ライフサイエンスコーパス: high-throughput

1 ted quantitative analysis of chemotaxis, and high throughput.

2 e large data sets of mitochondrial images in high throughput.

3 s are needed that are both high fidelity and high throughput.

4 Here we report the development of a high throughput, all-solution phase, and isothermal dete

5 In summary, the platform affords high-throughput analyses of antibodies, including bispec

6 For high-throughput analyses of sphingolipids, tandem mass s

7 curacy and velocity compatible with those of high-throughput analyses.

8 ia are inefficient, and often prevent rapid, high-throughput analyses.

9 High-throughput analysis of 3D cultures enabled by this

10 preparation method was developed, allowing a high-throughput analysis of a significant number of cell

11 nd enriched biophysical insights by enabling high-throughput analysis of biological data and dissecti

12 Patterning is combined with high-throughput analysis of grafted-from polymerization

13 Here we describe 'circularization for high-throughput analysis of nuclease genome-wide effects

14 within seconds, holding great potential for high-throughput analysis.

15 t, cost-effective and objective approach for high throughput analytical screening to discard defectiv

16 pendent acquisition (DIA) has potential as a high-throughput analytical method due to the reduced tim

17 Here we describe a high-throughput analytical platform based on denaturing

18 peed and uniformity at less cost, leading to high throughput and practical preclinical in vivo therap

19 technology to develop multiple all-inclusive high throughputs and customized organ-on-a-chip-like pla

20 Here we use high-throughput and DR subdomain-targeted single-cell tr

21 The high-throughput and high reproducibility provided by the

22 The convolutional neural network allowed high-throughput and large-scale, quantitative and compar

23 spitalized with COVID-19 were analyzed using high-throughput and ultrasensitive proteomic platforms a

24 ewly emerged enhanced SPR biosensors towards high-throughput and ultrasensitive screening of miRNAs u

25 sensing device (ToMMx), which is a portable, high-throughput and user-friendly microfluidic platform.

26 opy (SOCM) technique that offers label-free, high-throughput, and large-volume imaging of ex vivo mou

27 study has established a robust protocol for high-throughput anti-RABV drug screens and identified a

28 This high-throughput antibody assay is accurate, requires onl

29 To address this issue, we used a high-throughput approach to profile the alphabeta TCR re

30 Using a high-throughput approach, we have directly identified sp

31 d proteins using minimal sample volume and a high-throughput approach.

32 Whilst high throughput approaches have been used for more than

33 have developed a novel co-culture cell-based high throughput assay system to identify compounds that

34 of alternative splicing, no correspondingly high-throughput assay exists for functionally interrogat

35 sceptible to cytidine deaminase, we set up a high-throughput assay for assessing sgRNA-independent of

36 Hence, with the proliferation of high-throughput assay technology, there is an imminent n

37 Here, using a high-throughput assay that analyses both V(D)J segment u

38 Here we use a high-throughput assay that we term SaMBA (saturation mis

39 elopment of tools for predicting ligands and high throughput assays to identify ligand-receptor pairs

40 acological properties and the development of high-throughput assays for drug development targeting th

41 This Review discusses the use of high-throughput assays in human induced pluripotent stem

42 Over the past 30 years, only a few high-throughput AST methods have been developed and wide

43 Here we developed simultaneous high-throughput ATAC and RNA expression with sequencing

44 We used a high-throughput automated behavioral monitoring system t

45 eloped and validated an open-source tool for high-throughput, automated histological analysis of card

46 , high sensitivity, and ability to carry out high-throughput automation analysis (i.e., sensing array

47 gation from smaller peptide fragments, and a high-throughput bacterial expression and assay platform

48 l research and the computational analysis of high-throughput biochemical data.

49 al heterogeneity and wide-ranging quality of high-throughput biological data means that even data wit

50 Herein, we report a high-throughput bottom-up proteomic method enabled by a

51 encing with biological nanopores is fast and high-throughput but suffers reduced accuracy in homonucl

52 rug combinations using monotherapy data from high-throughput cancer cell line screens.

53 g in both academia and industry owing to its high throughput capability, prompt availability, and hig

54 ed HB catalysts, we developed a hierarchical high-throughput catalyst screening (HHTCS) approach base

55 ngineering approach enriches the toolbox for high-throughput cell imaging.

56 iscovery is revolutionizing the conventional high-throughput cell-based screening system, its limitat

57 To this end, a high-throughput, cellular NanoBRET assay was developed t

58 y from local pathology laboratories and into high-throughput, centralized (and often for-profit) labo

59 s droplet microfluidics-based method enables high-throughput chemical conversion on barcoded beads, e

60 (MEDEA), a computational tool that analyzes high-throughput chromatin accessibility genomic data to

61 range interactions (81), identified by Hi-C (high-throughput chromatin conformation assay) and HiChIP

62 We used high-throughput chromosomal conformation capture coupled

63 chromosome), using an optimized single-cell high-throughput chromosome conformation capture (HiC) pr

64 d by genetic, high-resolution microscopy and high-throughput co-immunoprecipitation strategies.

65 e organoid barcoding in situ (TOBis) enables high-throughput comparison of signaling networks between

66 aracterization, first-principles simulation, high throughput computation, machine learning, and artif

67 Machine learning and high-throughput computational screening have been valuab

68 s in various 3D culture applications such as high-throughput/content screening, drug discovery, disea

69 analytical platform that enables direct and high-throughput coupling to electrospray ionization mass

70 Here, we performed high-throughput CRISPR screening using a ubiquitin regul

71 Here, we apply Hi-C, a high-throughput, culture-independent method, to surveil

72 by combining metabarcoding analyses with mid/high-throughput culturing approaches.

73 powerful tool for unsupervised processing of high-throughput data across a range of single-molecule e

74 mmune system at high resolution, translating high-throughput data into knowledge of immune mechanisms

75 Inferring cell-signaling networks from high-throughput data is a challenging problem in systems

76 tions for organisms where these, or similar, high-throughput datasets are available.

77 Combining high-throughput discovery and subsequent structure-funct

78 ic carbohydrate-degrading systems and in the high-throughput discovery of alpha-l-arabinofuranosidase

79 PCR test and its modified version based on a high-throughput DNA extraction method (Fast96-qPCR).

80 With the development of the high-throughput DNA sequencing of organisms at the popul

81 g chromatin immunoprecipitation coupled with high-throughput DNA sequencing, with cells grown in the

82 ng of viral sequence diversity and allow for high throughput documentation of the virosphere.

83 we present an integrative bioinformatic and high throughput drug screening study to define the role

84 s and development of improved mixture-based, high-throughput drug discovery techniques.

85 therapeutic utility of BAs in a platform for high-throughput drug screening (HTS).

86 l short-term transplant platform amenable to high-throughput drug screening studies, yet animals even

87 ith standard epifluorescence microscopes for high-throughput efficiency and the new sequencing chemis

88 In this work, we report the combination of high-throughput elicitor screening (HiTES) with matrix-a

89 on/dNTP replication machinery, the amplified high-throughput emergence of CDNs is demonstrated.

90 readily adapted into an automated format for high-throughput engineering of small-molecule-binding ap

91 Together, our method enables a high-throughput enrichment of glycan, glycosites, and IG

92 ases, methylated TFBSs derived from in vitro high-throughput EpiSELEX-seq binding assays and in vivo

93 were obtained from 16 055 datasets using 12 high-throughput experiment methods (e.g. H3K4me1/H3K27ac

94 gy development are increasingly in demand as high-throughput experimentation protocols in academia an

95 y described herein was enabled in microscale high-throughput experiments to allow for the rapid ident

96 ce is a crucial step at the design stage for high-throughput experiments.

97 We are proving here the first high-throughput expression dataset of pepper fruits in r

98 s with arbitrary shapes and dimensions, in a high-throughput fashion (over approximately a few cm(2)

99 y element-sequencing) to identify fSNPs in a high-throughput fashion, SDCP-MS (SNP-specific DNA compe

100 l-molecule-binding aptamers in an automated, high-throughput fashion.

101 In this study, a high-throughput fluorescence assay method for determinat

102 ynthesis modeling through the integration of high-throughput fluorescence phenotyping data, resulting

103 Hepatoblast spheroids were reseeded in a high-throughput format and induced to form hepatic organ

104 We utilized a high-throughput full-factorial experimental system and t

105 We analyzed high throughput gene expression and chromatin accessibil

106 presses expression of clock-related genes in high throughput gene expression studies, compared with t

107 integrative analysis on publicly available, high-throughput gene expression data.

108 All high-throughput gene expression datasets of solid organ

109 Recently, using a high-throughput genetic screen of a human interferon-sti

110 As shown herein by genotyping assays and high-throughput genome-wide sequencing of DNA translocat

111 omic aberrations are routinely determined by high-throughput genomic measurements.

112 forerunners that pioneered the revolution of high-throughput genomic technologies is the genotyping m

113 Here, high-throughput growth, completed in 12 min, of 6-inch w

114 min), sensitive (>100-fold improvement), and high-throughput (>96 wells) characterization of bacteria

115 Image-based high throughput (HT) screening provides a rich source of

116 acterium Pseudomonas syringae by combining a high-throughput ice nucleation assay with surface-specif

117 ere, we combined NMR structural biology with high-throughput iCLIP approaches to identify a regulator

118 Nevertheless, high throughput identification within the LESA FAIMS ima

119 oop RNA binding domain interaction, enabling high-throughput identification of proteins with high sen

120 Here, we demonstrate that high-throughput in vitro DNA binding assays coupled with

121 High-throughput in vitro drug assays have been impacted

122 ook a multifaceted approach, starting with a high-throughput in vitro primary screen to identify inhi

123 This 3D printed device provides a unique high-throughput in vitro system that combines both mecha

124 in, a small polar substrate commonly used in high-throughput in vitro transporter inhibition assays i

125 ve mouse model of glioblastoma, we develop a high-throughput in vivo screening platform and discover

126 When high throughput is combined with high temporal and spati

127 bead-tracking applications, especially when high throughput is required and image artifacts are diff

128 In a recent high-throughput kinome screen in NF2-null human arachnoi

129 pite promising demonstrations, the lack of a high-throughput label-free method of detecting bacteria

130 ged from <=10 to 74 copies/ml for commercial high-throughput laboratory analyzers (Roche Cobas, Abbot

131 The recent development of high throughput magnetic tweezers has enabled the simult

132 utant resource for S. viridis in a rapid and high throughput manner, and has the potential to be wide

133 ions, using a conventional plate reader in a high-throughput manner.

134 ngle-cell RNA-sequencing (scRNA-seq) enables high-throughput measurement of RNA expression in single

135 New technologies allow high-throughput measurement of the relative fitness of b

136 kage for pollen tetrad analysis that enables high-throughput measurements of crossover frequency and

137 We demonstrate an autonomous, high-throughput mechanism for sorting of emulsion drople

138 ion-based on various clinical phenotypes and high-throughput metabolic profiles in the Angiography an

139 Progress in high-throughput metabolic profiling provides unprecedent

140 step batch correction and quantification for high-throughput metabolomics.

141 new computational framework that serves as a high throughput method to evaluate risk of genetic mutat

142 EV stiffness values measured with our high-throughput method are in very good quantitative acc

143 To address the limitation, we developed a high-throughput method for characterizing glycans, glyco

144 We have developed a novel, high-throughput method of quantifying seven terpenes (al

145 High-throughput methods for introducing mutations and ch

146 Several studies used high-throughput methods to identify various RREs in mRNA

147 In this study, we describe a novel high throughput, micro-macro approach for the identifica

148 High throughput microfluidic protocols in single cell RN

149 Here, we present a high-throughput microfluidic platform that enables the q

150 Here, we developed a high-throughput microscopy-based retrotransposition assa

151 onization mass spectrometry have enabled the high-throughput, multiplexed chemical analysis of single

152 We analyze high-throughput mutagenesis data obtained for an alterna

153 trometry (MALDI-MS) is an important tool for high-throughput N-glycan profiling and, upon use of tand

154 Here we present a high-throughput nanoluciferase severe respiratory syndro

155 bining the precision of digital PCR with the high-throughput nature of 16S rRNA gene amplicon sequenc

156 ion mode, without significantly altering the high-throughput nature of the analysis.

157 roposed several decades before the advent of high-throughput omic techniques, and it is unclear wheth

158 While high-throughput omics approaches have been increasingly

159 The advent of high-throughput (omics) technologies gives opportunities

160 demonstrates LAMIMS as a broadly applicable high-throughput operando screening method for heterogene

161 plet generation affords precise, low volume, high throughput opportunities for molecular diagnostics.

162 imized hardware and method setup resulted in high-throughput performance and enables further implemen

163 comprehensive serological profiling using a high-throughput phage immunoprecipitation sequencing ass

164 High-throughput phenomic projects generate complex data

165 High-throughput phenotyping (HTP) technologies can produ

166 High-throughput phenotyping and data mining can capture

167 tered and water-limited growth conditions, a high-throughput phenotyping facility was used to measure

168 Specifically, high-throughput phenotyping of 530 unique mouse gene kno

169 ecific angle data collected manually and via high-throughput phenotyping strategies.

170 In this study, we developed a high throughput platform for applying complex dynamic me

171 An automated high-throughput platform can screen for molecules that c

172 A high-throughput platform would greatly facilitate corona

173 nable to future integration into multiplexed high-throughput platforms for screening of molecules tha

174 cable technique for the precisely controlled high-throughput preparation of well-defined interfaces c

175 sma applications are examined, spanning from high-throughput, printing-technology-compatible synthesi

176 is inadequate at present and does not allow high-throughput processing.

177 situ and sequencing (PETRI-seq)-a low-cost, high-throughput prokaryotic scRNA-seq pipeline that over

178 In this study, we describe an optimized high-throughput proof-of-principle method for the expand

179 ut chromatin conformation assay) and HiChIP (high-throughput protein centric chromatin) performed on

180 n easy-to-manipulate system that enables the high-throughput protein characterization in insect cells

181 Metabolomics was performed using a high-throughput proton nuclear magnetic resonance metabo

182 ationship with WUE(i) , and can be used as a high-throughput proxy to screen for WUE(plant) in these

183 mpling device that holds great potential for high-throughput quantitative omics analysis of ultralow-

184 droplet microfluidic platform, which enables high-throughput reaction discovery in flow to generate p

185 High-throughput reporter assays dramatically improve our

186 machine learning (ML) is uniquely suited for high-throughput research.

187 RBDs) and assessed their specificities using high-throughput RNA-SELEX (HTR-SELEX).

188 ecific tissues or cells, process and analyze high-throughput RNA-sequencing data, and define sets of

189 g coupled with targeted gene knockouts and a high-throughput RNAi assay enabled the first characteris

190 an change nuclear morphology, we conducted a high-throughput RNAi screen to identify epigenetic regul

191 rumentation advancement, a single-tube-based high-throughput sample processing workflow is imperative

192 erformance, in particular the performance of high-throughput SARS-CoV-2 RT-PCR systems.

193 We employed a high-throughput scheduled multiple-reaction monitoring (

194 Specifically, we carry out a high throughput screen using Msi2-reporter blast crisis

195 argeted the regulatory site of ERAP1 using a high-throughput screen and discovered a small molecule h

196 Lastly, through a high-throughput screen designed to identify bile acid mi

197 In a high-throughput screen for inhibitors of HPIV3 (a major

198 We report here a cell-based high-throughput screen of a library containing two-milli

199 inoindazoles previously identified through a high-throughput screen of human kinase inhibitors, and t

200 ort the identification of CVM-05-002 using a high-throughput screen of PI5P4Kalpha against our in-hou

201 We developed a high-throughput screen to identify compounds approved by

202 rulence factors needed to cause pneumonia, a high-throughput screen was performed with an arrayed lib

203 Using a high-throughput screen, we identified decitabine as a po

204 A FRET-based high throughput screening identified NSC622608 as the fi

205 We use high throughput screening of large libraries of material

206 a costly and rate-limiting prerequisite for high throughput screening.

207 This need is being addressed using high-throughput screening (HTS) in vitro approaches and

208 High-throughput screening (HTS) of 997 locked nucleic ac

209 We performed high-throughput screening (HTS) of a chemical library to

210 High-throughput screening (HTS) research programs for dr

211 High-throughput screening and fragment-screening campaig

212 High-throughput screening and gene signature analyses fr

213 optimized CBS workflow allows for rapid and high-throughput screening and quantitation of 105 veteri

214 ure range, paving the way toward T-dependent high-throughput screening applications by HDX-MS.

215 er of seconds, opening up the possibility of high-throughput screening applications of relevance to t

216 rehensive drug discovery techniques allowing high-throughput screening are now required to develop ef

217 Using a FRET-based high-throughput screening assay that we previously repor

218 With the increase in high-throughput screening data, scaffold graphs have pro

219 -well plates, making it readily adaptable to high-throughput screening for PSD inhibitors.

220 grows, targeted biochemical assays enabling high-throughput screening have become increasingly inter

221 we report the multifactorial optimization of high-throughput screening hit 8 to a potent, metabolical

222 (1-octanoyl)phenyl]acetate (TMPA), and three high-throughput screening hit derivatives.

223 High-throughput screening identified doxorubicin (DXR) a

224 We searched for new agents by high-throughput screening of selected targeted compounds

225 time of the functional analysis step enables high-throughput screening of shRNA or CRISPR-Cas9 constr

226 te towards routine application of cryo-EM in high-throughput screening of small molecule modulators a

227 These observations prompted us to develop a high-throughput screening platform of cancer drugs in a

228 aches is often time consuming, thus limiting high-throughput screening tests.

229 as Sacchaomyces cerevisiae, which allow for high-throughput screening to patient-derived cell-lines

230 in vivo, and generating new developments in high-throughput screening used to identify functional ln

231 Label-free high-throughput screening using mass spectrometry has th

232 a fully automated platform for ESI-MS-based high-throughput screening.

233 generation of more physiologically relevant high-throughput screens (HTS).

234 try (IHC), to microarrays (protein, DNA), to high-throughput screens rely on probe-target hybridizati

235 to computational pipelines when dealing with high throughput scRNA-seq data.

236 bial split-pool ligation transcriptomics), a high-throughput scRNA-seq method for Gram-negative and G

237 rt the development and characterization of a high throughput sensing device for single liposome detec

238 t and quantitate cGAMP with an assay that is high-throughput, sensitive, and precise.

239 we performed a compound screen coupled with high throughput sequencing to assess key transcriptional

240 Transposase-Accessible Chromatin coupled to high-throughput sequencing (ATAC-Seq), we first find tha

241 High-throughput sequencing (HTS) provides opportunities

242 High-throughput sequencing and the availability of large

243 for entire mtDNA genome enrichment prior to high-throughput sequencing are not readily available.

244 ydia DNA as a clinically relevant target and high-throughput sequencing as an analytical tool, we inv

245 High-throughput sequencing can enhance the analysis of a

246 High-throughput sequencing can establish the functional

247 an inducing pseudouridylation of the miRNAs, high-throughput sequencing crosslinking immunoprecipitat

248 nrichment is a popular method for annotating high-throughput sequencing data.

249 to quickly, accurately and reliably process high-throughput sequencing data.

250 High-throughput sequencing experiments followed by diffe

251 Embedded viral barcoding in combination with high-throughput sequencing is a powerful technology with

252 Ribose-Map techniques, we built and analyzed high-throughput sequencing libraries of rNMPs derived fr

253 High-throughput sequencing of RNA (RNA-seq) has expedite

254 Streptomyces diversity was examined using high-throughput sequencing of rpoB amplicons generated w

255 in the context of cancer, the recent use of high-throughput sequencing techniques has led to the ide

256 However, even with standard high-throughput sequencing techniques, complex rearrange

257 nnual skeletal banding patterns, and utilise high-throughput sequencing to comprehensively characteri

258 High-throughput sequencing was used to characterize the

259 High-throughput sequencing, liposomal nanoallergen displ

260 arget family can routinely be identified via high-throughput sequencing, we believe our strategy offe

261 ulations, Argonaute-immunoprecipitations and high-throughput sequencing, we provide experimental evid

262 combines chromatin conformation capture with high-throughput sequencing.

263 g ribosome affinity purification followed by high-throughput sequencing.

264 ptavidin beads before library production and high-throughput sequencing.

265 laboratory-grown halite over 21 weeks, using high-throughput sequencing.

266 e in DNA copy number that can be measured by high-throughput sequencing.

267 were quantified after liver repopulation via high-throughput sequencing.

268 laboratory with access to FACS, robotic and high-throughput-sequencing facilities.

269 t the Ortho anti-SARS-CoV-2 total Ig and IgG high-throughput serological assays (HTSAs) and the Abbot

270 sources can be implemented in many different high-throughput settings to ultimately improve power.

271 , to evaluate and control reproducibility in high-throughput settings.

272 High-throughput short-read and long-read sequencing of V

273 types that comprise these pathways, we used high-throughput single-cell RNA sequencing (scRNAseq).

274 SAMOSA is a high-throughput single-molecule sequencing method that c

275 candidate RAN translation inhibitors from a high-throughput small-molecule screen for fragile X trem

276 Here, we develop a facile, general, and high throughput solvent-free self-assembly strategy to s

277 We describe a microfluidic system for high-throughput sorting of nanoliter droplets based on d

278 ell surface click chemistry in bacteria with high-throughput sorting, we developed a method to quanti

279 The recent work by Mann et al. used high-throughput synthesis and screening of polyacrylamid

280 ribes a rapid, low-cost, easy to-handle, and high-throughput TaqMan-MGB probe qPCR assay to perform b

281 tion is the first step in making EBSD into a high-throughput technique.

282 plementation will be hampered by the lack of high-throughput techniques for exfoliating single-crysta

283 l 'inverse drug discovery' programs that use high-throughput techniques to isolate effective compound

284 The widespread adoption of high throughput technologies has democratized data gener

285 High-throughput technologies for genomics, transcriptomi

286 roteomics, facilitated by recent advances in high-throughput technologies, have given us unprecedente

287 It was only recently, through the advent of high-throughput technologies, that scientists gained the

288 Using a high-throughput technology to interrogate most single tr

289 t enable both the collection and analysis of high-throughput temporal data.

290 In a previous high-throughput time-resolved FRET (TR-FRET) screen, we

291 ng the complex sample analysis necessary for high-throughput top-down proteomics.

292 Leveraging high-throughput transcriptomics we identify NMD targets

293 We propose a new high-throughput ultrafast method for large-scale proteom

294 ted behavior with PsychoGenics' SmartCube, a high-throughput unbiased automated phenotyping platform

295 e in a fast (less than 1 min per sample) and high-throughput (up to 384 samples per run) way.

296 rance barrier for labs who are interested in high-throughput variant calling applications on a large

297 We next conducted a high-throughput virtual screen against this site and ide

298 We performed a high-throughput whole-genome RNAi screen to identify nov

299 ver, demonstrations of the utility of IMS in high-throughput workflows such as liquid chromatography-

300 evaluate sperm at the microscopic level, at high-throughput, would be useful for assisted reproducti