ライフサイエンスコーパス: high-content

1 n insect diet (low content), or a seed diet (high content).

2 ipants); moderate, 12.0% (307 participants); high content, 1.8% (45 participants).

3 icipants]; moderate, 0.8% [20 participants]; high content, 2.0% [50 participants]).

4 High content analysis accurately monitored changes in ce

5 Here we developed a high content analysis framework for detailed quantificat

6 High content analysis generates voluminous multiplex dat

7 hmark chemicals based on data generated from high content analysis.

8 ntrol of mitotic progression, we developed a high-content analysis (HCA) approach that combines autom

9 ods for image-derived data sets generated by high-content analysis in which complex cellular phenotyp

10 zed by immunofluorescence, real-time RT-PCR, high-content analysis, or Western blot analysis in the f

11 Using high-content analysis, we identified a combination of ei

12 ell microarrays allowing high-throughput and high-content analysis.

13 developed a low-volume, high-throughput, and high-content analytical platform for at-line product qua

14 mple, criteria for clinical care should have high content and construct validity, timeliness, and low

15 (ssp. sinensis) from Sichuan had remarkably high contents and unique profiles of flavonol glycosides

16 Thus we suggest high-content and automated image analysis can be used fo

17 High-content and high-throughput analysis technologies,

18 phores, have considerable potential for both high-content and high-throughput testing of chemicals fo

19 With the goal of versatile, high-content, and scalable molecular phenotyping of inta

20 A high content approach was used to measure injury in a hy

21 We used high-content aptamer-based proteomics technology (SOMAsc

22 We envision applying this high-resolution, high-content assay to investigate a wide array of single

23 patially mapped the biological effects using high-content automated assays by employing an upgraded b

24 phoproteome and challenges stemming from its high-content but low-sample-throughput nature.

25 Using a high content cell-based screen, we identified fibroblast

26 Identifying phenotypes based on high-content cellular images is challenging.

27 We first performed an automated high-content cellular screen to characterize neuronal mo

28 Here we report a high content chemical screen, revealing that H1152, a RO

29 tiplexable assay system with applications to high-content chemical library screening of new antiplate

30 A high-content chemical screen identified a candidate drug

31 We performed a high-content chemical screen using human pluripotent ste

32 sponse modeling of large high-throughput and high-content chemical screening data.

33 ignal-to-noise ratio (SNR), large volume and high content complexity within cells, it remains difficu

34 Here, we use a high-content confocal image-based short hairpin RNA scre

35 from the application of new high-throughput, high-content cytometry and sequencing technologies.

36 rt cellular biomarker characterization using high-content cytometry and single cell RNA sequencing, a

37 ity to analyze and integrate the plethora of high-content data generated by fluorescence imaging.

38 f all-optical electrophysiology in providing high-content data to refine experimentally calibrated po

39 Using high-content digital imaging of RNA in situ hybridizatio

40 We propose a new method to handle high-content discovery phosphoproteomics data on perturb

41 tro model of evaporative dry-eye disease for high-content drug screening.

42 ght (CyTOF; Fluidigm) cytometry, and complex high-content experimental models including slice culture

43 It entails high-content feature extraction that permits accurate au

44 but current platforms rely on time-consuming high-content fluorescence imaging as read-out, limiting

45 c repeats (CRISPR)-Cas9 platform for in situ high-content functional analysis of RREs.

46 ation assay (CAPA) is coupled with automated high content (HC) imaging, a technique that combines the

47 fidelity and robustness of this approach for high content high throughput drug discovery.

48 erous hit molecules beginning to emerge from high-content/high-throughput screening as well as the bi

49 We developed a high content image analysis algorithm to quantify change

50 capacity suitable for both single image and high content image analysis.

51 To meet this need, we developed a high content image-based short hairpin RNA screen monito

52 High-content image analysis and parameterization of the

53 High-content image analysis coupled to RNA interference

54 cific fluorescent conjugate, phalloidin, and high-content image analysis of the complementary labels

55 of immunocytochemistry, gene expression, and high-content image analysis.

56 High-content, image-based screens enable the identificat

57 iously developed a sensitive high throughput/high content imaging assay that is based upon a stable c

58 Using high content imaging, we determined the effect of each t

59 We developed a high content imaging-based neutralization test (HINT) to

60 live cells by either confocal microscopy or high content imaging.

61 ata, as are often collected in screening and high content imaging.

62 High-content imaging (HCI) allows simultaneous measureme

63 designed a novel mAb screening method using high-content imaging (HCI) and image-based morphological

64 Using a combination of high-content imaging and a mammalian membrane two-hybrid

65 Combining high-content imaging and cluster analysis, we show that

66 nal tumor components, and is compatible with high-content imaging and high-throughput applications.

67 A genome-wide, high-content imaging approach, identified the E3 ubiquit

68 Importantly, quantitative high-content imaging assays indicated that the direction

69 ol, PhenoPlot, which represents quantitative high-content imaging data as easily interpretable glyphs

70 Here we demonstrate a robust high-content imaging method for the assessment of synapt

71 Here we describe a high-content imaging method in a zebrafish model of cryp

72 Using the multiparametric high-content imaging method, we evaluate cell viability,

73 Thus, high-content imaging of cryptococcal infection in vivo d

74 roughput screening of TGF-beta signaling via high-content imaging of nuclear translocation of the pro

75 Using human keratinocytes and a robotic high-content imaging platform, we screened for chemical

76 Flow cytometric and high-content imaging saturation and competition binding

77 receptor) signaling pathway-identified by a high-content imaging screen-or by a CagA-binding ASPP2 p

78 ompound at four concentrations in live-cell, high-content imaging screens against a panel of 15 repor

79 NET release was quantified using a High-Content Imaging System.

80 We show by using high-content imaging techniques and an in-house develope

81 most current laboratory workflows to achieve high-content imaging to reveal the complex cellular land

82 creening with microraft array technology and high-content imaging to screen image-based phenotypes (C

83 High-content imaging was used to evaluate cytotoxicity,

84 me-series reverse-phase protein microarrays, high-content imaging, and flow cytometry, showed a drama

85 dress this deficiency, we have adopted a new high-content imaging-based approach capable of defining

86 itochondria (mitophagy), here we developed a high-content imaging-based assay of parkin recruitment t

87 We demonstrate that the high-content imaging-based assay presented here is suita

88 endogenous vimentin upon induction of EMT by high-content imaging.

89 RNA sequencing and quantitative whole mount high-content imaging.

90 Application of high-content immune profiling technologies has enormous

91 We used a high-content immunofluorescence imaging-based kinase inh

92 d Japanese encephalitis virus (JEV), using a high-content immunofluorescence screen.

93 ts with promising nutritional properties and high content in added value compounds.

94 ns due to their low caloric intake and their high content in carbohydrates, proteins, dietary fibre,

95 Buriti fruit, with high content in carotenoids and antioxidant compounds, i

96 features of bakery foods characterised by a high content in carotenoids and other bioactive compound

97 These by-products showed a high content in glucose, citric and linoleic acids, toco

98 o its high economic value in the market, and high content in health-promoting antioxidant compounds.

99 (a) transports oxidized phospholipids with a high content in lysophosphatidylcholine.

100 pids are particularly pertinent due to their high content in melanosomal membranes.

101 Thanks to their high content in phenolic compounds, date by-products con

102 or the onset of Celiac Disease (CD) is their high content in proline residues.

103 cotina appear to be very similar with a very high content in transposons and protein-coding genes, ex

104 They offer a low throughput but high content in vitro experimental platform.

105 The whole flours presented high contents in almost all the tested microorganisms, h

106 High contents in anthocyanins, flavonol-3-O-glycosides,

107 hilic phenols (>600mgkg(-1)) were present in high contents in both VOO, for early ripening stages.

108 Thus, there is an urgent need for high-content in vitro systems that can better predict dr

109 g platform (htCIP) that allows us to extract high-content information about individual cells, includi

110 ar samples or compounds per hour, and yields high-content information about the action of a drug over

111 kinome-wide siRNA-phosphoproteomic screen, a high-content kinase inhibitor screen, and a kinase trapp

112 SPARKL integrates high-content live-cell imaging with automated detection

113 we show that OCT is capable of carrying out high-content, longitudinal assays of 3D culture treatmen

114 We then generated a high-content map of pairwise interactions between 171 mi

115 By decomposing many high content measurements into the effects of perturbati

116 of developmental phenotypes, we developed a high-content method that employs two custom strains: a G

117 larity from fluorescent images captured on a high-content microscope.

118 urthermore, in agreement with antibody-based high content microscopy analysis, the targeted proteomic

119 ion, segmentation, and feature extraction in high content microscopy experiments.

120 Quantitative high content microscopy revealed concentration-dependent

121 plate reader, demonstrate its suitability to high-content microscopy in 96-well high-throughput scree

122 In this study, we used high-content microscopy on a genome-wide scale to determ

123 ypic crosstalk (PHOCOS) that is suitable for high-content microscopy or other modalities that capture

124 a Snc1-based reporter and subsequently used high-content microscopy to classify these mutants based

125 d functionality, and used coculture methods, high-content microscopy, and RNA sequencing to study VWM

126 that could be incorporated into an automated high-content microscopy-based screen of kinase inhibitor

127 High-throughput/high-content microscopy-based screens are powerful tools

128 d decellularised ECM proteins with automated high-content microscopy.

129 of the ubiquitin-conjugation machinery using high-content microscopy.

130 integrating brain-wide activity imaging with high-content molecular phenotyping and volume registrati

131 provides a general framework for the use of high-content molecular profiling to identify NAFLD patie

132 apper allows for the generation of accurate, high-content, molecular specific virion models and detec

133 Here we employ high-content multi-parameter phospho-specific flow cytom

134 controlled by ImageJ-based software, making high-content, multimodal imaging easy to implement on an

135 dings suggest that it may be possible to use high-content multiplexed proteomics assays in combinatio

136 algorithm for Triple-Correlation analyses of high-content multiplexed super-resolution data.

137 We present a high content multiwell plate cell-based assay approach t

138 We propose the first such use of optical high content nanoscopy of histone epigenetic marks (epi-

139 poptosis and mitotic arrest as measured in a high content nuclear morphology assay.

140 ester) nanoparticles, distinguished by their high content of a hydrophobic lactone.

141 yl-CoA specificity may have, when aiming for high content of a particular fatty acid in plant triacyl

142 r of purple sweet potato (PSP) is due to the high content of acylated anthocyanins.

143 APIc and APIp exhibited high content of all the essential amino acids.

144 The high content of alpha-helices in Tra1 enabled tracing of

145 of processed products like cherry juice with high content of anthocyanins and polyphenols.

146 P40 possesses a high content of anthocyanins up to 14 mg/g dry matter.

147 diseases, has been intensified due to their high content of antimicrobial agents such as polyphenols

148 for 7min was the best condition to obtain a high content of antioxidant polyphenols and pleasant sen

149 tivars with high viscosity associated with a high content of beta-glucan suggests that they are good

150 Due to their high content of beta-glucan, the consumption of oat prod

151 nal properties of Allium genus come from the high content of bioactive compounds.

152 ee-like taste, high antioxidant activity and high content of bioactives such as rutin and 2-O-beta-d-

153 in extracts, which are expected to be with a high content of biologically active compounds.

154 g as functional ingredients because of their high content of bound phenolic compounds and particle ho

155 Results showed a high content of Ca in the medicinal plant studied, follo

156 emical responses at -0.75 V corresponding to high content of Cd(2+) ions loaded in TiP nanoparticles

157 a great nutraceutical potential due to their high content of compounds providing benefits for human h

158 nsidered as nutritionally valuable for their high content of essential fatty acids and amino acids.

159 ntional oilseeds crops because of relatively high content of fat (27.25%).

160 l data suggest that a 'healthy diet', with a high content of flavonoids indicates preventive properti

161 ubstrate, i.e. waste frying oils (WFOs) with high content of free fatty acids (FFAs), otherwise unsui

162 However, SSBs have a high content of fructose, the consumption of which acute

163 Unique characteristic is the high content of gamma-tocopherol (75.4mg/100g) and delta

164 ser in this experiment, turned out to have a high content of genes involved in cell wall polysacchari

165 The very high content of GlcN (30%) and low content of GlcNAc (4.

166 m HS oligosaccharides, we found an unusually high content of GlcN residue in a recently purchased bat

167 kale is a robust, cold tolerant plant with a high content of health-promoting compounds, grown at a r

168 nning process allows to produce pasta with a high content of healthy compounds and minimal effects on

169 -meat control [i.e., nondairy control with a high content of high-fat processed and unprocessed meat

170 ts that circulating MPs in CF disease have a high content of inflammatory cytokines and could increas

171 ve very high impedance values because of the high content of insulating thermoplastic required for FF

172 ortance and biological potential, due to its high content of K and low Na.

173 The Opole province was characterised by a high content of linoleic acid.

174 Commercial emulsifiers have a high content of lipids compared to TM.

175 7.5% or more of lysine mass, justifying the high content of lysine repeatedly reported in quinoa see

176 Buttermilk is a dairy by-product with a high content of milk fat globule membranes (MFGMs), whos

177 succulent plant, the leaves revealed a very high content of moisture, with several beneficial compou

178 The high content of monosaccharides promoted the progress of

179 caught in autumn and spring proved to have a high content of n-3 fatty acids and vitamin D, and hence

180 d fatty acids was between 48 and 71% and the high content of n3 fatty acids resulted in a favourable

181 water is scarce and/or of low quality due to high content of NaCl (coastal areas or areas where under

182 haracter of the N-terminus, coupled with its high content of negative charges, is likely important fo

183 m (goji berries) have been ascribed to their high content of nutrients and phenolics.

184 an interesting nutritional value, due to the high content of oleic acid and minor components with ant

185 Blends with high content of omega - 3 and omega - 6 fatty acids, bio

186 ained by cultivation were characterized by a high content of phenolic and indole compounds.

187 conditions, the obtained extract exhibited a high content of phenolic compounds (40.782 mg gallic aci

188 A high content of phenolic compounds (8600-15000mg/kg gall

189 RS Violeta grape presents pulp and skin with high content of phenolic compounds (PCs) and intense pur

190 at the systems characterized by a relatively high content of phenolics, either natural or by addition

191 wback to current fuel-cell technology is the high content of platinum-group-metal (PGM) electrocataly

192 ols (DAG) and monoacylglycerols (MAG) with a high content of polyunsaturated fatty acids (PUFA).

193 Aglianico grapes are known for their high content of proanthocyanidins (PAs), which are respo

194 cts, but it is sensitive to oxidation due to high content of PUFA.

195 rom those grown under FI and SD due to their high content of quercetin 3-O-rhamnoside and luteolin 7-

196 of a new variety of Stevia rebaudiana with a high content of rebaudioside A were pretreated with etha

197 contiguity and completeness for regions with high content of repeats such as centromeres.

198 Their large genomes are characterized by a high content of repetitive elements and large pericentro

199 In the tolerant cultivar Beauregard, the high content of RS was due to high invertases activity.

200 of blood proteins is challenging due to its high content of salts and charged small molecules.

201 WD, characterized by its high content of saturated fat, cholesterol, and sugar, s

202 This structure contains a substantially high content of single N-N bonds that exceeds the previo

203 formulated with single-chain amphiphiles and high content of sterols have been developed.

204 rcially in the sweetener industry due to the high content of steviol glycosides in its leaves.

205 High content of steviol glycosides in stevia leaves is a

206 Cultivars characterized by a high content of tannins and high antioxidant capacity we

207 Finally, freeze-dried D. hebecarpa showed high content of target phytochemicals (319 mg/100g and 1

208 ences of spidroin NTDs and find an unusually high content of the amino acid methionine.

209 ntent of anthocyanins, while L06P13 showed a high content of total carotenoids.

210 Sesbania grandiflora had a very high content of total oxalates, tannins and dietary fibe

211 g DUV microscopy and taking advantage of the high content of tryptophan residues in the sequence of P

212 ranslation, especially for polypeptides with high content of tyrosine codon such as ND4, ND5, ND6 and

213 rved up to 30 days even when formulas had an high content of unsaturated fatty acids and valuable Lon

214 elical hydrophobic protein with an unusually high content of valine residues.

215 Unmarinated meat showed high content of volatile lipid oxidation and Maillard re

216 more attention in recent years due to their high contents of antioxidant compounds.

217 The best quality of the dried product (high contents of bioactive compounds and high intensity

218 fruits of sweet cherry are characterized by high contents of bioactive compounds.

219 lages exhibited high yields (8.9 to 21.54%), high contents of carbohydrates (39.77 to 87.68%), protei

220 mental osmotic stress by adding and removing high contents of cryoprotectants.

221 osmarinic liposome (Rososome) which can load high contents of drugs (including 25.8% rosmarinic acid

222 s distinct from that of European beers, with high contents of gallic acid (0.5-14.7 mg/L) and low con

223 regions and are generally characterized with high contents of metal oxides.

224 while the 'GAL-E' and 'GAL-T' cultivars had high contents of oleic, palmitic and linoleic acids.

225 Linden seed oil was characterised by very high contents of phytosterols (2-2.5 g/100 g).

226 ofiles were investigated by GC-FID revealing high contents of PUFAs and a high omega-3/omega-6 ratio.

227 ine, phenolics, and scavenging capacity; ii) high contents of spermine, total biogenic amines and tot

228 reatment to make modified food starches with high contents of type 3 resistant starch (RS3).

229 ming skills with analysis and integration of high-content omics' data from various transcriptomic and

230 High-content Opera imaging identified 53 genes whose los

231 varieties may be of particular interest when high contents or special composition of flavonoids are d

232 rary CRISPR screening approach that combines high-content phenotype imaging with high-throughput sing

233 High-content phenotypic screening has become the approac

234 Here we develop high-content phenotypic screening methods for the system

235 pression, and vulnerability to ototoxin in a high-content phenotypic screening system.

236 High-content phenotyping approaches such as Perturb-seq

237 In the present study, we developed a high-content pipeline, the large-area spatial transcript

238 y chip provides a promising high-throughput, high-content platform for rapid, automated, parallel qua

239 High-content polysaccharides contained in the aerogel gu

240 To this end, here we developed a high content pro-arrhythmia screening platform consistin

241 Here, we performed high-content profiling of cellular survival following ex

242 e questions at a systems level, we conducted high-content profiling of Drosophila larval locomotor be

243 High-content quantification of immunocytochemical coloca

244 High content, quantitative phenotyping of larval locomot

245 Analyzing the high-content readout of scRNA-seq reveals both shared an

246 With a high-content RNAi imaging screen targeting more than 2,0

247 rants a general synthetic methodology toward high-content SACs (such as Fe(SA), Co(SA), Ni(SA)).

248 otection strategy has been developed to give high-content SACs by nanocasting SiO(2) into porphyrinic

249 The model was applied to the selection of high content samples (selection pressure 20% and 30%) ob

250 By applying our approach to a high content screen of 1,280 characterised drugs, we fou

251 Through a high-content screen (HCS) of >9,000 small molecules, we

252 To test this, we performed a high-content screen for miRNAs that inhibit the replicat

253 A high-content screen identified niclosamide as an effecti

254 Here we performed a high-content screen to identify drugs that block tumor c

255 le of SGs in pathophysiology, we performed a high-content screen to identify small molecules that alt

256 tely 367,000 small molecules in an automated high-content screen using an Xi-linked GFP reporter in m

257 Using a high-content screen, we identified the cardiac glycoside

258 glutathione reductase (SmTGR) inhibitors and high content screening (HCS) aiming to discover new anti

259 High content screening (HCS) showed that Silica NP expos

260 drug distribution in tissues by integrating high content screening (HCS) with U-Net based deep learn

261 identify inhibitors of DLK palmitoylation by High Content Screening (HCS).

262 Phenotypic high content screening against the intracellular parasit

263 hibition adopting a combined multiparametric high content screening and genomic approach.

264 phagy induction was examined by a cell-based high content screening system using LysoTracker, which w

265 d platform to monitor cell development using high content screening with a noninvasive and label-free

266 ve screening for cell-modulatory activity by High-Content Screening (HCS).

267 Here, we use a combination of high-content screening and mouse genetics to identify th

268 microfluidic systems for high-throughput and high-content screening applications.

269 additional targeting proteins using unbiased high-content screening approaches.

270 In the last decade, high-content screening based on multivariate single-cell

271 owerful and widely used method for analyzing high-content screening data.

272 genic compound identification and industrial high-content screening demands in the field of safety as

273 tor 4 alpha (HNF4alpha) positive, permitting high-content screening in a 96-well plate format.

274 le motorized positioning stage for automated high-content screening microscopy and provide detailed s

275 High-content screening microscopy relies on automation i

276 n of a robust in vitro platform that enabled high-content screening of multiple human pluripotent ste

277 e hemodynamic control that can be applied to high-content screening of new more efficacious antiplate

278 This robust platform now enables high-content screening of various C. elegans disease mod

279 ng EphA2 canonical signaling, we developed a high-content screening platform measuring inhibition of

280 his study, we developed a cell imaging-based high-content screening protocol to identify EMT-selectiv

281 a from several imaging modalities, including high-content screening, super-resolution and time-lapse

282 To explore high-content screening, we aimed to generate the largest

283 Here, we describe a novel high-content screening-based phenotypic assay that analy

284 plications for improved assay development in high-content screening.

285 ed from diversity-oriented synthesis through high-content screening.

286 In this context, we combined two genome-wide high-content screenings to assess the functional impact

287 This study demonstrates how high-content screens can be performed in oocytes, and al

288 High-content screens permit a readout (e.g., fluorescenc

289 Advances in in 3D cell cultures, high-content screens, robotic microscopy, CRISPR screeni

290 The advent of high-throughput/high-content single cell technologies is leading to an e

291 Learning cell identity from high-content single-cell data presently relies on human

292 identified islet-specific CD8+ T cells using high-content, single-cell mass cytometry in combination

293 A high-content siRNA microscopy screen allowed us to ident

294 to multidimensional images, thereby enabling high-content sorting of cells or cell clusters with uniq

295 We present a robot that enables high-content studies of alert adult Drosophila by combin

296 single cell lineage decisions by integrating high content super-resolution nanoscopy and imaging info

297 aditional hypothesis-driven methods but that high content system-wide efforts are required.

298 r researchers tuning tracking parameters for high-content time-lapse experiments.

299 ystematic analysis of cellular dynamics from high-content time-lapse imaging screens with little prio

300 igration tracts in brain parenchyma, allowed high-content time-resolved imaging of cell migration.