ライフサイエンスコーパス: high-dose

1 reblocking agents, except FTC146 and F4 at a high dose.

2 intraperitoneal administration of medium and high dose.

3 n without clear clinical indication for such high doses.

4 intracranial nicotine self-administration at high doses.

5 n and ganciclovir treatment was effective at high doses.

6 ed response to GA that was saturated only at high doses.

7 High doses (0.5 and/or 1 mM) of 3-MPA reduced mRNA expre

8 e comparisons, standard dose (0.5 mg/kg) and high dose (1 mg/kg) of intravenous ketamine were superio

9 vaccine provided protection against a lethal high dose (10(5) PFU) ZIKV challenge, but mtdVSV-NS1-bas

10 ins completely attenuated when inoculated at high doses (10(6) HAD(50)), demonstrating its potential

11 ls, injection of recombinant uPAR, even at a high dose (100 mug), did not induce proteinuria, effacem

12 Of those who started on high dose (120-199 morphine milligram equivalents [MME]/

13 moderate dose (20 mg MED, 27.3%), consistent high dose (150 mg MED, 15.0%), escalating dose (from <3

14 to be compromised by 24 hours of exposure to high doses (17.9 mug/cm(2)).

15 SV low dose, 31 who received the ChAd155-RSV high dose, 19 who received the placebo, and 15 who recei

16 After a single IV administration of high-dose (2 mg/kg) 5A7, opsonized platelets were rapidl

17 rticipants were randomly assigned to receive high dose (2000 IU) or standard dose (800 IU) daily vita

18 Effects of a high-dose 24-h infusion of tranexamic acid on death and

19 Addition to wine required high doses (25-32 g/L) for protein removal and haze prev

20 om a low dose (5 x 109 viral particles) to a high dose (5 x 1010 viral particles) occurred after the

21 After 21 days of treatment, a high dose (60 pmol) of ET-1 (E60) alone caused the great

22 elling rationale for testing combinations of high-dose AA and anti-PD1 agents in patients with aggres

23 High-dose AA treatment synergized with anti-PD1 therapy

24 huntingtin was generally tolerated, however high dose AAV5-miHTT did induce astrogliosis.

25 Finally, postsymptomatic therapy with high-dose AAV9 also significantly extended lifespan, sig

26 lating hormones at the lower doses, but post-high dose, acutely increased renin activity (Normal: p <

27 blethal (4 Gy), a lethal (9 Gy), or a single high-dose administration of (153)Sm-ethylenediamine-N,N,

28 ve four monthly infusions of low-dose AK002, high-dose AK002, or placebo.

29 ectories and reduced their variance, whereas high-dose AMPH expanded both.

30 were evaluated to investigate the effect of high-dose anakinra plus methylprednisolone on survival.

31 Initial high dose and extended taper of antiviral and steroid pr

32 es of FAs that function as antimicrobials at high doses and biofilm inhibitors at low doses.

33 gical barriers, as well as administration of high doses and frequent regimens.

34 s of disease phenotypes in groups exposed to high doses and high dose rates, such as the Japanese ato

35 High doses and long-term use of glucocorticoids lead to

36 0 additional patients received the selected (high) dose and of these, eight were evaluable for respon

37 Initial high-dose and extended taper of combined oral and topica

38 The high-dose and low-dose IV iron groups exhibited identica

39 d in 15 (20.8%) and 11 (15.7%) of the CsA CE high-dose and low-dose patients, respectively, most comm

40 ing detected differences between the low and high doses, and showed normalization of grey and white m

41 Although a fourth course of high-dose Ara-C reduced CIR and improved RFS, it did not

42 lowing an amendment to one or two courses of high-dose Ara-C.

43 ents are administered sequentially, but that high doses are less efficacious because of excessive ves

44 ta suggest that high concentrations and thus high doses are needed for COVID-19 infections, but as ye

45 nd septic shock treated with hydrocortisone, high-dose ascorbic acid, and thiamine (HAT therapy) was

46 assigned to 3-month treatment with either a high dose BDP/F 100/6 two inhalations b.i.d. (n = 31) or

47 High-dose beta-blockers (eg, 100 mg of metoprolol succin

48 ity to protect pigtail macaques from an i.v. high-dose cell-associated SHIVSF162P3 challenge.

49 infusion of Ab1485 protected macaques from a high dose challenge with SHIVAD8.

50 wed that the human vaccine protected against high-dose challenges of the nonencapsulated Sterne-based

51 spite new treatments and protocols including high doses chemotherapy associated with autologous stem

52 We compared second-line therapy with high-dose chemotherapy and autologous stem cell transpla

53 High-dose chemotherapy and autologous stem cell transpla

54 idates for aggressive salvage treatment with high-dose chemotherapy and autologous stem cell transpla

55 for AL amyloidosis involves choosing between high-dose chemotherapy and stem cell transplant or borte

56 anti-CD20 therapy), were not candidates for high-dose chemotherapy and subsequent autologous stem-ce

57 pite new treatments and protocols, including high-dose chemotherapy associated with autologous stem c

58 ase can be effectively treated or cured with high-dose chemotherapy followed by autologous haematopoi

59 venetoclax in combination with standard and high-dose chemotherapy in paediatric patients with relap

60 sed multiple myeloma and were ineligible for high-dose chemotherapy with autologous stem-cell transpl

61 agent chemotherapy, followed by 3 courses of high-dose chemotherapy with peripheral blood stem cell r

62 a plasma-cell neoplasm that is treated with high-dose chemotherapy, autologous stem cell transplant

63 malignancies that are currently treated with high-dose chemotherapy.

64 FRbeta 1 mg and aflibercept 2 mg (LD combo), high-dose combination intravitreal anti-PDGFRbeta 3 mg a

65 en." All 5 responded at least temporarily to high-dose corticosteroid treatment and regained bowel fu

66 to initiation of first-line therapy for CIP (high dose corticosteroids.

67 Systemic exposure to high-dose corticosteroids effectively combats acute reje

68 NS with combined plasmapheresis, HDIVig, and high-dose corticosteroids induced the complete remission

69 High-dose corticosteroids with IMT within 3 months resul

70 ts were all grade 1 to 2 and did not require high-dose corticosteroids; all nonendocrine immune-media

71 A CE 0.1% (1 mg/ml) eye drops 4 times daily (high dose), CsA CE twice daily (low dose) plus vehicle t

72 an anthracycline ("7+3") CLAG-M (cladribine, high-dose cytarabine, granulocyte colony-stimulating fac

73 The combination of precisely controlled high dose delivery, shorter exposure times, and eliminat

74 After symptomatic measures and high-dose dexamethasone, patients were randomly assigned

75 High-dose drugs, especially beta-lactam antibiotics, RCM

76 %) and cephalosporins (6/25, 24.0%), typical high-dose drugs, were most often identified as elicitors

77 henotypes underscore the need for caution in high-dose EGCG supplements as an intervention in DS.

78 ed with Fluzone (egg-based, n = 23), Fluzone High-Dose (egg-based, n = 16), Flublok (recombinant prot

79 ated with Fluzone (egg-based, n=23), Fluzone High-Dose (egg-based, n=16), Flublok (recombinant protei

80 0.88; 95% CI, 0.78-0.99) when compared with high dose epinephrine.

81 ) trial, which randomized patients to either high-dose eplerenone or placebo for 26 weeks.

82 High-dose erythropoietin has been shown to have a neurop

83 High-dose erythropoietin treatment administered to extre

84 lticenter, randomized, double-blind trial of high-dose erythropoietin, we assigned 941 infants who we

85 t mice were fed low dose fluoride (LF(-)) or high dose fluoride (HF(-)) and given intrauterine inject

86 exposed to unfractionated (600-1000 cGy) or high-dose fractionated (1440-1750 cGy) TBI.

87 The 20 patients in the high-dose fractionated (HDF) cohort had a 90% CR rate an

88 oth dose groups versus in the placebo group (high-dose group P = .047).

89 Patients in the high-dose group received a median monthly iron dose of 2

90 between control and moderate and control and high dose groups for constant pressure pain intensity (p

91 ally significant difference between low- and high-dose groups (P = .84).

92 75%, and 4.24% in the placebo, low-dose, and high-dose groups, respectively (P =.032 for the high-dos

93 oses of TSH and decreased cAMP production at high doses (>1 mU/ml).

94 Patients were randomised 1:1 to high dose (HD) IIV followed by standard dose (SD) vaccin

95 re the CD4+ and CD8+ T-cell responses of the high-dose (HD) and the standard-dose (SD) trivalent inac

96 relative vaccine effectiveness (RVE) for the high-dose (HD) influenza vaccine compared with standard-

97 low-dose (LD; 5 x 1010 vector particles) or high-dose (HD; 1 x 1011 vector particles) Ad26.RSV.preF

98 17 compared standard-dose (SD; 60 Gy) versus high-dose (HD; 74 Gy) radiation with concurrent chemothe

99 High-dose HIG may prevent fetal infection and disease an

100 B cells were sensitized and challenged with high-dose house dust mite (>10 mug) or with low-dose hou

101 Week-long transdermal delivery of high-dose hydrophilic drugs remains a big challenge.

102 an average of 2 doses (range, 1-6 doses) of high-dose hyperimmune globulin (HIG: 200 mg/kg/infusion)

103 ntrol in patients with type 2-high asthma on high-dose ICS at baseline.

104 In high-dose ICS type 2-high subgroups, dupilumab 200/300 m

105 Of those prescribed medium/high-dose ICSs as their first preventer, 13.0% already h

106 with guidelines-based therapy and requiring high-dose ICSs had reduced in vitro responsiveness to co

107 In mice, high dose immunization results in minimal local reactoge

108 or intravenous administration of the drug at high dose, improvements in both solubility and antibacte

109 viors in male mice but was only effective at high doses in female mice.

110 rver-blind, comparator-controlled (trivalent high-dose inactivated influenza vaccine [IIV3-HD], or qu

111 nization of the B cell compartment following high-dose infection by the intravenous route, which sugg

112 specifically in decidual macrophages during high-dose infections that result in fetal expulsion.

113 ections or exclusively for the mother during high-dose infections.

114 In patients on high-dose inhaled corticosteroids (ICS) with type 2-high

115 criptions of higher-level medication: medium/high-dose inhaled corticosteroids (ICSs) or ICSs + add-o

116 re recruited, including 208 (44%) prescribed high-dose inhaled corticosteroids and 122 (31%) with sev

117 year prior to enrollment, despite receiving high-dose inhaled corticosteroids and other controller(s

118 ip characterized by low-dose stimulation and high-dose inhibition.

119 ing toxicity issues associated with multiple high dose injections.

120 Listings with low-dose inotropes (-18%) and high-dose inotropes (-3%) significantly decreased.

121 High-dose insulin infusion stimulated glucose disposal s

122 survival (RFS) and overall survival (OS) for high-dose interferon alfa (HDI) and ipilimumab at 10 mg/

123 High dose interleukin-2 (IL-2) is active against metasta

124 histopathology throughout the brain with the high dose, intra-arterial treatment.

125 Here we show that high-dose intranasal SARS-CoV-2 infection in hamsters re

126 ssigned to receive placebo or SynGEM (low or high dose) intranasally by prime-boost administration.

127 We report the effect of high-dose intravenous immunoglobulin (IVIg) on safety, t

128 Corticosteroid and high-dose intravenous immunoglobulin achieved remission

129 uding immunoadsorption, plasma exchange, and high-dose intravenous immunoglobulin.

130 Pharmacological ascorbate (P-AscH(-), high-dose, intravenous vitamin C) is cytotoxic to tumor

131 harmacologic ascorbate treatment (P-AscH(-), high-dose, intravenous vitamin C) results in a transient

132 g maintenance hemodialysis to receive either high-dose iron sucrose, administered intravenously in a

133 cerns about negative side effects related to high-dose iron supplementation as well as the significan

134 However, the chronic use of ibuprofen at high doses is associated with increased risk for cardiov

135 e long-term opioid therapy (LTOT), which, at high doses, is theorized to induce maladaptive neuroplas

136 The activity of high-dose isoniazid against strains with katG mutations

137 High-dose isoniazid is recommended in short-course regim

138 SAINT, an accelerated, high-dose, iTBS protocol with fcMRI-guided targeting, wa

139 High-dose IV immunoglobulin (HDIVig), alone or in combin

140 found no significant difference between the high-dose IV iron group compared with the lose-dose grou

141 cally, mice were subject to oral gavage with high dose kanamycin, gentamicin, colistin, metronidazole

142 in life, but there have been few long-term, high-dose large-scale trials.

143 We aimed to determine the effectiveness of high-dose leucine supplementation on muscle morphology a

144 tigate the efficacy and safety of sublingual high-dose liquid birch pollen extract (40,000 allergy un

145 In parallel, chronic administration of high-dose lithium in CMS mice restored the firing proper

146 t the antidepressant-like effects induced by high-dose lithium were mediated by BNDF signaling in the

147 levels of Saa1 and Saa2 being comparable to high dose LPS.

148 results demonstrated the effectiveness of a high dose lutein/zeaxanthin supplement for MPOD volume a

149 The effect of a high dose lutein/zeaxanthin supplement on macular pigmen

150 f GluR or GLP-1R agonists and antagonists at high doses may lead to off-target effects at other recep

151 of TSH and that decreased cAMP production at high doses may represent a mechanism to prevent overstim

152 andard-of-care induction therapy followed by high-dose melphalan (200 mg/m(2)) conditioning and singl

153 The majority of the patients had received high-dose melphalan and stem cell transplantation and/or

154 single myeloma cell following treatment with high-dose melphalan therapy and autologous stem cell tra

155 m 388 newly diagnosed patients after in vivo high-dose methotrexate (HDMTX) (1 g/m2) treatment, defin

156 ) on courses 1, 3, 5, and 7 alternating with high-dose methotrexate and cytarabine on courses 2, 4, 6

157 e (POMP), with four intensification courses (high-dose methotrexate plus L-asparaginase and hyper-CVA

158 short regimen (9 to 11 months) that included high-dose moxifloxacin or a long regimen (20 months) tha

159 Non-inferiority was shown for low-dose and high-dose novel OPV2-c1 and high-dose novel OPV2-c2 desp

160 ovalent OPV2, 134 (94% [88-97]) of 143 after high-dose novel OPV2-c1, 122 (93% [87-97]) of 131 after

161 for low-dose and high-dose novel OPV2-c1 and high-dose novel OPV2-c2 despite monovalent OPV2 recipien

162 ovel OPV2-c1, 138 (95% [90-98]) of 146 after high-dose novel OPV2-c2, and 115 (91% [84-95]) of 127 af

163 High-dose NSAID prescriptions were associated with 2.83

164 e resulting wine after UV-C treatment with a high dose of 21 kJ/L.

165 ins; however, this system generally requires high dose of auxin to achieve effective depletion in ver

166 Moreover, a high dose of favipiravir decreased virus transmission by

167 Ingestion of a high dose of fructose for 8 wk was not associated with r

168 Administration of a high dose of GAd accomplished extensive transgene expres

169 Treatment with a high dose of granulocyte colony-stimulating factor incre

170 Fifty-four subjects received low, medium, or high dose of HB-101 or placebo by intramuscular administ

171 Exposure to a high dose of ionising radiation associated with this mod

172 uction of striatal Nurr1 despite receiving a high dose of l-DOPA.

173 The hypothesis is that a high dose of l-fucose delivered to the kidney obstructs

174 a from mice acutely inflamed by injection of high dose of lipopolysaccharide (LPS).

175 lls (CASMCs) from Asah1(fl/fl)/SM(Cre) mice, high dose of P(i) led to a significantly increased calci

176 etes female mice were injected with a single high dose of streptozotocin and 3 weeks thereafter used

177 In contrast, co-infection with a high dose of T. muris that induces a T helper cell type

178 jury in the heart by treatment with a single high dose of the beta-adrenergic agonist isoproterenol.

179 At D7 after the high dose of the study vaccine, the median frequencies o

180 However, a high dose of virus is needed to produce disease, and the

181 A high dose of vitamin C, in addition to delivering an acu

182 We then show that high doses of a physical stressor (increased temperature

183 groups received saline placebo, standard or high doses of Ad26 or MVA in two-dose regimens in 7-, 14

184 Exposure to high doses of alkylating agents is associated with incre

185 s was observed, unlike other models that use high doses of bacteria.

186 The present findings also revealed that high doses of BrdU lead to the activation of apoptotic c

187 He was treated with high doses of corticosteroids and acetylsalicylic acid a

188 Screens performed under high doses of DHA provide evidence that mitochondrial me

189 However, high doses of favipiravir significantly reduced infectio

190 Here we report measurements of the impact of high doses of gamma and neutron radiation on nanoscale p

191 High doses of ganciclovir resolved the viremia, which co

192 with poor disease control, even while taking high doses of inhaled corticosteroids (ICS).

193 ction or severe asthma that are treated with high doses of inhaled corticosteroids.

194 cardiologists are occupationally exposed to high doses of ionizing radiation.

195 health effects that occur after exposure to high doses of ionizing radiation.

196 eptible to injury induced by one or multiple high doses of isoproterenol, despite expressing ~57% dys

197 Instead, high doses of morphine increased the occurrence of apnoe

198 o effect on rate following administration of high doses of morphine.

199 ow dose, but had no effect on rate following high doses of morphine.

200 BALB/c mice were fed once with high doses of nCyp c 1 or mCyp c 1, before sensitization

201 ward sensitivity including increased ICSA at high doses of nicotine that is restored by re-expression

202 This preventive external application of high doses of NO(.) by wasp eggs represents an evolution

203 ated ICU patients who were given moderate-to-high doses of opioids and expected to remain alive and v

204 High doses of opioids cause severe rate depression and i

205 High doses of perfluorooctanesulfonic acid (PFOS) and pe

206 e first description of the administration of high doses of pooled serum IgG, also referred to as intr

207 The high doses of siRNA and delivery vehicle that are thus r

208 Exposure to high doses of solar long wavelength ultraviolet radiatio

209 e asthma with impaired lung function despite high doses of steroids.

210 High doses of the initial lead compound led to tumor sta

211 t OPV2 use, and a phase 2 study with low and high doses of two novel OPV2 candidates.

212 Pre-treatment with high doses of WS-CM abolished agonist-stimulated secreti

213 In conclusion, high-dose ondansetron reduces activation of several area

214 ine milligram equivalents [MME]/day) or very high dose opioids (>=200 MME/day), 10.3% and 18.7% remai

215 itiation of or escalation to more potent and high dose opioids may contribute to long-term use.

216 er and countering the respiratory effects of high dose opioids via the KF may be an effective approac

217 Only high-dose opium use was associated with pancreatic cance

218 Exposure to high doses or a high cumulative dose of erythropoiesis-s

219 going maintenance hemodialysis for ESKD to a high-dose or a low-dose IV iron regimen, with a primary

220 original regimen (CsA CE 4 times daily [QID, high-dose] or CsA CE twice daily [BID, low-dose] + vehic

221 A single high-dose oral administration of nCyp c 1 but not of mCy

222 a on the feasibility, efficacy and safety of high-dose oral immunotherapy (OIT) in children highly al

223 rom 1 to several days after infection with a high-dose, oral-nasal virus challenge were protected fro

224 Noise from excessive excitability at high doses overcomes stability enhancement to drive freq

225 Here, we administered high-dose pembrolizumab (10 mg/kg, day 1, every 2 wk) co

226 tients with malignant mesothelioma receiving high-dose pembrolizumab.

227 re chamber response to these high energy and high dose-per-pulse beams must be well understood.

228 ard ionisation chambers for the dosimetry of high dose-per-pulse VHEEs has been shown to require larg

229 with pulsed fields at low dose (PF(LD)) and high dose (PF(HD)) and followed for 4 and 2 weeks, respe

230 High-dose, pharmaceutical-grade biotin (MD1003) might en

231 High-dose POMA exerted significant effects on clinical s

232 High-dose POMA significantly reduced ketamine-induced BP

233 e pre-BCR/BCR stimulation but exacerbated by high-dose pre-BCR/BCR stimulation as well as antiapoptot

234 and deprivation were associated with greater high-dose prescribing rates.

235 ongs accounted for 11.7% of the variation in high-dose prescribing.

236 ing P. vivax, failure rates after supervised high-dose primaquine are significantly lower (~3%) than

237 In contrast, after supervised high-dose primaquine only 1 in 40 relapse.

238 Compared to controls, high-dose progesterone administration produced a signifi

239 G-MLPS; gemcitabine plus dacarbazine in LMS; high-dose prolonged-infusion ifosfamide in SS; etoposide

240 In contrast, high dose radiation (10 Gy and above) decreases miR-15a

241 Mimicking the effects of high dose radiation with a miR-15a inhibitor decreases c

242 High-dose radiation activates caspases in tumor cells to

243 the risk of, and associations with, SAE and high-dose radiation exposure using large-scale registry

244 High-dose radiation is the main component of glioblastom

245 ted a population of mice that recovered from high-dose radiation to live normal life spans.

246 The mechanism of tumor response to high-dose radiotherapy (HDRT) is controversial, with com

247 We compared the tumoricidal potency of ultra-high dose rate and conventional dose rate radiation usin

248 compare the safety and efficacy of TAI ultra-high dose rate FLASH irradiation to conventional dose ra

249 Recent reports have shown that very high dose rate radiation (35-100 Gy/second) referred to

250 apy, with the recent intriguing potential of high dose-rate irradiation.

251 E radiotherapy, FLASH radiotherapy and other high dose-rate modalities.

252 High dose-rate radiotherapy, known as FLASH, has been sh

253 enotypes in groups exposed to high doses and high dose rates, such as the Japanese atomic bomb surviv

254 ding of the radiobiological effects at ultra-high dose-rates is important for any future clinical ado

255 d 3c2.A2 were similar in Flublok and Fluzone High-Dose recipients, though seroconversion rates trende

256 d 3c2.A2 were similar in Flublok and Fluzone High-Dose recipients, though seroconversion rates trende

257 ion and randomized at birth to receive early high-dose recombinant human erythropoietin (rhEpo) vs pl

258 del, CPT31 prevented infection from a single high-dose rectal challenge.

259 uring the 8-month follow-up period, with the high-dose regimen continuing to provide greater benefits

260 Pharmacokinetic modeling predicts that most high dose regimens trialled in COVID-19 are unlikely to

261 High-dose remote ischemic preconditioning could stimulat

262 omodulation Therapy (SAINT), an accelerated, high-dose resting-state functional connectivity MRI (fcM

263 es, it is a diagnosis not to be missed since high-dose riboflavin per oral supplementation is often h

264 trong support for ongoing clinical trials of high-dose rifampicin regimens.

265 a nAb provides protection against disease in high-dose SARS-CoV-2 challenge in Syrian hamsters.

266 in cultured cancer cells using single-step, high-dose selection, these findings highlight that the s

267 etinopathy, to treatment with either low- or high-dose Sinemet (levodopa plus carbidopa) for 2 weeks

268 In the high-dose single infusion cohort, 3 of 6 patients with r

269 High-dose statin treatment seems to reduce cardiovascula

270 f ERCP; 118 and 245 participants were taking high dose statins (atorvastatin 40-80 mg or rosuvastatin

271 Possible rescue therapies (high-dose statins, octreotide, thalidomide, lenalidomide

272 rospinal fluid parameters was observed after high-dose steroid treatment, thus arguing for an inflamm

273 frequently hydroxychloroquine, azithromycin, high-dose steroids, lopinavir/ritonavir, and tocilizumab

274 High-dose synthetic estrogen therapy was the standard tr

275 rmore, the combination of dietary inulin and high-dose T. muris infection caused marked dysbiosis, wi

276 We demonstrate that single high dose TAI-FLASH produced less mortality from gastroi

277 ice were given intraperitoneal injections of high-dose tamoxifen to induce SPEM or gavaged with H pyl

278 progression, achieved response criteria for high-dose therapy (HDT), and had no resection before ind

279 curs in patients undergoing long-term and/or high-dose therapy with nitrogen-containing bisphosphonat

280 ociated mutations infrequently emerged after high-dose therapy.

281 acid) (PLGA) and showed reliable release of high dose TMZ for a period of 4 weeks.

282 Exposures included egg-based high-dose trivalent (HD-IIV3), egg-based adjuvanted triv

283 while inhibiting the enzyme activity at the high dose used in clinical practice.

284 We also found that the high-dose vaccine was consistently more effective than s

285 a direct regulatory effect, while continuous high dose vitamin D treatment could trigger multiple scl

286 fl)/SM(wt) and WT/WT mice) after receiving a high dose vitamin D.

287 Monthly high-dose vitamin D supplementation does not prevent ARI

288 Withdrawal of VKAs and high-dose vitamin K2 improve vitamin K status in patient

289 Of 35 studies that evaluated high-dose vitamin treatment for COVID-19, 27 (77%) exclu

290 ity were analyzed both within the irradiated high-dose volume (HDV) and on a patient basis.

291 h-dose groups, respectively (P =.032 for the high-dose vs placebo group).

292 omized trial reporting no apparent effect of high-dose vs standard-dose prenatal vitamin D supplement

293 Placebo-treated subjects crossed over to high-dose VWG OIT (maximum, 2748 mg of WP).

294 Low- and high-dose VWG OIT induced desensitization in about one h

295 placebo-treated subjects who crossed over to high-dose VWG OIT, 12 (57.1%) of 21 were desensitized af

296 gamma-secreting T-cells after a ChAd155-RSV high dose was 108.3/106 PBMCs at D30, with no increase a

297 o our knowledge, this is the first time that high-dose week-long sustained transdermal delivery of hy

298 r ratios (post/pre-immunization) following a high dose were 2.6 (D30) and 2.3 (D60).

299 hanol and the sedative-hypnotic effects of a high dose, while reduced astrocyte calcium signaling dim

300 inocytes (NHEK) from G2/M phase arrest under high-dose X-ray irradiation.