are needed to produce high-affinity antibodies of all isotypes.

116 Somatic hypermutation generates high-affinity antibodies of different isotypes that effi

117 ing mechanisms involved in the production of high-affinity antibodies of different isotypes.

118 ecombination (CSR) enable B cells to produce high-affinity antibodies of various isotypes.

119 ectively neutralising interleukin 17A with a high affinity antibody potentially gives patients with p

120 High-affinity antibodies produced by memory B cells diff

121 lar helper (Tfh) cells and the generation of high affinity antibody-producing B cells.

122 GC) is a microanatomical compartment wherein high-affinity antibody-producing B cells are selectively

123 many pathogens depend on the development of high-affinity antibody-producing plasma cells (PC) in ge

124 maturation of GC B cells, differentiation of high-affinity antibody-producing plasma cells, and produ

125 T follicular helper (T(FH)) cells select high-affinity, antibody-producing B cells for clonal exp

126 fferentiation of B cells to plasma cells and high affinity antibody production in germinal centers (G

127 llicular helper T (T(FH)) cells that mediate high-affinity antibody production in tandem with the ind

128 cytial virus (RSV), we show that TFH and the high-affinity antibody production they promote are vital

129 High-affinity antibody production through the germinal c

130 ecombination (CSR) before being selected for high-affinity antibody production.

131 to defective germinal formation and impaired high-affinity antibody production.

132 eipt of the IIV reflected the specificity of high-affinity antibody production.

133 High-affinity-antibody production, T-cell activation, an

134 tigen-activated B cells proliferate, express high-affinity antibodies, promote antibody class switchi

135 found that PC precursors (prePCs) expressing high-affinity antibodies received higher levels of T fol

136 TRIM21 is a high-affinity antibody receptor that allows antibodies t

137 lic IgA-virion complexes colocalize with the high-affinity antibody receptor tripartite motif-contain

138 TRIM21 is a high-affinity antibody receptor uniquely expressed in th

139 he adaptive immune system relies on specific high-affinity antibody receptors that are generated from

140 an effective and efficient way of selecting high affinity antibodies representing a diverse set of s

141 ived from germinal centers (GCs) secrete the high-affinity antibodies required for long-term serologi

142 High-affinity antibodies required to maximize killing de

143 The synthesis of high affinity antibodies requires activation-induced cyt

144 The generation of high-affinity antibodies requires germinal center (GC) d

145 The generation of high-affinity antibodies requires the presence of a popu

146 regulate B cell function and development of high affinity antibody responses but little is known abo

147 and modified to yield diverse, specific, and high affinity antibody responses to antigen.

148 lls, which are required for the induction of high-affinity antibody responses and the formation of lo

149 Protective high-affinity antibody responses depend on competitive s

150 nsitization with mP/O-B elicited high-titre, high-affinity antibody responses reactive with both the

151 g disrupted BCL6 loci demonstrate suppressed high-affinity antibody responses to T-dependent antigens

152 mplex is required for maintenance of GCs and high-affinity antibody responses.

153 T cells, critical steps to mount protective high-affinity antibody responses.

154 ctive specificities, but are unable to mount high-affinity antibody responses.

155 High affinity antibodies result from interactions betwee

156 possible to reorder the combining site of a high affinity antibody, resulting in altered specificity

157 tablishment of T-dependent B cell memory and high affinity antibody-secreting cells.

158 rs and a corresponding decrease in secondary high-affinity antibody-secreting cell formation.

159 e accumulation of a more restricted group of high-affinity antibody-secreting PC.

160 cells, promoted B cell entry into the GC and high-affinity antibody secretion.

161 oretical model and show that cells producing high-affinity antibodies shorten the G0/G1 phases of the

162 High-affinity antibodies specific for hHepc were generat

163 Pathogen exposure elicits production of high-affinity antibodies stimulated by T follicular help

164 perior immune kinetics, breadth, and durable high affinity antibodies support the need for booster va

165 is an integral process in the development of high-affinity antibodies that are important for recovery

166 generation of the somatically hypermutated, high-affinity antibodies that mediate adaptive immunity.

167 tations in the induction of stable titers of high-affinity antibodies that might help to increase vac

168 une response, resulting in the production of high-affinity antibodies that neutralize pathogens and c

169 ctors, capable of producing large amounts of high-affinity antibodies that protect against pathogenic

170 The human body generates a diverse set of high affinity antibodies, the soluble form of B cell rec

171 he immune synapse controls the production of high-affinity antibodies, thereby defining the efficienc

172 erminal centers and subsequent production of high-affinity antibodies through their interactions with

173 an immune system has generated high quality, high affinity antibodies to a wide range of antigens for

174 t the 14 days of observation, binding of the high affinity antibody to LD beads and of the low affini

175 The competitive assay format uses a high affinity antibody to paralytic shellfish toxins wit

176 d AZD8055 increased titers of class-switched high-affinity antibodies to a hapten-protein conjugate.

177 The potential therapeutic usefulness of high-affinity antibodies to cell wall carbohydrates is u

178 Our findings show that high-affinity antibodies to cell-bound MUC1 SEA domain e

179 e combinatorial antibody libraries to select high-affinity antibodies to every protein encoded by the

180 allenge ensuring the immediate production of high-affinity antibodies to homologous and closely relat

181 The discovery and optimization of high-affinity antibodies to important therapeutic target

182 uction by CD4 T cells, and the generation of high-affinity antibodies to specific antigens-all of whi

183 rinitrophenyl (TNP)-Ficoll and production of high-affinity antibodies to TNP-keyhole limpet hemocyani

184 croenvironment in which B cells that express high-affinity antibody variants produced by somatic hype

185 ighly efficient isolation of intermediate to high affinity antibodies, which preferentially reacted w

186 ide the selection of an animal that produces high affinity antibodies with a desired epitope coverage

187 gest that affinity maturation may select for high affinity antibodies with either "lock-and-key" prec

188 e most complex library, we produced multiple high-affinity antibodies with dissociation constants in

189 ntigen immunization results in production of high-affinity antibodies with long human-like complement

190 oped, which was key to the identification of high-affinity antibodies with the desired inhibitory pot

191 and plasmablasts) are an excellent source of high-affinity antibodies with therapeutic potential.

192 B cells cannot generate high-affinity antibodies without T cell help.

193 generation and selection of B cells bearing high-affinity antibodies, yet GC cell migration and inte