ライフサイエンスコーパス: high-throughput screening

1 c-Abl activators, initially identified by a high throughput screening.

2 aking it more user-friendly and suitable for high throughput screening.

3 from fast reaction kinetics to microfluidic high throughput screening.

4 ing of AZIN to antizyme that are amenable to high throughput screening.

5 er sensitivity, simplicity and capability of high throughput screening.

6 a costly and rate-limiting prerequisite for high throughput screening.

7 a fully automated platform for ESI-MS-based high-throughput screening.

8 rafish development is an excellent model for high-throughput screening.

9 ant phosphatase assays that are suitable for high-throughput screening.

10 ombinant RSV virus and applied the strain to high-throughput screening.

11 lenges that are currently encountered during high-throughput screening.

12 AP) is an efficient method for Ras inhibitor high-throughput screening.

13 a scintillation proximity assay suitable for high-throughput screening.

14 arget engagement, receptor pharmacology, and high-throughput screening.

15 ome-wide mRNA profiling method to complement high-throughput screening.

16 ntify stable reference miRNAs in CRC through high-throughput screening.

17 al nervous system disease while facilitating high-throughput screening.

18 vel SUCNR1 antagonist scaffold discovered by high-throughput screening.

19 most active MOF materials using a validated high-throughput screening.

20 diesterase 2A (PDE2A) inhibitor arising from high-throughput screening.

21 sted drug design, virtual drug screening and high-throughput screening.

22 ed by quantum mechanical simulations virtual high-throughput screenings.

23 ts quantitative character and capability for high-throughput screening, (1)H nuclear magnetic resonan

24 We previously identified, by high-throughput screening, 4,8-dimethylcoumarin inhibito

25 to monitor both sGC and PDE activities using high throughput screening adoptable method.

26 d these two optimized assays by quantitative high-throughput screening against the National Center fo

27 We previously identified, by high-throughput screening, aminophenyl-1,3,5-triazine CF

28 ased functional genomics method to perform a high throughput screening and identified TMEM43/LUMA as

29 ng application of the pipeline for automated high-throughput screening and chemotyping marijuana and

30 port, a two-stage pipeline was developed for high-throughput screening and chemotyping the spectra fr

31 A prevalent observation in high-throughput screening and drug discovery programs is

32 High-throughput screening and fragment-screening campaig

33 High-throughput screening and gene signature analyses fr

34 which we posit embodies the benefits of both high-throughput screening and high-resolution microscopy

35 High-throughput screening and lab-scale optimization wer

36 r desorption, for applications in areas like high-throughput screening and MS imaging.

37 optimized CBS workflow allows for rapid and high-throughput screening and quantitation of 105 veteri

38 Enzymes are common targets in high-throughput screening and related campaigns.

39 Microfluidic droplet sorting enables the high-throughput screening and selection of water-in-oil

40 he discovery of a new class of inhibitors by high-throughput screening and show how the difficulties

41 tent and selective ERK5 inhibitor BAY-885 by high-throughput screening and subsequent structure-based

42 n-cGAS-specific small-molecule inhibitors by high-throughput screening and the targeted medicinal che

43 straightforward enzymatic assay suitable for high-throughput screening and we identified inhibitors w

44 steric inhibitor of Akt through a FRET-based high-throughput screening, and characterization of its i

45 rter gene are useful for genetic selections, high-throughput screening, and multiplexing with omics t

46 zoisoquinolinedione series was identified by high-throughput screening, and subsequent structure-acti

47 ure range, paving the way toward T-dependent high-throughput screening applications by HDX-MS.

48 ecular probes is increasingly attractive for high-throughput screening applications including streaml

49 er of seconds, opening up the possibility of high-throughput screening applications of relevance to t

50 es (e.g., water quality, urine analysis), or high-throughput screening applications.

51 s shown great potential for various types of high-throughput screening applications.

52 We recently devised a chemogenetic high-throughput screening approach ("HiTES") to discover

53 A high-throughput screening approach for simultaneous anal

54 In this study, we applied a high-throughput screening approach to identify the diver

55 l-derived endothelial cells (iPSC-ECs) and a high-throughput screening approach were used to assess e

56 Second, we provide an overview of high-throughput screening approaches to identify SMIRNAs

57 A complexes have been identified by applying high-throughput screening approaches.

58 rehensive drug discovery techniques allowing high-throughput screening are now required to develop ef

59 Active variants identified by high-throughput screening are thus inherently likely to

60 itors developed by either rational design or high-throughput screening as antibiotics and anti-parasi

61 ecules beginning to emerge from high-content/high-throughput screening as well as the biochemical and

62 This high throughput screening assay quantitates IFNgamma rel

63 , the development of a cell-based, medium to high throughput screening assay that is capable of monit

64 opment of a fluorescence polarization-based, high-throughput screening assay (FP-tag) for beta-Kdo gl

65 We first developed a spectrophotometric high-throughput screening assay based on 1-methylindole

66 ases is hampered by the lack of a convenient high-throughput screening assay for the detection of mul

67 developed a two-step, microtiter plate-based high-throughput screening assay that allows quantificati

68 Using a FRET-based high-throughput screening assay that we previously repor

69 a miniaturized, automated AlphaScreen ultra-high-throughput screening assay to identify inhibitors t

70 We established a cell-free high-throughput screening assay to search for small mole

71 We have developed a high-throughput screening assay, based on the autoubiqui

72 We therefore devised a high-throughput screening assay, screened a small-molecu

73 dimer contacts, by implementing a cell-based high-throughput screening assay.

74 H binding site using an ADP-TAMRA probe in a high-throughput screening assay.

75 ntifying these mechanisms will help optimize high-throughput screening assays for molecules and mutat

76 with standard ELISA and multiplex DVD-array high-throughput screening assays, corroborating the viab

77 hodology specifically designed to complement high-throughput screening assays.

78 inetic parameters, as well as the results of high-throughput screening assays.

79 50) kinetic model fits, as well as hits from high-throughput screening assays.

80 tion, and has immense potential for fast and high-throughput screening bacterial chemotaxis.

81 tion, we prioritized candidate compounds via high-throughput screening based on reversal of green flu

82 F) play a vital role in genetic circuits and high-throughput screening because they transduce biochem

83 High throughput screening by fluorescence activated cell

84 Utilizing a high-throughput screening campaign and subsequent struct

85 From an original high-throughput screening campaign emerged hit 3 among o

86 We report on a high-throughput screening campaign performed on KDM1A/Co

87 studies, structural biology, and biochemical high throughput screening campaigns.

88 on all-optical electrophysiology, including high-throughput screening, cardiotoxicity testing and pe

89 viously required access to large and complex high-throughput screening centers ..." Read more in the

90 of false positives and false negatives under high-throughput screening conditions is particularly dif

91 itro assay data (including Tox21(TM)/ToxCast high-throughput screening data), and in silico model pre

92 With the increase in high-throughput screening data, scaffold graphs have pro

93 ed sensitivity and specificity, required for high throughput screening, diagnostics, and molecular bi

94 rrently available imaging approaches used in high-throughput screening drug discovery platforms, for

95 We also discuss high-throughput screening efforts that have led to the d

96 High-throughput screening efforts to discover inhibitors

97 ptimization of this assay and application to high-throughput screening enabled screening for inhibito

98 ethoxybenzyl) amine (ABMA) from a cell-based high throughput screening for its capacity to protect hu

99 mutagenesis of influenza virus with a rapid high-throughput screening for attenuation to generate W7

100 High-throughput screening for functional targets reveals

101 We apply SPARK2 to high-throughput screening for GPCR agonists and for the

102 a droplet microfluidics system that combines high-throughput screening for IgG activity, using fluore

103 temporal resolution and prospectively enable high-throughput screening for inhibitors of peptidoglyca

104 icrotiter plates and should prove useful for high-throughput screening for inhibitors of PSD enzymes

105 ctivity assays that can be easily applied to high-throughput screening for inhibitors of these enzyme

106 ed for characterization of HIV-1 latency and high-throughput screening for latency-reversing agents (

107 ht offer a potential alternative for massive high-throughput screening for NSCLC in clinical specimen

108 holds promise for the future development of high-throughput screening for plant phenotyping and the

109 ation of DSB-3-based fluorescent readouts in high-throughput screening for PSD inhibitors.

110 -well plates, making it readily adaptable to high-throughput screening for PSD inhibitors.

111 he VirD-GPCR array holds great potential for high-throughput screening for small molecule drugs, affi

112 stem that allows us to perform efficient and high-throughput screenings for ASOs.

113 bility to high-content microscopy in 96-well high-throughput screening format and validate its applic

114 High-throughput screening has revealed dark chemical mat

115 High-throughput screening has shown that Retro-1 inhibit

116 grows, targeted biochemical assays enabling high-throughput screening have become increasingly inter

117 Increasing the sp(3) character of high-throughput screening hit 40 afforded a novel morpho

118 we report the multifactorial optimization of high-throughput screening hit 8 to a potent, metabolical

119 ct NS5B palm site allosteric inhibitors, the high-throughput screening hit anthranilic acid 4, the kn

120 (1-octanoyl)phenyl]acetate (TMPA), and three high-throughput screening hit derivatives.

121 electivity problem was previously found in a high-throughput screening hit that binds in a nonconserv

122 A high-throughput screening hit was modified at three diff

123 Beginning with a high-throughput screening hit, we identified an imidazot

124 High throughput screening (HTS) assesses compound librar

125 Identification of a sulfoquinoline hit via high throughput screening (HTS) followed by optimization

126 High throughput screening (HTS) interrogates compound li

127 High throughput screening (HTS) is a vital automation te

128 the roadblocks related to scaling of iNs for high throughput screening (HTS)-ready assays.

129 ll culture, providing a robust phenotype for high throughput screening (HTS).

130 ail our efforts to identify FB inhibitors by high-throughput screening (HTS) and leveraging insights

131 Here, we validate a high-throughput screening (HTS) assay to discover potent

132 igand screening and separately by a chemical high-throughput screening (HTS) assay.

133 tes federal Tox21 research consortium in 971 high-throughput screening (HTS) assays whose targets wer

134 pectrometry (nESI-MS) has been developed for high-throughput screening (HTS) bioassays.

135 ism and pharmacokinetics (DMPK) analysis and high-throughput screening (HTS) campaigns, two stress te

136 1(st) century (Tox21) produces quantitative, high-throughput screening (HTS) data on thousands of che

137 o extrapolation (IVIVE) analyses translating high-throughput screening (HTS) data to human relevance

138 New sources of high-throughput screening (HTS) data, such as the ToxCas

139 Large high-throughput screening (HTS) efforts are widely used

140 High-throughput screening (HTS) has enabled millions of

141 Initial optimization of high-throughput screening (HTS) hit 1 led to the identif

142 Starting from a high-throughput screening (HTS) hit of our corporate com

143 These were derived from a phenotypic high-throughput screening (HTS) hit with suboptimal phys

144 rtual screening and re-mining of biochemical high-throughput screening (HTS) hits led to the discover

145 ure-property relationships around one of the high-throughput screening (HTS) hits, N(2)-(thiophen-3-y

146 This need is being addressed using high-throughput screening (HTS) in vitro approaches and

147 In this study, we utilized high-throughput screening (HTS) in vitro data of PAHs to

148 Developing effective high-throughput screening (HTS) methods is of paramount

149 rgently required, however current cell-based high-throughput screening (HTS) models to identify molec

150 We then conducted a high-throughput screening (HTS) of 267 FDA-approved comp

151 eporter assay, we undertook a small-molecule high-throughput screening (HTS) of 68, 979 compounds and

152 High-throughput screening (HTS) of 997 locked nucleic ac

153 We performed high-throughput screening (HTS) of a chemical library to

154 = 0.50) of a cell-based functional assay for high-throughput screening (HTS) of autoprocessing inhibi

155 um throughput, which reduces suitability for high-throughput screening (HTS) of PPI inhibitors.

156 Utilizing high-throughput screening (HTS) of the T cell receptor (

157 In this study, a high-throughput screening (HTS) platform integrating opt

158 High-throughput screening (HTS) research programs for dr

159 High-throughput screening (HTS) technologies have greatl

160 In parallel, high-throughput screening (HTS) was conducted using the

161 es of ATX inhibitors was identified out of a high-throughput screening (HTS).

162 novel compounds isolated by whole-cell-based high-throughput screening (HTS).

163 e assessment is predictive of the success of high-throughput screening (HTS).

164 [1,2,4]triazol-3-yl)thio)acetamide 1 through high-throughput screening (HTS).

165 virus-host interactions and for using IAV in high-throughput screenings (HTS) to identify novel antiv

166 aminopeptidase activity in vitro (including high-throughput screening [HTS]), in vivo, and ex vivo,

167 High throughput screening identified chymostatins, bacte

168 A FRET-based high throughput screening identified NSC622608 as the fi

169 Phosphoproteomics and high throughput screening identified phosphorylation sit

170 High-throughput screening identified anthracyclines incl

171 High-throughput screening identified Antimycin A as a sm

172 High-throughput screening identified doxorubicin (DXR) a

173 Here, the authors, through a high-throughput screening, identify HSP90 inhibitors as

174 certain small chemical compounds selected by high-throughput screening in Chlamydomonas reinhardtii c

175 d and parallelized, it can be considered for high-throughput screening in metabolic engineering.

176 tandard multiwell plates, enables its use in high throughput screening, in contrast to microfluidic c

177 Here we combine high-throughput screening, intracellular accumulation as

178 High-throughput screening led to a new class of P2X4 inh

179 f GPR84 antagonist hit 1, identified through high-throughput screening, led to the identification of

180 escence spectroscopy could offer a rapid and high-throughput screening method for identification of L

181 sis, described herein, provides an optimized high-throughput screening method for other binary or ter

182 We report a high-throughput screening method that allows diverse gen

183 Here, we establish a simple, high-throughput screening method to identify optimal det

184 s being considered for large-scale use, this high-throughput screening method will facilitate rapid s

185 ials with high entropy can be designed via a high-throughput screening method.

186 Modern high-throughput screening methods allow researchers to g

187 pid drug discovery, flexible, sensitive, and high-throughput screening methods are required.

188 High-throughput screening methods for fatty acid (FA) de

189 In this study, using a cell-based high-throughput screening model representing Runt-relate

190 thiazolidine-2,4-dione, was obtained from a high throughput screening of 40000 compounds against KGA

191 mized a FRET sensor which can be adapted for high throughput screening of either in vitro or intracel

192 We use high throughput screening of large libraries of material

193 This study provides a unique platform for high throughput screening of natural products for specif

194 iques of both bacterial and host factors and high throughput screening of novel therapeutics becoming

195 new approach offers key advantages including high throughput screening of reaction conditions, better

196 ection with droplet microfluidics to achieve high throughput screening of yeast strains engineered fo

197 Altogether, our workflow is suitable for high-throughput screening of >1000 samples per day using

198 We combined siRNA high-throughput screening of >20,000 genes with a multic

199 for detection, and (iii) its suitability for high-throughput screening of (RGD-)peptide libraries.

200 High-throughput screening of a chemical library yielded

201 uantitative sensing technology allowed for a high-throughput screening of a panel of polymer carriers

202 ate multiple TLRs, we performed a cell-based high-throughput screening of a small-molecule library ba

203 s the basis of an effective platform for the high-throughput screening of anti-cancer drugs in 3D tum

204 One of the promising approaches for high-throughput screening of cell mechanotype is microfl

205 High-throughput screening of cell-secreted proteins is e

206 creening protocol comprises four phases: (1) high-throughput screening of chemical compounds in cell

207 nteraction at the level of their DRBDs using high-throughput screening of chemical libraries by homog

208 -chip selection of functional nucleic acids, high-throughput screening of chemical libraries for drug

209 High-throughput screening of compound libraries against

210 d-shifted fluorophores that are suitable for high-throughput screening of compound libraries.

211 HOPS is a versatile tool for high-throughput screening of DNA from archaeological mat

212 This method is fast and is scalable for high-throughput screening of drugs targeting protein-pro

213 omplexes opens up the possibility to perform high-throughput screening of G-quadruplex ligands for th

214 he CRISPR/Ca9s system is also being used for high-throughput screening of genes, gene regulatory regi

215 inant HCMV was used as a reporter system for high-throughput screening of HCMV inhibitors.

216 nd leads to reproducible results that enable high-throughput screening of heterogeneous soil samples.

217 nt of the antiarrhythmic drug mexiletine via high-throughput screening of hiPSC-CMs derived from pati

218 scribe the state-of-the-art methods used for high-throughput screening of large datasets to identify

219 hanges in GTP levels in living cells and for high-throughput screening of molecules that modulate GTP

220 High-throughput screening of natural product extract and

221 n provide a valuable analytical tool for the high-throughput screening of nutrients and gut microbial

222 here, named qHRP2/3-del, is well suited for high-throughput screening of P. falciparum isolates to i

223 tional design of delivery vectors and enable high-throughput screening of peptides and other function

224 udy demonstrates the utility of LAESI-MS for high-throughput screening of plant phenotypes.

225 The former method is convenient for high-throughput screening of potential GLUT5 inhibitors

226 ssembly of structurally sorted nanotubes and high-throughput screening of properties that are control

227 atory element screening (CERES) for improved high-throughput screening of regulatory element activity

228 We searched for new agents by high-throughput screening of selected targeted compounds

229 This enables high-throughput screening of several functionalities in

230 time of the functional analysis step enables high-throughput screening of shRNA or CRISPR-Cas9 constr

231 te towards routine application of cryo-EM in high-throughput screening of small molecule modulators a

232 udies of the biochemistry of RBR E3s and for high-throughput screening of small-molecule activators o

233 utilized primary SSc patient lung cells for high-throughput screening of TGF-beta signaling via high

234 layer method may be generally applicable for high-throughput screening of the efficacy of cell-penetr

235 High-throughput screening of the host transcriptional re

236 represents a proof of concept for the use of high-throughput screening of the HSV-1 genome in investi

237 oducibility and validation of the system for high-throughput screening of therapeutic compounds.

238 Methods for rapid and high-throughput screening of transcription in vitro to e

239 rganization for fundamental studies, and for high-throughput screening of various biomolecules for st

240 high-throughput-screening of 997 LNA-MIR-inhibitors was

241 emand for faster, yet accurate assays (e.g., high-throughput screening) of proteins.

242 mal tubular epithelial cells, we performed a high-throughput screening on the basis of an in-cell ELI

243 Utilization of a quantitative high-throughput screening paradigm facilitated hit ident

244 the way to the development of an automated, high-throughput screening pipeline to identify modulator

245 We used a genetically encoded high throughput screening platform to screen a SICLOPPS

246 product libraries will require the use of a high throughput screening platform.

247 We previously applied a phenotypic high-throughput screening platform based on an infectiou

248 Furthermore, we have established a high-throughput screening platform for discovering GR-mo

249 Overall, zebrafish is expected to serve as a high-throughput screening platform for nanotoxicity and

250 These observations prompted us to develop a high-throughput screening platform of cancer drugs in a

251 Our high-throughput screening platform paves the way for ide

252 This study highlights SHG as a high-throughput screening platform that reveals structur

253 We envision this high-throughput screening platform to expand upon the ro

254 human myelin diseases and the development of high-throughput screening platforms for drug discovery.

255 High-throughput screening platforms for the identificati

256 arget information, and predicts a compound's high throughput screening promiscuity, to a higher degre

257 We sought to optimize a high throughput screening protocol to facilitate this ef

258 In this work, a high-throughput screening protocol is presented for the

259 f rabies PEP, we developed and implemented a high-throughput screening protocol utilizing a single-cy

260 High-throughput screening provided the initial hits.

261 Such fast methods can be very useful for high-throughput screening purposes in biopharmaceutical

262 Using a high-throughput screening Raman spectroscope (HTS-RS), R

263 f electrochemical methods for the purpose of high-throughput screening remains very limited.

264 High-throughput screening resulted in the identification

265 High-throughput screening revealed a new Pd catalyst sys

266 High-throughput-screening revealed that MIR1249-inhibiti

267 of this method through in vitro studies and high-throughput screening, revealing CRISPR GUARD as a r

268 ility of AsCpf1, we developed a multiplexed, high-throughput screening strategy that minimizes librar

269 We have developed a high-throughput screening strategy to identify potent an

270 We used a personalized high-throughput screening strategy to investigate whethe

271 gs and identification of novel inhibitors in high-throughput screening studies.

272 We describe a synthetic, high-throughput screening system to identify compounds t

273 es in genome sequencing, bioinformatics, and high-throughput screening techniques presents new opport

274 creased availability of 'omics' analyses and high-throughput screening technologies has enhanced our

275 Using a high-throughput screening technology (shotgun mutagenesi

276 aches is often time consuming, thus limiting high-throughput screening tests.

277 Here we used high-throughput screening to analyze 358 proteins and 76

278 report the development and application of a high-throughput screening to identify compounds that eit

279 We used high-throughput screening to identify convallatoxin as a

280 igned a robust binding assay compatible with high-throughput screening to identify molecules with low

281 as Sacchaomyces cerevisiae, which allow for high-throughput screening to patient-derived cell-lines

282 ate the potential of this culture system for high-throughput screening to prime and accelerate anti-P

283 s9 system, from efficient genome editing, to high-throughput screening, to recruitment of a range of

284 help fill the clinical need for a sensitive, high-throughput screening tool to aid public health effo

285 genetic level due to the lack of a suitable high-throughput screening tool.

286 -associated output profiles, particularly as high throughput screening tools for anti-inflammatory or

287 in vivo, and generating new developments in high-throughput screening used to identify functional ln

288 rapeutic effect of cisplatin, we conducted a high throughput screening using a kinase library contain

289 and selective CYP3A5 inhibitor identified by high-throughput screening using enzymatic and cell-based

290 Label-free high-throughput screening using mass spectrometry has th

291 ale double emulsion droplets compatible with high-throughput screening via fluorescence-activated cel

292 A luminescence assay adapted for high-throughput screening was used to measure inhibitory

293 Here, through cell-based high throughput screening we identified benzamide deriva

294 a combination of structure-based virtual and high-throughput screening, we assayed more than 10,000 c

295 notypic culture models and their utility for high-throughput screening, we hypothesized that multidim

296 By performing a high-throughput screening, we identified a myriad of miR

297 Through high-throughput screening, we previously identified seve

298 We show that our HTRF assay can be used for high-throughput screening, which will facilitate the dis

299 Using high-throughput screening with a targeted lipidomic anal

300 amino acids by optical methods adaptable to high-throughput screening with modern plate readers has